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Scopolamine-treated normal young human subjects exhibit memory dysfunctions analogous to those observed in demented patients. The dysfunctions are reversible by physostigmine but not by d-amphetamine which suggests that the memory impairment is specifically related to reduced cholinergic transmission caused by scopolamine. Scopolamine-induced amnesia has been proposed as a model for dementia where reduced cholinergic function is the suspected cause. We report seven experiments in young adult mice which examine scopolamine's effects on memory retention and whether its amnestic effects are specifically blocked by cholinergic agonists or cholinomimetics. Young adult mice were trained to avoid footshock in a T maze and their retention tested 1 week after training. Pretraining subcutaneous injection of scopolamine improved retention scores of "undertrained" mice at a dose of 0.01 mg/kg but impaired at a dose of 0.1 mg/kg. Post-training injection showed no effect at 0.01 mg/kg, enhanced retention scores at 0.1 mg/kg, and impaired at 1.0 mg/kg. The impairment by 1.0 mg/kg was blocked by injection 45 min post-training of each of two cholinergic drugs but was also counteracted by six drugs which act upon five other neural systems (catecholamine, serotonin, glycine, GABA, and hormonal). When scopolamine was injected 40 min pretraining, and each of eight drugs was injected immediately after training, the amnestic effect of scopolamine was only partially counteracted. This suggests that scopolamine impaired acquisition, in addition to some impairment of memory processing. This was confirmed by a direct study of acquisition rates of the avoidance response; 0.1 mg/kg of scopolamine impaired acquisition. The overall results indicate that pretraining administration of scopolamine impairs learning and to some degree memory processing. Counteracting scopolamine-induced amnesia, by either pretraining or post-training drug administration, is not specific to the cholinergic system. 相似文献
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Icek Ajzen Cornelia Czasch Michael G. Flood 《Journal of applied social psychology》2009,39(6):1356-1372
Implementation intentions are said to transfer control over goal‐directed behavior to situational cues, thereby automating initiation of the behavior ( Gollwitzer, 1999 ). Alternatively, implementation intentions may be effective because they create commitment to the intended behavior. In an empirical study, implementation intentions regarding a simple task (rating TV newscasts) varied in their specificity. In addition, explicit commitment to the task was manipulated, and chronic conscientiousness was assessed. Consistent with the commitment hypothesis, general and specific implementation intentions were equally effective in raising level of task performance, and they were no more effective than asking for an explicit commitment to carry out the task. Also, individuals high in conscientiousness were more likely than individuals low on this trait to enact their intentions. 相似文献
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One of the most pervasive beliefs about human way finding is that some people have a natural ability that distinguishes them from others. In this research, we asked children and adults to rate their own sense of direction, a promising index of orientation skills despite its simplicity and reliance on self‐assessment. Ratings were obtained before and after reversal of a newly learned outdoor route. Self‐ratings by children and adults before route reversal only weakly predicted two of a variety of measures of route and bearing knowledge. However, adults' ratings after the route reversal reflected performance on almost all of these same measures. In addition, route reversal performance was easily improved by instructing children and adults during route acquisition to look back in anticipation of the return. The pattern of results suggests that way finders' beliefs about their sense of direction are based on a recollection of the outcomes of the attentive and mnemonic strategies they use. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
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Sarah-Jane Cullinane Janine Bosak Patrick C. Flood Evangelia Demerouti 《European Journal of Work and Organizational Psychology》2017,26(4):541-554
The quality of working life under the production system known as lean manufacturing (LM) is a heavily debated topic. Little is known about the engagement level of employees under this system. Our study is concerned with how employees in this context craft their jobs to enhance their own engagement, and we specifically consider how daily skill utilization triggers this process. Using a cross-level perspective, we further consider whether job-level characteristics relevant to the lean context, namely task interdependence and boundary control, restrict or facilitate the effects of daily skill utilization. A daily diary study was conducted over 4 working days with 64 employees in a large company utilizing LM. The results of multilevel structural equation modelling demonstrated that on a given day, skill utilization was associated with seeking resources, and this relationship was stronger when employees had high boundary control and low task interdependence in their general job roles. Results further demonstrated that employees experienced higher work engagement on days when they sought resources and challenges. Our findings illustrate the motivational potential of job crafting under LM and how crafting activities can be facilitated by the design of jobs and allocation of daily tasks. 相似文献
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John Grimes Robin Rinehart Hillary Rodrigues John M Koller Elaine Craddock Ludo Rocher Will Sweetman Boyd H Wilson Edward C Dimock Thomas Forsthoefel Hal W French Timothy C Cahill William J Jackson John Powers Frederick M Smith Gavin Flood Lelah Dushkin Sheila McDonough Frank J Hoffman Karni Pal Bhati Anne E Monius Fred Dallmayr Marcia Hermansen Joseph A Bracken Carl Olson William P Harman Donatella Rossi Anna B Bigelow Jeffrey J. Kripal 《International Journal of Hindu Studies》1998,2(2):267-310
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Nitin Trasi Francis X. Clooney Maria Hibbets George Cronk Brian A. Hatcher Robin Rinehart Karen Pechilis Prentiss Hal W. French Francis X. Clooney Lisa Bellantoni Frank J. Korom Robert Menzies Constantina Rhodes Bailly Gavin Flood Rebecca J. Manring Loriliai Biernacki Brian K. Pennington John Grimes Richard D. MacPhail Glenn Wallis John J. Thatamanil John Grimes Thomas Forsthoefel Denise Cush Yasmin Saikia Joseph A. Bracken Lise F. Vail Jacqueline Suthren Hirst Judson B. Trapnell Ellison Banks Findly Paul Waldau D. L. Johnson John Grimes 《International Journal of Hindu Studies》2000,4(1):61-107
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The effect of a treatment package designed to reduce stereotypic body rocking was examined in a child diagnosed with autism. After baseline, the participant was taught to discriminate between inappropriate (e.g. sitting in a chair and rocking) and appropriate (e.g. sitting in a chair without rocking) behavior. During intervention, both a therapist and the participant himself monitored the occurrence of rocking behavior. A non‐resetting 5 min differential reinforcement of other behavior (DRO) schedule was also introduced. A multiple baseline across behaviors (sitting and standing) design was used to evaluate the effects of the intervention package. The results indicated that the intervention was effective in eliminating body rocking. In addition, the DRO schedule was successfully increased to 20 min for sitting and 17 min for standing and the treatment was successfully introduced at the child's school. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
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This study investigated the Minnesota Multiphasic Personality Inventory-Revised (MMPI-2; Butcher, Dahlstrom, Graham, Tellegen, & Kaemmer, 1989) and the Personality Assessment Inventory (PAI; Morey, 1991) with regard to each instrument's utility for discriminating post-traumatic stress disorder (PTSD) from depression and social phobia in a sample of college students with mixed civilian trauma exposure. Participants were 90 trauma-exposed undergraduates (16 male, 74 female) classified into one of four groups: PTSD, depressive disorders, social phobia, and well-adjusted. For both the PAI and the MMPI-2, profile analysis revealed that the groups differed in the elevation and shape of their profiles. The PAI Traumatic Stress subscale demonstrated good discriminant validity. 相似文献