A review of patient outcomes in pharmacological studies from the psychiatric literature, 1966–1993

A literature search was conducted on studies of new drugs used with patients with schizophrenia reported by U.S. and non-U.S. researchers from 1966–1993, yielding 41 U.S., and a total of 24 other non-U.S. studies, among them 11 British studies. Results of the U.S. and non-U.S. studies were pooled separately and compared. Among several comparable conditions discussed, the lack of any data on suicides in the U.S. studies was observed. For a second statistical analysis of suicide rates ‘person-years’ were calculated to adjust for differing washout durations. The results obtained include findings that the percentage of patients relapsing in U.S. studies was slightly lower (37.9%) than in non-U.S. studies (46%); the percentage of patients dropping out in U.S. studies (10.5%) was higher than in non-U.S. studies (7.6%); known location of dropout patients in U.S. studies was 1.7%, compared to 2.6% in non-U.S. studies. The most interesting finding was that no suicides were reported in U.S. studies, compared to 0.6% of patients reported in British studies. Some U.S. studies used ‘challenge doses’, such as amphetamines or L-dopa; no non-U.S. studies reported their use. Compared to U.S. studies, those by non-U.S., and particularly British, researchers appeared to report adverse events in their studies. ‘Challenge’ drugs were not used; suicides were reported. It is estimated that the probability that no patients suicided who participated in the U.S. is small—one in 500.     

The role of information technology in building public administration theory

Information technology, that assortment of technology that enables the conversion of data into information, has had an enormous impact on the field of public administration and its theoretical foundation. This article explores five of them. It begins with a discussion of one of the primary impacts of information technology on public administration theory: the development of systems theory and its descendants including the study of complex systems, chaos, and complexity theory. The importance of information technology in decision-making is explored next. Does information technology free us from the limits of bounded rationality or are we simply overwhelmed by the volume of information available via new sources, such as the Internet and the World Wide Web? The third role examined is the use of information technology as a research tool to make previously intractable problems solvable. Computer capability has enormously advanced the theoretical underpinnings of public administration. Fourth, the significance of information technology as a change agent that calls for revision of other theoretical postulates is investigated. As information technology has diffused into public organizations, how has it called into question what we previously thought about the foundation of bureaucracy? Finally, learning by doing and the manner through which practice informs theory is considered.     

LONGITUDINAL STUDY OF PROCRASTINATION, PERFORMANCE, STRESS, AND HEALTH:

Abstract— Procrastination is variously described as harmful, innocuous, or even benefical. Two longitudinal studies examined procrastination among students. Procrastinators reported lower stress and less illness than nonprocrastinators early in the semester, but they reported higher stress and more illness late in the term, and overall they were sicker. Procrastination thus appears to be a self-defeating behavior pattern marked by short-term benefits and long-term costs.     

Modifying Beliefs and Attitudes to Exceeding the Speed Limit: An Intervention Study Based on the Theory of Planned Behavior1

This study builds on previous theory of planned behavior (TPB) studies in which we identified the beliefs and values which predict intention to commit driving violations. Four short experimental videos were developed in order to assess the effectiveness of an intervention grounded in the TPB. Three of the videos featured the major constructs of the TPB model. The fourth video featured anticipated regret, an addition to the TPB model which had previously been shown to add significantly to its predictive performance (Parker, Manstead, & Stradling, 1995). Results indicated that two of the videos brought about statistically significant belief changes with respect to scores on TPB items, and significant changes in general attitudes toward speeding. Discussion centers on the problems encountered in operationalizing the TPB constructs and on the potential of theory-based interventions to induce attitude change.     

The influence of selective attention in peripheral and foveal vision

Previous research had indicated that there were differences in the kinds of stimulus information processed by concentrated and distributed attention in peripheral vision. Concentrated attention was necessary for perceiving line arrangement differences, while line slant differences could be detected with distributed attention. However, experiments with foveal presentation showed no facilitation by concentrating attention. Experiment I replicated these results. Experiment II showed that distributed attention did degrade foveal line arrangement discrimination if the attention system was overloaded by increasing the number of elements in the array. Experiment III demonstrated that high element density was not a sufficient condition for these effects to occur. Line arrangement discrimination was reduced as letter number increased even when maximum density was held constant. In Experim~ent IV, it was shown that concentrating attention facilitated line arrangement discrimination relative to line slant discrimination in foveal vision when element number and density were held constant. The results are discussed in terms of several models postulating a difference between spread-out and concentrated attention systems.     

Binocular depth discrimination depends on orientation

Using both the method of adjustment and forced-choice techniques, it was found that binocular depth thresholds depend on the orientation of the test targets, which in these experiments consisted of long, thin rods. Stereoacuity is greatest with vertical rods and decreases progressively as the angle of orientation approaches horizontal. The relationship between stereoacuity and orientation is governed by the orientation of the images of the targets on the retina, and is predicted fairly well by the sine of the angle of orientation, suggesting an equivalence between angular rotation and reductions in rod length.     

Social Anxiety Disorder and Perceived Criticism in Intimate Relationships: Comparisons With Normal and Clinical Control Groups

Individuals with social anxiety disorder (SAD) have difficulties in their romantic relationships, including decreased satisfaction and intimacy, but the reasons for these difficulties are poorly understood. Because fear of negative evaluation is a cardinal feature of SAD, perceived criticism from a romantic partner may play a central role in socially anxious individuals’ relationships. In the present study, we compared levels of perceived, expressed, and observed criticism and reactions to criticism among individuals with SAD and their partners (n = 21), individuals with other anxiety disorders and their partners (n = 35), and couples free of psychopathology (n = 30). Participants rated both global criticism and criticism during a 10-minute problem-solving task, which was also coded for criticism by observers. Individuals with anxiety disorders showed elevated levels of interaction-specific perceived criticism, expressed criticism, and upset and stress due to criticism relative to normal controls; they also reported that the interaction was more stressful. However, there were no group differences on global measures of criticism, and the two anxious groups did not differ on any measures. Findings suggest that the high levels of criticism anxious individuals perceive and their corresponding negative reactions to criticism, though not specific to SAD, may account for some of the relationship difficulties that have been identified in SAD. Results also indicate that anxious individuals may contribute to their relationship difficulties by being highly critical themselves. Overall, our findings point to the need for a clinical focus on decreasing perceived criticism among individuals with anxiety disorders.