Randomized controlled trial of an intervention to prevent adherence failure among HIV-infected patients initiating antiretroviral therapy.

OBJECTIVE: Compare the efficacy of a multicomponent social support intervention to standard-of-care counseling on medication adherence among HIV-infected patients initiating antiretroviral therapy. DESIGN: Randomized controlled trial. Generalized estimating equations tested for differences in the percentage of participants achieving 90% adherence. MAIN OUTCOME MEASURES: Pill-taking, electronically monitored over 6 consecutive months; plasma viral load (VL), assessed at 3 and 6 months following initiation of therapy. RESULTS: Of 226 participants who were randomized and began the trial, 87 (38%) were lost to the study by 6 months. The proportion of adherent participants declined steadily over time, with no time by group interaction. Sustained adherence was associated with increased odds of achieving an undetectable VL (OR=1.78; 95% CI=1.01, 3.13). In intention-to-treat analyses, a larger proportion of the intervention group than the control group was adherent (40.15% vs. 27.59%, p=.02) and achieved an undetectable VL p=.04). However, the majority of participants who remained on study experienced some reduction in VL (>or=1-log drop or undetectable), regardless of experimental condition. CONCLUSION: The multicomponent social support intervention significantly improved medication adherence over standard-of-care counseling; evidence for improved virologic outcomes was inconsistent. Early discontinuation of care and treatment may be a greater threat to the health of HIV patients than imperfect medication-taking.     

An inexpensive real-time microcomputer-based cognitive laboratory system

A computer system, based on the Radio Shack Color Computer, for running experiments in cognitive psychology is described. The system was designed according to the following principles: first, all of the equipment should consist of inexpensive, off-the-shelf components; second, the language used to implement experiments should have real-time commands embedded within the character strings to be displayed, and these real-time commands should be interpreted at run time; third, the system should serve multiple subjects, yet one host should be able to run display terminals for several subjects on independent experiments; and fourth, the system should be able to interface to other display devices and other response-recording devices. Two examples of other devices are discussed: an oscilloscope for rapid visual display and an Apple Macintosh for display of pictures.     

A model of visual spatio-temporal memory: The icon revisited

With a minimal set of assumptions resulting from considerations about the perception of temporal structure, we argue for the existence of a spatio-temporal memory established by the mapping of time into simultaneous physical properties. The important point of this model is the distinction between external, physical time and the internal representation of time. An immediate consequence of such a structure is the emergence of properties usually associated with the concept of iconic memory or informational persistence. Some of these properties may hence be regarded as epiphenomena produced by the testing of a spatio-temporal system with tachistoscopic spatial stimuli. The model can explain properties of the immediate memory span, the lack of effect of exposure duration on tachistoscopic report, the partial-report superiority, the decay of iconic memory, and effects of a backward mask. It does not only avoid the incompatibility problems of the frozen-image concept in dynamic vision, but also provides an adequate basis for the processing of time-varying scenes.     

Defeat and proficiencies

Virtue epistemology is the view that beliefs are attempts at truth (or perhaps knowledge) and, as a result, can be assessed as successful, competent, and apt. Moreover, virtue epistemology identifies central epistemic properties with normative properties of beliefs as attempts. In particular, knowledge is apt belief and justified belief is competent belief. This paper develops a systematic virtue epistemological account of defeat (of justification/competence). I provide reason to think that defeat occurs not only for beliefs but for attempts more general. The key constructive idea is that defeaters are evidence that attempting (in a certain way) isn't successful and that defeaters defeat the competence of an attempt when one stands in a certain normative relation to the defeater. I argue that while this account handles paradigm cases of defeat both within epistemology and beyond nicely, cases of external (sometimes also ‘normative’ or ‘propositional’) defeat continue to cause trouble. To handle these cases, I develop a distinctively functionalist version of virtue epistemology. This functionalist version of virtue epistemology allows me to countenance proficiencies, that is, roughly, abilities that have the function to produce successes under certain conditions. It is the normative import of proficiencies that delivers the normative relation that serves to explain defeat in cases of external defeat. In this way, the functionalist version of virtue epistemology ushers the way towards a satisfactory account even of external defeat.     

COVID-19, Sex,Addictions, Women's Health,Care of the Elderly,and Medical Education

Journal of Religion and Health -     

Subgroup differences in situational judgment test scores: Evidence from large applicant samples

To promote diversity in organizations it is important to have accurate knowledge about subgroup differences associated with selection procedures. However, current estimates of subgroup differences in situational judgment tests (SJTs) are overwhelmingly based on range‐restricted incumbent samples that are downwardly biased. This study provides much‐needed applicant level estimates of SJT subgroup differences (N = 37,530). As a key finding, Black‐White differences (d = 0.66) were higher than in incumbent samples (d = 0.38). Overall, sex differences were small. Females scored higher for management jobs (d = ?0.13) and males scored higher for administrative jobs (d = 0.15). By analyzing applicant samples that do not suffer from range restriction, this study adds knowledge about subgroup differences in SJTs.     

Priming of semantic classifications by novel subliminal prime words

Four experiments demonstrate category congruency priming by subliminal prime words that were never seen as targets in a valence-classification task (Experiments 1, 2, and 4) and a gender-classification task (Experiment 3). In Experiment 1, overlap in terms of word fragments of one or more letters between primes and targets of different valences was larger than between primes and targets of the same valence. In Experiments 2 and 3, the sets of prime words and target words were completely disjoint in terms of used letters. In Experiment 4, pictures served as targets. The observed subliminal priming effects for novel primes cannot be driven by partial analysis of primes at the word-fragment level; they suggest instead that primes were processed semantically as whole words contingent upon prime duration.     

How to make your own response boxes: A step-by-step guide for the construction of reliable and inexpensive parallel-port response pads from computer mice

Psychological research is based in large parts on response latencies, which are often registered by keypresses on a standard computer keyboard. Recording response latencies with a standard keyboard is problematic because keypresses are buffered within the keyboard hardware before they are signaled to the computer, adding error variance to the recorded latencies. This can be circumvented by using external response pads connected to the computer's parallel port. In this article, we describe how to build inexpensive, reliable, and easy-to-use response pads with six keys from two standard computer mice that can be connected to the PC's parallel port. We also address the problem of recording data from the parallel port with different software packages under Microsoft's Windows XP.     

Argumentational Integrity: A Training Program for Dealing with Unfair Argumentative Contributions

In this article we present a training program based on the empirical research conducted in the project 'argumentational integrity'. After a brief sketch of the problem dimensions concerning unfair argumentation we give an overview of the training concept and the underlying empirical research. Exemplification of the instructional design is given for the second and the fifth training dimension (standards of argumentational integrity and reactions to unfair contributions). Finally we indicate how the training is to be evaluated and present initial results demonstrating that in comparison with an untrained control group participants in the training significantly improve their skills in identifying and naming argumentative rule violations.