Automatic semantic priming with various category relations in Alzheimer's disease and normal aging.

The 6 experiments reported here tested the effects of various category relations on automatic semantic priming in 20 Alzheimer's disease (AD), 20 older control, and 22 younger control subjects. The tasks were either word pronunciation or lexical decision; the prime-target stimulus-onset asynchrony (SOA) was always 250 ms. A variety of category relationships between prime and target were examined: highly associated category comembers, subordinate-superordinate or superordinate-subordinate pairs, and pairs selected on the basis of category typically to form typical-typical, atypical-typical, typical-atypical, and atypical-atypical pairings. Both for AD versus older control subjects and for older versus younger control subjects, no significant group differences were found in the magnitude of overall semantic priming or in the effects on priming of factors pertaining to the prime-target relationship.     

Lexical and semantic fluency discrepancy scores in aMCI and early Alzheimer's disease

Episodic memory is compromised in amnestic mild cognitive impairment (aMCI), but lesser deficits in other cognitive domains are also commonly observed and may be helpful in identifying this group. The relative difference in performance on lexical and semantic fluency tasks may be a sensitive and specific measure in aMCI and early Alzheimer's disease (AD). We compared four groups of participants, 35 early AD, 47 aMCI, 24 healthy controls, and 18 depressive out‐patient controls, on semantic and lexical fluency as well as other neuropsychological tests. Early AD and aMCI patients showed a distinct pattern of semantic impairment in the two fluency measures compared with the healthy and depressive controls. The findings implicate early failure of the semantic memory system in aMCI and AD and suggest that consideration of the discrepancy in performance on semantic and lexical fluency measures may help in the early identification of AD.     

The deterioration of semantic memory in Alzheimer's disease.

Semantic memory impairment is a common feature of dementia of the Alzheimer type (DAT). Recent research has shown that patients with DAT are more impaired (relative to non-demented controls) in generating exemplars from a particular semantic category (e.g., animals) than words beginning with a particular letter, exhibit an altered temporal dynamic during the production of category exemplars, are impaired on confrontation naming tasks and make predominantly superordinate or semantically related errors, consistently misidentify the same objects across a variety of semantic tasks, and have alterations in multi-dimensional scaling models of their semantic network that are indicative of a loss of concepts and associations. These results are consistent with the view that Alzheimer's disease results in a breakdown in the organization and structure of semantic knowledge as neurodegeneration spreads to the association cortices that presumably store semantic representations.     

Picture priming in normal aging and Alzheimer's disease

The present study investigated age invariance for naming pictures and whether implicit memory is spared in Alzheimer's disease (AD). During the study phase, young adults, AD patients, and older controls were shown outlines of familiar pictures. After a distracter task, implicit memory was assessed incidentally. The results showed similar visual priming for the three groups, although young adults responded faster than the two older groups. Moreover, the number of errors was smaller for studied than for non-studied pictures. This pattern of results was repeated across the three groups, although AD patients produced more errors than young adults and older controls, and there were no differences between these latter groups. These results confirmed previous visual and haptic findings showing unimpaired perceptual priming in normal aging and AD patients when implicit memory is assessed using identification tasks. These results are interpreted from a cognitive neuroscience perspective.     

Preserved organization of semantic attributes in Alzheimer's disease

This study investigated whether Alzheimer's disease (AD) disrupts the basic organization of the semantic attributes of concepts. Young and normal older subjects and AD patients were presented with a target concept followed by a stimulus word and were to decide whether the stimulus was related to the target. On those trials where it was, the stimulus was either a high-, medium-, or low-dominance attribute of the target. The higher the normative dominance, the more important the attribute to concept meaning. In all 3 subject groups, decision time varied as a function of dominance. The higher the dominance, the faster the decision. Attribute dominance affected the performance of AD patients more than that of normal subjects. These results suggest that AD patients retain their knowledge of the relative importance that the different attributes of a concept have for concept meaning.     

Semantic priming from letter-searched primes occurs for low- but not high-frequency targets: automatic semantic access may not be a myth

Letter-search (LS) within a prime often eliminates semantic priming. In 2 lexical decision experiments, the authors found that priming from LS primes occurred for low-frequency (LF) but not high-frequency (HF) targets whether the target's word frequency was manipulated between or within participants and whether the prime-target pairs were associated symmetrically or forward asymmetrically. For the LF targets, LS priming was (a) equivalent for forward asymmetric and symmetric pairs and (b) equal to silent-read (SR) priming for forward asymmetric pairs but less than SR priming for symmetric pairs. The typical finding of greater SR priming for response times for LF than for HF targets occurred for symmetric priming but not for forward asymmetric priming, which showed the interaction for errors. The authors consider their findings' implications for various accounts of how LS affects priming and explain the findings within J. H. Neely and D. E. Keefe's (1989) 3-process model as follows: (a) LS eliminates expectancy and semantic matching but does not reduce semantic activation and (b) expectancy contributes to SR priming for HF targets but not for LF targets, whereas the opposite is so for semantic matching.     

Priming and semantic memory loss in Alzheimer's disease

Semantic memory (SM) was investigated in six patients with probable Alzheimer's disease (AD) by on-line measurement of semantic priming in a lexical decision task, and off-line tests of comprehension. Detailed assessment was carried out on naming, name comprehension, and probes of semantic knowledge with a battery of 150 items. The patients performed normally on perceptual tests and displayed an item-specific loss of knowledge on the semantic tests. In a primed lexical decision task, greater semantic priming was found relative to age-matched normals. The priming was substantially greater for items with "degraded" representations as determined by the off-line tests. Lexical decision was also performed more slowly on these items. These unexpected results demand a reevaluation of the concepts of the lexicon and semantic memory structure and their possible alteration in dementia.     

Episodic and semantic memory in early versus late onset Alzheimer's disease.

The aim of this study was to replicate and extend previous work demonstrating selective impairment of semantic, but not episodic, memory in late versus early onset Alzheimer's disease (AD). Measures of episodic and semantic memory were administered to 12 pairs of patients; early (less than or equal to 62) and late (greater than or equal to 68) onset pairs were matched on dementia severity and education. As hypothesized, the groups did not differ on the three episodic memory measures but did on two of three semantic memory measures. In conjunction with prior research, these findings indicate that late onset AD is characterized by more profound impairment on measures of semantic processing.     

The attribute priming effect in patients with Alzheimer's disease

Experiments with semantic priming (SP) paradigms have documented early hypopriming in patients with AD when concepts are used as primes and attribute concept features as targets, suggesting that concept attributes are vulnerable to damage very early in the disease course. The aims of this study were to confirm early priming reduction in the attribute condition in patients with AD and to determine which of several semantic indexes (such as the level of distinctiveness, correlation or feature dominance of concept features) best predicts the priming effect size in AD. We administered an SP attribute condition paradigm to 20 mildly demented patients with AD and to 10 NCs. We used concept–attribute pairs for which normative data of semantic indexes relative to both concept primes (i.e., number, type, mean level of dominance, distinctiveness and correlation of features constituting the concepts) and target features (i.e., level of feature dominance, correlation and distinctiveness) were available. Results showed that compared to NCs, the AD group obtained very reduced priming facilitation. Furthermore, the item regression analyses showed that the priming decrement in the AD group was predicted by the feature dominance of the target in the related pairs; that is, the lower the target feature dominance, the lower the priming effect elicited. These results confirmed hypopriming in the attribute condition from the very early phase of AD and support the view that attributes which are more salient for the identification of a given concept are also those most resistant to semantic memory degradation in AD pathology.     

Letter search does not affect semantic priming in a probe naming task

The normally robust semantic priming effect observed in lexical decision is usually reduced to the point of being absent, when a letter search has to be performed on the prime. It has been argued that semantic activation is thus not an automatic process but rather cognitively controlled and therefore adaptable to task demands. We examined the effects of letter search priming on pronunciation times and found a reliable semantic priming effect, following letter search that was not affected at all relative to a standard condition, where participants silently read the prime. Thus the nature of the prime task did not seem to affect the processing mode employed, semantic access occurred even though attention was focused on surface properties of the prime.     

Alzheimer's disease disrupts arithmetic fact retrieval processes but not arithmetic strategy selection

Three groups of healthy younger adults, healthy older adults, and probable AD patients, performed an addition/number comparison task. They compared 128 couples of additions and numbers (e.g., 4 + 9 15) and had to identify the largest item for each problem by pressing one of two buttons located under each item. Manipulations of problem characteristics (i.e., problem difficulty and splits between correct sums and proposed numbers) enabled us to examine strategy selection and specific arithmetic fact retrieval processes. Results showed that arithmetic facts retrieval processes, which were spared with aging, were impaired in AD patients. However, AD patients were able to switch between strategies across trials according to problem characteristics as well as healthy older adults, and less systematically than healthy younger adults. We discuss implications of these findings for further understanding AD-related differences in arithmetic in particular, and problem solving in general.     

Parafoveal information is not sufficient to produce semantic or visual priming

Marcel (1978) has shown that semantic priming can occur in the lexical-decision task even if the prime is masked to the point at which its presence cannot be detected. The purpose of the present experiments was to determine if primes that begin four or five spaces to the right of fixation can also produce semantic facilitation even though they are very difficult to recognize. Experiment 1 showed that facilitation did occur when the parafoveal primes used in the subsequent experiments were presented foveally. In Experiment 2, the primes were moved to the parafovea, but the task demands directed the subject’s attention toward the fovea. When subjects were ignoring the information presented to the parafovea (an allocation pattern that should correspond to that used during normal reading), neutral primes were just as effective as either semantically related or identical primes. In Experiment 3, the task demands were altered so that subjects were actively attending to the parafoveal primes. Although subjects were trying to process the primes, there was still no evidence that benefits could be derived from parafoveal primes. A final experiment showed that subjects given extensive practice with the materials will produce large amounts of identity and semantic priming. The results support the conclusion that readers can benefit little from the preprocessing of information in the parafovea unless that information can be supplemented with contextual expectations.     

Lexical priming from partial-word previews

Two naming and two lexical decision experiments examined the use of partial-word preview in visual word recognition. Replicating results of an earlier reading study, the results of Experiments 1 and 2 revealed significant benefits from position-specific beginning- and ending-letter previews. Furthermore, benefits from beginning letters were greater for words than for pseudowords. Ending-letter previews showed no corresponding lexical superiority. Experiment 3 revealed that preview of position-specific letters from the beginning plus the ending part of target stimuli, which did not reveal a unique word-beginning letter sequence, facilitated the classification of words but not pseudowords. The results support a two-route model of lexical access in which some partial-word previews afford activation of specific lexical representations, and some partial-word previews afford activation of subword representations.     

Pictorial priming and cued recall in Alzheimer's and Huntington's disease

A picture fragment test was used to compare the priming and cued recall performances of patients with Huntington's disease (HD), patients with dementia of the Alzheimer type (DAT), and neurologically intact normal control (NC) subjects. On the pictorial priming test, subjects were asked to say "the first thing you think of" when shown incompletely drawn pictures, half of which were previously exposed to the subject during an unrelated naming task. Normal controls and HD patients, but not DAT patients, demonstrated similar increases in their ability to identify fragmented versions of previously seen pictures relative to novel pictures. These results are consistent with the previously observed pattern of preserved and impaired verbal priming ability in HD and DAT patients, respectively. The NC subjects, as expected, also demonstrated better performance on the cued recall than on the priming version of the picture fragment test, whereas the HD patients evidenced the opposite relationship on these two tasks and DAT patients were found to be equally impaired on both tests. This finding provides further support for the notion that HD patients' memory impairment is characterized primarily by an inability to initiate systematic retrieval strategies.     

General slowing in semantic priming and word recognition.

Analyses of lexical decision studies revealed that (a) older (O) adults' mean semantic priming effect was 1.44 times that of younger (Y) adults, (b) regression lines describing the relations between older and younger adults' latencies in related (O = 1.54 Y-112 and unrelated conditions (O = 1.50 Y-93) were not significantly different, and (c) that there was a proportional relation between older and younger adults' priming effects (O = 1.48 Y-2). Analyses of word-naming studies yielded similar results. Analyses of delayed pronunciation data (Balota & Duchek, 1988) revealed that word recognition was 1.47 times slower in older adults, whereas older adults' output processes were only 1.26 times slower. Overall, analyses of whole latencies and durations of component processes provide converging evidence for a general slowing factor of approximately 1.5 for lexical information processing.     

The role of short-term memory in semantic priming.

Two theories of priming were compared: spreading activation theories, in particular ACT, and compound-cue theories. Whereas ACT assumes that priming is a result of diffusing activation in long-term memory, compound-cue models suggest that priming results from a formation process of prime and target in short-term memory. Thirty-eight participants took part in a study that combined a digit span task with a double lexical decision task consisting of a prime and a target item. Digit span length (low, medium, and high) and prime type (related or unrelated word or nonword) were both within-subject variables. As expected, results showed significant priming effects. In favor of ACT, no interaction between digit span length and prime type was found. Additionally, a nonword inhibition effect (unrelated versus nonword prime) was found, which was predicted by compound-cue theories. This finding is discussed in terms of the process interference and response competition hypotheses.     

Behavioral and electrical brain measures of semantic priming in patients with Alzheimer's disease: implications for access failure versus deterioration hypotheses

This study investigated the nature of anomia and semantic memory deficits in patients with Alzheimer's disease (DAT). We measured reaction time (RT) and the N400 event-related brain potential (ERP) in a word-picture semantic priming paradigm for DAT patients and elderly controls. For patients, pictures were classified as a function of the individual's naming ability to determine whether naming deficits reflected a failure to access a picture's name or reflected a deterioration of its semantic representation. As expected, DAT patients had significantly poorer naming performance than controls. For successfully named pictures, robust RT and ERP priming effects were obtained in both groups. In DAT patients, priming for unnamed pictures was heterogeneous. The results are discussed in terms of current hypotheses of semantic memory deficits in DAT.     

Preserved word-stem-completion priming of semantically encoded information in Alzheimer's disease

Alzheimer's disease (AD) patients and normal elderly control subjects completed 80 standardized sentence frames with single words, yielding a measure of semantic memory. Memory for best fit sentence endings was then tested either explicitly, with a forced-choice recognition task, or implicitly, with a word-stem-completion task. The patients completed fewer sentences with best fit word endings than did the control subjects. Explicit retention was markedly defective in the AD group, but word-stem completion was normal. The preserved word-stem completion in AD is discussed in terms of encoding operations and transfer-appropriate processing.