A low-cost spatial contrast sensitivity display driver

The circuit described here can provide the line and frame signals to drive anx, y display scope or oscilloscope at high resolution (1,000 lines) and repetition rate (50 Hz). Synchronizing circuitry at the input of the circuit allows the raster scan to be locked to an input signal, such as the square-wave output from a function generator, while another waveform from the same function genera-tor, the sine output, drives the z (intensity) input of the display scope. A stable spatial contrast display results. Spatial contrast depth is a direct function of z input modulation voltage. Spatial frequency is a direct function of the function generator frequency. The circuit can be used with a programmable function generator under computer control.     

A low-cost high-speed digital data acquisition and display system

A flexible and inexpensive data acquisition and display system based upon the KIM-1 microcomputer module is described. A simple signal-conditioning circuit and program are shown that will allow events to be counted at rates to 1,000/sec and stored in successive time bins. The program counts events from each of two event detectors and stores the count of each detector in an independent set of time bins. Up to 127 16-bit bins are available to each event detector and bin width can be varied from 1 msec to 1 min. A separate input can be used to time-lock data collection to a specific stimulus allowing poststimulus histograms or IRTs to be collected. The collected data can be sequentially displayed as a decimal number on a built-in LED display and stored for later analysis on an inexpensive audio cassette recorder.     

An apparatus for apparent conditioning ofOctopus cyaneus Gray

An ann-out-of-water response was conditioned as an operant inOctopus cyaneus Gray. The response was limited to a vertical tube, 2.54 em i.d, Photoresistive sensors, illuminated with modulated light arranged around the tube above the waterline, detect the presence of an opaque object in the tube. The signal from this response detector is amplified and used to initiate a commercial motor-driven universal feeder according to the reinforcement schedule maintained by the logic control circuit. A sample cumulative record for perfonnance on a CRF schedule is given.     

An eight-channel computer-controlled scanning electromyograph

A measurement system is described for the computerized detection, digitizing, and storage of electromyographic (EMG) signals from up to eight muscle groups. The use of a channel scanning technique allows almost simultaneous multichannel recording with minimal circuit redundancy. Specifically, the scanning electromyograph allows several EMG preamplifiers to share expensive isolation, signal-conditioning, and interface circuitry. The design incorporates monolithic integrated circuit preamplifiers and includes optical isolation of the preamplifier circuitry for protection of the subject. Hybrid active filter modules allow convenient selection of system bandpass characteristics. Key measurement parameters are software programmable. The scanning electromyograph is inexpensively constructed from readily available componentry. Specifications for all functional blocks within the instrument are comparable to those of commercial instrumentation.     

An inexpensive infrared detector to verify the delivery of food pellets

The reproducibility of experimental outcomes depends on consistent control of independent variables. In food-maintained operant performance, it is of utmost importance that the quantity of food delivered is reliable. To that end, some commercial food pellet dispensers have add-on attachments to sense the delivery of pellets. Not all companies, however, offer such add-ons. Aside from availability, cost and temporary reduction in throughput may be a problem for smaller labs. The present paper outlines our recent development of a simple, inexpensive infrared device to detect and confirm the delivery of pellets. The in-line construction of the detector routes the falling pellet through a barrel so that it passes between an infrared emitter and receiver. The circuitry was designed to be compatible with all commercially available behavioral measurement systems, and so may be retrofit to any existing system. Our tests with the detector so far have shown that it is 100% accurate in detecting pellet delivery. The individual unit cost is approximately 25 dollars. The low cost and versatility of the device offer an easy method to ensure the integrity of food delivery in operant settings.     

Learning and generalization on asynchrony and order tasks at sound offset: implications for underlying neural circuitry

Normal auditory perception relies on accurate judgments about the temporal relationships between sounds. Previously, we used a perceptual-learning paradigm to investigate the neural substrates of two such relative-timing judgments made at sound onset: detecting stimulus asynchrony and discriminating stimulus order. Here, we conducted parallel experiments at sound offset. Human adults practiced approximately 1 h/d for 6-8 d on either asynchrony detection or order discrimination at sound offset with tones at 0.25 and 4.0 kHz. As at sound onset, learning on order-offset discrimination did not generalize to the other task (asynchrony), an untrained temporal position (onset), or untrained frequency pairs, indicating that this training affected a quite specialized neural circuit. In contrast, learning on asynchrony-offset detection generalized to the other task (order) and temporal position (onset), though not to untrained frequency pairs, implying that the training on this condition influenced a less specialized, or more interdependent, circuit. Finally, the learning patterns induced by single-session exposure to asynchrony and order tasks differed depending on whether these tasks were performed primarily at sound onset or offset, suggesting that this exposure modified circuitry specialized to separately process relative-timing tasks at these two temporal positions. Overall, it appears that the neural processes underlying relative-timing judgments are malleable, and that the nature of the affected circuitry depends on the duration of exposure (multihour or single-session) and the parameters of the judgment(s) made during that exposure.     

Limbic hypertension induced by stress and septal stimulation

For this study, it was postulated that hypertension of emotional origin is generated within the limbic system. To validate this thesis, septal induced blood pressure elevations were combined with a stressful experience in adult rats (spontaneously hypertensive and Wistar Kyoto rats). Stress consisted of intermittent confinement in a plexiglass tube. The results revealed that hypertension induced by electric stimulation of the septum during the stressful state could subsequently be elicited by the stressful state alone, without electric stimulation of the septum. It was postulated that the cortically modulated stress circuit converged with the electrically activated limbic pressor circuit at the level of the septum. This convergence resulted in the formation of one cortico-limbic circuitry which could be activated by stress alone. This underlying mechanism may be considered as a model of neural sensitization in the production of stress-induced limbic hypertension.     

Insights for treatment in Tourette syndrome from fMRI

In a recent American Journal of Psychiatry article, Wang and colleagues used functional MRI (fMRI) to examine cortico-striatal-thalamo-cortical circuitry in Tourette syndrome (TS), advancing the field's investigation of circuit level dysfunction in vivo in individuals with TS. Their results provide insight for interrogating neural mechanisms underlying different treatment methods.     

Affective style, psychopathology, and resilience: brain mechanisms and plasticity

The brain circuitry underlying emotion includes several territories of the prefrontal cortex (PFC), the amygdala, hippocampus, anterior cingulate, and related structures. In general, the PFC represents emotion in the absence of immediately present incentives and thus plays a crucial role in the anticipation of the future affective consequences of action, as well as in the persistence of emotion following the offset of an elicitor. The functions of the other structures in this circuit are also considered. Individual differences in this circuitry are reviewed, with an emphasis on asymmetries within the PFC and activation of the amygdala as 2 key components of affective style. These individual differences are related to both behavioral and biological variables associated with affective style and emotion regulation. Plasticity in this circuitry and its implications for transforming emotion and cultivating positive affect and resilience are considered.     

A microcomputer-controlled solid-state dark adaptometer

A low-cost microprocessor-controlled light-emitting diode (LED) dark adaptometer is described. The apparent intensities of red and green stimuli are controlled by changing the duty cycles of LED display elements which are operated at constant pulse repetition rates. The psychophysical method of limits is used to obtain threshold data. Stimulus parameters and test procedures are under software control. The design utilizes programmable integrated circuitry that may be used with a variety of microprocessors.     

The Role of Cortico-Thalamo-Cortical Circuits in Language: Recurrent Circuits Revisited

Neuropsychology Review - Based on a review of recent literature, a recurrent circuit model describes how cortico-thalamo-cortical and cortico-cortical circuitry supports word retrieval,...     

A Constant-current AC shock generator

A device has been developed for the effective delivery of a preset constant current AC electric shock. The shock intensity is adjustable from zero to a maximum of 10 ma as the voltage varies between 0 to 5 kv. The 5-kv, 60-HZ, AC voltage insures a constant-current output regardless of skin contact resistance changes. Shock duration is internally controlled and a “fail safe” lockout circuit to render the apparatus inoperative is provided in case of accidental sticking or failure of control relay signals from either internal circuitry or from behavioral programming equipment.     

Capacitive sensors for detecting proximity and response

We have implemented an inexpensive circuit that indicates when a subject is in close proximity to a specified area of arbitrary shape and size. The circuit can transform an easily created metal surface or a preexisting metal object into an experimental sensor. The subject need not make physical contact with the sensor to activate the mechanism, which enables the detection of subjects through nonconductive materials, such as wood and plastics. The technology is readily adapted to existing experimental setups. Applications of this technology, using pigeons, rats, and mice, demonstrate its flexibility: a nose-poke/peck sensor for response or choice detection; a subject location detector that can be placed on a floor, wall, or ceiling; and a perch that detects when a bird is present. This technology can also be applied to the study of behavior in primates and many other animal species.     

A SIMPLE 2‐TRANSISTOR TOUCH OR LICK DETECTOR CIRCUIT

An easily constructed and inexpensive battery operated circuit is described for use as a lickometer or contact detector in behavioral studies with rodents.     

Transient sex differences during adolescence on auditory perceptual tasks

Many perceptual abilities differ between the sexes. Because these sex differences have been documented almost exclusively in adults, they have been attributed to sex‐specific neural circuitry that emerges during development and is maintained in the mature perceptual system. To investigate whether behavioral sex differences in perception can also have other origins, we compared performance between males and females ranging in age from 8 to 30 years on auditory temporal‐interval discrimination and tone‐in‐noise detection tasks on which there are no sex differences in adults. If sex differences in perception arise only from the establishment and subsequent maintenance of sex‐specific neural circuitry, there should be no sex differences during development on these tasks. In contrast, sex differences emerged in adolescence but resolved by adulthood on two of the six conditions, with signs of a similar pattern on a third condition. In each case, males reached mature performance earlier than females, resulting in a sex difference in the interim. These results suggest that sex differences in perception may arise from differences in the maturational timing of common circuitry used by both sexes. They also imply that sex differences in perceptual abilities may be more prevalent than previously thought based on adult data alone.     

A simple,inexpensive stimulus waveform generator

A simple circuit for a sine wave generator is described. The total cost for construction is approximately $30.00. At present, the unit is used to generate a sinusoidally modulated light stimulus for steady state visual evoked response experiments. Modifications of the circuit for other applications are discussed.     

Peripheral vision monitor: Presenting displays at known positions in the visual periphery

The peripheral vision monitor is an inexpensive device that ensures that visual stimuli can be successfully projected to a given extrafoveal location. The apparatus extinguishes the display lighting system when the observer attempts to view a region intended to be viewed only in peripheral vision, reinstating the illumination when that region is again in the peripheral field. This is achieved by focusing a small spot of light on the scleral-corneal boundary of the observer’s eye and detecting the reflected light with a photocell and circuit. Illumination changes produced at the photocell are used to trigger the display lighting.     

A delay timer for presenting auditory and visual probes

A circuit designed to present auditory or visual probes is described. The circuit allows the probes to be delayed by a specified amount of time, and the volume (for auditory probes) or intensity (for visual probes) may also be adjusted. The circuit may be triggered by any device capable of emitting an electronic pulse-such as a computer or a tachistoscope.     

Recalling safety: cooperative functions of the ventromedial prefrontal cortex and the hippocampus in extinction

Anxiety disorders are commonly treated with exposure-based therapies that rely on extinction of conditioned fear. Persistent fear and anxiety following exposure therapy could reflect a deficit in the recall of extinction learning. Animal models of fear learning have elucidated a neural circuit for extinction learning and recall that includes the amygdala, ventromedial prefrontal cortex (vmPFC), and hippocampus. Whereas the amygdala is important for extinction learning, the vmPFC is a site of neural plasticity that allows for the inhibition of fear during extinction recall. We suggest that the vmPFC receives convergent information from other brain regions, such as contextual information from the hippocampus, to determine the circumstances under which extinction or fear will be recalled. Imaging studies of human fear conditioning and extinction lend credence to this extinction network. Understanding the neural circuitry underlying extinction recall will lead to more effective therapies for disorders of fear and anxiety.     

A programmable circuit for varying light intensity

An inexpensive circuit is described for the control of light intensity. The control is obtained by a method that produces no color changes and may be programmed by any system that can express itself in four-digit binary numbers.