Neural correlates of rumination in adolescents with remitted major depressive disorder and healthy controls

The aim of the present study was to use fMRI to examine the neural correlates of engaging in rumination among a sample of remitted depressed adolescents, a population at high risk for future depressive relapse. A rumination induction task was used to assess differences in the patterns of neural activation during rumination versus a distraction condition among 26 adolescents in remission from major depressive disorder (rMDD) and in 15 healthy control adolescents. Self-report depression and rumination, as well as clinician-rated depression, were also assessed among all participants. All of the participants recruited regions in the default mode network (DMN), including the posterior cingulate cortex, medial prefrontal cortex, inferior parietal lobe, and medial temporal gyrus, during rumination. Increased activation in these regions during rumination was correlated with increased self-report rumination and symptoms of depression across all participants. Adolescents with rMDD also exhibited greater activation in regions involved in visual, somatosensory, and emotion processing than did healthy peers. The present findings suggest that during ruminative thought, adolescents with rMDD are characterized by increased recruitment of regions within the DMN and in areas involved in visual, somatosensory, and emotion processing.     

Ruminative Inertia,Emotion Regulation,and Depression: A Daily-Diary Study

Emotional suppression and cognitive reappraisal are emotion regulation strategies that have been linked to the severity of depression. Recent research has shown that greater ruminative inertia (i.e., rumination that is more resistant to change across time) is also associated with higher levels of depressive symptoms in clinical samples. However, it is unknown how tendencies to use suppression or reappraisal might be related to the inertia of rumination from day to day. After completing a baseline assessment of depressive symptoms and trait emotional suppression and cognitive reappraisal use, undergraduates (n = 94) completed daily-diary questionnaires assessing rumination for two weeks. Both higher depressive symptoms and greater tendencies to use suppression predicted stronger ruminative inertia, while tendencies to use reappraisal were unrelated to ruminative inertia. These results suggest that maladaptive emotion regulation strategies may contribute to a pattern of rumination that is more resistant to change over time. They also provide the first evidence that ruminative inertia is positively associated with depressive symptoms in a nonclinical sample.     

Perceived effects of other people’s emotion regulation on their vicarious emotional response

Across two studies, we investigated how friends’ typically used emotion regulation strategies (rumination or reappraisal) influence judgements about their vicarious emotions (sympathy, tenderness, and personal distress) when presented with a photograph of a suffering toddler. Results of both studies demonstrated that participants reporting on a ruminative friend indicated that their friend would feel greater personal distress and less tenderness and would perceive the toddler as experiencing more need and pain than participants reporting on a reappraising friend. These results are consistent with the behavioural trajectories associated with rumination and reappraisal, and are discussed in light of their implications for interpersonal emotion regulation.     

Specificity of parental bonding and rumination in depressive and anxious emotional distress

We examined how different dimensions of rumination may mediate the impact of parental bonding (lack of care and overprotectiveness) on negative emotional symptomatology (anxiety and depression). Survey data from participants were analyzed using structural equation modeling. Results indicated that brooding rumination fully mediated the relationship between maternal care and depressive and anxious symptomatology. These findings suggest that to the extent that maternal caregivers are low in warmth and support, offspring are more likely to develop a brooding style of ruminative thinking associated with heightened emotional distress. This research supports the growing body of evidence suggesting that cognitive variables form a pathway between troublesome parent/child interactions and psychopathology.     

Maternal Depression and Adolescent Emotions: The Role of Family Functioning

Maternal depression may affect children through various mechanisms, including the stressful contexts of the children’s lives and maternal maladaptive affection, behaviors, and cognition, which affect the psychopathological development of children and contribute to disorders. The aims of the present study were to explore how family functioning mediates the relationship between maternal depression and the positive and negative emotions of adolescents. A total of 430 paired questionnaires were collected from junior high school students and their mothers. The mothers completed the Center for Epidemiologic Studies Depression Scale (CESD), and the adolescents completed the CESD, Mood and Anxiety Symptom Questionnaire, and Family Function Scale. The results revealed significant correlations among maternal depression, family functioning, and positive and negative emotions in the adolescents. The family functioning subscales of conflict and emotional expression partially mediated the relationship between maternal depression and the positive and negative emotions of the adolescents. Furthermore, the family functioning subscales of cohesion, problem solving, and responsibility fully mediated the relationship between maternal depression and positive moods in the adolescents. Analysis of the results for maternal depression, family functioning, and the emotional adjustment of the adolescents indicated that family functioning is the mediator between maternal depression and the positive and negative emotions of the adolescents. The current results suggest that adequate family functioning can prevent depression being transmitted from mothers to their adolescent children.     

青少年孤独感与抑郁症状:反应风格的中介作用以及性别的调节作用

基于反应风格理论,本研究探索反应风格在青少年孤独感与抑郁症状之间的中介效应。使用孤独感量表、儿童反应风格量表以及儿童抑郁量表对 795 名 青少年进行调查。结果发现：（1）青少年孤独感能显著预测抑郁症状。（2）青少年孤独感能通过反刍、问题解决间接预测抑郁症状。（3）反应风格整体（比率分数）中介青少年孤独感与抑郁症状之间的关系。本研究结果显示,反应风格能够解释青少年孤独感与抑郁症状之间的内在机制。     

青少年孤独感与抑郁症状:反应风格的中介作用以及性别的调节作用

基于反应风格理论,本研究探索反应风格在青少年孤独感与抑郁症状之间的中介效应。使用孤独感量表、儿童反应风格量表以及儿童抑郁量表对 795 名 青少年进行调查。结果发现：（1）青少年孤独感能显著预测抑郁症状。（2）青少年孤独感能通过反刍、问题解决间接预测抑郁症状。（3）反应风格整体（比率分数）中介青少年孤独感与抑郁症状之间的关系。本研究结果显示,反应风格能够解释青少年孤独感与抑郁症状之间的内在机制。     

Cognitive inhibition in depression

Cognitive inhibition is a key mechanism in the regulation of emotion. There is emerging evidence that depression is characterized by deficits in the inhibition of mood-congruent material. These deficits could result in prolonged processing of negative, goal-irrelevant aspects of presented information thereby hindering recovery from negative mood and leading to the sustained negative affect that characterizes depressive episodes. Indeed, it has been suggested that deficits in cognitive inhibition lie at the heart of memory and attention biases in depression, and set the stage for ruminative responses to negative events and negative mood states. A ruminative response style results in a heightened vulnerability to experience episodes of major depression. Recent research has demonstrated that deficient inhibition of negative material is associated with heightened rumination. In this article, we review the depression literature with a focus on studies that investigate cognitive inhibition in depressed participants and in participants who report a history of major depressive episodes. In addition, we summarize neurobiological findings that indicate a strong relation between depression and deficits in inhibition and we take a closer look at the relation of inhibition, rumination and mood regulation.     

The Mediating Role of Rumination in the Relation Between Quality of Attachment Relations and Depressive Symptoms in Non-Clinical Adolescents

This study examined associations between indices of the quality of attachment relationships of adolescents with parents and peers, rumination, and symptoms of depression. More specifically, a mediation model was investigated in which rumination was hypothesized to mediate the relation between quality of attachment relations and symptoms of depression. A total of 455 high school students completed a battery of questionnaires, including quality of attachment relations, rumination, and depression. Results showed that most indices of quality of attachment relations were significantly associated with rumination and symptoms of depression. When examining the relative contribution of these variables in explaining variance in depression symptoms, trust in parents, communication with peers, and alienation from peers accounted for a significant portion of the variance in depression scores. Finally, the relation between communication with peers and depressive symptoms was fully mediated by rumination, whereas partial mediation was found for the relations between parental trust and depressive symptoms, and between alienation from peers and depressive symptoms. Implications of the findings may be that the treatment of depression in adolescence should consist of both cognitive interventions aimed at targeting ruminative thinking as well as a focus on interpersonal relationships of the adolescent with parents and peers.     

不同抑郁症状青少年日常情绪调节策略使用的差异

为了考察无抑郁、阈下抑郁和抑郁青少年日常情绪调节策略使用的差异,采用流调中心用抑郁量表和青少年日常情绪调节问卷测量了766名青少年的抑郁症状及其情绪调节策略使用。结果发现：青少年抑郁症状越多,使用认知重评越少,使用认知沉浸、表达抑制和表达宣泄越多。当调节积极情绪时,青少年抑郁症状越多,使用认知重评越少,使用认知沉浸和表达抑制越多,但使用表达宣泄无显著差异;当调节消极情绪时,青少年抑郁症状越多,使用认知重评越少,使用认知沉浸、表达抑制和表达宣泄越多。并且,阈下抑郁青少年的情绪调节策略使用均介于无抑郁和抑郁青少年之间。结果表明,青少年抑郁症状越多,使用认知重评等适应性情绪调节策略越少,使用认知沉浸等非适应性情绪调节策略越多,但具体情绪调节策略的使用可能会受所调节情绪效价的影响。同时,相比无抑郁和抑郁青少年,阈下抑郁青少年的情绪调节策略使用更具识别和干预的价值。     

Family and child influences on early academic and emotion regulatory behaviors

Research on child and family factors in early childhood has shown that both are associated with social and instrumental functioning at school entry. The present study sought to examine the direct and indirect effects of child negative emotionality, maternal education, depression, IQ, and quality of maternal instruction on children's academic and emotion regulatory behaviors from the toddler period to school entry using a sample of 174 boys from low-SES backgrounds. Results revealed direct effects of maternal IQ on academic outcomes at school entry that were mediated by maternal instruction. Further, maternal instruction predicted the child's academic and emotion regulation (ER) outcomes even after accounting for other maternal and child variables. The effects of both instruction variables moderated the impact of maternal education. The results suggest that maternal instruction plays an important role in early school success, particularly for children at risk for school problems.     

Ruminative and mindful self-focused processing modes and their impact on problem solving in dysphoric individuals

A mindful experiential rather than an analytical ruminative mode of information processing is beneficial in depression. However studies have not taken into account people’s trait mindfulness or trait rumination. This study aimed to examine the effects of state and trait analytical rumination and experiential mindfulness on affect and social problem solving (SPS). Participants filled in the trait mindfulness and trait rumination questionnaires. After mood induction, dysphoric participants with and without a history of depression were assessed for SPS and affect before and after induction of mindful (experiential) or ruminative (analytic) processing modes. Results showed trait mindfulness was negatively correlated with the BDI and trait rumination was positively correlated with the BDI. There was no significant difference between groups after the induced experiential mindful or analytical ruminative processing modes. However, participants who scored high on trait rumination showed significant improvement in SPS after induced mindfulness processing. No such effect was found on trait mindfulness. These findings suggest a useful way to prevent high trait ruminators from developing depressive symptoms or depression. Experiential mindful processing may help reduce the risk of developing depressive symptoms by increasing social problem solving ability in those with low mood and high levels of trait rumination.     

家庭压力源影响青少年抑郁体验:冗思的中介机制

采用方便抽样法从山东某初中和某高中抽取570名学生做问卷调查,考察家庭压力源对青少年抑郁体验的影响,特别是冗思作为应对方式的中介作用。路径分析的结果显示:(1)家庭冲突和父母期望均显著正向预测抑郁体验,且家庭冲突的预测作用更强,家庭规范对抑郁体验的预测作用不显著;(2)家庭冲突和父母期望均显著正向预测青少年冗思,家庭规范对冗思的预测作用不显著;(3)冗思显著正向预测抑郁体验;(4)冗思在家庭冲突与抑郁体验之间以及父母期望与抑郁体验之间均起中介作用。总体来看,冗思是家庭压力影响青少年抑郁体验的内部机制之一。     

Neural correlates of rumination in depression

Rumination, or recursive self-focused thinking, has important implications for understanding the development and maintenance of depressive episodes. Rumination is associated with the worsening of negative mood states, greater affective responding to negative material, and increased access to negative memories. The present study was designed to use fMRI to examine neural aspects of rumination in depressed and healthy control individuals. We used a rumination induction task to assess differences in patterns of neural activation during ruminative self-focus as compared with a concrete distraction condition and with a novel abstract distraction condition in 14 participants who were diagnosed with major depressive disorder and 14 healthy control participants. Depressed participants exhibited increased activation in the orbitofrontal cortex, subgenual anterior cingulate, and dorsolateral prefrontal cortex as compared with healthy controls during rumination versus concrete distraction. Neural activity during rumination versus abstract distraction was greater for depressed than for control participants in the amygdala, rostral anterior cingulate/medial prefrontal cortex, dorsolateral prefrontal cortex, posterior cingulate, and parahippocampus. These findings indicate that ruminative self-focus is associated with enhanced recruitment of limbic and medial and dorsolateral prefrontal regions in depression. Supplemental materials for this article may be downloaded from http://cabn.psychonomic-journals.org/content/supplemental.     

Gaze-fixation and pupil dilation in the processing of emotional faces: The role of rumination

Sustained attentional processing of negative information plays a significant role in the development and maintenance of depression. The present study examines the relationships between rumination, a relevant factor in information processing in depression, and the attentional mechanisms activated in individuals with different levels of depression severity when attending to emotional information (i.e., sad, angry and happy faces). Behavioural and physiological indicators of sustained processing were assessed in 126 participants (39 dysphoric and 87 non-dysphoric) using eye-tracking technology. Pupil dilation and total time attending to negative faces were correlated with a global ruminative style in the total sample once depression severity was controlled. Furthermore, in dysphoric participants the brooding component of rumination was specifically associated with the total time attending to sad faces. Finally, bootstrapping analyses showed that the relationships between global rumination and pupil diameter to emotional faces were accounted by total time attending to emotional faces, specifically for participants reporting lower levels of depression severity. The results support the idea that sustained processing of negative information is associated with a higher ruminative style and indicate differential associations between these factors at different levels of depressive symptomatology.     

Emotional Functioning in Children and Adolescents with Elevated Depressive Symptoms

Difficulties with emotion and its regulation are of central importance to the etiology and course of depression. The current study investigated these constructs in relation to childhood and adolescence by comparing the emotional functioning of 170 9- to 15-year-olds reporting high levels of depressive symptoms (HD) to a matched sample of 170 children and adolescents reporting low levels of depressive symptoms (LD). Compared to LD, HD participants reported significantly greater shame proneness, poorer functioning on emotion regulation competencies (emotional control, self-awareness and situational responsiveness), less healthy emotion regulation strategy use (less reappraisal and greater suppression), and lower levels of guilt proneness. Empathic concern did not differ between the two groups. The findings enhance current knowledge by providing a more comprehensive profile of the emotional difficulties experienced by children and adolescents with elevated depressive symptoms.     

The Impact of Maternal Depressive Symptoms on Adolescents’ Aggression: Role of Parenting and Family Mediators

Previous research has found an association between mothers’ depressive symptoms and their adolescents’ involvement in aggression. The present study examined three mechanisms believed to account for this relation: parenting practices, family functioning, and informant discrepancy. Participants were a high-risk sample of 927 mother–adolescent dyads (66% African American) who completed baseline assessments for the Multisite Violence Prevention Project. Maternal depressive symptoms were assessed using the Center for Epidemiologic Studies Depression scale. Adolescents’ aggression was assessed using parent- and teacher-report on the Behavior Assessment System for Children and student-report on the Problem Behavior Frequency Scale. Mothers’ reports of depressive symptoms were significantly related to their adolescents’ aggression based on student, teacher, and mothers’ reports, with the strongest correlations found with mothers’ reports. Multilevel modeling indicated that maternal depressive symptoms were related to the degree of discrepancy between mothers’ ratings of their adolescents’ aggression and ratings by adolescents and their teachers. Smaller discrepancies between mothers’ and teachers’ ratings of adolescents’ aggression were found for depressed mothers, as compared to non-depressed mothers. Structural equation models indicated that the relation between maternal depressive symptoms and mothers’ report of adolescents’ aggression was mediated by several parenting and family functioning variables, with the clearest effects for parenting practices. Similar findings were not found in analyses predicting adolescents’ ratings and teachers’ ratings. These findings underscore the potential direct and indirect benefits of interventions focused on reducing depression among mothers with adolescent children.     

A meta‐mood model of rumination and depression: Preliminary test in a non‐clinical population

Depressive rumination and trait meta‐mood (emotional attention, emotional clarity and emotional repair) have been suggested as vulnerability factors leading to depression, but less is known about the associations among them. In this study, we examined the relationships between trait meta‐mood, rumination and depressive symptomatology. Using structural equation analysis in a large sample of a non‐clinical population we found a preliminary test of the role of trait meta‐mood dimensions in rumination and depressive symptomatology. Results indicated that attention to feelings has two pathways in its relation with rumination and depressive mood. On the one hand, emotional attention was associated with emotional clarity, and emotional clarity with emotional repair, which was related to lower depressive symptomatology, in part, by reducing rumination. On the other hand, emotional attention was directly associated with ruminative thoughts which, in turn, were related to higher depressive mood. Findings are discussed in terms of the implications of beliefs about emotions in the treatment of depression.     

Rumination and intentional forgetting of emotional material

The tendency to respond to negative life events and negative mood states with ruminative thinking has been linked to emotion dysregulation and to a heightened risk for the onset and maintenance of emotional disorders. To further investigate this maladaptive response style, the present study examined whether rumination is linked to individual differences in the ability to intentionally forget emotional material. In a directed forgetting task, participants were instructed to memorise a list of positive and negative words and were subsequently told to forget these words. Next, participants were told to memorise a new list and, finally, recall was tested for all to-be-forgotten and to-be-remembered words. Our results demonstrate a close relation between rumination and recall in the forget condition but not in the remember condition. Specifically, compared to participants who scored low on the Ruminative Responses Scale (RRS), participants who scored high exhibited reduced forgetting of positive and negative to-be-forgotten words. These results remained stable when depression scores were included as a covariate suggesting that irrespective of depressive symptoms, rumination and intentional forgetting of emotional material are closely related.     

Multi-wave Prospective Examination of the Stress-Reactivity Extension of Response Styles Theory of Depression in High-Risk Children and Early Adolescents

The current study tested the stress-reactivity extension of response styles theory of depression (Nolen-Hoeksema Journal of Abnormal Psychology 100:569–582, 1991) in a sample of high-risk children and early adolescents from a vulnerability-stress perspective using a multi-wave longitudinal design. In addition, we examined whether obtained results varied as a function of either age or sex. During an initial assessment, 56 high-risk children (offspring of depressed parents; ages 7–14) completed measures assessing rumination and depressive symptoms. Children were subsequently given a handheld personal computer which signalled them to complete measures assessing depressive symptoms and negative events at six randomly selected times over an 8-week follow-up interval. In line with hypotheses, higher levels of rumination were associated with prospective elevations in depressive symptoms following the occurrence of negative events. Sex, but not age, moderated this association. Rumination was more strongly associated with elevations in depressive symptoms following the occurrence of negative events in girls than in boys.