Are Genetic Self-Tests Dangerous? Assessing the Commercialization of Genetic Testing in Terms of Personal Autonomy

Should a growing market for genetic self-tests be welcomed or feared? From the point of view of personal autonomy the increasing availability of predictive health information seems promising. Yet it is frequently pointed out that genetic information about future health may cause anxiety, distress and even loss of “life-hopes.” In this article the argument that genetic self-tests undermine personal autonomy is assessed and criticized. I contend that opportunities for autonomous choice are not reduced by genetic information but by misperceptions and misunderstandings of the results of genetic tests. Since the interpretation of genetic information is sometimes distorted by the information provided about the genetic products, more attention should be given to deceitful marketing that overblows the utility of genetic products. Yet personal autonomy is reduced neither by genetic tests nor by genetic information and there is consequently no compelling case for the conclusion that genetic self-tests should be prohibited.     

Ethical Conflicts in Commercialization of University Research in the Post–Bayh–Dole Era

Protection of intellectual property as well as its exploitation for monetary benefit have existed for centuries. However, commercialization of intellectual property had not entered the precincts of academic universities in a significant way until the introduction of the Bayh–Dole Act in the 1980s in the United States. The post–Bayh–Dole era has seen a quantitative increase in patenting activity in universities. This article summarizes the ethical conflicts ushered in by increasing commercialization of academic university research. Activities related to the protection and commercial exploitation of intellectual property have led to changes in academic culture that have given room for debate between the puritans and the modernists. Issues contended by the two groups have been identified, and both sides of the argument are discussed. The key to achieving “responsible commercialization of research” is to balance the Bayh–Dole ethos with the traditional Mertonian norms of academic research.     

Post-Divorce Maternal Disclosure and the Father–Adolescent Relationship: Adolescent Emotional Autonomy and Inter-Reactivity as Moderators

Utilizing longitudinal data from a project that examined the post-divorce lives of mothers and adolescents, we addressed two questions: (a) Does exposure to negative maternal disclosure about the ex-husband/father impact adolescents’ perceptions of the father-adolescent relationship? and (b) Are adolescents with low emotional autonomy and high emotional inter-reactivity especially vulnerable? Participants were 154 adolescents, who ranged in age from 12 to 18 years at wave two. Although there was no significant bivariate association between maternal negative disclosure about the father and father-adolescent relationship quality, boys’ level of emotional autonomy and emotional inter-reactivity moderated the association between maternal negative disclosure and the father–adolescent relationship. As hypothesized, boys with lower levels of emotional autonomy and higher levels of emotional inter-reactivity vis-à-vis their mothers perceived a lower quality of relationship with their father when their mother frequently disclosed negatively about the ex-husband/father. Research and applied implications are discussed.     

Degrees of Interpretive Autonomy: Ijtihād and the constraints of competence and context in late medieval Tilimsan

The social standing and religious legitimacy of learned Muslims ('ulamā') were founded on their access to a sacred body of knowledge and on their ability to remain integral and vital to their immediate communities. This duality in their roles and functions implies that the 'ulamā' were not exclusively concerned with the preservation and reproduction of an immutable dogma, but were continuously engaged in interpretive contextualizations and adaptations of religious tenets in order acceptably to fulfill their legal and social obligations. In the following paper, I briefly describe the influence of social and intellectual constraints in moderating the extent of the 'ulamā's engagement in interpretive contextualizations and adaptations of Islamic maxims. I will refer to Ibn Maryam's sixteenth-century biographical dictionary of ' ulam # ' from the city of Tilimsan to define prevailing attitudes towards socio-cultural continuity and change, legal consensus and autonomous interpretation.     

Who shall be Allowed to Give? Living Organ Donors and the Concept of Autonomy

Free and informed consent is generally acknowledged as the legal andethical basis for living organ donation, but assessments of livingdonors are not always an easy matter. Sometimes it is necessary toinvolve psychosomatics or ethics consultation to evaluate a prospectivedonor to make certain that the requirements for a voluntary andautonomous decision are met. The paper focuses on the conceptualquestions underlying this evaluation process. In order to illustrate howdifferent views of autonomy influence the decision if a donor's offer isethically acceptable, three cases are presented – from Germany, theUnited States, and India. Each case features a person with questionabledecision-making capacity who offered to donate a kidney for a siblingwith severe renal insufficiency. Although the normative framework issimilar in the three countries, different or sometimes even contraryarguments for and against accepting the offer were brought forward. Thesubsequent analysis offers two explanations for the differences inargumentation and outcome in spite of the shared reference to autonomyas the guiding principle: (1) Decisions on the acceptability of a livingdonor cannot simply be deducted from the principle of autonomy but needto integrate contextual information; (2) understandings of the wayautonomy should be contextualized have an important influence on theevaluation of individual cases. Conclusion: Analyzing the conceptualassumptions about autonomy and its relationship to contextual factorscan help in working towards more transparent and better justifieddecisions in the assessment of living organ donors.     

“Ethics wars”: Reflections on the Antagonism between Bioethicists and Social Science Observers of Biomedicine1

Social scientists often lament the fact that philosophically trained ethicists pay limited attention to the insights they generate. This paper presents an overview of tendencies in sociological and anthropological studies of morality, ethics and bioethics, and suggests that a lack in philosophical interest might be related to a tendency among social scientists to employ either a deficit model (social science perspectives accommodate the sense of context that philosophical ethics lacks), a replacement model (social scientists have finally found the “right way” of doing ethics), or a dismissal model (ethics should be abandoned all together as a misconstrued veil of power). Increased awareness of differences in styles of reasoning and objects of research interest might help to overcome the hostility, and an anthropological project is presented as an invitation to a dialogue informed by awareness of such differences.This paper was first presented at the 4S/EASST Conference in Paris, August 25–28,2004 in a panel co-convened with Richard Tutton, who came up with ‘‘Ethics Wars’’ as the appropriate title for the state of affairs we wanted to discuss. Bryn William-Jones contributed to the panel and provided detailed and very useful comments to the paper. The project on which the article reports was financially supported by the Swedish Ethics in Healthcare Programme (Grant 2000/56) and the Danish Social Science Research Council (Grant 24-03-0219).     

Honesty–Humility and the HEXACO Structure of Religiosity and Well-Being

Past research has shown that general and intrinsic religiosity is related to higher Big Five Agreeableness, Conscientiousness and, to some extent, Extraversion. With the rise of the six-factor HEXACO (Honesty–Humility, Emotionality, eXtraversion, Agreeableness, Conscientiousness, Openness) model of personality, however, a more differentiated look at religiousness and personality is called for. It has been suggested that religiosity is more associated with Honesty–Humility than with Agreeableness. The new personality factor, Honesty–Humility has also been shown to have null or weak relations with happiness. In 5 studies involving 1375 participants from Iran, Poland, and Malaysia, the relations of Honesty–Humility and other HEXACO dimensions to religious orientation and well-being outcomes were investigated. As expected, Honesty–Humility was one of the strongest personality correlate of religiosity. Higher scores on religiousness were also associated with Agreeableness, Conscientiousness, and to some extent, Extraversion showing that the main personality characteristics of religiosity are consistent across religious contexts and personality models. Relations of Honesty–Humility to psychological well-being scales were consistently positive and stronger than its relations to subjective well-being measures, suggesting that Honesty–Humility may not be “bad” for pleasure attainment and pain avoidance, but it is definitely “good” for living a virtuous, fully functioning life.     

Duhem and the origins of statics: Ramifications of the crisis of 1903–04

Much speculation on the sources of Duhem's historical interests fails to account for the major shifts in these interests: neither his belief in the continuous development of physics nor his Catholicism, when his Church was encouraging the study of generally Aristotelian scholastic thought, led to any interest in mediaeval science before 1904. Equally, his own claim that he was merely testing his views on the nature of physical theory is easily squared only with earlier work with no trace of mediaeval science. Behind this discontinuity lies a major crisis. Though not a positivist, Duhem had based all his work on assumptions acceptable to positivists. One of these, the sterility of the Middle Ages, was refuted by his chance discovery of evidence of genuine mediaeval science in the autumn of 1903, but that left the doctrine of scholastic sterility intact.Drafted for the Blacksburg conference, versions of this paper were also presented at colloquia at the University of Harvard Department of the History of Science and the University of Toronto Institute for the History and Philosophy of Science and Technology. I am grateful to all those who responded to earlier versions, but particularly to Phillip Quinn, the commentator on my paper at Blacksburg, and Jamil Ragep.     

Do Some People Need Autonomy More Than Others? Implicit Dispositions Toward Autonomy Moderate the Effects of Felt Autonomy on Well‐Being

The present studies examined whether implicit or explicit autonomy dispositions moderate the relationship between felt autonomy and well‐being. Study 1 (N = 187 undergraduate students) presents an initial test of the moderator hypothesis by predicting flow experience from the interaction of autonomy need satisfaction and autonomy dispositions. Study 2 (N = 127 physically inactive persons) used vignettes involving an autonomy (un)supportive coach to test a moderated mediation model in which perceived coach autonomy support leads to well‐being through basic need satisfaction. Again, the effects of need satisfaction on well‐being were hypothesized to be moderated by an implicit autonomy disposition. Study 1 showed that individuals with a strong implicit autonomy (but not power or achievement) motive disposition derived more flow experience from felt autonomy than individuals with a weak implicit autonomy disposition. Study 2 revealed that perceived autonomy support from sports coaches, which we experimentally induced with a vignette method, leads to autonomy satisfaction, leading in turn to positive effects on well‐being. This indirect effect held at high and average but not low implicit autonomy disposition. The results indicate that the degree to which people benefit from autonomy need satisfaction depends on their implicit disposition toward autonomy.     

Own and perceived parental religiosity and the quality of the parent–child relationship

This aim of this study was to investigate the association between perceived parental religiosity and the quality of the parent–child relationship. Eighty-nine adolescent boys and girls completed the Santa Clara Strength of Religious Faith Questionnaire (SCSRFQ) and the Parent–Child Relationship Survey (PCRS). The results showed that the girls had a better relationship with their mothers than with their fathers, while the boys tended to view their relationships with their father and mother of equal quality. It was also found that greater perceived religiosity of both the fathers and mothers was associated with a better parent–child relationship.     

Editorial ‘Political Normativity. Critical Essays on the Autonomy of the Political’

Ethical Theory and Moral Practice -     

On the notions of indiscernibility and indeterminacy in the light of the Galois–Grothendieck theory

We analyze the notions of indiscernibility and indeterminacy in the light of the Galois theory of field extensions and the generalization to \(K\) -algebras proposed by Grothendieck. Grothendieck’s reformulation of Galois theory permits to recast the Galois correspondence between symmetry groups and invariants as a Galois–Grothendieck duality between \(G\) -spaces and the minimal observable algebras that discern (or separate) their points. According to the natural epistemic interpretation of the original Galois theory, the possible \(K\) -indiscernibilities between the roots of a polynomial \(p(x)\in K[x]\) result from the limitations of the field \(K\) . We discuss the relation between this epistemic interpretation of the Galois–Grothendieck duality and Leibniz’s principle of the identity of indiscernibles. We then use the conceptual framework provided by Klein’s Erlangen program to propose an alternative ontologic interpretation of this duality. The Galoisian symmetries are now interpreted in terms of the automorphisms of the symmetric geometric figures that can be placed in a background Klein geometry. According to this interpretation, the Galois–Grothendieck duality encodes the compatibility condition between geometric figures endowed with groups of automorphisms and the ‘observables’ that can be consistently evaluated at such figures. In this conceptual framework, the Galoisian symmetries do not encode the epistemic indiscernibility between individuals, but rather the intrinsic indeterminacy in the pointwise localization of the figures with respect to the background Klein geometry.     

Attentional control of the creation and retrieval of stimulus–response bindings

Two experiments studied the degree to which the creation and retrieval of episodic feature bindings is modulated by attentional control. Experiment 1 showed that the impact of bindings between stimulus and response features varies as a function of the current attentional set: only bindings involving stimulus features that match the current set affect behavior. Experiment 2 varied the time point at which new attentional sets were implemented—either before or after the processing of the to-be-integrated stimuli and responses. The time point did not matter, suggesting that the attentional set has no impact on feature integration proper but controls which features get access to and can thus trigger the retrieval of bindings.     

Maternal depression and the timing of mother–child dialogue

Turn-taking in dialogue is an essential part of communication and early language experience. The prevalence of utterances and the timing of responses in dialogue were examined at 14 and 36 months of age in 104 mother–child dyads from the Early Head Start Research and Evaluation Project (EHSREP). Mothers varied in their level of depression risk (measured with the Center for Epidemiological Studies-Depression scale; CES-D). Although maternal utterance rate did not vary significantly across any factors, the latency of mothers' responses to their children decreased with development (12 ms/month) and was significantly related to that of their own children (i.e., slow-responding children had slow-responding mothers). Mothers with higher levels of depressive symptoms were 11% slower in responding to their children than mothers with low depression risk, suggesting that the interactive timing of speech to children may be particularly sensitive to maternal depression, modifying the contingent properties of children's early language experience.