Implementing Biosecurity Education: Approaches, Resources and Programmes

This paper aims to present possible approaches, resources and programmes to introduce the topic of biosecurity to life scientists and engineers at the higher education level. Firstly, we summarise key findings from a number of international surveys on biosecurity education that have been carried out in the United States, Europe, Israel and the Asia–Pacific region. Secondly, we describe the development of our openly-accessible education resource, illustrating the scope and content of these materials. Thirdly, we report on actual cases of biosecurity education that have been implemented. These include achievements in and lessons derived from the implementation of biosecurity education at the National Defense Medical College in Japan. These experiences are followed by presentation of the expert-level “Train-the-Trainer” programmes subsequently launched by the University of Bradford in the United Kingdom. These examples will help readers to understand how educators can enhance their own understanding about biosecurity issues and how they can then disseminate their knowledge through development of their own customised, relevantly-targeted and stage-tailored education programmes within their own life science communities. By providing these examples, we argue that education for life scientists, policy-makers and other stakeholders about social responsibility on dual-use issues is easily achievable and need not be expensive, time-consuming or over-burdening. We suggest that recurring classes or courses be held at appropriate times during educational programmes to accommodate the developing expertise and advancing learning stages of students.     

Data Sharing and Dual-Use Issues

The concept of dual-use encapsulates the potential for well-intentioned, beneficial scientific research to also be misused by a third party for malicious ends. The concept of dual-use challenges scientists to look beyond the immediate outcomes of their research and to develop an awareness of possible future (mis)uses of scientific research. Since 2001 much attention has been paid to the possible need to regulate the dual-use potential of the life sciences. Regulation initiatives fall under two broad categories—those that develop the ethical education of scientists and foster an awareness and responsibility of dual-use issues, and those which assess the regulation of information being generated by current research. Both types of initiatives are premised on a cautious, risk-adverse philosophy which advocates careful examination of all future endpoints of research endeavors. This caution advocated within initiatives such as pre-publication review of journal articles contrasts to the obligation to share underpinning data sharing discussions. As the dual-use debate has yet to make a significant impact on data sharing discussions (and vice versa) it is possible that these two areas of knowledge control may present areas of ethical conflict for scientists, and thus need to be more closely examined. This paper examines the tension between the obligation to share exemplified by data sharing principles and the concerns raised by the risk-cautious culture of the dual-use debates. The paper concludes by reflecting on the issues of responsibility as raised by dual-use as relating to data sharing, such as the chain of custody for shared data.     

Moving Life Science Ethics Debates Beyond National Borders: Some Empirical Observations

The life sciences are increasingly being called on to produce “socially robust” knowledge that honors the social contract between science and society. This has resulted in the emergence of a number of “broad social issues” that reflect the ethical tensions in these social contracts. These issues are framed in a variety of ways around the world, evidenced by differences in regulations addressing them. It is important to question whether these variations are simply regulatory variations or in fact reflect a contextual approach to ethics that brings into question the existence of a system of “global scientific ethics”. Nonetheless, within ethics education for scientists these broad social issues are often presented using this scheme of global ethics due to legacies of science ethics pedagogy. This paper suggests this may present barriers to fostering international discourse between communities of scientists, and may cause difficulties in harmonizing (and transporting) national regulations for the governance of these issues. Reinterpreting these variations according to how the content of ethical principles is attributed by communities is proposed as crucial for developing a robust international discourse. To illustrate this, the paper offers some empirical fieldwork data that considers how the concept of dual-use (as a broad social issue) was discussed within African and UK laboratories. Demonstrating that African scientists reshaped the concept of dual-use according to their own research environmental pressures and ascribed alternative content to the principles that underpin it, suggests that the limitations of a “global scientific ethics” system for these issues cannot be ignored.     

Beyond Patchwork Precaution in the Dual-Use Governance of Synthetic Biology

The emergence of synthetic biology holds the potential of a major breakthrough in the life sciences by transforming biology into a predictive science. The dual-use characteristics of similar breakthroughs during the twentieth century have led to the application of benignly intended research in e.g. virology, bacteriology and aerobiology in offensive biological weapons programmes. Against this background the article raises the question whether the precautionary governance of synthetic biology can aid in preventing this techno-science witnessing the same fate? In order to address this question, this paper proceeds in four steps: it firstly introduces the emerging techno-science of synthetic biology and presents some of its potential beneficial applications. It secondly analyses contributions to the bioethical discourse on synthetic biology as well as precautionary reasoning and its application to life science research in general and synthetic biology more specifically. The paper then identifies manifestations of a moderate precautionary principle in the emerging synthetic biology dual-use governance discourse. Using a dual-use governance matrix as heuristic device to analyse some of the proposed measures, it concludes that the identified measures can best be described as “patchwork precaution” and that a more systematic approach to construct a web of dual-use precaution for synthetic biology is needed in order to guard more effectively against the field’s future misuse for harmful applications.     

超越双螺旋:DNA对科学与社会文化的影响

50年前,DNA双螺旋结构的建立标志着生命科学一个崭新时代的到来。DNA双螺旋结构模型的建立不仅使生命科学及其相关领域发生了巨大变化,而且也深刻地影响到人类的社会生活与思想观念,甚至影响到社会文明的前景。今天,我们又站在一个历史的转折点上,中国科学家应当主动迎接生物技术世纪和知识经济时代的挑战,不仅在分子生物学的研究前沿作出自己的贡献,而且也应创造出更多的科学成果造福于人民。     

Dual-Use Research Codes of Conduct: Lessons from the Life Sciences

This paper considers multiple meanings of the expression ‘dual use’ and examines lessons to be learned from the life sciences when considering ethical and policy issues associated with the dual-use nature of nanotechnology (and converging technologies). After examining recent controversial dual-use experiments in the life sciences, it considers the potential roles and limitations of science codes of conduct for addressing concerns associated with dual-use science and technology. It concludes that, rather than being essentially associated with voluntary self-governance of the scientific community, codes of conduct should arguably be part of a broader regulatory oversight system.     

Knowledge Justice: An Opportunity for Counter-expertise in Security vs. Science Debates

ABSTRACT

Knowledge justice provides a conceptual framework to apply principles of social justice in environments of competing interests regarding science. Both knowledge and its making can be seen as a good to be distributed, including all voices for whom the science will matter. In this framework, knowledge production is shared among a broader constituency of knowers representing both local and cosmopolitan voices. The problem of knowledge injustice can be seen in the U.S. government’s recent attempt to secure scientific knowledge about H5N1 or avian bird flu virus. The censorship produced a global debate between scientists and policy-makers over how to balance the nation-state’s desire for security with the life science’s tradition of open and shared research. This conundrum, known as the dual-use dilemma, obscures larger questions that lie outside of expert-centered domains—namely the concerns of many communities in the Global South struggling with the impact of the virus in their daily lives. An example of such counter-expertise is that of the backyard poultry farmer whose ways of knowing are foreign to science and policy experts who frame the ways in which knowledge about H5N1 should be developed, controlled, and used. While the H5N1 debate illuminated competing positions regarding knowledge production between powerful elites, it ignored the social justice inequities produced by the dual-use dilemma. The concept of knowledge justice provides a way of thinking about science that can include locally situated counter-expertise, disrupting the dual-use dilemma produced by competing dominant priorities of security and public health.     

Evolution of Different Dual-use Concepts in International and National Law and Its Implications on Research Ethics and Governance

This paper provides an overview of the various dual-use concepts applied in national and international non-proliferation and anti-terrorism legislation, such as the Biological and Toxin Weapons Convention, the Chemical Weapons Convention and United Nations Security Council Resolution 1540, and national export control legislation and in relevant codes of conduct. While there is a vast literature covering dual-use concepts in particular with regard to life sciences, this is the first paper that incorporates into such discussion the United Nations Security Council Resolution 1540. In addition, recent developments such as the extension of dual-use export control legislation in the area of human rights protection are also identified and reviewed. The discussion of dual-use concepts is hereby undertaken in the context of human- and/or national-security-based approaches to security. This paper discusses four main concepts of dual use as applied today in international and national law: civilian versus military, peaceful versus non-peaceful, legitimate versus illegitimate and benevolent versus malevolent. In addition, the usage of the term to describe positive technology spin-offs between civilian and military applications is also briefly addressed. Attention is also given to the roles civil society and research ethics may play in the governance of dual-use sciences and technologies.     

Successful aging: Social theory,scripture, church teaching

ABSTRACT

Thanks to medical progress and better overall living conditions, a greater number of people are living well into old age, many more than in previous generations. However, we feel instinctively that there must be more to life than longevity and merely living longer. Religious communities and social scientists are both interested in what makes for “successful aging.” The dialogue between them can be enriched by fostering a mutual appreciation for biblical norms and stories, and a better working knowledge of the models and methods of the social sciences. To that end, I offer a sketch of four models of aging: disengagement, activity, continuity, and Tornstam’s theory of gerotranscendence. This sketch serves as a prelude to a discussion of three biblical stories: (1) the story of Barzillai and King David in 2 Samuel, which shows how the elderly can make a positive contribution to the common good, in spite of their limitations; (2) the intertwined stories of Jacob and Joseph in Genesis, which can help us understand the theological significance of life review, forgiveness, reconciliation, and life review in the aging process; and (3) the third phase of the encounter considers John Paul II’s Letter to the Elderly, and builds on several suggestions he makes concerning the life of Moses and successful aging.     

Uncertainty as a Fundamental Scientific Value

The author argues that, though social scientists generally value tolerance for ambiguity, and some even assert a fundamental indeterminacy in human systems, there is still a discipline-wide discomfort with uncertainty and ambiguity. It is argued that this distaste for uncertainty derives from a distorted view of the classical physical sciences, a view that ignores the essentially critical and radical foundations of scientific practice. The drive for certainty, it is argued, is essentially unscientific, in that certain, or adequate, forms of knowledge can only recapitulate the already known and in their dogmatic and institutionalized forms prevent the development of genuinely new knowledge. In contrast, uncertainty is defended as a positive condition, generative of new knowledge because it is open to discovery and to the mystery of the other. The conclusion drawn from this analysis is that the social sciences can only progress if uncertainty, or mystery, is protected and cultivated through a scientific discourse constituted in local and concrete terms (rather than in general and universal ones) and through a self-reflective and self-critical research praxis.     

Ethical and Philosophical Consideration of the Dual-use Dilemma in the Biological Sciences

The dual-use dilemma arises in the context of research in the biological and other sciences as a consequence of the fact that one and the same piece of scientific research sometimes has the potential to be used for bad as well as good purposes. It is an ethical dilemma since it is about promoting good in the context of the potential for also causing harm, e.g., the promotion of health in the context of providing the wherewithal for the killing of innocents. It is an ethical dilemma for the researcher because of the potential actions of others, e.g., malevolent non-researchers who might steal dangerous biological agents, or make use of the original researcher's work. And it is a dilemma for governments concerned with the security of their citizens, as well as their health. In this article we construct a taxonomy of types of "experiments of concern" in the biological sciences, and thereby map the terrain of ethical risk. We then provide a series of analyses of the ethical problems and considerations at issue in the dual-use dilemma, including the impermissibility of certain kinds of research and possible restrictions on dissemination of research results given the risks to health and security. Finally, we explore the main available institutional responses to some of the specific ethical problems posed by the dual-use dilemma in the biological sciences.     

Mismatches between ‘Scientific’ and ‘Non-Scientific’ Ways of Knowing and Their Contributions to Public Understanding of Science

As differentiation within scientific disciplines increases, so does differentiation between the sciences and other ways of knowing. This distancing between ‘scientific’ and ‘non-scientific’ cultures reflects differences in what are considered valid and reliable approaches to acquiring knowledge and has played a major role in recent science-oriented controversies. Scientists’ reluctance to actively engage in science communication, coupled with journalists’ reliance on the norms of balance, conflict, and human interest in covering scientific issues, have combined to exacerbate public mistrust of science on issues like the measles-mumps-rubella (MMR) vaccine. The failure of effective communications between scientists and non-scientists has hindered the progress of both effective science and effective policy. In order to better bridge the gap between the ‘scientific’ and ‘non-scientific’ cultures, renewed efforts must be made to encourage substantive public engagement, with the ultimate goal of facilitating an open, democratic policy-making process.     

The Science to Save Us from Philosophy of Science

Are knowledge and belief pivotal in science, as contemporary epistemology and philosophy of science nearly universally take them to be? I defend the view that scientists are not primarily concerned with knowing and that the methods of arriving at scientific hypotheses, models and scenarios do not commit us having stable beliefs about them. Instead, what drives scientific discovery is ignorance that scientists can cleverly exploit. Not an absence or negation of knowledge, ignorance concerns fundamental uncertainty, and is brought out by retroductive (abductive) inferences, which are roughly characterised as reasoning from effects to causes. I argue that recent discoveries in sciences that coped with under-structured problem spaces testify the prevalence of retroductive logic in scientific discovery and its progress. This puts paid to the need of finding epistemic justification or confirmation to retroductive methodologies. A scientist, never frightened of unknown unknowns, strives to advance the forefront of uncertainty, not that of belief or knowledge. Far from rendering science irrational, I conclude that catering well for the right conditions in which to cultivate ignorance is a key to how fertile retroductive inferences (true guesses) arise.     

What is Scientific Progress? Lessons from Scientific Practice

Alexander Bird argues for an epistemic account of scientific progress, whereas Darrell Rowbottom argues for a semantic account. Both appeal to intuitions about hypothetical cases in support of their accounts. Since the methodological significance of such appeals to intuition is unclear, I think that a new approach might be fruitful at this stage in the debate. So I propose to abandon appeals to intuition and look at scientific practice instead. I discuss two cases that illustrate the way in which scientists make judgments about progress. As far as scientists are concerned, progress is made when scientific discoveries contribute to the increase of scientific knowledge of the following sorts: empirical, theoretical, practical, and methodological. I then propose to articulate an account of progress that does justice to this broad conception of progress employed by scientists. I discuss one way of doing so, namely, by expanding our notion of scientific knowledge to include both know-that and know-how.     

Process Tracing as an Effective Epistemic Complement

In the last decades philosophers of science and social scientists promoted the view that knowledge of mechanisms might help causal inference considerably in the social sciences. Mechanisms, however, can only assist causal inference effectively if scientists have a means to identify them correctly. Some scholars suggested that process-tracing might be a helpful strategy in this respect. Shared criteria to assess its performance, however, are not available yet; furthermore, the criteria proposed so far tie the validity of process-tracing findings to the specific kind of evidence it uses. In this paper I shall propose a criterion to assess process-tracing performance in cases in which favorable epistemic circumstances do not occur and the existing criteria thus fail to apply. The criterion I propose does not double as a condition for validity. Rather, it aims to assess whether the mechanism process-tracing outlines constitutes admissible evidence for the hypothesis at hand. It will be argued that only if this requirement is fulfilled process-tracing can be used as an effective complement for causal inference.     

Career Experiences and Scientific Performance: A Study of Social,Physical, Life,and Health Sciences

The experiences people have over the course of their careers are commonly held to contribute to creative achievement. In this study, an attempt was made to identify the career events contributing to creative achievement in the sciences. Prior theoretical and empirical work was used to identify relevant career events in the areas of education, domain exposure, mentoring, adversity, work procedures, collaboration, laboratory leadership, and organizational influences. Obituaries were obtained for 499 scientists working in multiple fields in the social, physical, life, and health sciences and were used to assess whether these events were evident in scientists' careers. Comparisons of high achieving and low achieving scientists with regard to these events indicated that multiple events lying in each of these general areas contributed to career achievement. The nature of the events yielding significant differences were discussed regarding their implications for the development of creative potential in scientific fields.     

Historical and Philosophical Perspectives on Experimental Practice in Medicine and the Life Sciences

The aim of this paper is to discuss a key question in the history and philosophy of medicine, namely how scholars should treat the practices and experimental hypotheses of modern life science laboratories. The paper seeks to introduce some prominent historiographical methods and theoretical approaches associated with biomedical research. Although medical scientists need no convincing that experimentation has a significant function in their laboratory work, historians, philosophers, and sociologists long neglected its importance when examining changes in medical theories or progress in scientific knowledge. The reason appears to have been the academic influence of the then dominant tradition in the history of ideas, but was also due to a misconception of what could usefully be termed the view on “historical ontology.” During the last two decades, there have been many books and research articles that have turned towards the subject, so that the study of experimental practice has become a major trend in the contemporary history and philosophy of medicine. A closer look at the issue of laboratory research shows that concepts in medicine and the life sciences cannot be understood as historically constant, free-standing ideas, but have to be regarded as dependent on local research settings. They often carry particular “social memories” with them and thus acquire important ethical implications.     

THE RELIGIOUS PRECONDITIONS FOR THE RACE CONCEPT IN MODERN SCIENCE

The view that science and religion are necessarily in conflict has increasingly lost favor among scholars who have sought more nuanced theoretical frameworks for evaluating the configurations of these two bodies of knowledge in modern life. This article situates, for the first time, the modern study of race into scholarly assessments on the relations between religion and science. I argue that the formation of the race concept in the minds of Western European and American scientists grew out of and remained indebted to Christian intellectual history. Religion was not subtracted from nor stood in conflict with constructions of race developed across the modern life and health sciences.     

Managing Dual Use Technology: It Takes Two to Tango

Like nuclear energy, most technologies could have dual use—for health and well being and disaster and terror. Some research publications have brought to the forefront the tragic consequences of the latter potential through their possible use. Monitoring life science research and development (R&D) to prevent possible misuse is a challenging task globally, more so in developing economies like India, which are emerging as major biotech hubs. As a signatory to the Biological and Toxin Weapons Convention, India has put in motion a process of evolving a series of measures to manage dual-use technology. The Indian Council of Medical Research (ICMR) has taken a lead in drafting model codes of conduct, ethics and practice for use by other S&T agencies to tailor them as per their requirements. Taking cue from the discussions held by the editors of the various medical and science journals in the developed world, the Indian Journal of Medical Research, the official publication of the ICMR, is working on policy and uniform practice of publication of dual-use research results. The Government of India too has promulgated legal provisions to minimize the risks of misuse of technology, like the Weapons of Mass Destruction Act. Clearly, no single agency would be able to manage the dual-use of technology effectively. Multiple agencies have to come together to work in tandem for effective implementation of various measure and also like Janus, ensure that they are neither too restrictive nor intrusive to discourage the development of science.     

Do We Need Berlin Walls or Chinese Walls between Research, Public Consultation, and Advice? New Public Responsibilities for Life Scientists

During the coming decades, life scientists will become involved more than ever in the public and private lives of patients and consumers, as health and food sciences shift from a collective approach towards individualization, from a curative to a preventive approach, and from being driven by desires rather than by technology. This means that the traditional relationships between the activities of life scientists – conducting research, advising industry, governments, and patients/consumers, consulting the public, and prescribing products, be it patents, drugs or food products, information, or advice – are getting blurred. Traditional concepts of the individual, role, task, and collective responsibility have to be revised. This paper argues, from a pragmatic point of view, that the concept of public responsibility can contribute considerably in delineating new gray zones between the various roles of the life scientist: conducting research for governments or industry, giving advice, prescribing and selling products, and doing public consultation. The main issues are where new Chinese walls (not Berlin walls) need to be built between these activities, thereby increasing trust between life scientists and the public at large, and how to organize research agendas and to decide upon research topics. This revised version was published online in August 2006 with corrections to the Cover Date.