Hypothalamic-pituitary-adrenal axis function and the metabolic syndrome X of obesity

Obesity has negative health consequences related to fat distribution, particularly the central or visceral accumulation of fat. The major complications associated with visceral obesity, termed the "Metabolic Syndrome of Obesity," or "Syndrome X," are type II diabetes, hypertension, and dyslipidemia. As with certain mood disorders, the syndrome may be a consequence of neuroendocrine perturbations typically associated with chronic stress. Our work with bonnet macaque monkeys provides an animal model for the relationship between early stress, behavioral and hypothalamic-pituitary-adrenal (HPA) axis dysregulation, and Syndrome X. During their infant's first half-year, mothers face a variable foraging demand (VFD), in which ample food varies unpredictably in the difficulty of its acquisition, and the offspring show persistent abnormalities in systems known to modulate stress and affective regulation. Early work on the bonnet macaque noted the emergence of a sample of spontaneously obese subjects as they matured. Using the VFD model, the current study showed that there was a clear relationship between early cerebrospinal fluid corticotropin-releasing factor levels and subsequently measured body mass index, supporting the hypotheses regarding the interactive roles of early experience and HPA axis dysregulation in the ontogeny of both metabolic and mood disorders.     

Psychische Gesundheit von Studierenden der Medizin

Objectives and methods

Concerning mental disorders, both physicians and alumni of medical sciences report a higher symptom load than the average population. Up to now however only a few studies have been conducted concerning the mental health of medical students. The aim of this study is to explore, whether medical students show a higher symptom load than their peers and whether there are differences concerning sex, phases of the studies and point of origin. For this survey the Patient Health Questionnaire (PHQ) was applied to 390 medical students from the University Leipzig. Their results were compared to a representative sample of peers (n=225).

Results

The analysis of variance shows significant differences between the male and female student samples on the one side and the same sex peer samples on the other. Both student samples scored significantly higher on the scales Other Anxiety Syndrome, Major Depressive Syndrome and Stress. Additionally, male students scored higher on the Other Depressive Syndrome scale and the Somatoform Syndrome scale. Further analysing the medical students sample, the females’ measures were significantly higher for the Somatoform Syndrome, Depression and Stress scales. In addition, an interaction was found between sex and point of origin.

Conclusions

Medical students report more symptoms of mental disorders than their peers. Therefore extensive prevention concepts are needed for this group.     

Neuropsychological Deficits in Childhood Epilepsy Syndromes

Seizure disorders are relatively common in childhood, and the International League Against Epilepsy (ILAE) provides a hierarchical classification system to define seizure types. At the final level of classification, specific epilepsy syndromes are defined that represent a complex of signs and symptoms unique to an epilepsy condition. The present review discusses the issues related to several of these epilepsy syndromes in childhood, including those classified as generalized idiopathic epilepsies (e.g., childhood absence epilepsy, juvenile absence epilepsy, juvenile myoclonic epilepsy), focal epilepsies (benign rolandic epilepsy, occipital epilepsy, temporal lobe epilepsy, frontal lobe epilepsy) and the "epileptic encephalopathies," including Dravet's Syndrome, West Syndrome, Lennox-Gastaut Syndrome, Myoclonic Astatic Epilepsy, and Landau-Kleffner Syndrome. For each syndrome, the epidemiology, clinical manifestations, treatments, and neuropsychological findings are discussed.     

传统思想中的“礼”和“礼仪”——兼论“礼”和“礼仪”的道德功能

我国对“礼”和“礼仪”的认识经历了曲折的过程。传统道德中许多关于“礼”和“礼仪”的论述 ,包含着合理的思想内核。我们要很好地利用这笔财富 ,充分发挥它的道德功能 ,广泛地开展礼仪教育 ,加强公民道德建设和社会主义精神文明建设。     

There is more to anger coping than "in" or "out"

There is growing dissatisfaction with a dichotomized "anger-in" versus "anger-out" view of anger coping. Three studies using student and community adultsamples revealed a broader understanding of the nature of anger coping styles and led to the development of the new Behavioral Anger Response Questionnaire (BARQ). The BARQ is empirically derived and factorially validated and has good psychometrics. Results suggest that dichotomizing anger responses as "in" versus "out" is too coarse and that a 6-factor model may be more appropriate. The 6 factors identified here are Direct Anger-Out, Assertion, Support-Seeking, Diffusion, Avoidance, and Rumination. Women reported use of a wider range of anger coping styles, especially more social support-seeking and more use of anger diffusion strategies than men.     

The Presuicidal Syndrome

ABSTRACT: The Presuicidal Syndrome, first described in 1958, relates to that specific psychic state of mind that leads to suicidal acts. It is an alarm signal indicating a tendency to suicide. The Presuicidal Syndrome has three principal components: constriction; inhibited aggression turned toward the self; and suicidal fantasies. The clinical details of these components are explicated. It is proposed that the Presuicidal Syndrome provides a basis for better judgment of the danger of suicide, makes more focused suicide prevention possible, and is an aid in the disclosure of those factors in society that often lead to suicide.     

Validation of graphoanalysis by "global" or "holistic" method.

Graphoanalysis is the most systematically developed and best researched of all methods of handwriting analysis (genetically called graphology). This is a projective expressive movement that is neither better nor more poorly validated than most projective techniques as a means of personality assessment, which is inadequate because their subjectivity makes statistical study difficult. With all projective techniques "sign" or trait validation has been minimal, and the best validation has come from "global" or "holistic" methods. The present study presents a paradigm for the latter type of approach to handwriting analysis, using a matching technique with probabilities of 1/5, wherein five subjects were matched by people who knew them to one of five blind Graphoanalyses of the subjects' writing. This design is herein replicated five times, with total data significantly different from chance expectation (p less than .001), supporting the hypothesis that it is possible to evaluate personality through analysis of handwriting.     

"Anti-intellectualism" and genetics

The 2001 claim by Eigenberger and Sealander that "anti-intellectualism" has an important genetic component is discussed in reference to a rejoinder by Howley.     

The Public Perception of "Cults" and "New Religious Movements"

The term "cult" has attracted much criticism from several sociologists of religion and religious studies scholars in recent years, and many scholars have dropped the word for a less pejorative term such as "new religious movement" (NRM). This research note seeks to determine if simply substituting an alternative term for cult changes people's attitudes toward a religious group. To this end, over 2,400 randomly selected Nebraskans were asked how comfortable they would feel if their neighbor joined a cult, NRM, or a "new Christian church," and whether the government should regulate the activities of these groups. The survey results reveal the remarkably negative view Nebraskans have of cults, their general acceptance of NRMs, and their broad support for new Christian churches.     

Neuropsychological profile and neuroimaging in patients with 22Q11.2 Deletion Syndrome: a review.

22q11.2 Deletion Syndrome is associated with cognitive, behavioural, and psychiatric problems and is known to affect brain structure. Recently, 22q11.2 Deletion Syndrome has been proposed as a disease model for a genetic subtype of schizophrenia. In this paper we discuss the currently available literature on neurocognitive functioning and brain anatomy in patients with 22q11.2 Deletion Syndrome, and how this contributes to our understanding of the neurobiology of schizophrenia. Research on cognitive functioning in 22q11.2 Deletion Syndrome patients suggests a specific cognitive profile with impairments on arithmetical, visuo-spatial, and executive tasks and relatively preserved language skills. Prominent findings of neuroimaging studies in 22q11.2 Deletion Syndrome patients are: reduction of overall brain volume, midline defects, structural alterations of cerebellum and frontal lobe, white matter abnormalities, and decreased grey matter volumes in parietal and temporal areas. We describe how brain abnormalities in patients with 22q11.2 Deletion Syndrome may contribute to the understanding of the clinical syndrome including cognitive impairments, psychotic symptoms, and social and communication problems.     

Borderline and schizotypal personality disorders: mutually exclusive or overlapping?

This article is concerned with one aspect of the validity of DSM-III Axis II diagnoses, namely, the discriminability of borderline and schizotypal disorders. Forty-nine patients diagnosed by DSM-III criteria as borderline, schizotypal, or "mixed" personality disorders completed the Borderline Syndrome Index (BSI), an independent self-report 52-item instrument that has been shown to be reliable and to have discriminative validity. A one-way analysis of variance and a discriminant function analysis were conducted. Our major finding was that there were no significant differences among the groups on the BSI self-report test, although there were differences on clinical grounds. We discuss this in terms of "fuzzy set" theory and prototypic systems of classification.     

Empathic Insights From the Rorschach: Paul Lerner's Legacy

This article is concerned with one aspect of the validity of DSM-III Axis II diagnoses, namely, the discriminability of borderline and schizotypal disorders. Forty-nine patients diagnosed by DSM-III criteria as borderline, schizotypal, or "mixed" personality disorders completed the Borderline Syndrome Index (BSI), an independent self-report 52-item instrument that has been shown to be reliable and to have discriminative validity. A one-way analysis of variance and a discriminant function analysis were conducted. Our major finding was that there were no significant differences among the groups on the BSI self-report test, although there were differences on clinical grounds. We discuss this in terms of "fuzzy set" theory and prototypic systems of classification.     

Defining the cortical visual systems: "what", "where", and "how"

The visual system historically has been defined as consisting of at least two broad subsystems subserving object and spatial vision. These visual processing streams have been organized both structurally as two distinct pathways in the brain, and functionally for the types of tasks that they mediate. The classic definition by Ungerleider and Mishkin labeled a ventral "what" stream to process object information and a dorsal "where" stream to process spatial information. More recently, Goodale and Milner redefined the two visual systems with a focus on the different ways in which visual information is transformed for different goals. They relabeled the dorsal stream as a "how" system for transforming visual information using an egocentric frame of reference in preparation for direct action. This paper reviews recent research from psychophysics, neurophysiology, neuropsychology and neuroimaging to define the roles of the ventral and dorsal visual processing streams. We discuss a possible solution that allows for both "where" and "how" systems that are functionally and structurally organized within the posterior parietal lobe.     

Comments on so-called "chronic" and "therapy refractory" depression

The problems of so-called "therapy resistant or chronic" depression has been investigated on own patients of the year 1986, but simply one chronic example could be noticed. Configurations-frequence-analytic research didn't essentially result in significant statements. It is referred to that the frequent occurrence of the so-called "therapy resistant" depressions described by some authors, could be in connection with limited diagnosis inventories and insufficient to the personality orientated therapy regime.     

History and theory in "applied ethics"

Robert Baker and Laurence McCullough argue that the "applied ethics model" is deficient and in need of a replacement model. However, they supply no clear meaning to "applied ethics" and miss most of what is important in the literature on methodology that treats this question. The Baker-McCullough account of medical and applied ethics is a straw man that has had no influence in these fields or in philosophical ethics. The authors are also on shaky historical grounds in dealing with two problems: (1) the historical source of the notion of "practical ethics" and (2) the historical source of and the assimilation of the term "autonomy" into applied philosophy and professional ethics. They mistakenly hold (1) that the expression "practical ethics" was first used in a publication by Thomas Percival and (2) that Kant is the primary historical source of the notion of autonomy as that notion is used in contemporary applied ethics.     

A Case of Triple X Syndrome Manifesting with the Syndrome of Nonverbal Learning Disabilities

There has been a relative absence of studies that have examined comprehensively the neuropsychological profiles of females with Triple X Syndrome across a battery of tests and measures. A case is reported of a 9 1/2-year-old female with Triple X Syndrome whose neuropsychological test results were suggestive of greater right- versus left-cerebral hemisphere dysfunction. Overall, the patient's neuropsychological profile was indicative of the syndrome of Nonverbal Learning Disabilities (NLD) as proposed by Rourke (Rourke 1987, 1988, 1995; Rourke & Tsatsanis, 1996). The results are discussed in light of Rourke's NLD Syndrome and the related white matter model.     

"FEMINIZATION" OF PSYCHOLOGY

Women are participating in the field of psychology in increasing numbers relative to men. This development has been referred to as the "feminization of psychology," and it carries with it a number of implications. This article reviews statistical data relating to the changing sex ratio and discusses their implications. Participation rates of women in psychology are examined as they pertain to enrollment in doctoral programs, graduation from baccalaureate programs, and career progress within the profession. Implications of changing sex ratios for occupational prestige, income and economics, work structure, education and training, and theory, research, and practice are then discussed. In conclusion, the concept of "feminization" is challenged as questions are raised about whether the increase in the number of women in psychology is a problem, as has been alleged, or a symptom of other problems within the field     

"Show me" bioethics and politics

Missouri, the "Show Me State," has become the epicenter of several important national public policy debates, including abortion rights, the right to choose and refuse medical treatment, and, most recently, early stem cell research. In this environment, the Center for Practical Bioethics (formerly, Midwest Bioethics Center) emerged and grew. The Center's role in these "cultural wars" is not to advocate for a particular position but to provide well researched and objective information, perspective, and advocacy for the ethical justification of policy positions; and to serve as a neutral convener and provider of a public forum for discussion. In this article, the Center's work on early stem cell research is a case study through which to argue that not only the Center, but also the field of bioethics has a critical role in the politics of public health policy.     

Sellars and the "Myth of the Given"

Sellars is well known for his critique of the "myth of the given" in his "Empiricism and the Philosophy of Mind". That text does not make it unambiguous just how he understands the "myth". Here I take it that whatever else may be involved, his critique is incompatible with the view that there is a nonconceptual mode of "presentation" or "givenness" of particulars that is the heart of sense perception and what is most distinctive of perception as a type of cognition. A critical examination of Sellars' arguments, particularly those directed at the Theory of Appearing, results in the conclusion that he has failed to eliminate the above view of perception. Moreover, though Sellars is clearly opposed to the view that perceptual experience cannot provide justification for beliefs about perceived objects, I argue that Sellars has failed to shake the intuitive plausibility of that view.     

Tic Treatment Goes Tech: A Review of TicHelper.com

TicHelper.com (“TicHelper”) is an interactive online treatment program for youth with chronic tic disorders (CTDs) or Tourette Syndrome (TS) and their parents. It is based on Comprehensive Behavioral Intervention for Tics (CBIT), an individual, outpatient therapy protocol shown to effectively reduce tics in randomized controlled trials. The TicHelper website offers a user-friendly dashboard that is effective in making it easy to navigate through different treatment modules. Modules parallel core CBIT procedures and consist of interactive exercises, informational videos, and self-report ratings. TicHelper has some weaknesses (e.g., no outcomes research specific to the program has been published to date); however, its strengths (easily navigable, clear instructions, appropriate content) outweigh its weaknesses, making it a potentially useful dissemination tool to make CBIT more accessible to families and youth with tics.