Tradeoffs between attentional effects of spatial cues and abrupt onsets

We determined the relative effectiveness and tradeoffs among central, peripheral, and abrupt onset cues in directing attention to a potential target character. Central cues were arrows located at the fixation point, whereas peripheral cues were arrows occurring about 3° away from fixation, near the location of a potential target. These were contrasted with the abrupt onset of an ambiguous part of a character, which later was filled in to reveal a target or a distractor item. Each trial included an arrow cue and an abrupt onset cue, and both expected cue validities and cue-character SOAs were varied factorially. The results showed that, in general, abrupt onsets captured attention more effectively than either central or peripheral arrow cues. However, tradeoffs among separate cue effects indicated that the power of abrupt onsets to capture attention automatically could be overridden by a high-validity spatial cue presented in advance of the onset character. Tradeoffs between the effects of central and abrupt onset cues were additive, indicating that endogenous and exogenous cues have their main effects at different levels in the visual attention system. Peripheral cues and abrupt onsets showed mainly interactive effects, however, consistent with the idea that both types of cues have exogenous components that affect a common pool of attentional resources.     

Central inhibitory dysfunctions: mechanisms and clinical implications

Injury to the central or peripheral nervous system is often associated with persistent pain. After ischemic injury to the spinal cord, rats develop severe mechanical allodynia-like symptoms, expressed as a pain-like response to innocuous stimuli. In its short-lasting phase the allodynia can be relieved with the gamma-aminobutyric acid (GABA)-B receptor agonist baclofen, which also reverses the hyperexcitability of dorsal horn interneurons to mechanical stimuli. Furthermore, there is a reduction in GABA immunoreactivity in the dorsal horn of allodynic rats. Clinical neuropathic pain of peripheral and central origin often cannot be relieved by opiates at doses that do not cause side effects. The loss of sensitivity to opiates may be associated with the up-regulation of endogenous antiopioid substances, such as the neuropeptide cholecystokinin (CCK). CCK and its receptor (CCK-R) protein is normally not detectable in rat dorsal root ganglion cells. After peripheral nerve section, both CCK and CCK-R are up-regulated in the dorsal root ganglia. Furthermore, CI 988, an antagonist of the CCK-B receptor, chronically coadministered with morphine, reduces autotomy, a behavior that may be a sign of neuropathic pain following peripheral nerve section. Thus, opiate insensitivity may be due to the release of CCK from injured primary afferents. Similarly, in the chronic phase of the spinal ischemic model of central pain, the allodynia-like symptom is not relieved by systemic morphine, but is significantly reversed by the CCK-B antagonist. Consequently, up-regulation of CCK and CCK-R in the CNS may also underlie opiate drug insensitivity following CNS injury. Thus, dysfunction of central inhibition involving GABA and endogenous opioids may be a factor underlying the development of sensory abnormalities and/or pain following injury to neural tissue.     

The time course of attentional capture under dual-task conditions

Several recent studies have shown that attentional capture is not an automatic process. For example, abrupt peripheral onsets do not affect the processing of targets presented subsequently at that location when participants have to concurrently perform a perceptually demanding task elsewhere. This result leaves open the question of whether peripheral onsets lose their effectiveness in capturing attention or whether, instead, the performance of a perceptually demanding task entails a faster disengagement of attention from the cued location. Here, we measured exogenous spatial attentional-orienting effects either while participants performed a concurrent perceptually demanding central-monitoring task (a rapid serial visual presentation of letters for a to-be-detected digit target; Experiments 1 and 2) or in isolation (the baseline condition in Experiment 2). The results showed that peripheral onsets captured participants' attention at both the 80- and 190-ms stimulus onset asynchronies (SOAs) in the baseline condition. Crucially, however, during concurrent central monitoring, peripheral onsets were effective in capturing attention only at an 80-ms SOA, while the orienting effect disappeared as soon as a changing letter drew participants' attention back to the central stream (at an SOA of 190 ms). These findings demonstrate that task-irrelevant abrupt onsets cannot be entirely overridden by top-down attentional control, although attentional capture effects are dramatically reduced by an ongoing perceptually demanding task.     

Plucks and bows are not categorically perceived

Letter-like targets (a circle and a square) were presented in one of two fixed and cued visual field locations and were shown alone, flanked by a noise stimulus on the peripheral side (side of target farthest from fixation), on the central side, or on both sides simultaneously. The adjacent target and noise stimulus borders had similar featural properties (both curved or both straight lines) or dissimilar properties (one being a curved line and one a straight line). Each of 10 subjects made a go, no-go response only when his or her designated target appeared in a display. The results showed: (1) single targets were discriminated more accurately and more rapidly than were targets shown simultaneously with noise stimuli, (2) targets having dissimilar border relationships with noise items were discriminated more accurately than were targets having similar border relationships, (3) targets in central-noise displays were discriminated more accurately and rapidly than were targets in peripheral-noise displays, and (4) there was no interaction between border relationships and noise position. The principal result relating to target-noise border featural relationship was consistent with predictions derived from models which place the locus of noise effects at the stage of stimulus feature extraction. Aspects of the results were, however, seen to be consistent with both feature extraction and response competition conceptualizations.     

Altered Arm-Body Coordination with Triggered Pointing Responses as Influenced by Task Predictability

Abstract

Reaching movements generate reaction forces that affect postural stability, requiring sophisticated coordination between body and arm movement to maintain balance. In voluntary movement, this coordination involves feedforward shifts of posture, and such anticipatory postural muscle activity also accompanies the rapid modulation of an ongoing point to suddenly a shifting target (double-step). However, it is unknown if this early postural activity depends on target-shift predictability and whether arm and body motion are similar coordinated to voluntary movement. Body and arm motion coordination during double-step pointing movements from standing were done under differing conditions of target-shift predictability. In a proportion of trials, the pointing target was displaced, with the predictability of target-shift direction varied between two peripheral targets (target-shift direction known) and two central targets (target-shift direction uncertain). The target jump evoked an adjustment in the arm then body response, opposite to the pointing responses to the initial target. The triggered arm-then-body ordering was consistent across target-shift predictability, although known target-shift direction resulted in closer timing of arm and body onsets. The altered coordination in triggered corrections suggests that the body component in triggered reactions depend on response predictability, showing an altered control of arm and body motion.     

Tail-pinch hyperalgesia and analgesia: Test-specific opioid and nonopioid actions

Reactivity to noxious stimuli in rats is altered following acute exposure to tail-pinch. However, while our laboratory has reported that tail-pinch produces hyperalgesia as measured by the flinch-jump test and attenuates analgesic responses following morphine and cold-water swims, others have found that tail-pinch elicits an opioid-sensitive analgesia on the hot plate test and a nonopioid-sensitive analgesia on the writhing test. The first experiment of the present study examined whether tail-pinch altered responses on two somatic pain tests and showed that tail-pinch significantly decreased both jump thresholds and tail-flick latencies. In assessing whether tail-pinch hyperalgesia on the jump test was mediated by endogenous opioids, the second experiment indicated that low (0.1 and 0.5 mg/kg) doses of naloxone eliminated tail-pinch hyperalgesia by selectively lowering control thresholds and a high (10 mg/kg) dose of naloxone eliminated tail-pinch hyperalgesia by selectively increasing thresholds following tail-pinch. Further, the third experiment showed that morphine-tolerant rats (10 mg/kg morphine daily over 14 days) did not exhibit tail-pinch hyperalgesia on the 15th day, an effect attributable to a selective lowering of control thresholds. The fourth experiment was a direct replication of the observation that tail-pinch produces analgesia on the writhing test which is not antagonized by naloxone. These results demonstrate that the pain test employed and the amount of prior tail-pinch experience are critical variables in determining the direction of tail-pinch effects upon pain perception in rats.     

The reality of phantom limbs

This paper evaluates the joint influence of peripheral neurophysiological factors and higher-order cognitive and affective processes in triggering or modulating a variety of phantom limb experiences, including pain. Part 1 outlines one way in which the sympathetic nervous system may influence phantom limb pain. A model involving a sympathetic-efferent somatic-afferent cycle is presented to explain fluctuations in the intensity of sensations referred to the phantom limb. In part 2, the model is extended to explain the puzzling finding that onlyafter amputation are thoughts and feelings capable of evoking referred sensations to the (phantom) limb. While phantom pains and other sensations frequently are triggered by thoughts and feelings, there is no evidence that the painful or painless phantom limb is a symptom of a psychological disorder. In part 3, the concept of a pain “memory” is introduced and described with examples. The data show that pain experienced prior to amputation may persist in the form of a memory referred to the phantom limb causing continued suffering and distress. It is argued that two independent and potentially dissociable memory components underlie the unified experience of a pain memory. This conceptualization is evaluated in the context of the surgical arena, raising the possibility that under certain conditions postoperative pain may, in part, reflect the persistent central neural memory trace left by the surgical procedure. It is concluded that the experience of a phantom limb is determined by a complex interaction of inputs from the periphery and widespread regions of the brain subserving sensory, cognitive, and affective processes.     

The influence of semantic context on initial eye landing sites in words

To determine the role of ongoing processing on eye guidance in reading, two studies examined the effects of semantic context on the eyes' initial landing position in words of different levels of processing difficulty. Results from both studies clearly indicate a shift of the initial fixation location towards the end of the words for words that can be predicted from a prior semantic context. However, shifts occur only in high-frequency words and with prior fixations close to the beginning of the target word. These results suggest that ongoing perceptual and linguistic processes can affect the decision of where to send the eyes next in reading. They are explained in terms of the easiness of processing associated with the target words when located in parafoveal vision. It is concluded that two critical factors might help observing effects of linguistic variables on initial landing sites, namely, the frequency of the target word and the position where the eyes are launched from as regards to the beginning of the target word. Results also provide evidence for an early locus of semantic context effects in reading.     

Negative affect and sensitization to pain

Pain usually has a strong negative affective component, which is believed to modulate pain perception. After reviewing theories on the link between negative affect and pain, mechanisms are discussed by which negative affect may either increase or inhibit pain. Possible pain-inhibiting mechanisms are endogenous opioid release, blood pressure reactivity, and distraction of attention; possible pain-increasing mechanisms are autonomic and muscular reactivity, misattribution of arousal, hypervigilance to pain, worrying, and avoidance behavior. It is emphasized that each of these mechanisms can be very adaptive in acute pain situations to prevent injury and promote recovery. In chronic pain, however, ongoing physiological arousal and hypervigilance to pain, induced or magnified by negative affect, may cause sensitization to pain. Furthermore, worrying about pain and avoidance of pain-inducing activities may increase negative affect, ypervigilance, and functional disability. It is argued that, in the long run, pain-related negative affect has sensitizing and disabling effects.     

Peripheral and central contribution to the difficulty of speech in noise perception in dyslexic children

Noise typically induces both peripheral and central masking of an auditory target. Whereas the idea that a deficit of speech in noise perception is inherent to dyslexia is still debated, most studies have actually focused on the peripheral contribution to the dyslexics’ difficulties of perceiving speech in noise. Here, we investigated the respective contribution of both peripheral and central noise in three groups of children: dyslexic, chronological age matched controls (CA), and reading‐level matched controls (RL). In all noise conditions, dyslexics displayed significantly lower performance than CA controls. However, they performed similarly or even better than RL controls. Scrutinizing individual profiles failed to reveal a strong consistency in the speech perception difficulties experienced across all noise conditions, or across noise conditions and reading‐related performances. Taken together, our results thus suggest that both peripheral and central interference contribute to the poorer speech in noise perception of dyslexic children, but that this difficulty is not a core deficit inherent to dyslexia.     

The asymmetry of lateral interference in visual letter identification

Asymmetry of masking refers to the fact that a masking letter placed on the peripheral side of a target in the visual field will interfere more with recognition of the target than will a masking letter placed on the central side of the target. The experiments in this paper show that lateral masking for a pair consisting of a single target and a single mask cannot be entirely explained by processing interference caused by the mask but that masking ]has a component of purely sensory interference. Furthermore, the asymmetry of masking at the sensory level, when all sources of processing interference are eliminated, can be explained in terms of the falloff in acuity from the center to the periphery of the retina. The sensory component of masking is asymmetrical because, with the target at a constant retinal location, the target-plus-mask configuration is, as a whole, more peripherally located with a peripheral mask than a central one, and it is the location of the target-plus-mask configuration that determines performance.     

Peripheral and central sensation: multisensory orienting and recognition across species

Attentional bottlenecks force animals to deeply process only a selected fraction of sensory inputs. This motivates a unifying central-peripheral dichotomy (CPD), which separates multisensory processing into functionally defined central and peripheral senses. Peripheral senses (e.g., human audition and peripheral vision) select a fraction of the sensory inputs by orienting animals’ attention; central senses (e.g., human foveal vision) allow animals to recognize the selected inputs. Originally used to understand human vision, CPD can be applied to multisensory processes across species. I first describe key characteristics of central and peripheral senses, such as the degree of top-down feedback and density of sensory receptors, and then show CPD as a framework to link ecological, behavioral, neurophysiological, and anatomical data and produce falsifiable predictions.     

Saccadic localization of visual targets by the very young human infant

The direction, latency, and form of the 1- and 2-month-old human infant’s saccadic eye movements toward peripheral targets were investigated. Infants of both ages reliably executed a directionally appropriate first saccade toward a peripheral target introduced as far as 30 deg from the line of sight along the horizontal and both diagonal axes, but only to 10 deg along the vertical axis. The presence of a second target in the central visual field reduced the probability of peripheral target localization. A significant inverse relation was found between target distance from the line of sight and probability of initiating a directionally appropriate saccade. Electro-oculography revealed that latency to first saccade, although highly variable, was less than 500 msec on a significant proportion of trials. Unlike the adult, the first saccade to target was grossly hypometric and was followed by one or more saccades of approximately equal amplitude to the first.     

Cognitive-emotional sensitization and somatic health complaints

Sensitization is conceptually related to cognitive bias in experimental psychopathology, and they share the basic mechanism of neuronal sensitization. Every strongly relevant individual concern, like fears, can yield cognitive bias or "cognitive-emotional sensitization". It might also be present for bodily and environmental information related to illness, and could be an etiological factor in medically unexplained complaints. Physiological and cognitive sensitization are theoretically compared. There is evidence for cognitive-emotional sensitization in some medically unexplained somatic complaints, and negative affect is suggested as a catalyst. Prolonged cognitive-emotional sensitization ("perseverative negative cognition" or worry, rumination) might even have demonstrable somatic pathological effects. It is concluded that sensitization may be organized at different levels, both in the organism and in the larger living system within which the organism is subsumed. This view might not only help to clarify medically unexplained pain syndromes, but virtually every subjective complaint, both with and without recognized physiopathology.     

The effects of perceptual load in central and peripheral regions of the visual field

The perceptual load model claims that attentional selectively depends on perceptual load. Selectivity is high with high load, but low with low load. Previous studies only manipulated load levels at task-relevant regions. In this study, perceptual load was orthogonally manipulated in both relevant (central) and nonrelevant (peripheral) regions, by varying the similarity between the target and nontarget letters and the nontarget letters' heterogeneity. The participants had to identify a target-letter appearing in a central circle of letters. A distractor-letter, appearing in a peripheral circle, was compatible, neutral, or incompatible with the target. As expected, increasing peripheral load deteriorated performance, but only with low levels of central load. The pattern of distractor interference did not follow the model's predictions because distractor interference under high load levels was occasionally found. The expected pattern of results emerged only when the spatial uncertainty regarding the distractor position was low, implying that spatial uncertainty plays an important role in attentional selectivity.     

Separate mechanisms recruited by exogenous and endogenous spatial cues: evidence from a spatial Stroop paradigm

The present experiments tested whether endogenous and exogenous cues produce separate effects on target processing. In Experiment 1, participants discriminated whether an arrow presented left or right of fixation pointed to the left or right. For 1 group, the arrow was preceded by a peripheral noninformative cue. For the other group, the arrow was preceded by a central, symbolic, informative cue. The 2 types of cues modulated the spatial Stroop effect in opposite ways, with endogenous cues producing larger spatial Stroop effects for valid trials and exogenous cues producing smaller spatial Stroop effects for valid trials. In Experiments 2A and 2B, the influence of peripheral noninformative and peripheral informative cues on the spatial Stroop effect was directly compared. The spatial Stroop effect was smaller for valid than for invalid trials for both types of cues. These results point to a distinction between the influence of central and peripheral attentional cues on performance and are not consistent with a unitary view of endogenous and exogenous attention.     

Somatization,sensitization, and functional dyspepsia

Functional dysepsia (FD) is defined as persistent or recurrent pain or discomfort centered in the upper abdomen without evidence of organic disease likely to explain the symptoms. Visceral hypersensitivity, motor dysfunction, and impaired gastric accommodation are found in some patients with FD, and psychological factors like chronic stress, attention and perception bias are also likely to play a part in the symptom formation. There is considerable overlap of non-specific symptoms like fatigue, headache, abdominal discomfort, muscle pain, and sleep disturbance in patients with different functional disorders, in this article exemplified by FD, fibromyalgia, and chronic fatigue syndrome. This overlap of symptoms indicates a common underlying sensitization process, leading to somatization.     

Locally Bayesian learning with applications to retrospective revaluation and highlighting

A scheme is described for locally Bayesian parameter updating in models structured as successions of component functions. The essential idea is to back-propagate the target data to interior modules, such that an interior component's target is the input to the next component that maximizes the probability of the next component's target. Each layer then does locally Bayesian learning. The approach assumes online trial-by-trial learning. The resulting parameter updating is not globally Bayesian but can better capture human behavior. The approach is implemented for an associative learning model that first maps inputs to attentionally filtered inputs and then maps attentionally filtered inputs to outputs. The Bayesian updating allows the associative model to exhibit retrospective revaluation effects such as backward blocking and unovershadowing, which have been challenging for associative learning models. The back-propagation of target values to attention allows the model to show trial-order effects, including highlighting and differences in magnitude of forward and backward blocking, which have been challenging for Bayesian learning models.     

Perception-action coupling and S-R compatibility

How is an aiming movement toward a visual target amended when the target suddenly steps to a new position just before or after the movement has started? Three hypotheses are examined: (1) the initial movement needs to be actively terminated before the new movement can be planned and executed, (2) substitution of the initial target position code results, after a normal RT, in the simultaneous termination of the initial movement and initiation of the movement to the new target position, or (3) a second movement from the initial to the second target is initiated after a normal RT, and superimposed on the ongoing movement toward the initial target. The substitution hypothesis assumes a highly continuous and parallel mode of operation of the perceptual-motor system, whereas the other hypotheses assume a distinctly discrete mode of operation. Detailed analyses of double-step movement trajectories clearly favored the substitution hypothesis. These results are discussed with reference to current views on motor control, overlapping-task performance, and the discrete-continuous issue. It is argued that the nature of the perception-action interface depends on the ideomotor compatibility of the task. Perceptual and motor processes operate in a highly continuous and parallel fashion in ideomotor compatible tasks, whereas the interposition of a limited-capacity response selection mechanism results in a discrete and intermittent mode of communication between these processes in non-ideomotor compatible tasks.     

Selective response activation can begin before stimulus recognition is complete: a psychophysiological and error analysis of continuous flow

In discussions of process models of human information processing, the continuous flow conception (Eriksen and Schultz 1979) plays a prominent role. A central prediction of this conception is that any information in a display associated with a response activates that response as soon as it becomes available in the perceptual system. If it concerns the correct response channel, then response facilitation occurs. If it concerns the incorrect response channel, then response competition occurs. To assess these mechanisms more directly, we used psychophysiological measures as well as reaction time (RT). We used the latency of the P3 component of the event related brain potential (ERP) as an index of stimulus evaluation duration, the onset of lateralized motor activity derived from the ERP as an index of selective central motor activation, and the onset of electromyographic activity as an index of the start of peripheral motor activation. Subjects were required to respond to target letters that were either flanked by letters that signalled the opposite response (incompatible arrays), by the target itself (compatible arrays), by letters not associated with a response (neutral arrays), or by no other letters (targets alone). Our results replicated the basic findings obtained in this paradigm. RTs to targets alone did not differ from RTs to compatible arrays. The latter were faster than RTs to neutral arrays, which were faster than RTs to incompatible arrays. P3 latencies were longer on incompatible than on neutral trials, and longer on compatible than on target alone trials. Incorrect central response activation on incompatible trials and correct central response activation on compatible trials, both began earlier than on target alone trials. Peripheral responding on both trial types, however, began later than on target alone trials. More incompatible but less compatible trials than neutral ones exhibited incorrect peripheral response activation. Peripheral response execution was faster and more accurate on compatible than on target alone trials, while it was slower and less accurate on incompatible than on neutral trials. These results indicate, that the flankers activated their associated response channel while display evaluation was still going on, and that response facilitation and competition occurred. After applying criteria proposed by Miller (1988), it was concluded that the set of stimulus recognition processes and the set of response activation processes cannot be regarded as independent stages of processing.