Impulsivity, aggression, and serotonin: a molecular psychobiological perspective

The expression of aggressiveness, which constitutes many facets of behavior, is influenced by a complex interaction of biologic, psychologic, and social variables. Even though individual differences in impulsivity and the behavioral consequences, such as aggression, addiction, and suicidality, are substantially heritable, they ultimately result from an interplay between genetic variations and environmental factors. While formation and integration of multiple neural networks is dependent on the actions of neurotransmitters, such as serotonin (5HT), converging lines of evidence indicate that genetically determined variability in serotonergic gene expression influences complex traits including that of inappropriately aggressive behavior. This contribution reviews studies of major gene effects in inbred and knockout strains of mice with increased aggression-related behavior and discusses the relevance of several serotonergic gene variations in humans which include high aggressiveness as part of the phenotype. Although special emphasis is given to the molecular psychobiology of 5HT in aggression-related behavior in rodents, nonhuman primates, and humans, relevant conceptual and methodological issues in the search for candidate genes for impulsivity and aggressiveness and for the development of mouse models of aggressive and antisocial behavior in humans are also considered.     

Depression as a risk marker for aggression: A critical review

Depression is commonly thought of as counter-indicative of aggression because of apparent contradictions in energy requirements and blame orientation. However, empirical studies indicate that the presence of depression elevates risk for general aggression, intimate partner aggression, and self-aggression. Most of these studies are cross-sectional and retrospective, hence, there is scant empirical evidence for depression as a causal factor for aggression. However, there is considerable evidence for an association between depression and aggression. Depression as a risk marker for aggression may stem from a third factor such as genetics, personality disorder or insecure attachment. There are also a number of sequelae of depression that may contribute to this increased risk for aggression including isolation, lost social support, increased alcohol use, angry rumination, and impulsivity. Furthermore, affective swamping clouds attributional clarity so that internal and external attributions for negative feelings become fused and undifferentiated. Hence, negative events of sufficient affective impact can generate both depression and anger. One form of this affective swamping is scapegoating: finding an external person or persons to blame for “causing” aversive affect. For these reasons, depression should constitute a routine aspect of mental health assessment and where present, should be viewed as a risk factor for aggression.     

Infertility as boundary ambiguity: one theoretical perspective

Infertility as a life event can be understood from a number of conceptual perspectives: a developmental crisis, a grief reaction, a disruption of marital contracts and roles, a crisis of identity, sexuality, and/or values, or a challenge of decision-making processes. Stress theory and the construct of boundary ambiguity can augment the understanding of the crisis of infertility by providing a different approach and unique perspective. It is the hypothesis of this article that the involuntarily childless couple may experience infertility as a stress of boundary ambiguity, that is, not knowing who is in and who is out of the family system. As infertile couples attempt to make the transition to parenthood they may experience the child they wish to have as a family member who is psychologically present but physically absent.     

Childhood aggression and social adjustment as antecedents of delinquency

A sample of 2,453 grade school children were followed into young adulthood through record sources. Teacher interviews provided information about low-peer-status children that was assessed in relation to subsequent delinquency for both sexes and young adult criminality for males. A multivariate design evaluated the joint effects of social class, a measure of family disturbance, and childhood problem behavior factors as antecedents of delinquency. Childhood aggression emerged as the most prominent antecedent factor for males but not for females. Social class and family disturbance were associated with aggression but did not have significant direct effects on delinquency. Aggression was related to severity of delinquency. Dispositional status, reflecting severity, was the best indicator of which delinquent males would have adult criminal records. A causal model is presented.The study was supported by a grant from the Scottish Rite Schizophrenia Research Program, N.M.J., U.S.A. Portions of the study were presented at the Life History Research conference in Monterey, California, 1981. The authors wish to thank June White, Cindy Hanson, and Ned Worell for their help in conducting this research. Data for this research was originally gathered by Merrill Roff. Follow-up data were contributed by Ronald Peek, Donald Bamber, Charles Watson, Shiela Makie, William S. Ward, Edward S. Posey, Chris Hemlabs, and Harriet Barnes.     

Unemployment as a chronic stressor: A systematic review of cortisol studies

Objective: Unemployment is a type of chronic stressor that impacts human health. The reasons for how the stress of unemployment affect health is still a matter of discussion. One of the pathways from chronic stress to ill health is mediated by cortisol, and so we set out to compile extant data on how its secretion is affected by unemployment.

Design: A systematic literature search was conducted to establish the cortisol dysregulatory effects of this stressor.

Main outcome measures: Only studies that specifically examined the effects of unemployment on cortisol excretion, and were written in English were included.

Results: Ten reports were obtained and synthesised to determine the severity and complexity of the effect of unemployment on cortisol secretion. The resulting combined evidence is mixed in terms of degree or dynamic of relationship.

Conclusions: The differences between the cumulate findings of the studies can be understood in the context of the lack of both standardised methodology and an absence of consensus on unemployment definition. We propose existing methodologies may be strengthened by acknowledging and accounting for the individual characteristics that may be relevant to the stress experience of unemployment.     

The development of social aggression and physical aggression: A narrative analysis of interpersonal conflicts

Using conflict narratives reported by children and adolescents, this study investigated the development and social functions of social aggression in comparison to physical aggression. A total of 510 participants in two cohorts of a longitudinal study were involved (116 girls and 104 boys from Grade 4 and155 girls and 135 boys from Grade 7). Patterns of social aggression and physical aggression were identified based on interview reports in the first year of the study. Results showed that a triadic structure of social relationship was often reported in conflicts where social aggression was employed, whereas a dyadic structure was reported in conflicts involving physical aggression. Girls tended to use social aggression against girls, whereas boys tended to use physical aggression against boys. Children and adolescents who were central in peer social networks were more likely to employ social aggression than those who were peripheral in the networks. Social aggression was not reliably linked to concurrent or future problematic adjustment. Physical aggression, however, was not related to network centrality but was linked to concurrent and future maladjustment (e.g., low academic competence and school dropout). Aggr. Behav. 28:341–355, 2002. © 2002 Wiley‐Liss, Inc.     

Rage and aggression in youth: A self psychological perspective

The conceptual development of self psychology has emphasized that traditional psychoanalytic drives (sexuality, aggression) become pathological in their expression when self-selfobject ties at crucial developmental periods are problematic, flawed or damaged. This theory was derived from Kohut's psychoanalytic work with adult patients and not from direct observation of behaviorally and emotionally disturbed youth. This paper examines the experience of the self and its relationships in the development of aggressive behavior in children and adolescents. It argues from a largely self psychological perspective that rage and aggression in many youth may be conceptualized as reactions to actual or threatened loss of tenuously held selfobject relationships that render the self feeling anxious, helpless and without value. The aggression attempts to restore cohesion and self-value by punishing the deficient selfobject, nullifying its actions and/or by compelling the selfobject (or substitute) to reverse the behavior or deed that produced the initial self-selfobject rupture.     

Offensive and defensive aggression in humans: A longitudinal perspective

Offensive and defensive aggression were distinguished on the basis of associated events. Behavior delivering noxious stimuli was defined as defensive when it was a response a threatening situation and as offensive when it was an unprovoked act. The existence of a general aggression factor was implied by the finding that initiators of aggression also readily defend themselves if attacked. The use of a peer nomination and teacher rating variable for offensive aggression, “Attacks without reason, teases others, naughty things”; and another for defensive aggression, “Defends him/herself if teased, but does not tease or attack others without reason,” yielded differential results. Offensive aggression at age 14 was significantly predicted by aggressive behavior age 8, while defensive aggression was not. Intercorrelations of rating variables at 14 showed that offensive aggression was related to weak self-control and defensive aggression to strong self-control. Only offensive aggression at age 14 predicted criminality at age 20. The results indicate a diversity of motivations for aggressive behaviors, as suggested by observations on animal behavior.     

Networking as a job search behaviour: A social network perspective

Although networking is typically recommended as a job search strategy in the popular press, research on networking as a job search behaviour is scarce. On the basis of social network theory, the present study investigated whether the structure and composition of job seekers' social network determined their networking behaviour and moderated its relationship with job search and employment outcomes. The data were collected in a large, representative sample of 1,177 unemployed Flemish job seekers, using a two‐wave longitudinal design. Job seekers with a larger social network and with stronger ties in their network spent more time networking, beyond individual differences in extraversion and conscientiousness. Networking explained incremental variance in job offers beyond job seekers' use of print advertising, the internet, and public employment services, but not in employment outcomes. Some evidence was found indicating that networking might be more effective for job seekers whose social network contains weaker and higher‐status ties.     

application of the social marketing model to unemployment counseling: a theoretical perspective

A. R. Andreasen's (1995) social marketing model (SMM) is applied to structure feedback counseling for individuals who are unemployed. The authors discuss techniques used in commercial marketing and how they are equally applicable to solving societal problems; SMM and its application to social interventions; and structured feedback that moves a person from contemplating change to sustained behavioral modification, which can facilitate attitudinal and behavioral change. The relationship of SMM to motivational theories that support the potential of SMM for unemployment counseling is also discussed. The article concludes with a review of the integration of SMM by the New Zealand Employment Service.     

Moral cognition and moral action: A theoretical perspective

Considerable theoretical work has been done in the area of moral reasoning. However, little conceptual thinking has been done about the relations between moral cognition and moral action. As a result, empirical research in this area has been unsystematic and difficult to interpret. A theoretical model, the Self Model, is proposed here, starting from the assumption that moral reasons are functionally related to action. First, a concept of cognitive motivation is presented as necessary for any cognitive account of morality. Two cognitive approaches to moral conduct, Piaget's and Haan's, are then discussed in their positive contributions and in their limitations. The Self Model is finally described through a set of empirically testable propositions. Its major theoretical characteristics are: it is cognitive, recognizing as the central function of human cognition the appraisal of truth; it acknowledges a basic duality of motivation, but stresses the normative pull of cognitive motivation; it is developmental; it uses the self as the central explanatory concept, establishing both the sense of personal responsibility and the dynamism of self-consistency.     

Psychopathy and indirect aggression: the roles of cortisol, sex, and type of psychopathy

Salivary cortisol was examined in relation to indirect aggression and primary psychopathy (i.e., cold affect and interpersonal manipulation) and secondary psychopathy (i.e., criminal tendencies and erratic lifestyle) in a sample of 154 undergraduate students. Results revealed that although psychopathy and indirect aggression were strongly correlated, when statistically controlling for each of type of psychopathy, only primary psychopathy was related to indirect aggression. In women but not in men, lower cortisol was associated with higher levels of primary psychopathy and higher cortisol was associated with higher levels of secondary psychopathy. Cortisol was not related to indirect aggression. Results are discussed from both an evolutionary and developmental perspective.