白细胞介素-1在病态行为中的作用及其机制

白细胞介素－1（interleukin-1,IL-1）是介导神经－免疫活动的关键分子,在应激状态时出现IL-1活性增强,注射IL-1可以引发病态行为。外周释放的IL-1通过快通路和慢通路作用于大脑进而引发病态行为,快通路是指局部的初级传入神经将信息传入大脑,慢通路是指IL-1从环脑室器官和脉络从扩散进入大脑。     

Stress, Energy, and Immunity: An Ecological View

ABSTRACT— A common perspective on stress-related changes in the human immune system is that such changes are potentially harmful, especially those occurring during chronic stress. In contrast, an ecological perspective views the immune system as an energetically costly system that may or may not have priority over other uses of that energy. From this perspective, the immune system may have energy made available for it via reduction of other activities, may change in energetically conservative ways when the protection it confers needs to be balanced with the energetic demands of other activities such as fight or flight, or may be suppressed when other activities are more important than immunity for total well-being. This last type of change can explain why aspects of psychosocial health such as optimism relate to worse immunity under some circumstances and suggests that both benefits and costs of immunosuppression during stress should be considered in research on human stress and immunity.     

Occupational Stressors, Stress Responses, and Alcohol Consumption Among Professional Firefighters: A Prospective, Longitudinal Analysis

This dual-site longitudinal prospective study monitored and measured change in self-reported occupational stressors, emotional trauma, symptoms of stress, and alcohol consumption in urban firefighters. Study participants were 188 firefighters employed by two urban fire departments. The results showed that of 19 occupational stressors examined, only 5 (26%) changed significantly over time, and of those 5, only two—job skill concerns and concerns regarding reduction in force and benefits—decreased, reflecting less bothersome subjective ratings. Of the 12 measures of posttraumatic and other symptoms of stress, 9 (75%) increased significantly over time and none decreased significantly, whereas alcohol consumption was stable over time. Job stressors, trauma caseness, and stress response symptoms at baseline were strongly and significantly associated with the same measures at the two-year follow-up. The implications of the findings for prevention and remediation of stress disorders in fire service personnel are considered. It can be concluded that the stressful nature of urban firefighting is significantly associated with negative health outcomes, including the potential overreliance on alcohol use.     

Separation, Sickness, and Depression: A New Perspective on an Old Animal Model

ABSTRACT— Studies of prolonged separation from the attachment figure that were conducted with infant monkeys during the middle of the 20th century identified a passive behavioral response, termed "despair," that appeared to model human depressive illness. Studies in guinea pigs, which exhibit filial attachment that resembles attachment in monkeys, have described a similar passive response to briefer periods of maternal separation. Recent evidence indicates that elements of the immune system mediate the passive behavioral response of guinea pigs. These findings accord well with current ideas that immune responses contribute to depressive illness, suggest new hypotheses about how maternal separation might promote depression, and give us a rodent model in which such hypotheses might be tested.     

Spirituality and Healthy Lifestyle Behaviors: Stress Counter-balancing Effects on the Well-being of Older Adults

The goal of this study was to examine stress-ameliorating effects of religiosity, spirituality, and healthy lifestyle behaviors on the stressful relationship of chronic illness and the subjective physical well-being of 221 older adults. We also investigated whether the intervening variables functioned as coping behaviors and orientations or as adaptations in late life. Guided by the stress paradigm, path analysis was used to assess these relationships in a stress suppressor model and a distress deterrent model. No suppressor effects were found; however a number of distress deterrent relationships were detected. Spirituality, physical activities, and healthy diet all contributed to higher subjective physical well-being, as counter-balancing effects, in the distress deterrent model. The findings have implications for future research on the role of spirituality, religiosity and lifestyle behaviors on the well-being of chronically ill older adults. Findings also support the need for studying different dimensions of religiosity and spirituality in an effort to understand coping versus adaptation in behaviors and orientations. Gracie H. Boswell, Ph.D., M.Ed. (Case Western Reserve University) and (M. Ed.- Kent State University). She is a Carolina Program in Health and Aging Research Scientist at the Institute on Aging- University of North Carolina at Chapel Hill. Her research interests have been social gerontology and quality of life, emphasizing religiosity/spirituality. Eva Kahana, Ph.D. (University of Chicago) is Pierce T. and Elizabeth D. Robson Professor of Humanities and Director of the Elderly Care Research Center- Case Western Reserve University. Her research concentration has been the sociology of aging (coping & stress and institutionalization). Peggye Dilworth-Anderson, Ph.D. (Northwestern University) is Director- Center for Aging and Diversity, Institute on Aging, Professor- School of Public Health, Department of Health Policy and Administration at University of North Carolina at Chapel Hill. Her research interests have been caregiving and minority health disparities.     

不同时程应激对大鼠行为、免疫和交感神经系统反应的影响

研究旨在研究不同时程情绪应激诱导的大鼠行为、免疫和神经内分泌反应的动态变化及其相互关系。实验采用一种在程序性饮水的固定时间点不确定性给予大鼠空瓶刺激诱发其情绪反应的应激模式,测定不同时程（14,21和28天）应激对大鼠行为、交感神经系统反应、体液免疫功能及体重增长的影响。结果表明,情绪应激导致大鼠攻击行为显著增加,且在整个应激过程中情绪应激组大鼠的攻击行为都被稳定地诱导;不同时程的情绪应激均导致大鼠特异性抗OVA抗体水平明显降低,且降低的程度类似;在情绪应激的第14天和28天应激组大鼠血中去甲肾上腺素水平明显高于对照组,但后者升高的水平明显低于前者。此外,14天应激明显抑制大鼠的体重增长,但随着应激时程的延长,体重增长逐渐恢复。这些结果表明,随着应激时程的延长,大鼠行为、免疫和神经内分泌反应的适应性改变存在时程差异,有助于进一步了解应激诱发的各种反应间的复杂关系     

Health and Sickness: The Meaning of Menstruation and Premenstrual Syndrome in Women's Lives

The experience of menstruation was examined through an analysis of women's narratives in order to understand perceptions of menstrual cycle changes. Research within a medical anthropology perspective was conducted with 43 women who volunteered for a study on the knowledge and understanding of menstruation and premenstrual syndrome (PMS) in Winnipeg, Manitoba, Canada, from 1997 to 1999. Although most women accepted the PMS label and placed their cyclic changes within the realm of sickness, a small group of women were identified who conceptualized their cyclic changes in an extremely positive way thus reframing their experiences. More positive perceptions of menstrual changes may have a significant impact on the reevaluation of menstrual cycle fluctuations as sickness without devaluing the experiences of those women with severe changes.     

Patterns of Coping Among Persons with HIV Infection: Configurations, Correlates, and Change

This study examines coping in response to HIV infection, using longitudinal data from a nationally representative sample (n = 2,864) of HIV-infected persons. We investigated configurations of coping responses, the correlates of configuration membership, the stability of coping configurations, and the relationship of coping to emotional well-being. Four coping configurations emerged from cluster analyses: relatively frequent use of blame-withdrawal coping, frequent use of distancing, frequent active-approach coping, and infrequent use of all three coping strategies (passive copers). Passive copers had few symptoms, high levels of physical functioning, and high emotional well-being; blame-withdrawal copers had the opposite pattern. Of those completing a second interview 1 year after baseline, 46% had the same coping configuration. Increases in the number of HIV-related symptoms raised the probability of blame-withdrawal coping at follow-up, whereas decreases raised the probability of passive coping. Infrequent use of coping responses at baseline was related to greater emotional well-being 1 year later. This result, in conjunction with the high levels of emotional well-being in the passive cluster, suggests that high levels of distress can induce blame-withdrawal coping whereas coping efforts are minimal when social support and emotional well-being are high. Results highlight issues in ascertaining the causal direction between coping and psychological outcomes, as well as in specifying the nature of stressful situations with which people are coping.     

Work Stress,Chinese Work Values,and Work Well-Being in the Greater China

ABSTRACT

Work values influence our attitudes and behavior at work, but they have rarely been explored in the context of work stress. The aim of this research was thus to test direct and moderating effects of Chinese work values (CWV) on relationships between work stressors and work well-being among employees in the Greater China region. A self- administered survey was conducted to collect data from three major cities in the region, namely Beijing, Hong Kong, and Taipei (N = 380). Work stressors were negatively related to work well-being, whereas CWV were positively related to work well-being. In addition, CWV also demonstrated moderating effects in some of the stressor–job satisfaction relationships.     

Perceived Stress and Comorbid Illness Predict Depressive Symptomatology in People with Coeliac Disease

A high prevalence of depression is found in people with coeliac disease (CD). People with CD who are depressed are less likely to manage their illness effectively, which may lead to complications. Identification of variables associated with depression in people with CD may facilitate early detection and intervention. Participants were 749 members (125 males, 622 females) of the Queensland Coeliac Society (aged 18–88 years), recruited via a mailout. Participants completed the Modified Zung Self‐Rating Depression Scale, the Perceived Stress Scale, and the Perceived Consequences Subscale (from the Revised Illness Perception Questionnaire). Stress (p = .001) and comorbid medical illness (p = .01) were significantly associated with depression in CD. The current study made an original contribution to the body of literature by identifying stress and comorbid medical illness as predictors of depression in CD.     

The Daily Stress Inventory: Validity and effect of repeated administration

The Daily Stress Inventory (DSI) is a self-report measure of minor stressors which is administered daily. One test of the validity of a measure of daily stress is its sensitivity to the difference between the stressors of workdays and those of weekends. A second concern in establishing the validity of a test administered repeatedly is that self-monitoring may influence the obtained scores. The present study investigated these two issues using a sample of 70 community adults who reported full-time employment. These subjects provided a week of self-monitoring with the DSI. The results indicated that the DSI was sensitive to the difference between weekends and weekdays. The analyses of the effect of repeated administration suggested that the first day of self-monitoring may differ from the other days of self-monitoring. When the first day was eliminated, there was no significant difference among the days of self-monitoring, and the difference between the weekdays and the weekends remained. The data suggest that the DSI is a valid measure of the construct of daily stress and that any influence of repeated self-monitoring with the scale may be easily resolved.     

Predictors of the Peer Acceptance of Children with Diabetes: Social Behavior and Disease Severity

Objective. Investigated illness severity (medical control, disease impact, obviousness) and social behavior style as predictors of the peer acceptance of children with diabetes. Method. Sixty-five children (10–12.5 years old) with diabetes and their parents, teachers, and physicians participated. Physician ratings and laboratory tests indicated medical control. Parents and children reported disease impact and teachers rated disease obviousness. Children and teachers rated social behavior. Teachers reported peer acceptance. Results. Consistent with hypotheses, favorable social behavior positively predicted acceptance and disease impact negatively predicted acceptance; medical control did not relate to acceptance. Disease obviousness and social behavior interacted to predict acceptance. Children with more obvious disease were not stigmatized by unfavorable social behavior. Conclusions. Aspects of disease severity and social behavior influence peer acceptance and may be appropriate predictors and targets for remediation of peer problems.     

Homelessness, Mental Illness, and Criminal Activity: Examining Patterns Over Time

This study examined whether street homelessness, sheltered homelessness, and the severity of psychological symptoms predicted non-violent and violent crime among 207 mentally ill participants who were homeless at baseline. Participants were interviewed at 9 time points over 4 years. Hierarchical linear modeling (HLM) was used to examine whether changes in homelessness status and symptom severity predicted changes in criminal activity over time. Results indicated that homelessness both on the streets and in shelters and psychological symptom severity predicted increases in non-violent crime. Sheltered homelessness and symptom severity predicted increases in violent crime, although street homelessness did not. A separate mediational analysis with 181 participants showed that the relationship between diagnosis of a psychotic disorder and both non-violent and violent criminal activity was partially mediated through the severity of psychotic symptoms. Implications for research and intervention are discussed.     

Development and Validation of the Weekly Stress Inventory-Short Form

The Weekly Stress Inventory (WSI) has been used both in research and in clinical settings to measure minor stress. Although this tool offers a reliable and valid measure to assess minor stress, it lacks brevity that would make it more feasible for rapid assessments of stress needed in many research and clinical settings. The current study assessed the psychometrics of the newly developed Weekly Stress Inventory Short Form (WSI-SF), a 25-item scale to measure minor stress. Adults attending general medicine clinics (n = 171) at a public teaching hospital completed the WSI-SF and the WSI. The WSI-SF was found to have good internal consistency for both the events score (.92) and impact score (.91) and good convergent validity with the WSI. The results of the present study suggest that the WSI-SF is a reliable and valid instrument for use in assessing minor stress.     

神经颗粒素与脑老化、疾病及应激关系

神经颗粒素是一种神经元特异性、Ca2＋敏感性的鈣调蛋白（CaM）结合蛋白,是蛋白激酶C的突触后底物,与信号传导和长时程增强（LTP）有关。这是一种新发现的脑特异性蛋白质。主要分布在前脑和海马,在皮质、海马CA1-CA3区、齿状回、纹状体和杏仁核中高表达。在大脑发育的不同阶段,神经颗粒素在脑内的含量和分布区域会发生变化,其生物学作用受到国内外学者的关注。近年来国外学者开始对神经颗粒素与脑老化、疾病及应激关系进行考查。该文将着重介绍对神经颗粒素在脑老化、疾病和应激过程中所扮演的角色的研究工作及其新发现,目的是对脑与行为关系的理解及有关的脑机制的研究提供一个新的视点。     

Creative Activity,Personality, Mental Illness,and Short‐Term Mating Success

It has been argued that creativity evolved, at least in part, through sexual selection to attract mates. Recent research lends support to this view and has also demonstrated a link between certain dimensions of schizotypy, creativity, and short‐term mating. The current study delves deeper into these relationships by focusing on engagement in creative activity and employing an expansive set of personality and mental health measures (Five Factor Model, schizotypy, anxiety, and depression). A general tendency to engage in everyday forms of creative activity was related to number of sexual partners within the past year in males only. Furthermore, schizotypy, anxiety, and Neuroticism were all indirectly related to short‐term mating success, again for males only. The study provides additional support for predictions made by sexual selection theory that men have a higher drive for creative display, and that creativity is linked with higher short‐term mating success. The study also provides support for the contention that certain forms of mental illness may still exist in the gene pool because particular personality traits associated with milder forms of mental illness (i.e., Neuroticism & schizotypy) are also associated directly with creativity and indirectly with short‐term mating success.     

The Role of Human Resource Practices in Reducing Occupational Stress and Strain

The current study examined the occupational stress-strain relationship among a sample of 109 white-collar employees in Singapore. Participants completed a survey that assessed the presence of 8 human resource practices (job training, communication, job redesign, promotional opportunities, employee involvement, family-friendly policies, pay systems, and individual-focused stress interventions [SMIs]), 2 major stressors (role overload and responsibility), 2 types of strain (vocational and interpersonal), and organizational commitment. Results indicate that human resource (HR) practices did not reduce the sources of stress (role overload and responsibility) within the workplace. However, there was a direct negative relationship between HR practices and interpersonal strain. In particular, family-friendly practices, job training, and SMIs reduced interpersonal strain. An examination of vocational strain showed that it was negatively associated with SMIs and job training. In addition, organizational commitment mediated the relationship between HR practices and vocational strain. It was concluded that HR practices may be effective as part of a symptom-directed approach to stress intervention and that further replication of these results in both Asian and Western samples is required.     

工作应激与个体归因特点关系的研究

工作应激一直是组织行为中的热点问题,但综观前人研究,很少有研究者从归因的视角揭示其产生过程。本研究从个体的应激源感受性出发,探讨了个体归因特点与其工作应激的关系,建构了相应的模型,并结合压力管理问题,对研究进行了有益展望。     

精神疾病、行为控制及其伦理冲突

精神疾病的诊治,不仅具有基于治病的医学目的,而且还带有行为控制的社会目的和功能.因此,精神疾病的诊断和治疗的本身,与诊断和治疗的过程一样,需要伦理的思考和论证.在医生、社会和精神病患者之间的互动、而又充满矛盾的三角关系之中,医生对于社会和对于病人所承担的不同角色冲突,尤其需要伦理的审视.医生被赋予特殊权力的同时,也应被柯加与之相称的伦理责任.