Methylphenidate speeds evaluation processes of Attention Deficit Disorder adolescents during a continuous performance test

Fortysix Attention Deficit Disorder (ADD) adolescents took a Continuous Performance Test (CPT) under placebo and methylphenidate (35.33 mg/day). The task required pressing one button for targets (p=133),and another button for nontargets. Subjects displayed a strong bias to make the more frequent negative response before completely evaluating stimuli. Consistent with this assumption, subjects responded faster (by an average of 87 ms) to nontargets than to targets. Methylphenidate increased accuracy and speeded reaction times (RTs) to targets. The drug also increased the amplitude of the P3b component of the eventrelated potential for nontargets and shortened the latency of P3b for both targets and nontargets. These results suggest increased capacity allocation to and faster evaluation of task stimuli. Finally, the stimulant lengthened relative motor processing time (RT-P3b latency) for nontargets, a finding implying that response processing was accomplished with the benefit of earlier completion of evaluation processes for these stimuli.Portions of these findings were reported at the meeting of the Society for Research in Child and Adolescent Psychopathology, Costa Mesa, California, January 24–26, 1990. This research was supported by NIMH grant MH38118 to the first author. We thank the late Helen Pollock and the University of Rochester's Strong Memorial Hospital Pharmacy Manufacturing Department for their help.     

Learning in repeated visual search

Visual search (e.g., finding a specific object in an array of other objects) is performed most effectively when people are able to ignore distracting nontargets. In repeated search, however, incidental learning of object identities may facilitate performance. In three experiments, with over 1,100 participants, we examined the extent to which search could be facilitated by object memory and by memory for spatial layouts. Participants searched for new targets (real-world, nameable objects) embedded among repeated distractors. To make the task more challenging, some participants performed search for multiple targets, increasing demands on visual working memory (WM). Following search, memory for search distractors was assessed using a surprise two-alternative forced choice recognition memory test with semantically matched foils. Search performance was facilitated by distractor object learning and by spatial memory; it was most robust when object identity was consistently tied to spatial locations and weakest (or absent) when object identities were inconsistent across trials. Incidental memory for distractors was better among participants who searched under high WM load, relative to low WM load. These results were observed when visual search included exhaustive-search trials (Experiment 1) or when all trials were self-terminating (Experiment 2). In Experiment 3, stimulus exposure was equated across WM load groups by presenting objects in a single-object stream; recognition accuracy was similar to that in Experiments 1 and 2. Together, the results suggest that people incidentally generate memory for nontarget objects encountered during search and that such memory can facilitate search performance.     

Methylphenidate slows reactions of children with attention deficit disorder during and after an error

A Sternberg memory search task was administered under placebo and methylphenidate to 42 children with cross-situational attention deficit disorder (ADD), 31 children with cross-situational ADD plus oppositional features, and 25 patients with marginal ADD. Overall, stimulant medication enhanced accuracy and speed. In addition, patients reacted faster on correct responses not preceded by an error than on errors (especially false alarms) or on correct responses following an error. The slowness during error reactions may reflect decreased confidence or confusion during stimulus classification. This uncertainty may also lead subjects to respond with greater caution, hence more slowly, on correct responses following errors. Notably, methylphenidate increased the slowing of reactions on error trials as well as on correct reactions following an error. Stimulant medication may augment subjects' persistence when they are uncertain or confused, thereby heightening caution and promoting accuracy on succeeding trials. Consistent with previous reports of the generality of enhancement of performance by stimulant medication, the impact of methylphenidate was comparable for the three subtypes of ADD studied.Jaine Strauss is at Macalester College.This research was supported by National Institute of Mental Health Grants MH32103 and MH38118. We thank Rachel Avery, Christine Carriuolo, Lawrence Ota, the late Helen Pollock, and the University of Rochester's Strong Memorial Hospital Pharmacy for their assistance.     

Cue-focused and reflexive-associative processes in prospective memory retrieval

Several theories of event-based prospective memory were evaluated in 3 experiments. The results depended on the association between the target event and the intended action. For associated target-action pairs (a) preexposure of nontargets did not reduce prospective memory, (b) divided attention did not reduce prospective memory, (c) prospective memory was better than when the target event and intended action were not associated, and (d) prospective memory was characterized by retrieval of the precise intended action. These results converge on the view that retrieval is mediated by a reflexive-associative process. In contrast, for unassociated pairs (a) preexposure of nontargets reduced prospective memory, and (b) divided attention reduced prospective memory. These results implicate cue-focused retrieval processes and are most consistent with a discrepancy-plus-search model. The entire pattern implicates both cue-focused and reflexive-associative processes and more generally supports a multiprocess framework of prospective memory (M. A. McDaniel & G. O. Einstein, 2000).     

Boundary conditions on parallel processing in human vision

A new theory of visual search is tested experimentally with simple colour patches. The essential element of this new theory is that, whatever the search materials, efficiency increases continuously with (i) decreasing similarity between targets and nontargets, and (ii) increasing similarity between one nontarget and another. Control of 'attention' (access to visual short-term memory) is seen as a competitive interaction between display elements, and the theory shows how stimulus similarities influence the outcome of this competition. One alternative view is that parallel visual processes are limited to local mismatch detection. Search is parallel if the target forms a break in an otherwise homogeneous field, but is serial when absolute stimulus identification is required. It is shown, however, that even colour identification can be parallel, providing targets and nontargets are sufficiently dissimilar. A second alternative view is that search for simple features is parallel whereas search for conjunctions is serial. Conjunction search, however, has a characteristic similarity structure: different kinds of nontarget each share one relevant attribute with the target, but none with one another. When this structure is mimicked in search for colour patches, correspondingly poor performance is obtained.     

Direct and indirect memory tests: What they reveal about age differences in interference

The effects of interference on memory in younger and older adults were examined in a series of three experiments. In the study task, subjects were presented with a series of sentences, each having both a target, to-be-remembered ending, and a nontarget ending. Older adults showed equal priming of targets and nontargets on an indirect memory test (Experiment 1), whereas younger adults showed greater priming of the targets. In contrast, on direct memory tests (Experiments 2 and 3) both age groups were more accurate for targets than nontargets. This pattern of results is interpreted as evidence that age differences in interference involve selective attention mechanisms, but not elaborative rehearsal processes.     

Auditory event related potentials during lexical categorization in the oddball paradigm.

Event related potentials (ERPs) and reaction times (RTs) were recorded from 18 subjects, performing lexical categorization of words and nonwords. Three sets of monosyllable utterances, differentiated in semantic and rhyming attributes, were presented using the "oddball paradigm." ERPs included a sustained negativity which began approximately 100 msec after stimulus onset and peaked at approximately 400 mses (SN4) poststimulus, in response to target as well as to nontarget word stimuli. Semantic effects on SN4 latency were observed only for target utterances. Nonmeaningful word targets were associated with longer SN4 peak latencies as well as slower RTs compared to meaningful word targets. It is suggested that these longer latencies are due to a longer time required for an exhaustive search in permanent memory before categorizing a stimulus as a nonmeaningful word.     

What is learned about nontarget items in simple visual search?

Human sensitivity to correlational structure between nontargets and likelihood of target presence in a visual letter-search task were studied in two experiments. In each of these experiments, the performance of subjects for whom the nontarget information was altered in the final trial block was compared with the performance of subjects for whom the nontarget information did not change. When stimulus strings were presented individually on a computer screen and subjects were required to make a yes-no decision about target presence (Experiment 1), the change in nontarget structure resulted in increased reaction times for target-absent trials. When subjects searched simultaneously for three possible targets (Experiment 2), the change in nontarget structure produced increased error rates and increased reaction times for both target-absent and target-present trials. Correlations between the amount of predictive information in individual stimulus strings and reaction times also showed that both switching and nonswitching subjects were sensitive to the nontarget context. However, neither self-reports of strategy nor postexperiment choices between context-consistent and -inconsistent letter strings indicated any explicit knowledge of the predictive information in the nontarget stimuli. Subjects can thus acquire and benefit from, apparently without awareness, information about subtle correlational structure in nontarget elements in simple visual search.     

Encoding and retrieval processes in normal children and retarded adolescents

Information processing capabilities of normal and retarded individuals were studied within the context of a modified Sternberg recognition memory task. Presentation of items in the memory set was self-paced, and stimulus exposure times and response latencies were recorded.It was found that normal and retarded individuals spent the same amount of time processing subspan lists during input to the memory system; however, the normal subjects spent less time retrieving information from that system than did the retarded subjects. Part of the superiority of normal subjects was attributable to their higher scanning speeds during the stimulus comparison stage of memory retrieval. The scanning strategy of normal and retarded subjects, on the other hand, was found to be the same: serial and exhaustive. It was further demonstrated that the binary decision stage of retrieval was not related to differences in intelligence.     

The associated non-targets effect: evidence of nontarget processing at and beyond the level of letter recognition

In four visual search tasks participants were asked to make a target response if either of two targets was present and to make a nontarget response if neither target was present. Some target-absent displays included only nontarget stimuli or features that never occurred in the same displays as targets, whereas other target-absent displays included nontarget stimuli or features that did sometimes occur with targets. Nontarget responses were reliably faster in the former case than in the latter. This “associated nontargets effect” indicates that nontargets are not simply classified as nontargets but in addition are discriminated from one another. Current visual search models may underestimate the degree to which nontargets are processed during search.     

The associated nontargets effect: Evidence of nontarget processing at and beyond the level of letter recognition

In four visual search tasks participants were asked to make a target response if either of two targets was present and to make a nontarget response if neither target was present. Some target-absent displays included only nontarget stimuli or features that never occurred in the same displays as targets, whereas other target-absent displays included nontarget stimuli or features that did sometimes occur with targets. Nontarget responses were reliably faster in the former case than in the latter. This “associated nontargets effect” indicates that nontargets are not simply classified as nontargets but in addition are discriminated from one another. Current visual search models may underestimate the degree to which nontargets are processed during search.     

Implicit memory is vulnerable to proactive interference

We investigated the possibility that implicit memory, like explicit memory, can be disrupted by proactive interference. Participants first viewed a list of words, with nontargets in the first half of the list and targets in the second. Nontargets were either similar in structure (e.g., "ANALOGY") or unrelated (e.g., "URGENCY") to the targets (e.g., "ALLERGY"). After several filler tasks, participants completed an implicit fragment-completion test (e.g., "A_L__ GY") for the target items. Participants who viewed similar nontargets completed fewer fragments with target items and made more intrusions than did participants who viewed unrelated nontargets. Together with previous findings, these results suggest that similar nontargets can compete with target items to produce interference in implicit memory.     

Category effects in visual search: A failure to replicate the “oh-zero” phenomenon

In the experiment of Jonides and Gleitman (1972), subjects searched displays of digits or letters for single, specified digit or letter targets. The slope of the function relating reaction time to display size was positive (mean=25 msec/item) if target and nontargets belonged to the same alphanumeric category (within-category search), but zero if target and nontargets belonged to different categories (between-category search). This held even for the target O, whose categorical relationship to nontargets was determined entirely by the name it was given. In the present paper, two attempted replications are reported, one as close as practically possible. For the unambiguous targets A, Z, 2, and 4, slopes were greater in within-category search than in between-category search, but positive and very variable in both cases. For the ambiguous target O, slopes were identical in within-category and between-category search, and again positive. The results suggest that with single, specified targets, differences between within-category and between-category search may be due entirely to variation in the average physical resemblance between target and nontargets. In line with previous findings, they show that one cannot characterize within-category search as generally “serial” and between-category search as generally “parallel.”     

Perceptual integration of motion and form information: evidence of parallel-continuous processing

In three visual search experiments, the processes involved in the efficient detection of motion-form conjunction targets were investigated. Experiment 1 was designed to estimate the relative contributions of stationary and moving nontargets to the search rate. Search rates were primarily determined by the number of moving nontargets; stationary nontargets sharing the target form also exerted a significant effect, but this was only about half as strong as that of moving nontargets; stationary nontargets not sharing the target form had little influence. In Experiments 2 and 3, the effects of display factors influencing the visual (form) quality of moving items (movement speed and item size) were examined. Increasing the speed of the moving items (> 1.5 degrees/sec) facilitated target detection when the task required segregation of the moving from the stationary items. When no segregation was necessary, increasing the movement speed impaired performance: With large display items, motion speed had little effect on target detection, but with small items, search efficiency declined when items moved faster than 1.5 degrees/sec. This pattern indicates that moving nontargets exert a strong effect on the search rate (Experiment 1) because of the loss of visual quality for moving items above a certain movement speed. A parallel-continuous processing account of motion-form conjunction search is proposed, which combines aspects of Guided Search (Wolfe, 1994) and attentional engagement theory (Duncan & Humphreys, 1989).     

Implicit expectations influence target detection in children and adults

When a sound occurs at a predictable time, it gets processed more efficiently. Predictability of the temporal structure of acoustic inflow has been found to influence the P3b of event‐related potentials in young adults, such that highly predictable compared to less predictable input leads to earlier P3b peak latencies. In our study, we wanted to investigate the influence of predictability on target processing indexed by the P3b in children (10–12 years old) and young adults. To do that, we used an oddball paradigm with two conditions of predictability (high and low). In the High‐predictability condition, a high‐pitched target tone occurred most of the time in the fifth position of a five‐tone pattern (after four low‐pitched non‐target sounds), whereas in the Low‐predictability condition, no such rule was implemented. The target tone occurred randomly following 2, 3, 4, 5, or 6 non‐target tones. In both age groups, reaction time to predictable targets was faster than to non‐predictable targets. Remarkably, this effect was largest in children. Consistent with the behavioral responses, the onset latency of the P3b response elicited by targets in both groups was earlier in the predictable than the unpredictable conditions. However, only the children had significantly earlier peak latency responses for predictable targets. Our results demonstrate that target stimulus predictability increases processing speed in children and adults even when predictability was only implicitly derived by the stimulus statistics. Children did have larger effects of predictability, seeming to benefit more from predictability for target detection.     

Repetition and laterality effects on recognition memory for words and pictures*

Recognition memory for a list of words was tested by presenting a series of items with Ss instructed to make positive responses to targets (list items) and negative responses to distractors (nonlist items). The test items were either words or pictures, and they were presented tachistoscopically either to the left or right visual field. The results showed mean response latencies to be generally faster for stimuli presented to the right visual field. Response times were faster for target and distractor stimuli on their second test presentations than on initial tests, but this effect was much larger for targets. Repetitions were shown to decrease the amount of time necessary to execute the stimulus encoding and initial retrieval stages of recognition. This was also true, although to a lesser extent, if different stimulus forms (words or pictures) were used on the two tests. Subsequent recognition stages, including memory search and decision processes. were apparently independent of test stimulus form.     

The locus of redundant-targets and nontargets effects: evidence from the psychological refractory period paradigm

In target detection tasks, responses are faster when displays have 2 targets (redundant-targets effect; RTE) and slower when they have no targets (nontargets effect; NTE) relative to displays with a single target. The psychological refractory period paradigm was used to localize these effects. In Experiment 1, participants classified tones as high or low and then classified letters as targets or nontargets after a short or long stimulus onset asynchrony (SOA). The magnitudes of the RTE and NTE did not depend on SOA. In Experiment 2, the order of the tasks was reversed, and at short SOAs the RTE and NTE had similar magnitudes for both tone discrimination and target detection responses. These findings suggest that the RTE and NTE arise during response selection. Interactive effects of tone pitch with the number and type of target features were also observed, and these were tentatively interpreted as synesthetic effects.     

The equivalence of target and nontarget processing in visual search

A comparison of a forced-choice visual search task with an item recognition task did not support Neisser’s (1967) hypothesis of a preattentive stage that processes targets and nontargets differentially. In the forced-choice condition, Ss indicated which of two items in a visual display was a target; in item recognition, Ss determined whether or not the single item in the visual display was a target. The size of the memorized set of possible targets was varied from one to six items for both tasks. Latencies increased linearly with memory set size in both conditions; the slopes for forced choice and item recognition were 41.8 and 27.9 msec per item, respectively. The ratio of 1.38 between the two slopes was well fit by Sternberg’s (1967) item recognition model, which predicts a ratio of 1.50.     

Effects of dehydroepiandrosterone sulfate and progesterone on spatial learning and memory in young and aged mice

Young (2-4 months) and aged (14-16 months) male Swiss-Webster albino mice (n = 7 per group) were subcutaneously injected with 20 mg/kg/day dehydroepiandrosterone sulfate (DHEAS), progesterone (P), DHEAS + P, or vehicle control and trained over a 5-day period in a Morris water maze. The subjects were tested 48 hr after training for memory recall as measured by latencies to locate the hidden platform, and trunk blood was collected immediately thereafter. As expected, latency to platform decreased for all groups over the 6 testing days, with aged mice taking longer to reach platform than did young mice. However, results did not support the hypotheses that DHEAS-treated mice would exhibit shorter latencies and that P-treated mice would show longer latencies to platform in comparison with age-matched controls. These results raise doubts about the effectiveness of commercially available supplements claiming to promote enhanced memory in humans.     

Event-related potentials in adolescents with combined ADHD and CD disorder: a single stimulus paradigm

Some studies of the event-related potentials demonstrated a reduction of the voluntary component P3 (P300 or P3b) in youngsters with the attention deficit/hyperactivity disorder (ADHD) or in conduct disorders (CD), and a reduction of the automatic processing component, mismatch negativity, in patients with both ADHD and CD (ADHD+CD). Recently, a passive auditory P3 potential has been elicited by a single stimulus. We therefore tried this potential study in 20 healthy subjects and 20 teenagers with ADHD+CD to search for further evidence of the altered automatic cerebral processing in the latter. Subjects also answered a self-report Dimensional Assessment of Personality Pathology (DAPP). The patient group scored significantly higher on most DAPP traits that reflect problems of emotion control, showed significantly prolonged P2, N2, and P3, and reduced P3. In all subjects Stimulus Seeking was positively correlated with P3 latencies at Fz, Cz, and Pz, and with P3 amplitude at Cz. This study suggests that youngsters with ADHD+CD had pronounced emotion dysregulation, and prominent deficit in passive attention, as reflected by the automatic processing of auditory stimuli.