Cerebrospinal fluid cytologic diagnosis--possibilities and limits

Findings of functionally active and proliferating cells in CSF, such as granulocytes, macrophages, lymphoid cells and blastoma cells are of diagnostic importance in pathological reactions of meninges. Such findings have a special significance in different phases in the course of meningoencephalitis, subarachnoid haemorrhage and infiltrations of neoplasms with subependymal localization which can not be obtained even by modern methods in neuroradiology. A correct diagnostic assessment is only given by knowledge and in consideration of all clinical and laboratory findings. The diagnostic value is limited in cases of deeply intracerebral localized diseases, of chronic recurrent processes, of cases with previous lesions or of concommitant symptoms because the results are atypical.     

Normal cerebrospinal fluid findings in spinal tumors--an analysis of 503 cases

Till now almost nothing has been published about normal liquor findings in spinal cord tumours. Out of 503 cases there were normal findings of total proteins and cells in 30 cases (6 per cent). A connection with the severity of the compression-syndrome was not evident. Nevertheless liquor examinations are important in diseases of the medulla spinalis. This is especially useful in the differential diagnostical demarcation of inflammable spinal cord diseases, accompanying reactions or bleedings into the spinal channel.     

Consciousness of Social Face: the development and validation of a scale measuring desire to gain face versus fear of losing face

This article describes the development and validation of a scale that measures two distinct needs for individuals to manage their social "face". Scale development process resulted in an 11-item Consciousness of Social Face (CSF) scale made up of the following two correlated dimensions: desire to gain face and fear of losing face. The two-factor correlated structure of CSF scale was stable across multiple samples of both students and non-students subjects. The construct validity of CSF scale, including convergent validity, discriminant validity, and criterion-related validity was also demonstrated by examining relationships with other personality or demographical variables.     

Consciousness of Social Face: The Development and Validation of a Scale Measuring Desire to Gain Face Versus Fear of Losing Face

ABSTRACT

This article describes the development and validation of a scale that measures two distinct needs for individuals to manage their social “face”. Scale development process resulted in an 11-item Consciousness of Social Face (CSF) scale made up of the following two correlated dimensions: desire to gain face and fear of losing face. The two-factor correlated structure of CSF scale was stable across multiple samples of both students and non-students subjects. The construct validity of CSF scale, including convergent validity, discriminant validity, and criterion-related validity was also demonstrated by examining relationships with other personality or demographical variables.     

Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms

Among people exposed to major psychological stressors in early life, there are elevated rates of morbidity and mortality from chronic diseases of aging. The most compelling data come from studies of children raised in poverty or maltreated by their parents, who show heightened vulnerability to vascular disease, autoimmune disorders, and premature mortality. These findings raise challenging theoretical questions. How does childhood stress get under the skin, at the molecular level, to affect risk for later diseases? And how does it incubate there, giving rise to diseases several decades later? Here we present a biological embedding model, which attempts to address these questions by synthesizing knowledge across several behavioral and biomedical literatures. This model maintains that childhood stress gets "programmed" into macrophages through epigenetic markings, posttranslational modifications, and tissue remodeling. As a consequence these cells are endowed with proinflammatory tendencies, manifest in exaggerated cytokine responses to challenge and decreased sensitivity to inhibitory hormonal signals. The model goes on to propose that over the life course, these proinflammatory tendencies are exacerbated by behavioral proclivities and hormonal dysregulation, themselves the products of exposure to early stress. Behaviorally, the model posits that childhood stress gives rise to excessive threat vigilance, mistrust of others, poor social relationships, impaired self-regulation, and unhealthy lifestyle choices. Hormonally, early stress confers altered patterns of endocrine and autonomic discharge. This milieu amplifies the proinflammatory environment already instantiated by macrophages. Acting in concert with other exposures and genetic liabilities, the resulting inflammation drives forward pathogenic mechanisms that ultimately foster chronic disease.     

Cerebrospinal fluid diagnosis of multiple sclerosis]

Starting from the knowledge accumulated with respect to the etiopathogenesis and the components of immunoreaction a minimal to maximal program by steps has been developed for the cerebrospinal fluid (CSF) in multiple sclerosis (MS). It is based on fundamental methods (I), special supplementary methods (II), and relatively specific immunological methods (III). For MS five possible conditions of the CSF could be determined from alterations of cells and variations in protein: a (1) typically complete and (2.) typically incomplete immunoreactive encephalomyelitic (encephalitic) syndrome, a (3.) nonspecific CSF-syndrome of low degree and less typical character (in the sense of an acute or subacute irritation syndrome) an (4.) atypical syndrome of a considerable degree, and a (5.) normal condition of the cerebrospinal fluid. The significance of immunoreactive cerebrospinal fluid syndromes to the diagnostic criteria of multiple sclerosis as well as further relatively disease-specific methods (such as the MEM test and MSF assay) of determining cellular immunity, are discussed.     

Catheterization of the lumbar subarachnoid space for long-term CSF collection in unanesthetized nonhuman primates

Chronic indwelling spinal catheters facilitate administration of drugs and serial sampling of cerebrospinal fluid (CSF). Most catheters used in primates enter the ventricles or rostral subarachnoid space. This paper describes a procedure for catheterizing the lumbar subarachnoid space. Although the technique is invasive, maintenance and utilization of the catheter do not disturb the subject. The preparation remains patent for up to 21 days and permits both intrathecal drug administration and collection of CSF samples from unanesthetized subjects.     

Building spiritual fitness in the Army: an innovative approach to a vital aspect of human development

This article describes the development of the spiritual fitness component of the Army's Comprehensive Soldier Fitness (CSF) program. Spirituality is defined in the human sense as the journey people take to discover and realize their essential selves and higher order aspirations. Several theoretically and empirically based reasons are articulated for why spirituality is a necessary component of the CSF program: Human spirituality is a significant motivating force, spirituality is a vital resource for human development, and spirituality is a source of struggle that can lead to growth or decline. A conceptual model developed by Sweeney, Hannah, and Snider (2007) is used to identify several psychological structures and processes that facilitate the development of the human spirit. From this model, an educational, computer-based program has been developed to promote spiritual resilience. This program consists of three tiers: (a) building awareness of the self and the human spirit, (b) building awareness of resources to cultivate the human spirit, and (c) building awareness of the human spirit of others. Further research will be needed to evaluate the effectiveness of this innovative and potentially important program.     

Bringing science to bear: an empirical assessment of the Comprehensive Soldier Fitness program

This article outlines the U.S. Army's effort to empirically validate and assess the Comprehensive Soldier Fitness (CSF) program. The empirical assessment includes four major components. First, the CSF scientific staff is currently conducting a longitudinal study to determine if the Master Resilience Training program and the Comprehensive Resilience Modules lead to lasting resilience development in soldiers. Second, the CSF program has partnered with other researchers to conduct a series of longitudinal studies examining the link between physiological, neurobiological, and psychological resilience factors. Third, the CSF program is also incorporating institutional-level data to determine if its material influences health, behavioral, and career outcomes. Fourth, group randomized trials are being conducted to ensure that resilience training incorporated under the CSF program is effective with soldiers. A specific rationale and methodologies are discussed.     

Allergy and spirituality

This article considers the relationships of allergic reactions to substances and emotions. It deals with spiritual sensitivity as well. Resistance is a key to allergic reactions: Allergic reactions involve the body's resistance to substances, emotions, and their energies. A major problem in spiritual formation is resistance to giving up the prideful and self-centered position and moving into loving relationships. It is sometimes possible from an alternative approach to promote spirituality by treating allergy. In spiritual formation, one may sometimes decrease allergic tendencies by giving up pride and other negative emotions. I propose that the alternative method I advocate not only reduces symptoms but deals with causes on an energetic level. It works with physical, emotional and spiritual factors. It provides new ways for counselors and spiritual directors to quickly get to basic issues and clear negative emotions and beliefs. This may be accomplished within or in connection with the therapists' or directors' particular religions, practices and/or therapeutic approaches.     

Comprehensive soldier fitness: building resilience in a challenging institutional context

The Comprehensive Soldier Fitness (CSF) program is designed to increase psychological strength and positive performance and to reduce the incidence of maladaptive responses of the entire U.S. Army. Based on the principles of positive psychology, CSF is a historically unique approach to behavioral health in a large (1.1 million members) organization. There are four program elements: (a) the assessment of emotional, social, family, and spiritual fitness; (b) individualized learning modules to improve fitness in these domains; (c) formal resilience training; and (d) training of Army master resilience trainers (MRTs) to instill better thinking skills and resilience in their subordinates. In contrast to traditional approaches, CSF is proactive; rather than waiting to see who has a negative outcome following stress, it provides ways of improving resilience for all members of the Army. CSF aims to move the full spectrum of responses to trauma and adversity-ranging from stress-related disorders to ordinary resilience-toward personal growth. This program may provide a model for implementing similar interventions in other very large institutions.     

Assessment of prealbumin in cerebrospinal fluid

The paper describes statistical relationship between prealbumin and total protein in lumbal CSF of a control group and a total group of patients with neurological diseases. The equations of the regression lines and the boundary lines of the distribution areas did not significantly differ between both groups. Therefore, prealbumin seems to be not qualified for differential diagnosis. On the other hand, its application to characterize functional states of blood-brain-CSF barrier systems is discussed.     

An examination of the assumptions in the demand characteristics thesis: With special reference to the Velten mood induction procedure

We examine the assumptions that are generally made when it is argued that a set of experimental findings is due to the subjects' compliance to demand characteristics. There is little evidence supporting many of these assumptions: that many experimental subjects disbelieve the cover story given them, that they are eager to search for clues revealing the study's actual purpose, that they are highly sophisticated in making inferences on the basis of any cues they detect, and that they are motivated to confirm the experimenter's hypothesis, whether to aid science or to make their participation meaningful. Our argument is applied to studies contending that results obtained with the Velten mood induction procedure are substantially affected by demand compliance. In particular, we question an assumption often made by these studies and point out the following: A demonstration that subjects can accurately mimic the reactions of participants given the Velten statements when they are explicitly asked to do so, or when they are instructed how to simulate these reactions, does not necessarily mean that subjects will voluntarily engage in such accurate play-acting when they are not asked to engage in this make-believe. Research has also noted that a number of Velten-induced reactions are probably too subtle to have been deliberately faked.     

Comprehensive soldier fitness: a vision for psychological resilience in the U.S. Army

The stress and strain on the U.S. Army's community due to nearly a decade of protracted war is well documented in the press and in scientific literature. In response, the Army's Comprehensive Soldier Fitness (CSF) program is a preventive program that seeks to enhance psychological resilience among all members of the Army community, which includes soldiers, family members, and Department of the Army civilians. CSF is not a medical treatment program. Rather, CSF helps those community members who are psychologically healthy face life's adversities-including combat and prolonged separation from loved ones-by providing evidence-based training.     

Cerebrospinal fluid concentrations of biogenic amines and corticotropin-releasing factor in adolescent non-human primates as a function of the timing of adverse early rearing

Adolescent bonnet macaques nursed as infants by mothers facing unpredictable requirements for food procurement (variable foraging demand, VFD) display persistent neurobiological disturbances. This study examined the long-term neurochemical and behavioral effects of adverse rearing initiated later in infancy than in previous cohorts of subjects to test the hypothesis that the timing of an early adverse experience would influence patterns of biobehavioral outcome. Cisternal cerebrospinal fluid (CSF) monoamine and corticotropin-releasing factor (CRF) concentrations were obtained from 20 bonnet macaques (11 VFD-reared and 9 normally reared controls) approximately 2 years after the end of differential rearing. VFD-reared primates displayed on multiple samplings significantly lower CSF CRF concentrations and higher CSF 5-hydroxyindoleacetic acid (5-HIAA) concentration compared to controls. In the VFD-reared, significant inverse correlations between CRF and all three monoamines were found (5-HIAA, 3-methoxy-4-hydroxyphenethyleneglycol and homovanillic acid), most prominently for 5-HIAA. In controls, but not VFD-reared subjects, CSF CRF was positively correlated with changes in "gregariousness" upon presentation of a fear stimulus. VFD-reared subjects displayed greater baseline hierarchical engagement than controls. In contrast to prior findings, in which rearing under VFD conditions at an earlier age led to increased CSF CRF compared with controls, CSF CRF was lower after later exposure to VFD rearing than in controls. Thus, the timing of exposure to VFD conditions early in life evidently determines whether CSF CRF was found to be elevated or decreased, within the context of increased serotonin metabolism, during the course of primate maturation.     

近三十年小儿肾小球疾病治疗的回顾

总结了28年共2453篇有关小儿肾小球疾病治疗的文献,发现其发展规律符合科学的发展观药物的选择趋向于疗效肯定而且毒副作用小的药物,新方法新技术不断涌现,药物疗效的评价日趋合理,药物作用机制从系统、器官水平深入到细胞、分子及基因水平,各学科间的合作与联系增加。     

Function of the blood-cerebrospinal fluid barrier and selected biochemical cerebrospinal fluid components in senile dementias of various types

Some selected CSF and serum components were determined in demental patients classified by the Hachinski test into vascular and primary-degenerative groups. As for the vascular group, the frequency distribution of the serum/CSF albumin ratios characterizing the barrier function corresponds to that of controls, in primary-degenerative cases, however, it is shifted to higher values. In vascular dementia higher CSF LAP activities pointing to actual cell damaging processes in the CNS were found. The concentrations of lactate and some trace metals in CSF and serum are not suitable for differential diagnostic purposes.     

人事选拔中的应聘者反应研究述评

应聘者反应是个体在选拔情境下由公平知觉导致的一种针对组织的态度或行为后果.应聘者反应的首个理论模型是Gilliland的选拔公正模型,随后,启发模型、整合模型和信任模型相继建立,极大丰富了应聘者反应的理论内涵.然而,应聘者反应的测量明显滞后于理论的发展,主要表现在测量工具不统一、测量结构混乱、信效度研究匮乏等方面.未来的研究方向有:(1)加强现有模型中论证不充分的环节;(2)进一步丰富跨文化研究;(3)从一般性问题向特定情境的研究进行深入;(4)结合跨领域内容,朝着多元化的方向发展.     

The vicissitudes of metaphysics in the Modern Age

Following Hans Blumenberg and others, an account is given of the coming about of Modernity and of its major characteristics. The aim of the paper is to show that, from the very beginning, a restricted number of philosophical reactions are developed towards the phenomenon of Modernity. These reactions are represented in the major ‘modern’ philosophers: Descartes, Spinoza, Hume (and Kant) and French Enlightenment thinkers (as, e.g., Condorcet). These major reactions repeat themselves mutatis mutandis well into the 20th century. The paper ends with a brief discussion of the possibility of (modern) metaphysics at the present moment.     

Biochemical correlates of personality traits in normals: An exploratory study

This study attempted to identify biochemical systems associated with the personality dimensions of Extraversion (E), Neuroticism (N), Psychoticism (P), Sensation Seeking (SS) and Impulsivity (Imp). The subjects were 43 normal volunteers who volunteered to take a battery of psychological tests and allow investigators to obtain samples of blood, urine and cerebrospinal fluid (CSF) for biochemical assessment.Substantial positive correlations were found between CSF norepinephrine (NE), MHPG (the principal metabolite of NE), DBH (an enzyme involved in the production of NE) and plasma MHPG and DBH; all of these are regarded, in some part, as putative indicators of central noradrenergic activity. After partialling out the influences of age, height and weight, a number of significant relationships were found between psychological traits and biochemical variables. Extraversion correlated positively and introversion and neuroticism correlated negatively with CSF Ca. Neuroticism also correlated negatively with plasma MHPG. Ego Strength (inversely related to Neurotic Introversion), P and Disinhibitory SS correlated negatively with CSF cort. General SS correlated negatively with CSF NE and plasma DBH, and these correlations were significant in both males and females, as well as in the total group. The results are consistent with some biological models of personality, but suggest the need for modification in others.