Effects of d-amphetamine, cocaine, and phencyclidine on the acquisition of response sequences with and without stimulus fading.

In each of three components of a multiple schedule, monkeys were required to emit a different sequence of four responses in a predetermined order on four levers. Sequence completions produced food on a fixed-ratio schedule. Errors produced a brief timeout. One component of the multiple schedule was a repeated-acquisition task where the four-response sequence changed each session (learning). The second component of the multiple schedule was also a repeated-acquisition task, but acquisition was supported through the use of a stimulus-fading procedure (faded learning). In a third component of the multiple schedule, the sequence of responses remained the same from session to session (performance). At higher doses, d-amphetamine, cocaine, and phencyclidine decreased the overall rate of responding and increased the percent errors in all three components. At lower doses, however, the three drugs produced selective effects on errors. Errors were increased in the learning component at lower doses than those required to disrupt the behavior in the faded-learning component. The performance component tended to be the least sensitive to disruptive drug effects. The data are consistent with the view that stimulus fading can modulate the effects of drugs on acquisition.     

Repeated diazepam administration: effects on the acquisition and performance of response chains in humans.

The effects of repeated diazepam administration (80 mg) were assessed across a 12-hr time course with humans responding under a two-component multiple schedule of repeated acquisition and performance of response sequences. Subjects resided in an inpatient clinical research ward for the duration of the study. In each component of the multiple schedule, subjects completed sequences of 10 responses in a predetermined order using three keys of a numeric keypad. In the acquisition component, a new response sequence was to be acquired each session. In the performance component, the response sequence always remained the same. After stable responding was obtained and the effects of the placebo assessed, diazepam was administered for 3 consecutive days. The effects of repeated diazepam administration on overall percentage of errors across the two components of the multiple schedule were selective. In the acquisition component, the first dose of diazepam increased percentage errors with the magnitude of effects decreasing across the second and third days of diazepam administration. In the performance component, the percentage of errors was either minimally affected across all 3 days of diazepam administration or substantively increased on Day 1 with subsequent diazepam administrations having minimal effects. Effects on response rate were not selective. Diazepam decreased rates of responding in both schedule components, with the magnitude of effects decreasing across successive administrations. These results replicate previous findings in humans and nonhumans on the selective effects of diazepam on acquisition versus performance baselines. Also, the results suggest that the selective effects do not result from differences in reinforcement rate. Finally, the present results demonstrate that the selective recovery from repeated drug administration previously demonstrated in nonhumans using a repeated acquisition arrangement has generality to human behavior.     

Repeated measurements of reinforcement effects on gradients of stimulus control

Two experiments studied the effects of reinforcement schedules on generalization gradients. In Exp. 1, after pigeons' responding to a vertical line was reinforced, the pigeons were tested with 10 lines differing in orientation. Reconditioning and the redetermination of generalization gradients were repeated from 8 to 11 times with the schedule of reinforcement varied in the reconditioning phase. Stable gradients could not be observed because the successive reconditionings and tests steepened the gradients and reduced responding. Experiment 2 over-came these effects by first training the birds to respond to all of the stimuli. Then, brief periods of reinforced responding to the stimulus correlated with reinforcement alternated with the presentation of the 10 lines in extinction. The development of stimulus control was studied eight times with each bird, twice with each of four schedules of reinforcement. Gradients were similar each time a schedule was imposed; the degree of control by the stimulus correlated with reinforcement varied with particular schedules. Behavioral contrast occurred when periods of reinforcement and extinction alternated and was more durable with fixed-interval, variable-interval, and variable-ratio schedules than with fixed-ratio or differential-reinforcement-of-low-rate schedules.     

Early and late introduction of probes and stimulus control acquisition in fading

College students learned to name Braille patterns presented visually using a fading procedure in which Braille patterns were superimposed on letter names after which letter names were attenuated. Measurement of acquisition was accomplished by presenting probes—consisting of the Braille stimuli only—throughout fading. Effects of probes upon acquisition were assessed by introducing probes early or late in fading. Fewer fading levels were needed for Braille elements to acquire control when probes were introduced early rather than late. When probes were introduced late, all subjects learned to name the Braille elements as the letters were being faded out. When probes were introduced early, however, most subjects learned to name the Braille elements as they were being faded in. Since virtually no errors occurred during compound-stimulus presentations, the probe procedure did not induce errors during acquisition. Quantitative analysis of probe data suggested that inclusion of probes enhanced the control acquired by the Braille elements during compound-stimulus presentations. The reported effects may have been due to differences in the relative frequency of reinforcement presented during compounds and probes.     

Reinforcement of probe responses and acquisition of stimulus control in fading procedures

Stimulus control of pigeons' key pecking was transferred from colors to lines by the method of stimulus fading. Fading was conducted with the addition of probes consisting of the line stimuli presented alone at each fading level. Probe responding was used to measure stimulus-control acquisition by the lines. Effects of reinforcement and nonreinforcement of probe responding upon acquisition of stimulus control were assessed using a single-organism repeated-acquisition design in which three fades were conducted serially. Probe responding was not reinforced in the first and third fade but was in the second. Reinforcement of probe responding substantially reduced the number of fading levels needed to complete fading. The outcome of a control experiment ruled out the possibility of accounting for these results in terms of the specific stimuli used in each fade or in terms of the sequential exposure to the three discriminations. Although probes permitted measurement of stimulus-control acquisition in fading, a measurement/acquisition interaction was also present.     

The effects of diazepam and triazolam on repeated acquisition and performance of response sequences with an observing response.

Drugs often disrupt the acquisition of new response sequences at doses that fail to disrupt the performance of a previously acquired response sequence. This selective drug effect may result from differences in the control exerted by the stimuli presented after each response in the acquisition and performance sequences. To examine the function of these stimuli, an observing procedure was incorporated into a multiple schedule of repeated acquisition and performance of response sequences, in which stimulus presentations were contingent upon an observing response. Three experiments were conducted with humans. Experiment 1 compared responding with and without the observing contingency. No difference was found in the overall percentage of errors across the two conditions. Within the observing condition, observing behaviour was maintained in the acquisition component as long as errors occurred, but was not maintained in the performance component. Experiment 2 examined whether a contingency that increased errors also would increase observing in both the acquisition and performance components. Specifically, reinforcer delivery in each component was contingent upon emitting 10 correct responses and one, two, or four errors. Observing responses increased in the acquisition component as the error requirement increased, whereas observing responses in the performance component increased only when the error requirement was four. Experiment 3 assessed the effects of diazepam (0, 7.5, 15, and 30 mg/70 kg, p.o.) and triazolam (0, 0.375, and 0.75 mg/70 kg, p.o.) on repeated acquisition and performance baselines with the observing contingency. Selective drug effects were obtained in this modified procedure; that is, the percentage of errors in the acquisition component increased at doses that failed to affect the percentage of errors in the performance components. Importantly, drug effects were selective, even though observing responses were not emitted in the performance component and, hence, the stimulus presentations did not occur in that component. These findings suggest that alternative explanations for these differential effects are needed; in that regard, a response-unit account of the selective drug effects is discussed.     

Effects of atropine on the repeated acquisition and performance of response sequences in humans.

The present study assessed a 24-hr time course for the acute effects of intramuscular injections of atropine sulfate (0, 1.5, 3.0, and 6.0 mg/70 kg) in healthy adult humans responding under a two-component multiple schedule of repeated acquisition and performance of response sequences. Subjects resided in an inpatient research ward for the duration of the study. In each component of the multiple schedule, subjects completed a different sequence of 10 responses in a predetermined order using three keys of a numeric keypad. In the acquisition component, the subjects' task was to acquire a new sequence each session. Eight sessions were conducted daily: one immediately before administration of the drug and then 0.5, 1.5, 3.0, 5.0, 7.0, 9.0, and 24.0 hr after administration. In the performance component, the response sequence always remained the same. Overall percentage of errors increased and overall response rates decreased in the acquisition and performance components as an orderly function of drug dose. However, these effects were selective in that behavior in the acquisition component generally was affected at lower doses than in the performance component. When behavior was affected in both the acquisition and performance components, the time courses of effects were similar. Drug effects began at 0.5 or 1.5 hr, reached peak effects between 3.0 and 5.0 hr, and returned to placebo levels between 7.0 and 9.0 hr postdrug in both schedule components. None of the drug doses produced reliable effects the day after drug administration (24-hr postdrug) in either schedule component. The present study provides the first within-subject assessment of the magnitude and duration of the effects of an anticholinergic on repeated acquisition and performance baselines and extends to atropine the selective effects on these two baselines demonstrated previously with other compounds in humans and nonhumans.     

Repeated acquisition of conditional discriminations

A new technique was developed to study the repeated acquisition of conditional discriminations. Using a discrete trial procedure, pigeons were required to learn during each session a different two-member chain of conditional discriminations. Key color and geometric forms were used as stimuli. After the pigeons had reached a steady state of relearning (40 to 60 sessions), the technique was used to investigate variables that have previously been shown to affect the repeated acquisition of response sequences. Various (0 to 90 seconds) durations of timeout for errors were investigated in Experiment I. The stimulus change associated with a timeout, rather than its duration, was found to be the critical variable in acquisition of the discrimination. Extended training on a single chain was found to reduce total errors across sessions in Experiment II. Extended training (three sessions) did not, however, change the pattern of within-session error reduction. In some cases, extended training facilitated acquisition of a partially reversed discrimination. In Experiment III, color rather than chain position was found to control behavior, for three of the four birds, as the second stimulus dimension in the conditional situation. The results of these experiments replicate and extend previous findings concerning some of the variables that affect the repeated acquisition of response sequences.     

Aspects of programmable calculator stimulus control and data acquisition in a psychophysiology laboratory

Advantages and disadvantages of programmable calculator control of research laboratories are discussed. Comparisons are drawn with microcomputers such as the Imsai 8080. While microcomputers have greater flexibility in sampling multiple measures at multiple rates and combining timing tasks with data acquisition, calculators are easier to program for applications combining data acquisition with mathematical processing. Calculators also offer advantages to laboratories that do not have access to programming or maintenance services.     

Antecedent stimulus control: using orienting cues to facilitate first-word acquisition for nonresponders with autism

Although considerable progress has been made in improving the acquisition of expressive verbal communication in children with autism, research has documented that a subpopulation of children still fail to acquire speech even with intensive intervention. One variable that might be important in facilitating responding for this nonverbal subgroup of children is the use of antecedent orienting cues. Using a multiple baseline design, this study examined whether individualized orienting cues could be identified, and whether their presentation would result in the production of verbal expressive words. The results showed that this antecedent stimulus control procedure produced improvements in responding to verbal models in all of the children, and subsequent gains in speech for some of the children. Theoretical and applied implications of orienting cues as they relate to antecedent stimulus control for children with autism are discussed.     

Preconditioning exposure to the unconditined stimulus affects the acquisition of a conditioned emotional response

Four experiments examined the UCS preexposure phenomenon using conditioned suppression of food-reinforced responding as a measure of excitatory conditioning, and electric shock as a UCS. In Experiment 1, groups of rats were preexposed to unsignaled 0.8-mA electric shocks for 0, 1, 3, 5, or 10 days, and then conditioned with a 0.8-mA electric shock. Preexposure to electric shock 1 day prior to conditioning enhanced the acquisition of a CER, whereas preexposure to electric shock for 3, 5, or 10 days prior to conditioning attenuated the acquisition of a CER as a direct function of the number of days of preexposure. In Experiments 2 and 2A, groups of rats were preexposed to unsignaled electric shocks of 0.3, 0.5, 0.8, or 1.3 mA for 10 days, and then conditioned with a 0.8-mA electric shocl. All groups preexposed to electric shock acquired the CER at a slower rate than a group not preexposed to electric shock. The greatest attenuation of CER conditioning occurred when the same intensity electric shock was used during both the preexposure and conditioning phases. In Experiment 3, groups of rats were preexposed to signaled electric shocks of either 0.5, 0.8, or 1.3 mA, and then conditioned with a 0.8-mA electric shock. All groups preexposed to electric shock acquired the CER at a slower rate than a group not preexposed to electric shock. As in Experiments 2 and 2A, the greatest attenuation of CER conditioning occurred when the same intensity electric shock was used during both the preexposure and conditioning phases. In Experiment 4, groups of rats were preexposed to series of 0.5, 0.8, or 1.3-mA electric shocks which they could escape by performing a chain-pull response. Rats in each of these groups had yoked partners which received the same number, intensity, and temporal pattern of electric shocks, but could not perform a response to escape shock. All groups were then conditioned with a 0.8-mA electric shock. Rats preexposed to escapable electric shocks showed equal or greater attenuation of CER conditioning than rats which could not escape shock during the preexposure phase. These results are discussed in terms of nonassociative and associative explanations of the UCS preexposure phenomenon.     

Pro- and antisaccades: dissociating stimulus and response influences the online control of saccade trajectories

The authors examined whether the diminished online control of antisaccades is related to a trade-off between movement planning and control or the remapping of target properties to a mirror-symmetrical location (i.e., vector inversion). Pro- and antisaccades were examined in a standard no-delay schedule wherein target onset served as the movement imperative and a delay cuing schedule wherein responses were initiated 2,000 ms following target onset. Importantly, the delay cuing schedule was employed to equate pro- and antisaccade reaction times. Online control was evaluated by indexing the strength of trajectory amendments at normalized increments of movement time. Antisaccades exhibited fewer online corrections than prosaccades, and this result was consistent across cuing schedules. Thus, the diminished online control of antisaccades cannot be tied to a trade-off between movement planning and control. Rather, the authors propose that the intentional nature of dissociating stimulus and response (i.e., vector inversion) engenders a slow mode of cognitive control that is not optimized for fast oculomotor corrections.     

Reinforcer frequency and restricted stimulus control.

Stimulus control was evaluated in 3 individuals with moderate to severe mental retardation by delayed identity matching-to-sample procedures that presented either one or two discrete forms as sample stimuli on each trial. On pretests, accuracy scores on one-sample trials were uniformly high. On two-sample trials, the correct stimulus (i.e., the one that subsequently appeared in the comparison array) varied unpredictably, and accuracy scores were substantially lower, suggesting that both sample stimuli did not exert stimulus control on every trial. Subjects were then given training sessions with the one-sample task and with a new set of four stimuli. For two of the stimuli, correct matching responses were followed by reinforcers on a variable-ratio schedule that led to a high reinforcer rate. For the other two stimuli, correct responses were followed by reinforcers on a variable-ratio schedule that led to a substantially lower reinforcer rate. Results on two-sample tests that followed showed that (a) on trials in which comparison arrays consisted of one high reinforcer-rate and one low reinforcer-rate stimulus, subjects most often selected the high-rate stimulus; and (b) on trials in which the comparison arrays were either two high reinforcer-rate stimuli or two low reinforcer-rate stimuli and the samples were one high reinforcer- and one low reinforcer-rate stimulus, accuracy was higher on trials with the high-rate comparisons. These results indicate that the frequency of stimulus control by high reinforcer-rate samples was greater than that by low reinforcer-rate samples. Following more training with the one-sample task and reversed reinforcement schedules for all stimuli, the differences in stimulus control frequencies on two-sample tests also reversed. These results demonstrate experimental control by reinforcement contingencies of which of two sample stimuli controlled selections in the two-sample task. The procedures and results may prove to be relevant for understanding restricted stimulus control and stimulus overselectivity.     

Discriminated response and incentive processes in operant conditioning: a two-factor model of stimulus control

Understanding stimulus control generated in instrumental learning requires the direct investigation of discriminated response and reinforcer (incentive) processes acquired exclusively through the response-reinforcer contingencies operating on complex (multicomponent) baselines. Two series of stimulus-compounding studies accomplished this direct investigation. In one series, the independent variable was the relative reinforcement between schedule components; in the second series, it was relative response rate between components. Stimulus-compounding tests revealed that response and incentive processes enhanced each other when in agreement, counteracted each other when in opposition, and produced intermediate results when only one factor was operating. This pattern of results led to the conclusion that these factors were algebraically combining and to the development of a response/incentive matrix reflecting these dynamics. This two-factor analysis was extended to the peak-shift effect in stimulus generalization experiments and to the generation of inhibitory control. Two decades of stimulus compounding and peak-shift research were organized within this two-factor framework, extending this traditional approach to learning to active research areas heretofore not systematically considered in these terms.