Electrolyte disorders, EEG changes and epileptic seizures in alcohol withdrawal delirium

For 180 patients suffering alcohol-withdrawal induced delirium, electrolytic concentration in the serum of Na, K, Ca, and Mg was determined in the early withdrawal phase, and the electroencephalograms of 95 delirium patients evaluated in respect of local and diffuse changes and epileptic activity, and compared in delirium patients with and without initial seizures. Delirium patients who had initial seizures suffered significantly longer-lasting periods of delirium and significantly more frequent electrolytic changes in the form of hypomagnesemia and hypopotassemia (hypokalemia). There was no significant difference in the EEG changes. A temporary metabolic disorder in the initial phase of the two-phase withdrawal process should be assumed to be the cause of seizures during alcohol withdrawal, and the pathogenetic significance of hypomagnesemia and hypopotassemia should be taken into consideration.     

Attitudes,knowledge, and use of alcohol in university students

This paper investigated attitudes towards alcohol, knowledge of alcohol, parents drinking behaviour, reasons for drinking and television viewing habits varied in relation to actual drinking behaviour. A sample of 106 University students completed a questionnaire which enabled their classification as non, light, medium and heavy drinkers on the basis of their self-reported consumption levels. Results revealed 9% to be non-drinkers, 22% to be light, 38% to be moderate and 31% to be heavy. They also showed that alcohol drinking habits differed significantly with age, sex, smoking habits and in particular with parents drinking habits. Alcohol drinking habits also differed significantly with knowledge of alcohol, heavier drinkers being found to have a better overall knowledge, but reasons for drinking and attitudes towards drinking did not show any overall difference between the drinking habit categories. Finally, there was no indication that television viewing independently contributed to alcohol beliefs, knowledge, attitudes or habits. The results are discussed in terms of future research implications.     

Developmental effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning

Pre-adolescence and adolescence are developmental periods associated with increased vulnerability for tobacco addiction, and exposure to tobacco during these periods may lead to long-lasting changes in behavioral and neuronal plasticity. The present study examined the short- and long-term effects of nicotine and nicotine withdrawal on fear conditioning in pre-adolescent, adolescent, and adult mice, and potential underlying substrates that may mediate the developmental effects of nicotine, such as changes in nicotinic acetylcholine receptor (nAChR) binding, CREB expression, and nicotine metabolism. Age-related differences existed in sensitivity to the effects of acute nicotine, chronic nicotine and nicotine withdrawal on contextual fear conditioning (no changes in cued fear conditioning were seen); younger mice were more sensitive to the acute effects and less sensitive to the effects of nicotine withdrawal 24 h post treatment cessation. Developmental differences in nAChR binding were associated with the effects of nicotine withdrawal on contextual learning. Developmental differences in nicotine metabolism and CREB expression were also observed, but were not related to the effects of nicotine withdrawal on contextual learning 24 h post treatment. Chronic nicotine exposure during pre-adolescence or adolescence, however, produced long-lasting impairments in contextual learning that were observed during adulthood, whereas adult chronic nicotine exposure did not. These developmental effects could be related to changes in CREB. Overall, there is a developmental shift in the effects of nicotine on hippocampus-dependent learning and developmental exposure to nicotine results in adult cognitive deficits; these changes in cognition may play an important role in the development and maintenance of nicotine addiction.     

Longitudinal associations between adolescent alcohol use and parents' sources of knowledge

The aim of this study was to test the direction of effect in the relationship between parents' sources of knowledge (parental monitoring and child disclosure) and adolescent alcohol use. The participants were 215 adolescents and their mothers, randomly selected from urban and rural areas in Cyprus. A 3‐month, two‐timepoint longitudinal design was used in which adolescents completed the alcohol use disorders identification test while mothers completed a parental knowledge questionnaire. The results of this study showed that parental monitoring did not predict subsequent adolescent alcohol use. However, child disclosure at Time 1 negatively predicted adolescent alcohol use at Time 2. Moreover, adolescents' alcohol dependence symptoms at Time 1 negatively predicted both sources of parental knowledge at Time 2.     

Demonstrating knowledge: The effects of group status on outgroup helping

We examined, in two experiments, the notion that members of low status groups, more than members of high status groups, use outgroup helping as a strategic tool to demonstrate their group's knowledge and boost its reputation. In Study 1 (N = 103), we compared outgroup helping in response to requests for help with offering help. As predicted, participants' knowledge was positively related to outgroup helping in response to requests, but only among members of low status groups. Knowledge also predicted the offering of help among members of high status groups. The second study (N = 75) replicated the findings from the requested help condition and showed that the effect disappeared in a condition in which help could not reflect ingroup knowledge. Additional data support a conclusion in terms of a collective strategy to boost the ingroup's reputation by demonstrating ingroup knowledge to the outgroup. The implications for promoting outgroup helping in a salient intergroup context are discussed.     

Impact of the hormonal milieu on the neurobiology of alcohol dependence and withdrawal

Alcoholism, or alcohol dependence, is a complex disorder with withdrawal symptoms that are often problematic for those trying to recover from their dependence. As researchers attempt to elucidate the neurobiological underpinnings of alcohol dependence and withdrawal, it is becoming clear that numerous factors, including the hormonal environment, impact the manifestations of this disorder. Of particular interest is the observation that women have fewer and less severe withdrawal symptoms than do men even though they tend to suffer greater physiological harm from excessive alcohol consumption. In this article, the authors present an overview of their understanding of how gonadal and stress hormones interact with alcohol, which results in differential neurobiological responses between males and females. Thus far, data generated from representative animal models have shown significant differences between the sexes in behavioral responses and neuroadaptations to chronic alcohol consumption and withdrawal. Accumulating evidence suggests that treatment of alcoholism, including withdrawal, should be tailored to the patient's gender and hormonal status.     

The mediation of mothers' self-fulfilling effects on their children's alcohol use: self-verification, informational conformity, and modeling processes

This research examined whether self-fulfilling prophecy effects are mediated by self-verification, informational conformity, and modeling processes. The authors examined these mediational processes across multiple time frames with longitudinal data obtained from two samples of mother-child dyads (N-sub-1 = 486; N-sub-2 = 287), with children's alcohol use as the outcome variable. The results provided consistent support for the mediational process of self-verification. In both samples and across several years of adolescence, there was a significant indirect effect of mothers' beliefs on children's alcohol use through children's self-assessed likelihood of drinking alcohol in the future. Comparatively less support was found for informational conformity and modeling processes as mediators of mothers' self-fulfilling effects. The potential for self-fulfilling prophecies to produce long-lasting changes in targets' behavior via self-verification processes are discussed.     

The development of children's intentions to use alcohol: direct and indirect effects of parent alcohol use and parenting behaviors

The purpose of this study was to explore the effect of parent alcohol use and parenting behavior on the development of children's intentions to use alcohol in Grades 1 through 8. The authors hypothesized that the effect of parent alcohol use on children's intention to use alcohol would be mediated through parenting behavior, specifically monitoring/supervision, positive parenting, and inconsistent discipline. Using cohort-sequential latent growth modeling (LGM), the authors tested 3 models examining the effect of the development of parent alcohol use on the development of children's intentions to use alcohol, as mediated by the development of each of the 3 parenting behaviors. Multiple group analyses were used to explore gender differences. The effect of growth in parent alcohol use on growth in children's intentions was mediated only by parent monitoring/supervision and was significant only for girls. The effect of inconsistent discipline was directly related to growth in intentions for both boys and girls. Although parent alcohol use was related to less positive parenting, positive parenting was unrelated to children's intentions to use alcohol.     

Stress and alcohol use: moderating effects of gender, coping, and alcohol expectancies.

A stressor vulnerability model of stress-induced drinking was tested in a stratified random sample of 1,316 Black and White adult drinkers. Stressors were highly predictive of both alcohol use and drinking problems among men who relied on avoidant forms of emotion coping or held strong positive expectancies for alcohol's effects and accounted for more than 35% of the variance in alcohol use among the subgroup of men who were high in both vulnerability factors. In contrast, stressors were negatively related among men who were low in both and were unrelated among women regardless of their coping or expectancies. These findings suggest that tension reduction theories of alcohol use are overly broad and that individual characteristics must be considered to account for stress-related effects on alcohol use and abuse.     

Relations of parental status with alcohol use patterns and attitudes about underage drinking

In a sample of 143 adults from a population of households in Idaho, significant differences in patterns of alcohol use and attitudes about underage drinking were related to parental status. Nonparents reported drinking alcohol more frequently than parents. Parents were significantly more likely than nonparents to report that it is never acceptable for minors to drink alcohol, that minors should not be allowed to drink alcohol at parties with no parents present, and that "sting" operations by police are warranted. Surprisingly, nonparents were significantly more likely than parents to report stores and bars are not careful enough about selling alcohol to minors.     

The effects of alcohol and extreme provocation on the use of a highly noxious electric shock

Intoxicated and nonintoxicated subjects were given the opportunity to administer a potentially injurious level of shock to an opponent who behaved in either a provocative or an extremely provocative manner. The provocative opponent attempted to administer high-intensity shocks to the subject. The extremely provocative opponent attempted to administer high-intensity shocks and the potentially injurious level of shock. The intoxicated subjects in the extreme provocation condition evidenced the greatest increase in the use of the potentially injurious shock. It was concluded that aggression is a function of the interaction of alcohol consumption and level of provocation.     

Attention and the acquisition of new knowledge: their effects on older adults' associative memory deficit

Older adults experience a selective associative memory deficit by demonstrating intact item memory relative to impaired associative memory when compared with younger adults. Age-related deficits in associative memory have been suggested to arise from declines in attentional resources, and the role of attention during encoding and retrieval in associative memory for words and their spatial locations was investigated in the current experiment. Additionally, the tendency of younger and older adults to use knowledge acquired during encoding to improve their associative memory judgments through a strategic associative memory process was also investigated. Younger and older adults studied a list of words with each word belonging to one of four categories, which followed one of four mathematical probability structures for their presentation. Older adults exhibited intact item memory and impaired associative memory relative to full attention younger adults. In addition, both older and younger adults demonstrated an ability to engage in strategic associative memory, by learning and later using the probability structure introduced at study to guide their associative memory judgments. In contrast, dividing the attention of younger adults during encoding impaired item memory, associative memory and strategic associative memory, whereas dividing attention at retrieval did not result in similar deficits. These data add to a growing body of literature demonstrating older adults to exhibit a selective associative memory deficit that is not simulated by dividing the attention of younger adults at encoding or retrieval. Furthermore, younger and older adults maintain the ability to use new knowledge to guide their associative judgments.     

Direct and interactive effects of parent,friend and schoolmate drinking on alcohol use trajectories

Objective: This study considered the unique and interactive roles of social norms from parents, friends and schools in predicting developmental trajectories of adolescent drinking and intoxication.

Design and outcome measures: Using data from the National Longitudinal Study of Adolescent Health, which followed adolescents (N = 18,921) for 13 years, we used discrete mixture modelling to identify unique developmental trajectories of drinking and of intoxication. Next, multilevel multinomial regression models examined the role of alcohol-related social norms from parents, friends and schoolmates in the prediction of youths’ trajectory group membership.

Results: Results demonstrated that social norms from parents, friends and schoolmates that were favourable towards alcohol use uniquely predicted drinking and intoxication trajectory group membership. Interactions between social norms revealed that schoolmate drinking played an important moderating role, frequently augmenting social norms from parents and friends. The current findings suggest that social norms from multiple sources (parents, friends and schools) work both independently and interactively to predict longitudinal trajectories of adolescent alcohol use.

Conclusions: Results highlight the need to identify and understand social messages from multiple developmental contexts in efforts to reduce adolescent alcohol consumption and alcohol-related risk-taking.     

The effects of familial risk, personality, and expectancies on alcohol use and abuse

This study tested a structural model of the association between familial risk, personality risk, alcohol expectancies, and alcohol abuse in a sample of 224 young adult offspring of alcoholics and 209 offspring of nonalcoholics. The results provided support for 2 personality-risk pathways, a social deviance proneness and an excitement/pleasure seeking path, that accounted for a significant portion of the association between a familial alcoholism and alcohol abuse. The path from familial alcoholism to social deviance proneness lead directly to alcohol problems. The path from familial alcoholism to excitement/pleasure seeking was associated with increased drinking, which, in turn, was associated with alcohol problems. Positive alcohol expectancies accounted for part of the association between excitement seeking and alcohol use. The results suggest 2 different biopsychosocial mechanisms that elevate risk for abuse in the offspring of alcoholics.     

Concurrent and prospective effects of multi‐dimensional aggression and anger on adolescent alcohol use

This study examined the relationship between alcohol, anger, and aggression in high school students. Anger and three types of aggressive expression (verbal, physical toward people, and physical toward objects) were evaluated cross‐sectionally and prospectively, via structural equation modeling for relationships to alcohol use in Mexican American and white non‐Latino 9–10th (Time 1) and 11–12th grade (Time 2) students. At both times cross‐sectionally, anger and aggressive anger expression tended to correlate positively with alcohol use in each ethnicity/gender group. However, prospectively, aggressive forms of anger expression tended not to be related to alcohol use two years later. Only verbally aggressive anger expression was related to alcohol use two years later and then, only for Mexican American and white non‐Latino females. There was, therefore, little basis for causal links between aggressive anger expression and alcohol use in a general population of high school students. Aggress. Behav. 30:356–372, 2004. © 2004 Wiley‐Liss, Inc.     

Identifying two potential mechanisms for changes in alcohol use among college-attending and non-college-attending emerging adults

This study tested whether pro-alcohol peer influences and prosocial involvement account for increases in drinking during the transition into emerging adulthood and whether these mechanisms differ depending on college attendance and/or moving away from home. The authors used structural equation modeling of prospective data from 825 young men and women. For 4 groups defined by college and residential status, more drinking in the spring of 12th grade predicted more pro-alcohol peer influences the following fall, and more pro-alcohol peer influences in the fall predicted increases in drinking the following spring. Going to college while living at home was a protective factor against increases in drinking and selection of pro-alcohol peer involvements. Prosocial involvement (measured by involvement in religious activities and volunteer work) was not significantly related to post-high school drinking except among college students living away from home. Prevention efforts should focus on (a) reducing opportunities for heavy drinking for college and noncollege emerging adults as they leave home and (b) increasing prosocial involvement among college students not living at home.     

Gender and marital status differences in depression: The effects of chronic strains

Although women evidently have higher depression levels than men and singles have higher depression levels than the married, the reasons for these differences are yet unclear. This paper investigates whether differences in the stress-producing circumstances of the lives of men and women, and the married and unmarried, might explain the differences in their levels of depression. Using data from the National Survey of Families and Households, we found that gender differences in depression were accounted for by chronic strains. Family-based strains and economic hardship are significant predictors of higher distress in women. Chronic strains also explain why variations in depression are more pronounced among the married than among the unmarried.Bowling Green State University     

Young children's knowledge of their memory span: effects of task and experience

This study investigated the hypothesis that young children have knowledge about their memory that they may be unable to articulate, but are able to reflect on and use in problem-solving. Forty-eight kindergarteners made one of two types of judgments about their memory span for words. Half of the children made prospective verbal predictions about the number of words they thought they could recall from a list of 10. The other half made concurrent, nonverbal predictions by listening to words on a tape and manually stopping the tape when they heard as many words as they thought they could recall. Children's actual recall for words was then assessed. All children participated in multiple trials to assess the effect of task experience on their predictions. Analyses revealed that predictions made in the concurrent task were significantly more accurate than those made in the prospective task. All children lowered their predictions across trials, although only in the concurrent task were children's final-trial predictions not significantly greater than their actual recall. No meaningful effects or interactions were associated with actual recall scores. These results revealed that young children manifested greater memory knowledge when this knowledge was assessed through their concurrent problem-solving behavior rather than through their prospective verbal predictions.