Frequency of Attendance at Religious Services and Exposure to Environmental Tobacco Smoke

Journal of Religion and Health - Exposure to environmental tobacco smoke (ETS) is associated with increased risk of disease and death. Reports on ETS and religion are lacking. Data from the...     

小鼠新颖寻求特质对酒精的运动激活效应的影响

新颖寻求(或感觉寻求)特质与许多成瘾药物的易感性密切相关。例如, 高、低新颖寻求动物对可卡因、苯丙胺和吗啡等成瘾药物的奖赏、运动激活、强化效应的反应存在差异。长期饮用酒精也容易成瘾, 但尚未发现关于新颖寻求特质影响酒精成瘾的报道。本实验采用药物成瘾研究中常用的自发活动模型, 考察了高、低新颖寻求动物在酒精急性处理、慢性处理和激发过程中的行为表现。实验过程中首先采用两种新颖寻求模型, 即新颖环境中自发活动模型和新颖客体偏爱模型, 将昆明小鼠分别区分为高、低自发活动组和高、低新颖客体偏爱组, 连续10天给予酒精(2g/kg/d, i.p.)或等量盐水处理, 戒断2天后所有小鼠接受酒精(2g/kg)激发。实验结果表明, 新颖环境低自发活动小鼠比新颖环境高自发活动小鼠对酒精急性、慢性处理导致的运动激活效应更敏感; 在酒精激发期前者的自发活动水平也高于后者。本实验结果说明新颖环境中自发活动特质影响动物对酒精导致的运动激活效应的反应。     

Effects on Youth of Exposure to Retail Tobacco Advertising1

The absence of significant restrictions on tobacco advertising in stores has prompted concern about the proliferation of these messages and their impact on youth. This is among the first studies to investigate the effects of adolescents’ exposure to retail tobacco advertising. Under the guise of testing teen‐interest news stories, 8th and 9th graders (n= 385) saw photographs of a convenience store that was either dominated by or devoid of tobacco advertising while listening to a story about a proposed tobacco control law or one about teen food purchases. Regardless of the news story they heard, students exposed to the tobacco‐saturated store perceived significantly easier access to cigarettes, believed more peers tried and approved of smoking, and expressed weaker support for tobacco‐control policies than did the comparison group. The study results suggest that widespread tobacco advertising in stores might distort adolescents’ perceptions about the availability, use, and popularity of this product.     

成年期双酚A暴露对小鼠行为的影响

探究成年期环境雌激素双酚A(bisphenol A, BPA)暴露对不同性别小鼠行为的影响。出生5周的小鼠灌胃染毒BPA (40、400 µg/kg/d), 同时设对照组。染毒8周后, 以开场行为检测小鼠的自发活动及探究行为, 以高架十字迷宫检测小鼠的焦虑和探究行为, 以水迷宫检测小鼠的空间学习记忆行为, 以跳台检测小鼠的被动回避记忆行为。结果显示, BPA暴露不影响同性别小鼠在开场中的各种行为, 但消除了悬空站立和扶壁站立频率的性别差异。高架十字迷宫行为测试中, BPA暴露显著减少雄鼠进入开放臂的次数和停留时间(p<0.05和p<0.01), 却显著增加雌鼠进入开放臂的次数和停留时间(p<0.05和p<0.01); 同时, BPA暴露显著减少雄鼠(p<0.05和p<0.01)却增加雌鼠在中央区的探头次数(p<0.01), 消除甚至反向诱导成年小鼠焦虑行为和探究行为的性别分化。BPA (40 µg/kg/d)暴露显著延长成年雄鼠在水迷宫中搜寻平台的平均距离(p<0.05), 但对雌鼠没有影响, BPA因此消除了正常成年小鼠空间记忆行为的性别差异。BPA(40 µg/kg/d)暴露显著缩短了雄鼠在遭电击24h后跳下平台的潜伏期(p<0.05), 但对雌鼠没有明显影响, 并因此诱导成年小鼠被动回避行为的性别差异。以上结果表明, 成年期BPA 暴露可性别特异性地影响小鼠的多种行为, 干扰成年小鼠行为的性别差异。     

The Effects of Prenatal Alcohol Exposure on Behavior: Rodent and Primate Studies

The use of alcohol by women during pregnancy is a continuing problem. In this review the behavioral effects of prenatal alcohol from animal models are described and related to studies of children and adults with FASD. Studies with monkeys and rodents show that prenatal alcohol exposure adversely affects neonatal orienting, attention and motor maturity, as well as activity level, executive function, response inhibition, and sensory processing later in life. The primate moderate dose behavioral findings fill an important gap between human correlational data and rodent mechanistic research. These animal findings are directly translatable to human findings. Moreover, primate studies that manipulated prenatal alcohol exposure and prenatal stress independently show that prenatal stress exacerbates prenatal alcohol-induced behavioral impairments, underscoring the need to consider stress-induced effects in fetal alcohol research. Studies in rodents and primates show long-term effects of prenatal and developmental alcohol exposure on dopamine system functioning, which could underpin the behavioral effects.     

Social Costs of Smoking: Effects of Tobacco Smoke on Hostile Behavior1

Male and female undergraduates interacted with a same-sex experimenter and a same-sex assistant of the experimenter. Either the experimenter or the assistant smoked. Subjects were provoked or not provoked by the experimenter and then smoked. Subjects were provoked or not provided by the experimenter and then provided with an opportunity to treat him or her in a hostile manner. Additionally, subjects were classified as smokers or nonsmokers and as supporting or opposing smoking in public places. Tobacco smoke was found to facilitate hostile behavior whether or not subjects were independently annoyed and whether or not it originated from the annoyer or a bystander. No sex differences were observed in this effect. Also, no appreciable difference was observed in the hostile behavior of smokers and nonsmokers. Persons opposed to public smoking reacted more strongly to the provocation than persons supportive of public smoking, but this effect was independent of the presence or absence of smoke.     

The Effects of Tobacco Smoke and Nicotine on Cognition and the Brain

Tobacco smoke consists of thousands of compounds including nicotine. Many constituents have known toxicity to the brain, cardiovascular, and pulmonary systems. Nicotine, on the other hand, by virtue of its short-term actions on the cholinergic system, has positive effects on certain cognitive domains including working memory and executive function and may be, under certain conditions, neuroprotective. In this paper, we review recent literature, laboratory and epidemiologic, that describes the components of mainstream and sidestream tobacco smoke, including heavy metals and their toxicity, the effect of medicinal nicotine on the brain, and studies of the relationship between smoking and (1) preclinical brain changes including silent brain infarcts; white matter hyperintensities, and atrophy; (2) single measures of cognition; (3) cognitive decline over repeated measures; and (4) dementia. In most studies, exposure to smoke is associated with increased risk for negative preclinical and cognitive outcomes in younger people as well as in older adults. Potential mechanisms for smoke’s harmful effects include oxidative stress, inflammation, and atherosclerotic processes. Recent evidence implicates medicinal nicotine as potentially harmful to both neurodevelopment in children and to catalyzing processes underlying neuropathology in Alzheimer’s Disease. The reviewed evidence suggests caution with the use of medicinal nicotine in pregnant mothers and older adults at risk for certain neurological disease. Directions for future research in this area include the assessment of comorbidities (alcohol consumption, depression) that could confound the association between smoking and neurocognitive outcomes, the use of more specific measures of smoking behavior and cognition, the use of biomarkers to index exposure to smoke, and the assessment of cognition-related genotypes to better understand the role of interactions between smoking/nicotine and variation in genotype in determining susceptibility to the neurotoxic effects of smoking and the putative beneficial effects of medicinal nicotine.     

Prenatal Smoke Exposure Predicts Hyperactive/Impulsive but Not Inattentive ADHD Symptoms in Adolescent and Young Adult Girls

We examined the longitudinal associations between prenatal tobacco smoke exposure (PSE) and attention‐deficit hyperactivity disorder (ADHD) symptom domains in adolescence and young adulthood. A sample of girls with ADHD combined presentation (N = 93), ADHD predominantly inattentive presentation (N = 47), and matched comparisons (N = 88) was assessed prospectively. Symptoms of hyperactivity/impulsivity (HI), inattention (IA), and oppositionality (oppositional defiant disorder) were measured via multiple informants 5 (M age = 14 years; retention rate = 92%) and 10 years (M age = 20 years; retention rate = 95%) following childhood ascertainment. PSE was captured via maternal self‐report. We used linear regressions to examine the prediction from PSE to both HI and IA in adolescence and early adulthood after stringent control of relevant confounding variables. PSE significantly predicted HI during adolescence and young adulthood across multiple informants but did not predict IA at either wave. Symptoms of HI may have partial etiological independence from IA symptoms. Copyright © 2015 John Wiley & Sons, Ltd.     

Functional Neuroimaging in the Examination of Effects of Prenatal Alcohol Exposure

Functional neuroimaging offers the opportunity to understand the effect of prenatal alcohol exposure on the activities of the brain as well as providing a window into the relationship between neural activation and the behavioral outcomes that have been described in affected individuals. Several different methodologies have been used to examine the neurophysiological signal changes associated with different brain functions in prenatally exposed individuals and those diagnosed with fetal alcohol syndrome (FAS) or other fetal alcohol spectrum disorders (FASD). These include electroencephalography (EEG), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and functional magnetic resonance imaging (fMRI). These studies demonstrate that it is feasible to use these technologies with this clinical population and that the damage to the central nervous system associated with prenatal alcohol exposure has widespread functional implications; however, currently, the literature in these areas is limited and unsystematic. Functional MRI with this clinical population has just begun to explore the implications of prenatal alcohol exposure with the first paper published in 2005. Other methodologies are similarly limited in scope. Nonetheless, these functional neuroimaging studies suggest that prenatal alcohol exposure, or a diagnosis of FAS, may lead to restrictions in neural efficiency or a global decrement in processing resources.     

长期双酚A暴露对成年小鼠恐惧记忆的影响

双酚A (bisphenol, BPA)是一种广泛应用于塑料制品的环境内分泌干扰物, 具有弱雌激素和抗雄激素活性, 与雌激素受体有一定的亲和力。本实验探讨长期BPA暴露对成年小鼠恐惧记忆的影响及其神经机制。将9周龄雄性小鼠暴露于BPA (0.4、4、40 mg/kg/d) 90 d, 建立小鼠亚慢性BPA暴露模型后, 进行场景性条件恐惧训练, 然后分别在电击后1 hr及24 hr检测小鼠的僵立时间, 同时在电击前、电击后1 hr及24 hr检测海马相关蛋白表达变化。结果表明, BPA (4、40 mg/kg/d)暴露延长小鼠场景性条件恐惧训练后1 hr及24 hr的僵立时间。Western blot蛋白检测结果显示, 行为训练前, BPA降低了小鼠NMDA受体NR1亚基表达水平, 上调组蛋白去乙酰化酶2表达。行为训练后1 hr及24 hr, BPA促进海马NMDA受体亚基NR1和组蛋白H3乙酰化表达, 抑制组蛋白去乙酰化酶2表达, 同时促进ERK1/2磷酸化水平。以上结果表明, 长期BPA暴露提高成年小鼠恐惧记忆获得的同时延长恐惧记忆的保持; 该作用可能通过激活海马的ERK1/2通路而改变核内组蛋白乙酰化和NMDA受体水平进行。     

Behavioral Consequences of Exposure to Uncontrollable and Unpredictable Noise1

A laboratory experiment was conducted to investigate behavioral consequences of exposure to high-intensity predictable and unpredictable noise, under conditions where subjects believed or did not believe they had control over noise termination. Subjects were a group of men and women, averaging 50 years of age, who had lived in an urban environment for most of their lives. Results showed that the work of adapting to uncontrollable, in contrast to controllable noise, produced greater performance impairments following termination of the noise. Predictable noise had minimal effects on postadaptive performance, even though subjects could not control its offset. Comparisons of these data with previous findings reported by the authors indicated that people living in urban settings for long periods of time show essentially the same negative consequences of noise adaptation as those living in cities for shorter durations.     

Prenatal Exposure to Maternal Smoking and Childhood Behavioural Problems: A Quasi-experimental Approach

This retrospective cross-sectional paper examines the relationship between maternal smoking during pregnancy and children’s behavioural problems at 9?years of age independent of a wide range of possible confounders. The final sample comprised 7,505 nine-year-old school children participating in the first wave of the Growing Up in Ireland study. The children were selected through the Irish national school system using a 2-stage sampling method and were representative of the nine-year population. Information on maternal smoking during pregnancy was obtained retrospectively at 9?years of age via parental recall and children’s behavioural problems were assessed using the Strengths and Difficulties Questionnaire across separate parent and teacher-report instruments. A quasi-experimental approach using propensity score matching was used to create treatment (smoking) and control (non-smoking) groups which did not differ significantly in their propensity to smoke in terms of 16 observed characteristics. After matching on the propensity score, children whose mothers smoked during pregnancy were 3.5?% (p?<?0.001) and 3.4?% (p?<?0.001) more likely to score in the problematic range on the SDQ total difficulties index according to parent and teacher-report respectively. Maternal smoking during pregnancy was more strongly associated with externalising than internalising behavioural problems. Analysis of the dose–response relationship showed that the differential between matched treatment and control groups increased with level of maternal smoking. Given that smoking is a modifiable risk factor, the promotion of successful cessation in pregnancy may prevent potentially adverse long-term consequences.     

The Aura of Tobacco Smoke: Cigars and Cigarettes as Image Makers

Male and female college undergraduates evaluated the character traits of men and women who were seen smoking cigars, smoking cigarettes, or not smoking. The evaluated adults were about 10 years older than the students. Irrespective of the evaluated persons' gender, ratings of appeal were specific to the gender of the evaluator. Men and women agreed in their perception of cigarette smokers as being less appealing than nonsmokers. However, whereas men ascribed markedly less appeal to cigar smokers than to cigarette smokers, women perceived cigar smokers as being as appealing as nonsmokers. This pattern was observed for all positive aspects of appeal; the inverse pattern was apparent for all negative aspects of appeal. In contrast, men and women concurred in judging cigar smokers as being more confident and secure than either nonsmokers or cigarette smokers.     

Affective Comorbidity Associated with Symptoms,Lung Function,and Differences Between Patients with COPD for Biomass and Tobacco Smoke Exposure

Journal of Clinical Psychology in Medical Settings - Anxiety and depression are common entities in patients diagnosed with Chronic Obstructive Pulmonary Disease (COPD). This study aimed to...     

Rules and Self-Rules: Effects of Variation Upon Behavioral Sensitivity to Change

The Psychological Record - Four experiments compared the effects of self-rules and rules, and varied and specific schedules of reinforcement. Participants were first exposed to either several...     

The Long-Term Neurocognitive Consequences of Prenatal Alcohol Exposure: A 14-Year Study

Prenatal alcohol exposure, at doses not generally associated with maternal alcohol problems, produces a broad array of neurocognitive deficits in offspring even in the absence of effects on growth and morphology. This report presents a summary of neurobehavioral, growth, and morphology findings from long-term follow-up of a birth cohort of 500 from apopulation-based study that has revealed attention, memory, and information processing deficits from birth through 14 years. Also observed (from school age through 14 years) have been problems with antisocial and delinquent behaviors, and classroom learning and behaviors; some of these problems may be secondary to earlier neurocognitive disabilities. Continuing research in behavioral and neurobehavioral teratology provides important opportunities for the neurosciences and for improved health of future generations.     

The Effects of Children's Exposure to Domestic Violence: A Meta-Analysis and Critique

A wide range of children's developmental outcomes are compromised by exposure to domestic violence, including social, emotional, behavioral, cognitive, and general health functioning. However, there are relatively few empirical studies with adequate control of confounding variables and a sound theoretical basis. We identified 41 studies that provided relevant and adequate data for inclusion in a meta-analysis. Forty of these studies indicated that children's exposure to domestic violence was related to emotional and behavioral problems, translating to a small overall effect (Z _r = .28). Age, sex, and type of outcome were not significant moderators, most likely due to considerable heterogeneity within each of these groups. Co-occurrence of child abuse increased the level of emotional and behavioral problems above and beyond exposure alone, based on 4 available studies. Future research needs are identified, including the need for large-scale longitudinal data and theoretically guided approaches that take into account relevant contextual factors.     

Cumulative Effects of Prenatal Substance Exposure and Early Adversity on Foster Children's HPA Axis Reactivity During a Psychosocial Stressor

Dysregulated hypothalamic-pituitary-adrenocortical (HPA) axis stress response has been reported among individuals with prenatal substance exposure and those with early adversity. However, few researchers have examined the combined effects of these risk factors. Patterns of HPA reactivity among maltreated foster children with and without prenatal substance exposure (N = 53; ages 9-12 years) were examined using the Trier Social Stress Test for Children. Area under the curve with respect to increase (AUC(I)) analyses revealed that prenatal substance exposure or physical abuse significantly increased the likelihood of a negative AUC(I) (i.e., little or no HPA reactivity). Among children with prenatal substance exposure and physical abuse, 85% exhibited a negative AUC(I). The results underscore the importance of addressing this combined risk.     

A Prospective Study of Maternal Exposure to Smoking during Pregnancy and Behavioral Development in the Child

Prenatal smoke exposure (PSE) is a risk factor for adverse outcomes in the offspring, including those affecting psychological development. However, it is uncertain whether these associations are the direct result of PSE or other confounding factors. The aim of this study was to examine the possible relationship between PSE and behavioral development in children at 7.5 years of age, considering several prenatal, neonatal and postnatal covariates. A cohort of 266 mother-child pairs was followed from the first trimester of pregnancy until the children reached 7.5 years of age. PSE was assessed using a questionnaire from prenatal clinical records and corroborated by plasma cotinine determinations in the first and second trimesters and in the cord. Mother-child pairs were classified into one of four groups: unexposed, exposed to passive smoking, first trimester active smoking only and active smoking throughout pregnancy. Child behavior was assessed using the Child Behavior Checklist for ages 6–18 and the Childhood Autism Spectrum Test. In multiple linear regression models, smoking during pregnancy was associated with higher scores in affective problems (β?=?0.298; p?=?0.004). No significant associations were found between smoking during pregnancy and externalizing problems. Findings indicate that PSE is negatively associated with behavioral development in childhood.