Functions and Health at the Interface of Biology and Technology

Synthetic biology promises to eliminate the distinction between biology and engineering by delivering a philosophically interesting new kind of entity: a biological organism that is wholly designed and constructed by humans. The possibility of such organisms raises interesting questions in three domains: the analysis of (1) biological functions, (2) engineering functions, and (3) health and disease. This paper identifies and systematically answers these questions. This does not only establish how we should think about functions and health and disease in synthetic biological organisms, but it also reveals insights that are of broader relevance: (1) aetiological accounts of biological function need to omit or reinterpret reference to natural selection. This results in complete continuity between aetiological analyses of function in engineering and philosophy; (2) considering synthetic biology prompts interesting further questions about heritability, ancestry, and biological individuals; and (3) accounts of disease as biological dysfunction do not straightforwardly map onto our intuitive health and disease judgments regarding non-human animals. In response to the latter point I examine three possible avenues, and tentatively defend one on behalf of the ‘disease as dysfunction’ theorist.     

Naturalising deconstruction

Most contemporary readings of Derrida’s work situate it within a transcendental tradition of philosophical enquiry explicitly critical of naturalistic accounts of knowledge and mind. I argue that Derrida provides the naturalist with some of the philosophical resources needed to rebut transcendental critiques of naturalism, in particular the phenomenological critiques which derive from Husserl’s philosophy. I do this by showing: a) that Derrida’s account of temporality as differance undermines phenomenological accounts of the meaning of naturalistic theories and assumptions; and b) that it is itself both usable and interpretable within the naturalistic framework of current cognitive science.     

The function debate: between “cheap tricks” and evolutionary neutrality

We examine the use of the notion of natural selection in the philosophical debate on functions in biology. This debate has been largely shaped by the way in which different accounts assess various selective pressures in justifying claims about biological functions. Cummins (Functions: new essays in the philosophy of psychology and biology. Oxford University Press, Oxford, pp 157–172, 2002), one of the main proponents of the causal role account of biological functions, argues that a correctly understood neo-Darwinian notion of natural selection has nothing to do with functional talk in biology. In this paper, we counter Cummins’ account by showing that progress in the molecular approaches to evolutionary biology—specifically scientific data available in neo-functionalization research—offers valuable support to the etiological selectionist approach to functions in biological and biologically-related sciences. Finally, we use the presented data to build our own account of biological functions, which tries to avoid the wrong turns taken by both major strands in the biological function debate, namely causal role and etiological accounts. According to our account, the function of a certain gene or a protein in the biological system that contains it is a particular causal activity, or a group of causal activities whose manifestation is in a specific way determined by corresponding mechanisms of genetic expression. Also, we argue that in many important cases this particular expression of genetic activity was positively selected at a certain point in evolutionary history. Since we take selection as an important but not the only factor that grounds biological functions, we are committed to a weak etiological account.     

自然主义集合实在论与数学哲学研究范式

In recent 50 years,the debate between mathematical realism and anti-realism has been dominating the mainstream development in the contemporary philosophy of mathematics. Penelope Maddy proposed a naturalistic set theoretic realism in 1990. This project brings the philosophy of mathematics a new research idea,that is,philosophy should attach importance to mathematical practice. This article will critically analyze Maddy's naturalistic set theoretic realism on the basis of research paradigm background belief....     

Deducing the Mind

Frank Jackson has argued that, in principle, all mental truths are deducible from all physical science truths: 'deducibility'. Jackson's defence of deducibility relies upon the method for producing naturalistic definitions of mental states championed in the analytical functionalism of himself, David Lewis, and others. Two arguments are presented. The first contends that the particular naturalistic definitions of analytical functionalism fail because they do not take account of the extraordinary kind of bodily animation displayed by human beings, which I argue is necessary to (at least one kind of) mentality; machines lacking (at least this one kind of) mentality can satisfy the naturalistic definitions of analytical functionalism. So Jackson's defence of deducibility fails as it stands. The second argument contends that no naturalistic conceptual analysis of the mental can be adequate, because understanding (certain) mental concepts requires a special kind of affective reaction here named 'personal response', while understanding naturalistic concepts does not require this- therefore no naturalistic analysis can ever capture our common-sense mental concepts. The upshot is that Jackson's defence of deducibility cannot be repaired. No defence of deducibility will work which relies upon the possibility of naturalistic conceptual analyses of mentality.     

Philosophy and the ‘anteriority complex’

The project of naturalising phenomenology is examined within the larger context of the philosophy of science. Transcendental phenomenology, as defended by Husserl, in opposition to the naturalistic enterprise, reflects a particular way of thinking about philosophy and its relationship to the empirical sciences that stands as an obstacle to the project of naturalisation. This paper develops a critique of a basic assumption made in this conception of philosophy, namely that it is possible to ask and answer questions concerning knowledge in the abstract, prior to and independently of the various investigative contexts which are the immediate concern of practicing scientists. To successfully naturalise phenomenology, we need to abandon this conception of philosophy.     

On the Possibility of Naturalistic and of Pure Epistemology

This paper deals with two opposite metaphilosophical doctrines concerning the nature of philosophy. More specifically, it is a study of the naturalistic view that philosophical, hence also epistemological, knowledge cannot be distinguished from empirical knowledge, and of the antinaturalistic view that philosophical, hence also epistemological, knowledge, is pure, that is, independent of empirical knowledge and particularly of the special sciences. The conditions of the possibility of naturalistic and of pure epistemology are studied in terms of phenomenological philosophy. It is concluded that pure epistemology is possible under relatively strong conditions but that the version of naturalistic epistemology which denies the pure basis leads to contradiction. That, however, does not shake the possibility of cognitive science. Following Husserl, we may argue that studies of human cognition are possible on the condition that a first basis is assumed which is not naturalized.     

Empirical evaluation and justification of methodologies in psychological science.

The purpose of this article is to describe a relatively new movement in the history and philosophy of science, naturalism, a form of pragmatism emphasizing that methodological principles are empirical statements. Thus, methodological principles must be evaluated and justified on the same basis as other empirical statements. On this view, methodological statements may be less secure than the specific scientific theories to which they give rise. The authors examined the feasibility of a naturalistic approach to methodology using logical and historical analysis and by contrasting theories that predict new facts versus theories that explain already known facts. They provide examples of how differences over methodological issues in psychology and in science generally may be resolved using a naturalistic, or empirical, approach.     

What are theories for? Concept use throughout the continuum of dinosaur expertise

Although it is now well established that object concepts are situated within broader systems of theoretical knowledge, it is less clear how theories influence the use of object concepts at various points throughout the continuum of expertise. Two studies were conducted to investigate the impact of specific theories (concerning dinosaurs) and overarching framework theories (of biology) on children's and adults' performance on categorization tasks involving familiar and less familiar concepts. Although expertise increased the quantity of deep feature knowledge possessed by children and increased their understanding of biologically adaptive relations among features, few aspects of children's performance generalized beyond highly familiar dinosaurs. Children's specific theories related to dinosaurs were empirically constrained and relatively dissociated from other types of biological knowledge. The interaction of specific concept knowledge with broader framework theories of biology throughout the continuum of expertise is considered.     

A Cybernetic Theory of Psychopathology

Abstract

Cybernetics, the study of principles governing goal-directed, self-regulating systems, offers a useful approach to understanding psychopathology or psychological dysfunction, overcoming limitations of other naturalistic approaches. Whereas influential theories of psychopathology have relied on definitions of dysfunction rooted in evolution and fitness, we define psychopathology in terms of cybernetic dysfunction, failure to make progress toward important goals. Cybernetic function in organisms is not identical to evolutionary function, despite their causal phylogenetic relationship. We define psychopathology as persistent failure to move toward one’s goals, due to failure to generate effective new goals, interpretations, or strategies when existing ones prove unsuccessful. This definition allows a thorough integration of dimensional approaches to psychopathology and personality and provides a new perspective on the nosology of mental disorder. We review evidence that the major dimensions of psychopathology correspond to major trait dimensions of personality, but we assert that extremity on these dimensions is neither necessary nor sufficient for psychopathology, which requires cybernetic dysfunction. Drawing from psychological and neurobiological research on personality and psychopathology, we present a theory of the mechanisms underlying the five major dimensions of psychopathology, some of their subdimensions, and the general risk factor for psychopathology. We conclude by discussing implications of our theory for research, diagnosis, and mental health interventions.     

A Critical Taxonomy of the Theories About the Paths into the Reduction

The paths or ways to the transcendental reduction are a pivotal phenomenological notion in Husserl’s philosophy. The metaphor of path, in fact, alludes to the demonstrative proofs of transcendental phenomenology. Nonetheless, Husserlian scholarship has not yet been able to end the disputes surrounding this topic, and as a result, competing interpretations continue to prevail. Since existing theories about the paths have not yet been cataloged or analyzed in their global context, I intend to classify the main existing theories about the paths and evaluate the trend established by Iso Kern. Thus, this paper answers the following questions: how many kinds of theories about the paths are there? And, how plausible is the trend and approach initiated by Kern? In order to evaluate each theory, I will compare the interpretation with its exemplary cases. The key contribution of this investigation is therefore twofold: to distinguish with unequivocal concepts the two main trends of hermeneutical theories in play and to evaluate the plausibility of the aforementioned Kernian one. The paper also attempts to show that the hermeneutical approach initiated by Kern has no contextual examples for its conceptual scheme and should consequently be abandoned in favor of an alternative solution.     

Psychopharmacological enhancement: a conceptual framework

The availability of a range of new psychotropic agents raises the possibility that these will be used for enhancement purposes (smart pills, happy pills, and pep pills). The enhancement debate soon raises questions in philosophy of medicine and psychiatry (eg, what is a disorder?), and this debate in turn raises fundament questions in philosophy of language, science, and ethics. In this paper, a naturalistic conceptual framework is proposed for addressing these issues. This framework begins by contrasting classical and critical concepts of categories, and then puts forward an integrative position that is based on cognitive-affective research. This position can in turn be used to consider the debate between pharmacological Calvinism (which may adopt a moral metaphor of disorder) and psychotropic utopianism (which may emphasize a medical metaphor of disorder). I argue that psychiatric treatment of serious psychiatric disorders is justified, and that psychotropics are an acceptable kind of intervention. The use of psychotropics for sub-threshold phenomena requires a judicious weighing of the relevant facts (which are often sparse) and values.     

Phenomenology and its application in medicine

Phenomenology is a useful methodology for describing and ordering experience. As such, phenomenology can be specifically applied to the first person experience of illness in order to illuminate this experience and enable health care providers to enhance their understanding of it. However, this approach has been underutilized in the philosophy of medicine as well as in medical training and practice. This paper demonstrates the usefulness of phenomenology to clinical medicine. In order to describe the experience of illness, we need a phenomenological approach that gives the body a central role and acknowledges the primacy of perception. I present such a phenomenological method and show how it could usefully illuminate the experience of illness through a set of concepts taken from Merleau-Ponty. His distinction between the biological body and the body as lived, analysis of the habitual body, and the notions of motor intentionality and intentional arc are used to capture the experience of illness. I then discuss the applications this approach could have in medicine. These include narrowing the gap between objective assessments of well-being in illness and subjective experiences which are varied and diverse; developing a more attuned dialogue between physicians and patients based on a thick understanding of illness; developing research methods that are informed by phenomenology and thus go beyond existing qualitative methods; and providing medical staff with a concrete understanding of the impact of illness on the life-world of patients.     

Philosophers should prefer simpler theories

Recent years have seen considerable attention paid to the methodology of philosophy. The puzzle is simple—if philosophy is not an empirical discipline, how can one philosophical theory be rationally preferred over another? One answer to this question is that we should apply the theoretical virtues. Foremost among these theoretical virtues is simplicity—so perhaps we should prefer simpler philosophical theories to more complex ones. Huemer (Philos Q 59:216–236, 2009) objects that the reasons to prefer simpler theories in science do not apply in philosophy. I will argue that Huemer is mistaken—the arguments he marshals for preferring simpler theories in science can also be applied in philosophy. Like Huemer, I will focus on the philosophy of mind and the nominalism/Platonism debate. But I want to engage with the broader issue of whether simplicity is relevant to philosophy.     

Attitudinal and Phenomenological Theories of Pleasure

On phenomenological theories of pleasure, what makes an experience a pleasure is the way it feels. On attitudinal theories, what makes an experience a pleasure is its relationship to the favorable attitudes of the subject who is having it. I advance the debate between these theories in two ways. First, I argue that the main objection to phenomenological theories, the heterogeneity problem, is not compelling. While others have argued for this before, I identify an especially serious version of this problem that resists existing solutions, and I explain why even this version of the problem does not undermine phenomenological theories. Second, I argue that a grand reconciliation can be effected between the two types of theory: it can be true both that pleasures are pleasures in virtue of the way they feel and that they are pleasures in virtue of how they are related to their subjects' favorable attitudes, so long as the attitudes that are constitutively related to pleasures are ones that feel a certain way. Hybrid views of this sort have significant advantages over pure attitudinal or phenomenological views.     

Causal Reasoning and Clinical Practice: Challenges from Molecular Biology

Not only has the philosophical debate on causation been gaining ground in the last few decades, but it has also increasingly addressed the sciences. The biomedical sciences are among the most prominent fields that have been considered, with a number of works tackling the understanding of the notion of cause, the assessment of genuinely causal relations and the use of causal knowledge in applied contexts. Far from denying the merits of the debate on causation and the major theories it comprises, this paper is meant as a stimulus for theorists of causation in the philosophy of biomedicine, with a focus on clinical matters. Without aiming at putting forward an original theory of causation and starting from the narration of two actual but paradigmatic cases at the joints between biomedical research and clinical practice, we want to point out that some pathological situations addressed by molecular medicine actually prove resistant to (at least) some of our major epistemological accounts of causal explanation. Given this scenario, which is very frequent in our hospitals, our analysis aims to provide a stimulus for the debate among theorists of causation in biomedicine interested in real cases in science in practice. We believe that this might in turn encourage some more general rethinking of the complex intertwinement of science, philosophy of science and ethics, as well as of the role of philosophy of science for clinical medicine itself.

     

The fine-grained metaphysics of artifactual and biological functional kinds

In this paper we consider the emerging position in metaphysics that artifact functions characterize real kinds of artifacts. We analyze how it can circumvent an objection by David Wiggins (Sameness and substance renewed, 2001, 87) and then argue that this position, in comparison to expert judgments, amounts to an interesting fine-grained metaphysics: taking artifact functions as (part of the) essences of artifacts leads to distinctions between principles of activity of artifacts that experts in technology have not yet made. We show, moreover, that our argument holds not only in the artifactual realm but also in biology: taking biological functions as (part of the) essences of organs leads to distinctions between principles of activity of organs that biological experts have not yet made. We run our argument on the basis of analyses of artifact and biological functions as developed in philosophy of technology and of biology, thus importing results obtained outside of metaphysics into the debate on ontological realism. In return, our argument shows that a position in metaphysics provides experts reason for trying to detect differences between principles of activities of artifacts and organs that have not been detected so far.     

What is Phenomenological Sociology Again?

In this paper, I seek to caution the increasing number of contemporary sociologists who are engaging with continental phenomenological sociology without looking at the Anglo-American tradition. I look at a particular debate that took place during the formative period in the Anglo-American tradition. My focus is on the way participants sought to negotiate the disciplinary division between philosophy and sociology. I outline various ways that these disciplinary exigencies, especially the institutional struggles with the sociological establishment, shaped how participants defined phenomenological sociology. I argue that despite the supposed theoretical, methodological, and substantial differences between these waves of phenomenological sociology, the contemporary wave could benefit from some of the lessons that were learned by their predecessors.     

Dreaming in the multilevel framework

Biological realism ( [Revonsuo, 2001] and [Revonsuo, 2006] ) states that dreaming is a biological phenomenon and therefore explainable in naturalistic terms, similar to the explanation of other biological phenomena. In the biological sciences, the structure of explanations can be described with the help of a framework called ‘multilevel explanation’. The multilevel model provides a context that assists to clarify what needs to be explained and how, and how to place different theories into the same model. Here, I will argue that the multilevel framework would be useful when we try to construct scientific explanations of dreaming.