Translational behavior analysis: from laboratory science in stimulus control to intervention with persons with neurodevelopmental disabilities

Throughout its history, laboratory research in the experimental analysis of behavior has been successful in elucidating and clarifying basic learning principles and processes in both humans and nonhumans. In parallel, applied behavior analysis has shown how fundamental behavior-analytic principles and procedures can be employed to promote desirable forms of behavior and to prevent or ameliorate undesirable forms in clinical, educational, and other settings. Less obviously, there has also emerged a small but identifiable bridging field that can potentially connect and inform both basic and applied behavior analysis. Although such translational behavior analysis uses laboratory methodologies, research targets are selected largely for their value in ultimate application to improve the human condition. I will discuss the distinction of translational behavior analysis from basic and applied behavior analysis and consider the potential contribution that translational research can make in the development of the science of behavior.     

Translational contributions of the experimental analysis of behavior

It has been argued that to increase societal impact behavioral researchers must do more to address problems of obvious practical importance. The basic science wing of behavior analysis has been described as especially detached from this goal, but is it really necessary that basic science demonstrate social relevance? If so, why hasn''t this occurred more often, and what can be done to improve the status quo? To address these questions and to stimulate discussion about the future of basic behavior science, I describe two widely embraced arguments in favor of pure basic science (that which is undertaken without concern for practical applications); explain why a translational research agenda is likely to better recruit tangible support for basic science; propose that addressing practical problems does not require basic science to abandon its focus on fundamental principles; and identify some possible impediments to translational innovation that may need to be addressed for basic behavior science to increase its translational footprint.     

Translational research in behavior analysis: historical traditions and imperative for the future

"Pure basic" science can become detached from the natural world that it is supposed to explain. "Pure applied" work can become detached from fundamental processes that shape the world it is supposed to improve. Neither demands the intellectual support of a broad scholarly community or the material support of society. Translational research can do better by seeking innovation in theory or practice through the synthesis of basic and applied questions, literatures, and methods. Although translational thinking has always occurred in behavior analysis, progress often has been constrained by a functional separation of basic and applied communities. A review of translational traditions in behavior analysis suggests that innovation is most likely when individuals with basic and applied expertise collaborate. Such innovation may have to accelerate for behavior analysis to be taken seriously as a general-purpose science of behavior. We discuss the need for better coordination between the basic and applied sectors, and argue that such coordination compromises neither while benefiting both.     

The importance of problem-driven research: Bringing Wachtel's argument into the present

There is no one best way to do psychological research. Rather, the “best” way depends on the fit to the problem. Research should be problem-driven rather than method-driven. Psychologists sometimes envy certain natural scientists, and over-reward those who do research with a surface structure more like that of research in the natural sciences, leading to sub-optimal progress in the field.     

Renewed behavior produced by context change and its implications for treatment maintenance: A review

Behavioral treatment gains established in one setting do not always maintain in other settings. The present review examines the relevance of basic and translational research to understanding failures to maintain treatment gains across settings. Specifically, studies of the renewal effect examine how transitioning away from a treatment setting could evoke a return of undesirable behavior, rather than newly trained appropriate behavior. Studies of renewal typically arrange three phases, with a response trained and reinforced under a particular set of contextual stimuli in the first phase. Next, that response is extinguished, often under a different set of contextual stimuli. Finally, that response returns despite extinction remaining in effect upon returning to the original training context or transitioning to a novel context. Thus, removing the extinction context is sufficient to produce a recurrence of the response. The findings suggest treatment effects can become specific to the context in which the treatment was delivered. This literature offers promising methods for systematically assessing the factors contributing to treatment maintenance and improving generalization of treatment gains across contexts. Therefore, the present review suggests basic and translational research on renewal provides an empirical literature to bring greater conceptual systematization to understanding generalization and maintenance of behavioral treatment.     

When Technologies Makes Good People Do Bad Things: Another Argument Against the Value-Neutrality of Technologies

Although many scientists and engineers insist that technologies are value-neutral, philosophers of technology have long argued that they are wrong. In this paper, I introduce a new argument against the claim that technologies are value-neutral. This argument complements and extends, rather than replaces, existing arguments against value-neutrality. I formulate the Value-Neutrality Thesis, roughly, as the claim that a technological innovation can have bad effects, on balance, only if its users have “vicious” or condemnable preferences. After sketching a microeconomic model for explaining or predicting a technology’s impact on individuals’ behavior, I argue that a particular technological innovation can create or exacerbate collective action problems, even in the absence of vicious preferences. Technologies do this by increasing the net utility of refusing to cooperate. I also argue that a particular technological innovation can induce short-sighted behavior because of humans’ tendency to discount future benefits too steeply. I suggest some possible extensions of my microeconomic model of technological impacts. These extensions would enable philosophers of technology to consider agents with mixed motives—i.e., agents who harbor some vicious preferences but also some aversion to acting on them—and to apply the model to questions about the professional responsibilities of engineers, scientists, and other inventors.     

Basic research needed for stimulating the development of behavioral technologies

The costs of disconnection between the basic and applied sectors of behavior analysis are reviewed, and some solutions to these problems are proposed. Central to these solutions are collaborations between basic and applied behavioral scientists in programmatic research that addresses the behavioral basis and solution of human behavior problems. This kind of collaboration parallels the deliberate interactions between basic and applied researchers that have proven to be so profitable in other scientific fields, such as medicine. Basic research questions of particular relevance to the development of behavioral technologies are posed in the following areas: response allocation, resistance to change, countercontrol, formation and differentiation/discrimination of stimulus and response classes, analysis of low-rate behavior, and rule-governed behavior. Three interrelated strategies to build connections between the basic and applied analysis of behavior are identified: (a) the development of nonhuman animal models of human behavior problems using operations that parallel plausible human circumstances, (b) replication of the modeled relations with human subjects in the operant laboratory, and (c) tests of the generality of the model with actual human problems in natural settings.     

Further evaluation of a nonsequential approach to studying operant renewal

Basic‐laboratory assessments of renewal may inform clinical efforts to maintain reduction of severe destructive behavior when clients transition between contexts. The contextual changes arranged during standard renewal procedures, however, do not necessarily align with those that clients experience during outpatient therapy. More specifically, clients transition between clinical (associated with extinction for target behavior) and home/community (associated with reinforcement for target behavior) contexts during outpatient treatment. Standard renewal assessments do not incorporate these contextual alternations during treatment. The present experiment aimed to directly compare renewal of rats' lever pressing following a standard (“sequential”) ABA renewal procedure (i.e., baseline in Context A, extinction in Context B, renewal test in Context A) and a “nonsequential” renewal assessment wherein treatment consisted of daily alternation between Context A (associated with reinforcement for lever pressing) and Context B (associated with extinction). Lever pressing renewed to a greater extent for rats in the Nonsequential group than for rats in the Sequential group, suggesting the contextual changes that clients experience during outpatient treatment for severe destructive behavior may be a variable that is important to consider in translational research on renewal. Potential implications of these findings for basic and clinical research on renewal are discussed.     

Science, Ethics and War: A Pacifist’s Perspective

This article considers the ethical aspects of the question: should a scientist engage in war-related research, particularly use-inspired or applied research directed at the development of the means for the better waging of war? Because scientists are simultaneously professionals, citizens of a particular country, and human beings, they are subject to conflicting moral and practical demands. There are three major philosophical views concerning the morality of war that are relevant to this discussion: realism, just war theory and pacifism. In addition, the requirements of professional codes of ethics and common morality contribute to an ethical analysis of the involvement of scientists and engineers in war-related research and technology. Because modern total warfare, which is facilitated by the work of scientists and engineers, results in the inevitable killing of innocents, it follows that most, if not all, war-related research should be considered at least as morally suspect and probably as morally prohibited.     

Moral Rules,Moral Ideals,and Use-Inspired Research

Moral rules provide the baseline for ethics, proscribing unacceptable behavior; moral ideals inspire us to act in ways that improve the human condition. Whatever the moral ideals for pure research, science has a practical side so it is important to find a moral ideal to give guidance to more applied research. This article presents a moral ideal for use-inspired research based on Norman Care’s idea of shared-fate individualism This ideal reflects the observation that all human lives, both present and future are tightly coupled and, as a result, research projects should be chosen, where possible, with the goal of service to others. Together with the ideals of the habit of truth and the gift economy, shared-fate individualism provides the basis for a humane ethics of science.     

What Are We Doing When We Translate from Quantitative Models?

Although quantitative analysis (in which behavior principles are defined in terms of equations) has become common in basic behavior analysis, translational efforts often examine everyday events through the lens of narrative versions of laboratory-derived principles. This approach to translation, although useful, is incomplete because equations may convey concepts that are difficult to capture in words. To support this point, we provide a nontechnical introduction to selected aspects of quantitative analysis; consider some issues that translational investigators (and, potentially, practitioners) confront when attempting to translate from quantitative models; and discuss examples of relevant translational studies. We conclude that, where behavior-science translation is concerned, the quantitative features of quantitative models cannot be ignored without sacrificing conceptual precision, scientific and practical insights, and the capacity of the basic and applied wings of behavior analysis to communicate effectively.     

Behavioral contrast: Research and areas for investigation

Behavioral contrast occurs when a change in reinforcement rate in one context results in a change in behavior in the opposite direction in an unchanged context. Despite decades of study by basic researchers, behavioral contrast has remained largely an unstudied phenomenon among applied researchers. The purpose of this paper is to occasion translational and applied research on behavioral contrast with the aim of predicting and controlling socially significant behavior in unchanged contexts. We present a brief history of contrast and related definitions, review research with human and nonhuman subjects, and suggest future directions for applied and translational researchers.     

The Central Importance of Laboratories for Reducing Waste in Biomedical Research

The global biomedical research enterprise is driving substantial advances in medicine and healthcare. Yet it appears that the enterprise is rather wasteful, falling short of its true innovative potential. Suggested reasons are manifold and involve various stakeholders, such that there is no single remedy. In the present paper, I will argue that laboratories are the basic working units of the biomedical research enterprise and an important site of action for corrective intervention. Keeping laboratories relatively small will enable better training and mentoring of individual scientists, which in turn will yield better performance of the scientific workforce. The key premise of this argument is that people are at the heart of the successes and failures of biomedical research, yet the human dimension of science has been unduly neglected in practice. Renewed focus on the importance of laboratories and their constituent scientists is one promising approach to reducing waste and increasing efficiency within the biomedical research enterprise.     

Joseph V. Brady: Synthesis Reunites What Analysis Has Divided

Joseph V. Brady (1922–2011) created behavior-analytic neuroscience and the analytic framework for understanding how the external and internal neurobiological environments and mechanisms interact. Brady''s approach offered synthesis as well as analysis. He embraced Findley''s approach to constructing multioperant behavioral repertoires that found their way into designing environments for astronauts as well as studying drug effects on human social behavior in microenvironments. Brady created translational neurobehavioral science before such a concept existed. One of his most lasting contributions was developing a framework for ethical decision making to protect the rights of the people who participate in scientific research.     

Dialoguing Height Psychology into a life of interconnectedness: Response to commentaries by Hwang,Bhawuk, King & Hodgetts,Kashima, and Xie,Su, & Zhong

Liu (Asian Journal of Social Psychology, 000, 000) attempts to articulate an epistemology for the aspirational practice of Height Psychology as a human science informed by Kantian epistemology in dialogue with other philosophies, especially Confucianism and Taoism. Height Psychology is a framework or metatheory for the practice of teaching, research, and service rooted in Kantian epistemology, in dialogue with other philosophies. It provides a holistic philosophy for social scientists responding to wicked problems unfolding over long periods of time. In responding to commentaries, I suggest a corollary to Shweder's (Asian Journal of Social Psychology, 3, p. 207) ‘One mind, many mentalities’: ‘Many indigenous psychologies, interconnected by one epistemology’. Height Psychology is about holding to an invisible moral centre. The practical postulates are foundational to the moral and ethical practices of human societies: they are for doing, their value is ontological. Human agency, proscribed by natural science epistemologies takes centre stage in Height Psychology by facilitating social scientists to act reflexively from multiple positions (from basic to action research) to benefit society. Height Psychology is dedicated to articulating and actioning the moral and ethical basis of a human science that can assist present and future generations of social scientists to meet the grave situational futures facing us in different parts of the world.     

抑郁症神经成像研究的临床转化:预防、诊断和治疗的新取向

抑郁症的预防、诊断和治疗是临床所面临的主要问题,其效果的提升有待超越传统方法,寻求新的方法和技术。其中抑郁症的神经成像转化研究为此提供了一个新的突破口,该研究取向旨在将抑郁症的神经成像基础研究的发现转化为临床运用。文章综述了其在抑郁症的预防、诊断和治疗上的潜在运用价值。未来方向需要更好地促进抑郁症神经成像转化研究的双向自由流通、强调将新的方法转化到日常的临床实践和健康决策上去、促进多学科的合作和相关人才的培养,以及进一步探究转化过程中所面临的特定基础和临床主题。     

转化医学与肿瘤诊治

转化医学是促进基础研究成果向临床应用转化和根据临床医学的需求从事应用基础研究的桥梁。本文以转化医学在肿瘤防治研究的实例,分析转化医学的意义,以期为使大家重视转化医学,提高肿瘤诊治水平。