系统性红斑狼疮误诊的反思

系统性红斑狼疮是一种极为复杂的自身免疫性疾病,临床表现变化多端,早期误诊率高.对1328例系统性红斑狼疮误诊病例进行分析,剖析了该病的本质及特征,并探讨导致误诊的原因,提出了预防误诊的对策,以期提高对本病的早期诊断.     

系统性红斑狼疮的临床决策

系统性红斑狼疮是临床上表现最复杂多变的疾病之一,其诊断、评价、患者教育、治疗及随访工作中既要遵循临床决策的共同法则,又有其特殊之处.减少误诊漏诊、正确看待和应用各种临床指南和病情评价方法以及提高诊疗水平的关键,是应用临床决策学的方法进行综合分析、评价、再分析和再评价,并且要贯穿患者的终生.     

系统性红斑狼疮的临床决策

系统性红斑狼疮是临床上表现最复杂多变的疾病之一,其诊断、评价、患者教育、治疗及随访工作中既要遵循临床决策的共同法则,又有其特殊之处。减少误诊漏诊、正确看待和应用各种临床指南和病情评价方法以及提高诊疗水平的关键,是应用临床决策学的方法进行综合分析、评价、再分析和再评价,并且要贯穿患者的终生。     

糖皮质激素治疗系统性红斑狼疮中“度”的把握

系统性红斑狼疮是一种与遗传、免疫、种族、环境等因素有关的侵犯多系统结缔组织的全身性自身免疫性疾病。该病多器官受累,症状重且复杂,病情反复缓解和发作,故本病的治疗是一个长期的过程,需要终身治疗。糖皮质激素在系统性红斑狼疮的治疗中为最关键的药物,糖皮质激素的剂量、合理运用及“度”的掌握是治疗疾病成败的关键。     

系统性红斑狼疮病因病理与防治的思考

系统性红斑狼疮(SLE)是一种临床表现有多系统损害症状的慢性系统性自身免疫病。虽然对SLE的病因、病理的研究有了较大的进展,但SLE的治疗并不理想,目前仍然有约10%的患者在发病5年内死亡。从哲学角度对SLE的病因、病理与防治中存在的问题进行了综合分析,并为SLE的临床实践和进一步研究提供了思路。     

糖皮质激素治疗系统性红斑狼疮中"度"的把握

系统性红斑狼疮是一种与遗传、免疫、种族、环境等因素有关的侵犯多系统结缔组织的全身性自身免疫性疾病.该病多器官受累,症状重且复杂,病情反复缓解和发作,故本病的治疗是一个长期的过程,需要终身治疗.糖皮质激素在系统性红斑狼疮的治疗中为最关键的药物,糖皮质激素的荆量、合理运用及"度"的掌握是治疗疾病成败的关键.     

系统性红斑狼疮病因病理与防治的思考

系统性红斑狼疮(SLE)是一种临床表现有多系统损害症状的慢性系统性自身免疫病.虽然对SLE的病因、病理的研究有了较大的进展,但SLE的治疗并不理想,目前仍然有约10%的患者在发病5年内死亡.从哲学角度对SLE的病因、病理与防治中存在的问题进行了综合分析,并为SLE的临床实践和进一步研究提供了思路.     

专科医生应注重整体性和系统思维训练——由一例甲亢患者门诊长期误诊引发的哲学思考

临床医学专科的发展对促进医学科学的进步起到了重要的推动作用,尽管它可能缺乏整体性、系统性临床思维,但在可预见的将来,它仍是综合性医院医疗实践的主旋律,医学界应对此有较为清醒的认识。本文从哲学的角度分析了造成误诊的原因,然后指出防止或减少误诊的途径是培养科学的临床思维,并提出了在临床过程中培养整体思维和系统性科学思维的一些方法。     

专科医生应注重整体性和系统思维训练——由一例甲亢患者门诊长期误诊引发的哲学思考

临床医学专科的发展对促进医学科学的进步起到了重要的推动作用,尽管它可能缺乏整体性、系统性临床思维,但在可预见的将来,它仍是综合性医院医疗实践的主旋律,医学界应对此有较为清醒的认识.本文从哲学的角度分析了造成误诊的原因,然后指出防止或减少误诊的途径是培养科学的临床思维,并提出了在临床过程中培养整体思维和系统性科学思维的一些方法.     

“缺乏运动”是“慢性病”吗?

《中国青年报》1987年11月10日第2版刊登了一篇题为《严寒将至防冻疮》的文章,其中有一段话为: “患有某些慢性病如贫血、类风湿性关节炎,肢端型或系统性破皮病、系统性红斑狼疮、营养不良、体弱或缺乏运动等更容易发生冻疮。”“患有”的宾语是“慢性病”。“如……等”表示举例,从逻辑上来讲,实际上     

诊断中的异化与异化的诊断——1例误诊病例的反思

随着诊断技术的日新月异,极大地拓展了临床医师对疾病的认识,但同时也限制了医师的临床思维,形成诊断过程中的"异化"现象。本文以1例患者的误诊过程为例,说明诊断中的异化现象及其对诊断的影响。为减少误诊,医师必须回到"人"的位置,避免成为医疗技术的"奴隶"。     

误诊误治病例所致医疗纠纷分析——附3例报告

当前医疗科技发展的相对性、疾病规律本身的复杂多变性、医生医疗知识的局限性等,导致了临床误诊误治的不可避免性,而医院发生的医疗纠纷事件中,大多是由于误诊误治所致。通过对3例误诊病例及所致医疗纠纷的分析,指出临床误诊误治的客观性、主观性及不可避免性。同时提示临床医师在疾病诊治过程中,随时更新医疗知识,注意疾病的鉴别诊断,及时完善相关的辅助检查,积极治疗,减少对疾病的延误诊治,减轻病人痛苦,改善医患关系,从而减少医疗纠纷。     

老年人肺栓塞临床特点及误诊原因分析

通过对38例临床表现、实验室检查、放射性核素肺灌注显像等方法确诊的老年肺栓塞患者进行回顾性分析,并比较老年患者和非老年患者在致病原因、临床表现及误诊方面的差异,证实下肢深静脉血栓的形成、恶性肿瘤、高血压动脉硬化等是老年人肺栓塞的主要危险因素。老年组肺栓塞的误诊率高达60.5%,高于非老年组(53.2%),最易误诊为肺炎,其次为心肌梗死。因此,老年人肺栓塞应引起临床医生高度重视。     

The influence of subjective life expectancy on retirement transition and planning: A longitudinal study

This study examines the construct of subjective life expectancy (SLE), or the estimation of one's probable age of death. Drawing on the tenets of socioemotional selectivity theory (Carstensen, Isaacowitz, & Charles, 1999), we propose that SLE provides individuals with their own unique mental model of remaining time that is likely to affect their retirement planning and decision making. Longitudinal data from 1908 participants showed that SLE measured at Time 1 predicted mature-aged workers' intended retirement age and the extent that they were engaged in retirement preparation 12 months later at Time 2. Furthermore, a shorter SLE at Time 1 increased the odds of actual retirement by Time 2 after controlling for a set of known predictors of retirement. In contrast, a longer SLE at Time 1 increased the odds that a Time 1 retiree had returned to paid work by Time 2. The discussion highlights ways in which SLE can inform financial and vocational counselling for late career decision-makers.     

Do Cognitive Therapy Skills Neutralize Lifetime Stress to Improve Treatment Outcomes in Recurrent Depression?

Cognitive therapy (CT) is an efficacious treatment for major depressive disorder (MDD), but not all patients respond. Past research suggests that stressful life events (SLE; e.g., childhood maltreatment, emotional and physical abuse, relationship discord, physical illness) sometimes reduce the efficacy of depression treatment, whereas greater acquisition and use of CT skills may improve patient outcomes. In a sample of 276 outpatient participants with recurrent MDD, we tested the hypothesis that patients with more SLE benefit more from CT skills in attaining response and remaining free of relapse/recurrence. Patients with more pretreatment SLE did not develop weaker CT skills, on average, but were significantly less likely to respond to CT. However, SLE predicted non-response only for patients with relatively weak skills, and not for those with stronger CT skills. Similarly, among acute-phase responders, SLE increased risk for MDD relapse/recurrence among patients with weaker CT skills. Thus, the combination of more SLE and weaker CT skills forecasted negative outcomes. These novel findings are discussed in the context of improving CT for depression among patients with greater lifetime history of SLE and require replication before clinical application.     

Cognitive and Emotional Abnormalities in Systemic Lupus Erythematosus: Evidence for Amygdala Dysfunction

Systemic lupus erythematosus (SLE) is a multi-system autoimmune disorder characterized by the production of autoantibodies. Approximately 30-50?% of patients produce autoantibodies directed against N-Methyl-D-aspartic acid receptors (NMDARs). Once they have gained access to brain tissue, these autoantibodies bind to the NR2A subunit of the NMDARs and synergize with glutamate to cause excitatory, non-inflammatory cell death or alter neuron function. Both humans with SLE and animal models of SLE have shown structural and functional damage to the amygdala. The amygdala is a brain region important for processing the emotional relevance of stimuli in the environment. It also serves to modulate perception, attention, and memory to facilitate the processing and learning of relevant stimuli. Research has linked amygdala damage to deficits in emotional memory and emotional behavior. Individuals with SLE often exhibit emotional dysregulation, such as lability and depression; however, the behavioral impact of possible amygdala dysfunction has yet to be studied in this population. The purpose of this review is to 1) examine possible associations between SLE, anti-NMDAR antibodies, amygdala damage, and emotional processing deficits and 2) to identify the clinical, social, and treatment implications for individuals with SLE who suffer from deficits in emotional processing.     

Personality Predicts Health Declines Through Stressful Life Events During Late Mid‐Life

Personality predicts the occurrence of dependent stressful life events (SLE; i.e., events reliant, at least in part, on an individual's behavior). This process, termed stress generation, contributes to psychiatric outcomes, but its role in physical health is unknown. Data were included from 998 participants (aged 55–64) in the St. Louis Personality and Aging Network (SPAN) study. Assessments occurred every 6 months for 18 months. Neuroticism, impulsivity, and agreeableness were measured with the Revised NEO Personality Inventory. Dependent (e.g., divorce) and independent (e.g., family death) SLE occurring within 6 months following baseline were assessed with the List of Threatening Experiences and confirmed by interviews. Health problems occurring within a year after SLE were the outcome. Analyses examined whether neuroticism, impulsivity, and agreeableness indirectly predict the onset of new health problems through exposure to dependent SLE. Each personality trait was associated with dependent, but not independent, SLE. Only dependent SLE predicted new health problems. Each personality trait indirectly predicted the onset of new health problems through dependent SLE. Findings suggest that personality‐driven stress generation influences physical health during late mid‐life. Addressing personality in interventions may reduce the occurrence of SLE, in turn decreasing health risks.     

A brief assessment tool for body image in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) may adversely affect body image in multitude ways. Development and validation of a brief and valid SLE specific body image tool were undertaken. Eleven items were identified on interview of 21 SLE patients for the Body Image Lupus Scale (BILS v1.0). The tool was administered to 70 SLE patients. Based on analysis, feedback, and refinement of items, the final iteration BILS v1.2 with five items was administered to 233 SLE patients along with validated body image measures (Situational Inventory of Body Image Dysphoria and Body Image Quality of Life Inventory) and health-related quality of life measures for a subsample. The BILS scores' had an internal consistency reliability of .94. It correlated with both the referent body image measures, and with health-related quality of life. It differentiated participants by health status and disease activity. Test-retest reliability estimates exceeded .90. These results support the psychometric properties of BILS.     

Stressful life events and suicidal behaviour in countries with different development levels: Nicaragua,El Salvador,Chile and Spain

This paper presents a study conducted on 709 Latin American undergraduates from four countries with different development levels (Nicaragua, El Salvador, Chile and Spain). The intention of this paper is to value the differences in the number and characteristics of stressful life events (SLE) suffered by the participants. Another purpose is to confirm the relation between SLE and suicidal conduct in Spanish cultural contexts, through the study of a multicultural sample of Spanish‐speaking university students, and finally, to isolate the SLE that allow predicting a later suicidal conduct to a greatest extent. The information was collected by means of a self‐applied questionnaire. The results indicate a greater presence of SLE among those who live in countries with lower development levels and among those who have attempted committing suicide. It is observed that the fact of having suffered certain SLE—physical or sexual mistreatment, excessive alcohol or drug consumption and having left home during childhood or adolescence—aid in the prediction of later suicidal conducts in the studied samples. Copyright © 2010 John Wiley & Sons, Ltd.