科学发明中原型启发的创造性思维成分及其脑机制

目前对创造性思维的测量及神经机制的研究, 国际上大多采用发散思维任务、远距离联想测验、顿悟问题解决等任务。但这些测量工具大多停留在对非科学类问题解决的研究上, 因此生态效度和预测效度都不高。本项目在前面研究的基础上, 探讨更符合现实生活的科学发明中原型启发的创造性思维成分及机制。研究一通过两个行为实验探索原型启发能力的创造性思维成分测试的结构效度; 研究二运用大样本磁共振数据, 从脑机制上进一步验证创造性思维成分的结构效度; 研究三通过3个核磁任务态探索原型启发能力的主要创造性思维成分的脑机制; 研究四试图在高校和企业研发机构进行跟踪研究, 检验创造性思维成分测试的预测效度。通过本项目的开展, 希望开发具有更高预测效度和生态效度的用于发明创造领域的创造性测量工具。     

Shackling the shoulders of giants

This paper informally summarizes a two-day symposium held at the U.S. National Academy of Sciences in Washington, D.C., September 5–6, 2002. The issue was to what extent the progress of science and societal capacity for continued technological innovation are threatened by excessive protection of intellectual property. Excessive protection creates disadvantages not only for scientists and inventors but also for educators/students and for librarians/clientele. Speakers from a variety of disciplines and institutions agreed unanimously that scientific and technological progress is, indeed, under serious threat. Various opinions were expressed about the degree of threat, currently and prospectively, as well as what counter-measures are best suited to resist undue restrictions on creative uses of scientific and technical data and information. This summary is based entirely on the author’s notes from the symposium, and the commentary offered is his alone. My apologies to the speakers if this paper does not accurately reflect the primary intent of their presentations. The “Suggested Readings” offered at the end are not specific to the speakers’ statements but rather are offered as a general resource to aid further research. The definitive record of the symposium is planned to be available from the National Academies Press as a Proceedings publication in the summer of 2003. John Gardenier is an independent researcher, ethicist and science writer.     

从反义RNA到RNA干扰:科学突破的机遇与创新

RNA干扰是近年发现的存在于真核细胞内的一种重要防御机制,现已发展成为一种全新的基因阻断技术,广泛用于抗病毒、抗肿瘤和后基因组时代基因功能研究.它是在反义RNA研究中意外获得的重大科学突破,其发现过程对科学研究有重要启示意义.     

反社会行为的遗传基础:基因多态性和DNA甲基化

反社会行为是受遗传与环境共同影响的不良行为。分子遗传学和神经生物学的研究发现,基因以基因多态性和DNA甲基化的方式影响脑结构、功能及脑内神经递质的产生和释放,进而影响反社会行为的发生发展。本文从基因多态性和DNA甲基化两方面整理了5-HTT、MAOA、OXTR等8个候选基因与反社会行为的关联。并提出未来研究需进一步探讨基因、脑和神经递质对反社会行为的联合作用。同时,扩展多基因位点、基因多态性与DNA甲基化、积极环境与基因交互作用对反社会行为影响的研究,以全面探索反社会行为发生的遗传基础,进而更加有效的预防反社会行为。     

反社会行为的遗传基础:基因多态性和DNA甲基化

反社会行为是受遗传与环境共同影响的不良行为。分子遗传学和神经生物学的研究发现,基因以基因多态性和DNA甲基化的方式影响脑结构、功能及脑内神经递质的产生和释放,进而影响反社会行为的发生发展。本文从基因多态性和DNA甲基化两方面整理了5-HTT、MAOA、OXTR等8个候选基因与反社会行为的关联。并提出未来研究需进一步探讨基因、脑和神经递质对反社会行为的联合作用。同时,扩展多基因位点、基因多态性与DNA甲基化、积极环境与基因交互作用对反社会行为影响的研究,以全面探索反社会行为发生的遗传基础,进而更加有效的预防反社会行为。     

Expressing the Nature and Meaning of DNA: Six Books for Teachers and Students

DNA is an important agent not only in chemistry and biology but also in technology and modern culture. A number of books approach the double helix from different angles. These perspectives include (1) the science of DNA and genetics; (2) genetic engineering; (3) the ethics of manipulating genetic material; and (4) DNA in culture and religion. Various views of DNAprovide insights into human nature beyond its molecular composition.     

Costs and Utilities Perspective of Consumers' Intentions to Engage in Online Music Sharing: Consumers' Knowledge Matters

Online music sharing, deemed illegal for invading intellectual property rights under current laws, has become a crucial issue for the music industry in the modern digital age, but few have investigated the potential costs and utilities for individuals involved in such online misbehavior. This study aimed to fill in this gap to predict consumers' intentions to engage in online music sharing and further consider consumers' online music sharing knowledge as a moderator in the research model. The results of repeated measures analysis of variance of costs and utilities of online music sharing not only give more detailed information to grasp empirical implications but also provide some suggestions to the music industry in Taiwan.