Functional neuroimaging of autobiographical memory

Functional neuroimaging studies of autobiographical memory have grown dramatically in recent years. These studies are important because they can investigate the neural correlates of processes that are difficult to study using laboratory stimuli, including: (i) complex constructive processes, (ii) recollective qualities of emotion and vividness, and (iii) remote memory retrieval. Constructing autobiographical memories involves search, monitoring and self-referential processes that are associated with activity in separable prefrontal regions. The contributions of emotion and vividness have been linked to the amygdala and visual cortex respectively. Finally, there is evidence that recent and remote autobiographical memories might activate the hippocampus equally, which has implications for memory-consolidation theories. The rapid development of innovative methods for eliciting personal memories in the scanner provides the opportunity to delve into the functional neuroanatomy of our personal past.     

The neural basis of autobiographical and semantic memory: new evidence from three PET studies

A novel, neuropsychologically informed paradigm (extended retrieval of events in response to a cue word) was used to investigate the neural basis of autobiographical and semantic memory. Contrasting retrieval of autobiographical memories with retrieval of semantic facts (ABM-SEM) in 24 subjects across three PET studies revealed bilateral involvement of the middle temporal gyrus (BA 21) and medial frontal cortex (BA 9/10). The opposite contrast, SEM-ABM, resulted in increased regional cerebral blood flow in left posterior temporal regions (BA 37) and left prefrontal cortex (BA 45/46). Laterality maps suggest that the bilateral pattern seen in our studies, but not often in other neuroimaging investigations, reflects the use of a task stressing retrieval of specific personal events. Further comparisons revealed that the activation in the right anterior temporal lobe during autobiographical recall was virtually identical to that seen during retrieval of information about famous people or events in contrast with retrieval of general semantic facts. These findings suggest that the retrieval of an autobiographical event requires participation from conceptual knowledge, and that this type of knowledge is bilaterally distributed in the temporal lobes.     

Similarities within event clusters in autobiographical memory

The organization of autobiographical memory is critical for both theory and application in many areas of psychology. Several theories of autobiographical memory state that memories are nested within higher‐order cognitive structures. A procedure developed by Brown and Schopflocher is extended and used to explore similarities of various characteristics within these structures, which they call ‘event clusters’. This phrase, event cluster, is used to describe events which cue one another. The purpose of this paper is to explore the similarities of events within the same cluster. We find that memories within a cluster are more likely to be similar with respect to clarity, emotion, importance, happiness and the estimated date in which they occurred compared with events from other clusters. Further, having nearly 1900 memories allows hypotheses about the relationships among clarity, emotion and importance to be examined in a way that is not possible with many other autobiographical data sets. Copyright © 2000 John Wiley & Sons, Ltd.     

Measuring Parents’ Elaborative Reminiscing: Differential Links of Parents’ Elaboration to children’s Autobiographical Memory and Socioemotional Skills

ABSTRACT

Parents’ elaboration plays an important role in autobiographical memory and socioemotional development. Two types of coding approaches have been used to assess parents’ elaboration: a frequency-based coding (absolute frequencies of different types of elaborative utterances) and a scale-based coding (a 5-point scale based on relative frequencies of types of questions). We examined whether these two coding approaches were related and whether they were differentially associated with child autobiographical memory and socioemotional skills. Sixty-eight preschoolers (M = 50.32) reminisced about positive and negative past events, with their parents and with a researcher. Parents’ elaboration was assessed using the frequency- and scale-based coding approaches. Child autobiographical memory and emotion references were assessed in shared recall (parent–child conversations). Child autobiographical memory was also assessed in independent recall (researcher-child conversations). Child emotion regulation was assessed using the Challenging Situation task. The two coding approaches were moderately related. Parents’ elaboration was related to child autobiographical memory and emotion references in shared recall, regardless of the coding approach. Whereas the frequency-based coding was uniquely related to child memory in the independent recall, the scale-based coding was uniquely related to child emotion regulation. Implications of using diverse coding approaches to understand the role of parents in child development are discussed.     

Autobiographical memory and the self in time: brain lesion effects, functional neuroanatomy, and lifespan development

Autobiographical remembering reflects an advanced state of consciousness that mediates awareness of the self as continuous across time. In naturalistic autobiographical memory, self-aware recollection of temporally and spatially specific episodes and generic factual information (both public and personal) operate in tandem. Evidence from both laboratory and real-life studies, however, suggests that these two processes can be dissociated. This paper reviews aging, lesion, and functional neuroimaging research on the anatomical substrates of autobiographical memory processes using a new measure, the Autobiographical Interview, and prospective collection of autobiographical material. Results indicate that autobiographical recollection is mediated by a distributed fronto-temporo-parietal system, with the anteromedial prefrontal cortex positioned to integrate sensory information with self-specific information. The emergence of autobiographical recollection at around age four coincides with the timing of prefrontal regressive cortical and progressive white matter changes that may support the development of this high-level capacity.     

Emotion regulation,autobiographical memories and life narratives

Few studies have examined the relationships between emotion regulation, autobiographical memory and autobiographical narrative despite evidence that suggests that these constructs are linked. The lack of research is likely ascribed to the specificity of the construct of emotion regulation. The present review examines this area of investigation and indicates two directions for the research: first, emotion regulation is considered to be an effect of autobiographical narratives; thus, individuals engage in the construction of a life story to regulate emotions. Second, emotion regulation is an ability that improves the processes of encoding and retrieving memories. The results of this research are presented, and the potential developments are discussed in terms of the relations among these three constructs.     

Brain, emotion and decision making: the paradigmatic example of regret

Human decisions cannot be explained solely by rational imperatives but are strongly influenced by emotion. Theoretical and behavioral studies provide a sound empirical basis to the impact of the emotion of regret in guiding choice behavior. Recent neuropsychological and neuroimaging data have stressed the fundamental role of the orbitofrontal cortex in mediating the experience of regret. Functional magnetic resonance imaging data indicate that reactivation of activity within the orbitofrontal cortex and amygdala occurring during the phase of choice, when the brain is anticipating possible future consequences of decisions, characterizes the anticipation of regret. In turn, these patterns reflect learning based on cumulative emotional experience. Moreover, affective consequences can induce specific mechanisms of cognitive control of the choice processes, involving reinforcement or avoidance of the experienced behavior.     

Anxiety and disgust: Evidence for a unidirectional relationship

This paper reports the results of three studies using mood induction procedures (MIPs) designed to investigate the relationship between anxiety and disgust. Study 1 used guided imagery vignettes (i.e., asking participants to imagine themselves in a series of described situations) and music (Mayer, Allen, & Beauregard, 1995). Study 2 used video clips (Gross & Levenson, 1995). Study 3 used autobiographical recall and music (Blagden & Craske, 1996). In order to be as sure as possible that target moods were being induced, and that manipulation checks provided good evidence of mood induction, Studies 1 and 2 measured six moods (anxiety, sadness, happiness, anger, disgust, and contempt) on visual analogue scales. In addition, Study 3 included two further mood measures: a 30-adjective rating scale measuring 10 emotions, the Differential Emotion Scale (DES; Izard, 1972) and a free label questionnaire, allowing participants to record how they feel without any prior imposed structure. Results from all three studies demonstrated that induced anxiety will produce increases in reported disgust, but there was no evidence for an effect of induced disgust on reported anxiety. These findings were independent of the type of MIP (guided imagery vignette and music, video clips, and autobiographical recall and music), and the type of dependent mood measure used (visual analogue scale, differential emotion scale or a free label questionnaire). The findings have important implications for the putative role of disgust in anxious psychopathologies, and suggest that if disgust does have a causal influence in some anxious psychopathologies, this influence is not mediated simply by experienced disgust facilitating experienced anxiety.     

Neuroimaging and Depression: Current Status and Unresolved Issues

ABSTRACT— Major depression is among the most debilitating, prevalent, and recurrent of all psychiatric disorders. Over the past decade, investigators have examined the neural mechanisms associated with this disorder. In this article we present an overview of neuroimaging research that has assessed the structure and functioning of the amygdala, subgenual anterior cingulate cortex, and dorsolateral prefrontal cortex in major depression. We then describe results of studies that have attempted to elucidate the nature of the relations among these brain structures. The picture that emerges from these investigations is one in which heightened activity in limbic structures that underlie the experience and expression of emotion dampens activation in dorsal cortical structures that are involved in affect regulation, reducing their ability to influence limbic activation. We conclude by highlighting unresolved issues concerning the roles of these structures in depression and their relation to specific symptoms of this disorder.     

More emotional facial expressions during episodic than during semantic autobiographical retrieval

There is a substantial body of research on the relationship between emotion and autobiographical memory. Using facial analysis software, our study addressed this relationship by investigating basic emotional facial expressions that may be detected during autobiographical recall. Participants were asked to retrieve 3 autobiographical memories, each of which was triggered by one of the following cue words: happy, sad, and city. The autobiographical recall was analyzed by a software for facial analysis that detects and classifies basic emotional expressions. Analyses showed that emotional cues triggered the corresponding basic facial expressions (i.e., happy facial expression for memories cued by happy). Furthermore, we dissociated episodic and semantic retrieval, observing more emotional facial expressions during episodic than during semantic retrieval, regardless of the emotional valence of cues. Our study provides insight into facial expressions that are associated with emotional autobiographical memory. It also highlights an ecological tool to reveal physiological changes that are associated with emotion and memory.     

Emotion regulation during social remembering: differences between emotions elicited during an event and emotions elicited when talking about it

This paper examines emotion regulation as a function of autobiographical remembering in social contexts. Two studies (n = 38 and 123, respectively) are presented that provide evidence that autobiographical remembering in social settings can result in changes in the emotions associated with an experience. However, the results also suggest that whether changes occur depends on features of the recall context, including the gender of participants, and the responses of their listeners. Across both studies, men showed greater emotional benefits from talking about events than women. Moreover, greater listener agreement was associated with greater benefits for emotion. The results are discussed in terms of functions of autobiographical remembering, gender, social support, and emotion regulation.     

Differential effects of arousal in positive and negative autobiographical memories

Autobiographical memories are characterised by a range of emotions and emotional reactions. Recent research has demonstrated that differences in emotional valence (positive vs. negative emotion) and arousal (the degree of emotional intensity) differentially influence the retrieved memory narrative. Although the mnemonic effects of valence and arousal have both been heavily studied, it is currently unclear whether the effects of emotional arousal are equivalent for positive and negative autobiographical events. In the current study, multilevel models were used to examine differential effects of emotional valence and arousal on the richness of autobiographical memory retrieval both between and within subjects. Thirty-four young adults were asked to retrieve personal autobiographical memories associated with popular musical cues and to rate the valence, arousal and richness of these events. The multilevel analyses identified independent influences of valence and intensity upon retrieval characteristics at the within- and between-subject levels. In addition, the within-subject interactions between valence and arousal highlighted differential effects of arousal for positive and negative memories. These findings have important implications for future studies of emotion and memory, highlighting the importance of considering both valence and arousal when examining the role emotion plays in the richness of memory representation.     

Gender differences in autobiographical memory: Developmental and methodological considerations

Gender differences have surfaced in inconsistent ways in autobiographical memory studies. When apparent, researchers find gender differences such that women report more vivid memory experiences than men and women include more details about emotions, about other people, and about the meaningfulness of their memories. Specifically, females include more emotion, more elaboration, and a greater sense of connectedness to others in their narratives, and we consider the possible connection between these tendencies and women’s advantage on a number of autobiographical and episodic memory tasks. However, not all studies of autobiographical memory find gender differences. We propose that gender differences in autobiographical memory development and interpersonal socialization contribute to the differences found, and that gender differences can be attributed, at least in part, to the influence of conversations with parents when autobiographical memory skills are developing. An examination of studies in which gender differences are not found suggests that specific instructions, context, gender salience, and the type of autobiographical memory measure used can mitigate gender differences. We conclude by outlining future directions for research, including longitudinal studies and experiments designed to systematically examine gender in autobiographical memory for its own sake.     

The relationship between autobiographical memory,cognition, and emotion in older adults: a review

Over the past 30 years, the concept of “autobiographical memory” has been highlighted in numerous behavioral and neuroanatomical studies. Importantly, episodic autobiographical memory, an aspect of autobiographical memory, has been shown to decrease with age but can be improved by training. Autobiographical memory is deeply associated with the default mode network (especially posterior cingulate cortex and medial prefrontal cortex), which is particularly interesting in the context of better understanding the relationship between autobiographical memory, cognition, and emotion in older adults. This article provides an overview of the behavioral and neuroanatomical characteristics of autobiographical memory, as well as its relationship with the default mode network, cognition, emotion, and aging. This article also provides an overall review of autobiographical memory training.     

Functional neuroanatomy of emotions: A meta-analysis

The application of functional neuroimaging to the study of human emotion has yielded valuable data; however, the conclusions that may be drawn from any one study are limited. We applied novel statistical techniques to the meta-analysis of 106 PET and fMRI studies of human emotion and tested predictions made by key neuroscientific models. The results demonstrated partial support for asymmetry accounts. Greater left-sided activity was observed for approach emotions, whereas neural activity associated with negative/withdrawal emotions was symmetrical. Support was also found for affect program emotion accounts. The activation distributions associated with fear, disgust, and anger differed significantly. These emotions were most consistently associated in activity in regions associated with selective processing deficits when damaged: the amygdala, the insula and globus pallidus, and the lateral orbitofrontal cortex, respectively. In contrast, the distributions for happiness and sadness did not differ. These findings are considered in the context of conceptualizations of the neural correlates of human emotion.     

Inducing changes in arousal and valence: Comparison of two mood induction procedures

This research examined the relative effectiveness of two mood induction procedures (MIPs) for inducing four specific moods varying along the dimensions of both valence and arousal. Participants were randomly assigned either to an autobiographical recall or to a music and guided imagery MIP and underwent a happiness, serenity, anger, or sadness mood induction. The findings confirmed the effectiveness of the two MIPs in producing changes on both the valence and arousal dimensions of mood. The results also revealed an unexpected greater efficiency of the autobiographical recall than of the combined procedure.     

Effects of handedness and saccadic bilateral eye movements on components of autobiographical recollection

The effects of handedness and saccadic bilateral eye movements on autobiographical recollection were investigated. Recall of autobiographical memories was cued by the use of neutral and emotional words. Autobiographical recollection was assessed by the autobiographical memory questionnaire. Experiment 1 found that mixed-handed (vs. right handed) individuals demonstrated greater levels of autobiographical recollection on the components of seeing, hearing, and emotion. Experiment 2 found that following 30 s of bilateral eye movements, greater levels of autobiographical recollection were demonstrated on the components of reliving, seeing, hearing, emotion, self-perspective and veridicality. The results extend previous research by showing that the recollective components of real world memories can be enhanced by either mixed-handedness or eye movements. In addition, these results provide a bridge between laboratory studies of recollection and autobiographical recollection. The findings are considered in terms of research on the cognitive neuroscience of autobiographical memory.     

Autobiographical remembering regulates emotions: a functional perspective

Emotional deviation has been considered an essential factor in emotion regulation, in that, attempts to compensate for the deviation is reflected on cognitive processes. In the present study, we focused on autobiographical remembering and tested the functional role of memory on emotion regulation. We specifically examined the congruence effect in individuals’ subsequent memory reports after recalling emotional events. Individuals were randomly assigned to three groups to report either sadness or anger evoking events or emotionally unspecified events that they experienced in the last five years. Results supported mood-incongruence, but only for the emotional memory groups. Despite highly negative memories reported in the initial recall, individuals in anger- and sad-memory groups revealed an up-regulation trend in subsequent recall. Furthermore, sadness and anger induction affected phenomenological features of the subsequently reported memory. Overall, our findings supported for the emotion regulation function of remembering that serves counter-regulation of the negative emotion. We discuss potential mechanisms in the light of explanations by a functional approach to autobiographical memory.