Observation and discrimination learning in the rat: Effects of stimulus substitution

Effects of prior observation of modeling performances upon learning simultaneous visual discriminations were studied in nine groups of rats. Stimulus patterns which had been positive (“Cued”) or negative (“Uncued”) for the model animal and novel stimuli were presented. Observers learned faster if discriminations required approach to, rather than avoidance of, the previously positive stimulus. Approach to the negative stimulus was acquired more rapidly only if the second stimulus was novel. Approaches to a substituted new stimulus combined with either of the previously viewed stimulus patterns required nearly twice the training needed for a similar response attachment when both stimuli were novel. Attentional changes appear to underlie the stimulus control exerted over the observer rat in instrumental learning situations.     

Aging and repetition effects: separate specific and nonspecific influences

The research reported in this article focuses on processes that contribute to the repetition effect in 2-alternative forced-choice tasks and on how these processes change with age. An analytical approach is presented that allows researchers to discriminate between 2 components of performance. The results of Experiment 1 show that differences in the relative contributions of these 2 processes can produce differences in repetition effects between younger and older adults. Furthermore, as in the negative priming domain, increasing the contribution of 1 of these 2 components can eliminate this age difference. Together, the results argue against the practice of attributing age differences in repetition effects to deficits in any single cognitive process.     

Hebbian learning of cognitive control: dealing with specific and nonspecific adaptation

The conflict monitoring model of M. M. Botvinick, T. S. Braver, D. M. Barch, C. S. Carter, and J. D. Cohen (2001) triggered several research programs investigating various aspects of cognitive control. One problematic aspect of the Botvinick et al. model is that there is no clear account of how the cognitive system knows where to intervene when conflict is detected. As a result, recent findings of task-specific and context-specific (e.g., item-specific) adaptation are difficult to interpret. The difficulty with item-specific adaptation was recently pointed out by C. Blais, S. Robidoux, E. F. Risko, and D. Besner (2007), who proposed an alternative model that could account for this. However, the same problem of where the cognitive system should intervene resurfaces in a different shape in this model, and it has difficulty in accounting for the Gratton effect, a hallmark item-nonspecific effect. The authors of the current article show how these problems can be solved when cognitive control is implemented as a conflict-modulated Hebbian learning rule.     

Contrast and inhibition in discrimination learning by the pigeon: Analysis through drug effects

In a series of four experiments, pigeons were trained on either an easy, red/green discrimination with or without a penalty for errors, or a more difficult left/right discrimination with penalty. Some groups of birds were injected with chlorpromazine or desipramine prior to acquisition sessions or to sessions following learning of the discrimination. Drug injection caused substantial impairment of acquisition or retention of the left/right discrimination alone, whereas in all discriminations the behavioral contrast effect was abolished. The results suggest that inhibition of errors depends upon the difficulty of discrimination and the presence of a penalty procedure, and determines both contrast in the saline-injected groups and the extent of impairment in the drug-injected groups.     

Stimulus-specific contrast effects during operant discrimination learning

In two experiments, pigeons' responding was equally reinforced in the presence of four line-orientation stimuli. Responding was then reinforced when only two of the four orientation stimuli were present; the remaining two orientations appeared during extinction. Response rates were often highest in the stimulus adjacent to the orientations presented during extinction and often lowest in that orientation adjacent to the orientations presented with reinforcement. These effects were stronger and more persistent when the stimuli were separated by a smaller angle, rendering the discrimination more difficult. These and other data suggest that discrimination training may not be accurately explained in terms of the simple effects of reinforcement and nonreinforcement associated with isolated stimuli, nor by accounts that depend upon stimulus generalization. Recent accounts of contrast that depend upon “emotionality” produced by nonreinforced responding or upon reinforcement-elicited responses are also difficult to apply to these data.     

Knockdown of Nurr1 in the rat hippocampus: implications to spatial discrimination learning and memory

Nurr1 expression is up-regulated in the brain following associative learning experiences, but its relevance to cognitive processes remains unclear. In these studies, rats initially received bilateral hippocampal infusions of control or antisense oligodeoxynucleotides (ODNs) 1 h prior to training in a holeboard spatial discrimination task. Such pre-training infusions of nurr1 antisense ODNs caused a moderate effect in learning the task and also impaired LTM tested 7 d later. In a second experiment, ODN infusions were given immediately after the animals had received two sessions of training, during which all animals showed normal learning. Although antisense treated rats were significantly impaired during the post-infusion stages of acquisition of the task, no group differences were observed during the LTM test given 7 d later. These animals were subjected 3 d later to reversal training in the same maze in the absence of any additional treatments. Remarkably, rats previously treated with antisense ODNs displayed perseveration: The animals were fixated with the previously learned pattern of baited holes, causing them to be significantly impaired in the extinction of acquired spatial preferences and future learning. We postulate that Nurr1 function in the hippocampus is important for normal cognitive processes.