Self- and interview-rated negative mood states in schizophrenia: Their convergence and prediction of thought disturbance

This longitudinal study evaluated the relations between self- and interview-rated negative mood in schizophrenics and compared the prognostic utility of these two methods. Thirty schizophrenics who had been stabilized on neuroleptic medications were evaluated with self-report and interview-based measures of mood and symptomatology at an initial assessment and again at 6-month follow-up. Results indicated that measures of self- and interview-rated negative mood showed little agreement at the initial assessment; however, at follow-up, significant convergent correlations between the two methods were obtained. Self-reported negative mood at the initial evaluation predicted the severity of thought disturbance at follow-up, whereas interview-based ratings of mood did not. The results underscore the importance of conducting multimethod assessments of mood and support other research suggesting that self-reported negative mood states may predict course of the illness in schizophrenia.This research was supported by National Institute of Mental Health (NIMH) Grants MH38636 and MH39998 and by a grant from the National Alliance for Research in Schizophrenia and Depression (NARSAD). Jack J. Blanchard was also supported in part by NIMH Grant MH18932 for the Collaborative Training Program in Schizophrenia Research at the Medical College of Pennsylvania/EPPI. Portions of this research were presented at the 24th Annual Meeting of the Association for the Advancement of Behavior Therapy, San Francisco, California, November 2, 1990, and at the 3rd International Congress on Schizophrenia Research, Tucson, Arizona, April 22, 1991.     

Bodily states of anxiety: the movement from somatic states to thought

My paper attempts to stimulate thought about the relationship between physical and mental 'states of anxiety' by looking at some experiences in the consulting room, particularly at those moments when shifts from predominantly somatic to predominantly psychic forms of representation appeared to be taking place. These experiences are considered in conjunction with some of the ideas of Jung, Fordham, Bion, Winnicott, Meltzer and others relevant to the body-mind question. I conclude with some imaginative speculations.     

The effects of haloperidol on thought disorder and IQ in schizophrenia

The impact of haloperidol treatment on the Wechsler Adult Intelligence Scale (WAIS) and the Thought Disorder Index was investigated in a group of 19 patients with schizophrenia tested both before and after 26 days of treatment with haloperidol. Thought disorder scores declined significantly over the course of treatment and fewer patients demonstrated severe forms of thought disorder at the end of the trial. WAIS performance improved significantly but the magnitude of change was consistent with the literature on expected practice effects. Thought disorder scores were negatively correlated with IQ at baseline, but not at Day 26. The results suggest a partial dissociation of thought disorder and other cognitive functions in schizophrenia.     

The neural-cognitive basis of the Jamesian stream of thought

William James described the stream of thought as having two components: (1) a nucleus of highly conscious, often perceptual material; and (2) a fringe of dimly felt contextual information that controls the entry of information into the nucleus and guides the progression of internally directed thought. Here I examine the neural and cognitive correlates of this phenomenology. A survey of the cognitive neuroscience literature suggests that the nucleus corresponds to a dynamic global buffer formed by interactions between different regions of the brain, while the fringe corresponds to a set of mechanisms in the frontal and medial temporal lobes that control the contents of this global buffer. A consequence of this account is that there might be conscious imagistic representations that are not part of the nucleus. I argue that phenomenology can be linked to psychology and neuroscience and a meaningful way that illuminates both.     

Stability of formal thought disorder and referential communication disturbances in schizophrenia

This study examined the degree to which different types of communication disturbances in the speech of 48 schizophrenia patients and 28 controls were variable and state related versus stable and traitlike. Clinically rated formal thought disorder and 5 types of referential disturbance showed substantial stability within participants over time. The sixth type of referential disturbance, the vague reference, was not stable over time. Formal thought disorder was associated with the severity of core psychotic symptoms in patients. whereas referential disturbances showed little or no association with positive or negative symptom severity. Furthermore, changes in psychotic symptoms over time were accompanied by corresponding changes in formal thought disorder but not referential disturbances. These results support the idea that some types of referential disturbances are traitlike and may be reflective of vulnerability as well as manifest illness.     

Cognitive impairments associated with formal thought disorder in people with schizophrenia

Formal thought disorder (FTD), or disorganized speech, is one of the central signs of schizophrenia. Despite extensive research, the cognitive processes associated with FTD are still unclear. However, the authors' review of FTD theories and research indicates that considerable progress has been made in identifying possible cognitive impairments associated with FTD. Specifically, FTD is strongly associated with impaired executive functioning and with impaired processing of semantic information. Their review indicates that previous research has not yet supported an association between FTD and either an increase in spreading activation or an impairment within the language production system.     

Altered states of consciousness, dissociation, and dream recall

In a sample of 71 medical students, dream recall frequency was positively correlated with proneness to altered states of consciousness (r = .26) measured by the State of Mind and Consciousness Questionnaire and dissociation (r = .29) measured by the Dissociative Experiences Scale II. A regression analysis, however, yielded neither altered states of consciousness nor dissociation, sex, or age to be significant predictors of dream recall frequency. Among women dream recall frequency was associated with proneness to dissociation; among men it was correlated with proneness to altered states of consciousness.     

"三阳劫变"思想浅析

中国民间宗教有着久远的历史和繁多的教派 ,其思想极为复杂 ,不可一概而论。但在长期的发展演变过程中 ,各个教派不免相互影响 ,于是形成了具有共通性的思想特质 ,如“三阳劫变”说。本文即重在考察“三阳劫变”说的内容、思想来源及其流行的思想背景 ,希望借此厘清“劫变”说与佛、道二教 (主要是佛教 )之间的关系。     

A paradoxical dissociation in the effects of midazolam on recollection and automatic processes in the process dissociation procedure

This study used midazolam-induced amnesia to explore the plausibility of the estimates provided by the process dissociation procedure (PDP), which is designed to estimate the contributions of recollection (R) and automatic (A) processes to implicit memory performance. In a double-blind, placebo-controlled, within-subject design with 24 participants, single midazolam doses were administered intravenously, and word stem completion performance was used to calculate PDP estimates. A dissociation was observed such that midazolam decreased R but increased A estimates relative to placebo. Given that a manipulation that induces amnesia would not be expected to facilitate a memory process, these results add to the accumulating body of evidence suggesting that PDP estimates are not always theoretically plausible. Such evidence raises important questions about the use of the PDP.     

天台学生态智慧管窥

当前生态危机的思想根源在于人们根深蒂固的人类中心论,从而导致对自然的无所顾忌的践踏和掠夺,而古老的天台学中则蕴含着疗治时蔽的丰富而深邃的"生态智慧",其"色心不二"的思想将人与自然置于亲密无间的关系之中,"十界互具"、"一念三千"学说揭示了作为有机的整体的世界的各部分之间的相摄相入,是对当今机械的、孤立的世界观的彻底否定,"中道实相"、"无情有性"理论赋予了自然以无上的内在价值.天台学的这些古老而珍贵的"生态智慧"值得当今的生态学和环境哲学好好加以思考和借鉴.     

Using broad measures of maladjustment to assess psychological states of outpatients with schizophrenia

Two broad indexes of maladjustment derived from two projective tests and administered at two separate points to the same 50 outpatients with schizophrenia showed substantial convergent validity at both testings (r=.52, p<.001; r=.58, p<.001). Conversely, test-retest reliabilities for both indexes were nonsignificant. These findings suggest that broad measures of maladjustment may be more suitable for reflecting current states of adjustment for subjects known to be diagnosed with certain symptoms, the manifestations of which fluctuate over time.     

《道德经》道统论生态思想研究

根植于中华沃土的道教,承传发展中华传统文化“天地人和谐共生”的思想,在其教义思想中,蕴涵着人对自然环境、生态体系、生命组织的深刻理解,对宇宙天地、山川大地的无限崇拜,对所有生命物体的至诚热爱,对人类作用地位的冷静思考,对万物共生共荣的神圣憧憬。从历代哲人深邃的天人之辨,到众多仙真洒脱的逍遥人生;     

Cognitive impairments and disordered speech in schizophrenia: thought disorder, disorganization, and communication failure perspectives

This article posits that basic cognitive impairments in schizophrenia are more highly related to speech disorder measured as communication failures than speech disorder measured as thought disorder or disorganization. The author tested 47 schizophrenia patients and 36 control participants for sustained attention, sequencing, and conceptual sequencing ability. Their speech was also rated for communication failures, thought disorder, and conceptual disorganization. Attention and sequencing impairments, examined hierarchically, explained a substantial 38% of the variance in the communication measure of speech disorder but little of the variance in formal thought disorder or conceptual disorganization. The author concludes that (a) impairments in attention and sequencing abilities contribute substantially to schizophrenic communication failures, and (b) it is important to consider lower level cognitive "3rd variables" when examining higher level cognitive associates of speech disorder.     

Determinants of tonic and phasic reactions in transswitching

Forty-eight college students were assigned randomly to four groups in a 2 × 2 factorial arrangement of phasic conditional stimuli (samevs. different) and tonic conditional stimuli (samevs. different) to receive 2 days of classical conditioning with a transswitching procedure. Tonic stimuli were a 5-minute projected white triangle or circle; phasic stimuli were a 5-second red or green square superimposed over the tonic stimuli. There were six tonic stimulus segments each day, separated by 20-second periods of no stimulus, three containing six trials of the phasic stimulus paired with shock and three containing six trials of the phasic stimulus alone, in the counterbalanced order. Tonic responding at the onset of the tonic stimuli or during brief periods following its onset were recorded, along with phasic responses to the phasic stimuli. Responses included magnitude of skin conductance responses, frequency of unelicited skin conductance responses, and tonic heart rate. Both skin conductance measures of responding to the tonic stimuli differentiated significantly between positive and negative tonic segments during Day 2, but only in the group with two different tonic stimuli and one phasic stimulus (“standard” transswitching). This supported the hypothesis that tonic stimulus differentiation would be absent when two different phasic stimuli were present. The heart rate data did not support this hypothesis, showing tonic differentiation in both groups with two tonic stimuli. Phasic differentiation controlled by the different phasic stimuli was observed on Day 1; on Day 2, phasic differentiation was present only in the group with two tonic and one phasic stimuli and the group with one tonic and two phasic stimuli. The results were interpreted to mean that temporal contiguity between the tonic stimuli and shock or no shock is not sufficient to establish tonic response differentiation in transswitching.