Disrupted attentional learning in high schizotypy: Evidence of aberrant salience

The relationship between learned variations in attention and schizotypy was examined in two experiments. In Experiment 1, participants low on a negative subscale of schizotypy exhibited an explicit bias in overt attention towards stimuli that were established as predictive of a trial outcome, relative to stimuli that were irrelevant. The same participants also showed a bias in learning about these stimuli when they presented in a novel context. Neither of these effects was observed in participants high in schizotypy. In Experiment 2, participants low on the negative subscale of schizotypy exhibited faster reaction times towards a target that was cued by a stimulus that had a history of predictive validity relative to a stimulus that had a history of irrelevance. Again, this effect was not present in participants high in schizotypy. These results imply a disruption in the normal allocation of attention to cues that have predictive significance in schizotypy.     

On "risk" and reward: investigating state anhedonia in psychometrically defined schizotypy and schizophrenia

Anhedonia, defined as dysfunction in the experience of pleasant emotions, is a hallmark symptom of the schizophrenia spectrum. Of interest, it is well documented that patients with schizophrenia, at least as a group, do not show reductions in their state experience of pleasant stimuli. However, there is emerging evidence to suggest that individuals with schizotypy--defined as the personality organization reflecting the latent vulnerability for schizophrenia--do show these state deficits. This is paradoxical in that schizophrenia reflects a more pathological state in virtually every conceivable domain as compared with schizotypy. The present study examined self-reported affective reactions to neutral-, bad-, and good-valenced stimuli in individuals with psychometrically defined schizotypy and schizophrenia. Two separate control groups were also included, comprising psychometrically defined controls and stable outpatients with affective disorders. With no exceptions, the schizotypy group reported significantly less pleasant affect for each of the three conditions than each of the other groups. Conversely, the schizophrenia group did not statistically differ from the control groups for any of the conditions. Within both the schizotypy and schizophrenia groups, severity of negative symptoms/traits was associated with less pleasant report. We found that individuals with prominent negative symptoms and traits from the schizophrenia and schizotypy groups resembled each other in terms of state anhedonia. The present findings did not appear to reflect comorbid depression or anxiety. Our discussion centers on this apparent paradox in the schizophrenia spectrum--that individuals with schizotypy exhibit state anhedonia, whereas patients with schizophrenia do not.     

Lack of an Attention Bias Away From Relatively Negative Faces in Dysphoria Is Not Related to Biased Emotion Identification

Eye-tracking-based attention research has consistently shown a lack of a normative attentional bias away from dysphoric face stimuli in depression, characterizing the attention system of non-depressed individuals. However, this more equal attention allocation pattern could also be related to biased emotion identification, namely, an inclination of depressed individuals to attribute negative emotions to non-negative stimuli when processing mood-congruent stimuli. Here, we examined emotion identification as a possible mechanism associated with attention allocation when processing emotional faces in depression. Attention allocation and emotion identification of participants with high (HD; n = 30) and low (LD; n = 30) levels of depression symptoms were assessed using two corresponding tasks previously shown to yield significant findings in depression, using the same face stimuli (sad, happy, and neutral faces) across both tasks. We examined group differences on each task and possible between-task associations. Results showed that while LD participants dwelled longer on relatively positive faces compared with relatively negative faces on the attention allocation task, HD participants showed no such bias, dwelling equally on both. Trait anxiety did not affect these results. No group differences were noted for emotion identification, and no between-task associations emerged. Present results suggest that depression is characterized by a lack of a general attention bias toward relatively positive faces over relatively negative faces, which is not related to a corresponding bias in emotion identification.     

阈下抑郁个体对负性情绪刺激的注意解脱困难

本研究拟采用点探测范式及不同情绪内容的面孔刺激（高兴、中性、悲伤和愤怒）考察阈下抑郁个体的负性注意偏向及其内在机制。点探测任务中情绪面孔配对呈现（负性-中性、正性-中性）,配对面孔中的情绪线索位置与靶刺激的位置构成负性一致/不一致和正性一致/不一致条件,同时实验中加入“中性-中性”面孔线索作为一致和不一致条件的对比基线来考察注意偏向的内在机制。结果发现,阈下抑郁个体在负性不一致条件下的反应时显著长于负性一致条件,表明阈下抑郁个体具有对负性刺激的注意偏向;进一步比较发现,阈下抑郁个体在负性不一致条件下的反应时显著的长于“中性-中性”基线条件,而负性一致条件与基线之间差异不显著,表明阈下抑郁个体的负性注意偏向为对负性刺激的注意解脱困难。结果另发现,阈下抑郁个体未能像无抑郁对照组个体表现出对正性刺激的注意偏向。结果表明,处于阈下抑郁状态的个体表现出对负性刺激的注意偏向,具体为对负性刺激的注意解脱困难,其原因可能是由于阈下抑郁个体在注意控制和情绪调节功能上的紊乱。     

Positive schizotypy and emotion processing

This study examined whether emotion processing traits and task performance are associated with positive schizotypy. Positive schizotypy individuals (n=34, assessed with the Magical Ideation and Perceptual Aberration Scales) reported greater attention to emotions but less emotional clarity than controls (n=56). Moreover, a significantly larger percentage of the schizotypy group was classified as emotionally overwhelmed. Positive schizotypy individuals also exhibited absent affective priming and increased incongruent errors at a short stimulus onset asynchrony and an absence of an effect of emotion on recognition memory, but an increased memory response bias for negative words. Results could not be accounted for by level of neuroticism or current mood. These results suggest that positive schizotypy is associated with the processing of emotional information.     

Extreme elemental processing in a high schizotypy population: Relation to cognitive deficits

The cognitive deficits observed in schizophrenia have been characterized as a failure to utilize task-setting information to guide behaviour, especially in situations in which there is response conflict. Recently, we have provided support for this account; high schizotypy individuals demonstrated inferior biconditional discrimination performance compared to low scorers, but were not impaired on a simple discrimination that did not require the use of task-setting cues. These results may, however, also be explained by the way in which individuals with high schizotypy process stimulus compounds. Here, we examine the initial approaches to solving biconditional and control discrimination tasks of participants with high and low schizotypy scores. In particular, we focus on performance during the first block of training trials to capture processing style before the acquisition of the discrimination tasks. Participants scoring highly on the introvertive anhedonia subscale (which has been allied to the negative and cognitive symptoms of schizophrenia) demonstrated better biconditional performance during the first block of training trials than did low-schizotypy individuals, consistent with a highly elemental approach to stimulus processing. Subsequent recognition tests confirmed this analysis demonstrating that the pattern of performance observed in participants with high schizotypy was associated with a failure to discriminate conjunctions of items that had been seen before from those that had not. These results suggest that the negative/cognitive symptoms of schizophrenia may reflect an extreme bias towards elemental, as opposed to configural, processing of stimulus conjunctions.     

Attenuation of attention bias in obsessive-compulsive disorder

Cognitive theories of obsessive-compulsive disorder (OCD) suggest that the disorder is characterized by an attention bias towards personally relevant threatening material. However, existing research on attention bias in OCD has yielded conflicting findings. One possibility that might account for the null findings is that attention bias may diminish over the course of the experiment. The present study tested this hypothesis using a visual dot-probe task with idiographic word selection. Results from our study confirmed that individuals with OC symptoms show an attention bias towards idiographically selected, threatening information in the first block of trials, and that the degree of this bias is correlated with the severity of OC symptoms. The temporal pattern of attention bias over the course of the experiment was consistent with our hypothesis. A comparison of early and late blocks of trials revealed an attenuation of attention bias in individuals with OC symptoms, potentially reflecting habituation to threatening information over the course of the experiment.     

P50 sensory gating deficits in schizotypy

Sensory gating is the ability to filter out irrelevant stimuli from the environment. Individuals with schizophrenia consistently demonstrate deficits in this ability leading to sensory overload and cognitive fragmentation. This dysfunction has also been found in schizotypy, which is defined as a manifestation of nonclinical symptoms qualitatively similar to those found in schizophrenia. In the present study, auditory sensory gating was assessed in healthy individuals by testing the attenuation of the P50 event-related potential. The degree of suppression was then correlated with schizotypy by using the O-LIFE questionnaire. Relative to the low-scoring individuals, P50 suppression was significantly reduced in those with high levels of schizotypy. Furthermore, the degree of deficit in P50 gating correlated with both cognitive disorganisation and impulsive nonconformity dimensions of schizotypy. These results suggest that schizotypal individuals may have early sensory gating deficits similar to schizophrenia patients, especially if they display a disorganised or impulsive profile. As they do not exhibit overt psychotic symptoms, it is likely that such deficits represent an underlying core cognitive dysfunction within the schizophrenia spectrum.     

Understanding associations between negatively biased attention and depression and social anxiety: positively biased attention is key

ABSTRACT

Background and objectives: Although research supports the premise that depressed and socially anxious individuals direct attention preferentially toward negative emotional cues, little is known about how attention to positive emotional cues might modulate this negative attention bias risk process. The purpose of this study was to determine if associations between attention biases to sad and angry faces and depression and social anxiety symptoms, respectively, would be strongest in individuals who also show biased attention away from happy faces.

Methods: Young adults (N?=?151; 79% female; M?=?19.63 years) completed self-report measures of depression and social anxiety symptoms and a dot probe task to assess attention biases to happy, sad, and angry facial expressions.

Results: Attention bias to happy faces moderated associations between attention to negatively valenced faces and psychopathology symptoms. However, attention bias toward sad faces was positively and significantly related to depression symptoms only for individuals who also selectively attended toward happy faces. Similarly, attention bias toward angry faces was positively and significantly associated with social anxiety symptoms only for individuals who also selectively attended toward happy faces.

Conclusions: These findings suggest that individuals with high levels of depression or social anxiety symptoms attend preferentially to emotional stimuli across valences.     

Expectancy bias and the persistence of posttraumatic stress

Anxious individuals tend to overestimate the probability that encounters with anxiogenic stimuli (CS) will be followed by aversive consequences (UCS). This study examined whether such (biased) UCS expectancies predict the persistence of PTSD symptoms. A total of 265 soldiers were recruited before a four-month deployment to Iraq in 2004. About 2-5 months after deployment, 171 (65%) soldiers completed self-report scales about adverse events in Iraq and PTSD symptoms, and a UCS expectancy task. In this task, participants were exposed to a series of deployment-related and deployment-unrelated (control) picture stimuli. For each trial, the participants indicated the subjective probability that a particular slide would be followed by an imminent loud noise. Around 15 months after deployment, 130 (76%) soldiers completed surveys about PTSD symptoms again. Only a small group of participants had high levels of PTSD symptoms. Regression analyses showed that the level of PTSD symptoms at 15 months was predicted by earlier PTSD symptoms, but also and independently by an enhanced UCS expectancy to deployment-related stimuli. The findings support the notion that UCS expectancy bias contributes to the persistence of PTSD symptoms.     

Jumping to Conclusions bias,BADE and Feedback Sensitivity in schizophrenia and schizotypy

Several studies about schizophrenia have shown a cognitive bias named “Jumping to Conclusions” (JTC), defined as a decision made quickly on the basis of little evidence that occurs in these patients when performing probabilistic reasoning paradigms. The main objective of this study is to compare JTC bias and BADE (Bias Against Disconfirmatory Evidence) in patients with schizophrenia vs. participants with high/low schizotypy to understand the underlying mechanism of these cognitive biases. Probabilistic reasoning was assessed using a modified version of Drawing to Decision task. In addition to the traditional parameters of this task (Plausibility Rating (PR), Draws to Decision (DTD), BADE) we also calculated new parameters, overall accuracy and one named Feedback Sensitivity (FS) which lower scores shows greater use of feedback. The results of the study suggest a context effect: in the cued condition, there were not main differences between groups. In the uncued condition, we found higher JTC bias at stage 1 for patients. At the same time, PR at first stages related positively with Feedback Sensitivity and negatively with accuracy for patients and high schizotypy participants (high confidence is associated with worse performance and lower feedback use). BADE seems unrelated to JTC bias and FS. The results are discussed in terms of JTC like as a clinical bias and whether patients with schizophrenia are less able to use feedback.     

广泛性焦虑个体的注意偏向

探讨广泛性焦虑个体在一般情境和不确定性情境下注意偏向的特点。采用点探测注意搜索任务研究了在一般情境下和不确定性情境下广泛性焦虑个体的注意偏向, 结果表明高广泛性焦虑个体的注意偏向以对威胁性刺激的注意转移困难为主, 不确定性情境会让广泛性焦虑个体更容易处于紧张焦虑的状态当中, 从而对情绪性刺激尤其是消极刺激表现出更多的注意偏向和对情绪性刺激直接的注意敏感性。     

Identity recognition and happy and sad facial expression recall: influence of depressive symptoms

Relatively few studies have examined memory bias for social stimuli in depression or dysphoria. The aim of this study was to investigate the influence of depressive symptoms on memory for facial information. A total of 234 participants completed the Beck Depression Inventory II and a task examining memory for facial identity and expression of happy and sad faces. For both facial identity and expression, the recollective experience was measured with the Remember/Know/Guess procedure (Gardiner & Richardson-Klavehn, 2000). The results show no major association between depressive symptoms and memory for identities. However, dysphoric individuals consciously recalled (Remember responses) more sad facial expressions than non-dysphoric individuals. These findings suggest that sad facial expressions led to more elaborate encoding, and thereby better recollection, in dysphoric individuals.     

Identity recognition and happy and sad facial expression recall: Influence of depressive symptoms

Relatively few studies have examined memory bias for social stimuli in depression or dysphoria. The aim of this study was to investigate the influence of depressive symptoms on memory for facial information. A total of 234 participants completed the Beck Depression Inventory II and a task examining memory for facial identity and expression of happy and sad faces. For both facial identity and expression, the recollective experience was measured with the Remember/Know/Guess procedure (Gardiner & Richardson-Klavehn, 2000). The results show no major association between depressive symptoms and memory for identities. However, dysphoric individuals consciously recalled (Remember responses) more sad facial expressions than non-dysphoric individuals. These findings suggest that sad facial expressions led to more elaborate encoding, and thereby better recollection, in dysphoric individuals.     

The jumping to conclusions bias associated with symptoms in schizophrenia: which factors influence this bias?

ABSTRACT

Jumping-to-conclusions (JTC) bias has been found to be associated with delusions. However, there is limited data about which other factors are related to JCT bias. The aim of the current study was to investigate the effects of psychotic, cognitive, impulsivity and anxiety symptoms on JTC bias. We compared individuals with paranoid schizophrenia, non-paranoid schizophrenia, generalized anxiety disorder and healthy individuals in terms of JTC bias. Beads task (90:10 and 60:40 versions), Tower of London task, BPRS, SAPS, SANS and BIS-11 were applied. Our results show that the factors related with JTC bias were different on each version of the Beads task. Education levels, anxiety and negative symptoms of individuals with schizophrenia were found to affect JTC bias on 90:10 version of task, whereas positive symptoms and impulsivity levels were related to JTC bias on 60:40 version. These results are important as they contribute to our understanding of this relationship.     

Variability of attention bias in socially anxious adolescents: differences in fixation duration toward adult and adolescent face stimuli

Prior research on attention bias in anxious youth, often utilising a visual dot probe task, has yielded inconsistent findings, which may be due to how bias is assessed and/or variability in the phenomenon. The present study utilises eye gaze tracking to assess attention bias in socially anxious adolescents, and explores several methodological and within-subject factors that may contribute to variability in attention bias. Attention bias to threat was measured in forty-two treatment-seeking adolescents (age 12–16 years) diagnosed with Social Anxiety Disorder. Bias scores toward emotional stimuli (vigilant attention) and bias scores away from emotional stimuli (avoidant attention) were explored. Bias scores changed between vigilance and avoidance within individuals and over the course of stimulus presentation. These differences were not associated with participant characteristics nor with self-reported social anxiety symptoms. However, clinician rated severity of social anxiety, explained a significant proportion of variance in the bias scores for adult, but not the adolescent, stimuli. Variability in attention bias among socially anxious adolescents is common and varies as a function of stimulus duration and type. Results may inform stimulus selection for future research.     

The relationship between social anxiety and the perception of depth-ambiguous biological motion stimuli is mediated by inhibitory ability

Orthographically projected biological motion stimuli are depth-ambiguous. Consequently, their projection when oriented towards the viewer is the same as when oriented away. Despite this, observers tend to interpret such stimuli as facing the viewer more often. Some have speculated that this facing-the-viewer bias may exist for sociobiological reasons: Mistaking another human as retreating when they are actually approaching could have more severe consequences than the opposite error. An implication of this theory is that the facing-towards percept may be perceived as more threatening than the facing-away percept. Given this, as well as the finding that anxious individuals have been found to display an attentional bias towards threatening stimuli, we reasoned that more anxious individuals might have stronger facing-the-viewer biases. Furthermore, since anxious individuals have been found to perform poorer on inhibition tasks, we hypothesized that inhibitory ability would mediate the relationship between anxiety and the facing-the-viewer bias (i.e., difficulty inhibiting the threatening percept). Exploring individual differences, we asked participants to complete anxiety questionnaires, to perform a Go/No-Go task, and then to complete a perceptual task that allowed us to assess their facing-the-viewer biases. As hypothesized, we found that both greater anxiety and weaker inhibitory ability were associated with greater facing-the-viewer biases. In addition, we found that inhibitory ability significantly mediated the relationship between anxiety and facing-the-viewer biases. Our results provide further support that the facing-the-viewer bias is sensitive to the sociobiological relevance of biological motion stimuli, and that the threat bias for ambiguous visual stimuli is mediated by inhibitory ability.     

Is schizotypy taxonic? Response to

Beauchaine, Lenzenweger, and Waller (2008) criticize our taxometric study of schizotypy (Rawlings, Williams, Haslam, & Claridge, in press) on a variety of methodological and philosophical grounds. We argue that their critique selectively applies more stringent standards to our work than to studies supporting their view that schizotypy is taxonic (i.e., categorical). Many of their criticisms apply at least equally to existing studies that offer support for a schizotypy taxon, and these studies are vulnerable to biases favouring taxonic conclusions that were controlled for in our study. Contrary to their criticisms, we did not claim to have disconfirmed previous taxonic findings about schizotypy, and our findings positively support dimensional models of schizotypy rather than merely being null results. Similarly, our findings are not artefacts of the sampling or measurement decisions that they question. Even well-replicated taxometric findings are not immune to empirical challenge, and evaluation of such challenges must be even-handed.     

社交焦虑个体对正性面孔刺激的解释偏差

本研究分别在短时（60ms）和长时（无时间限制）条件下呈现匹配的正性和中性面孔,要求高、低社交焦虑被试选择更具威胁性的面孔,以验证两者对正性刺激是否存在主观解释偏差,并考察该偏差产生于认知加工的哪一阶段。结果发现,长时条件下,高焦虑组选择正性面孔的比例显著高于低焦虑组;短时条件下无显著差异。提示高社交焦虑个体对正性刺激存在主观、外显的解释偏差,他们更倾向于对正性刺激做出消极解释,并且这种偏差产生于认知加工的后期。     

The Contributions of Creative Cognition and Schizotypal Symptoms to Creative Achievement

Although previous research has suggested that people with subclinical levels of schizophrenic symptoms achieve a greater number of creative accomplishments, the contention that there is a creative cognitive advantage in schizotypy has received mixed support. It was hypothesized that accounting for complex relationships between (a) creative cognition abilities (moderated relationships), and (b) creative cognition and schizotypy variables (mediated, moderated, and curvilinear relationships) would significantly increase the ability to predict creative performance and provide a more accurate survey of the schizotypic creative cognitive advantage. One hundred and fourteen participants completed a creative problem solving measure, measures of cognitive creative abilities (Remote Associates Test, a divergent thinking task, and a deductive reasoning task) and measures of positive and negative symptoms of schizotypy. Regression analyses supported the conception of a multistage process in which creative cognition variables interact with each other to predict performance on a creative problem solving task. There was no evidence of a creative cognitive advantage in schizotypy: People high in schizotypy performing the same or worse than people reporting few schizotypic symptoms on measures of creative cognition and creative problem solving performance. If people with schizotypy are, indeed, more creative than those without, it is because of factors other than the cognitive processes surveyed in this investigation.