Temporal summation of pain from radiant stimulation

Latency thresholds of pricking pain, using radiant thermal stimulation, were obtained. Ten Ss were tested for 10 sessions, and, in each session, single latency determinations were made at each of 10 stimulus intensities. Each intensity was administered to a different spot along the volar surface of S’s nonpreferred forearm. Thus, 10 latency thresholds were obtained from each S at. each intensity and each spot. Initial skin temperature was controlled so that a threshold determination was made when skin temperature measured 33.5° ± 0.5° C. Analysis of variance of the log₁₀ t (seconds) values revealed a highly significant linearity of regression of log t on log intensity, thus confirming the hypothesized inverse and exponential relationship between latency and intensity. The parameters (slope and x-intercept) of the curve were discussed. The x-intercept may be interpreted as an index of an aversive threshold and could be used as a possible measure of the physiological component of pain.     

Is there low frequency vibrotactile temporal summation?

Reaction times of subjects to threshold vibratory stimuli of various durations and frequencies were measured simultaneously with the thresholds in order to test whether more time is needed for the detection of stimuli of long than short duration at threshold intensities. Vibratory stimuli of 20 or 150 Hz frequency and 50, 150, or 300 ms duration were applied to the back of the hand. Lower detection thresholds and longer reaction times were obtained for both 20 and 150 Hz vibration with increase of stimulus duration. The results suggest that temporal summation of high frequencies is due to energy integration , whereas at low frequencies probability summation explains better the threshold decrement.     

Response latencies of rats during behavioral thermoregulation

The cutaneous thermal stimulation that elicits behavioral thermoregulatory behavior was investigated in these experiments. In Experiment I, rats were placed in a cool environment and allowed to barpress for 3-sec bursts of radiant heat reinforcement. In various phases of the study, rats could earn different intensities of anterior, posterior, or whole-body radiation. Identical response rates were exhibited at each intensity for all exposure conditions; this information, when considered with existing literature on behavioral and neurophysiological studies, suggests that the rat’s thermoregulatory behavior depends on information carried by nonmyelinated fibers that supply thermoreceptors in the skin. Experiment II investigated the hypothesis that cooling of the skin is the stimulus that elicits each thermoregulatory response. Time series measures of skin temperature fluctuations and reaction times (RTs) were obtained. Tails of the RT distributions were shown to conform to exponential probability density functions, and mean RT varied linearly over the domain of reinforcement intensities used. A computer simulation model that describes temperature gradients across layers of skin was employed to estimate temperature fluctuations at the level of the cool receptors. Comparison of simulated skin temperatures with obtained RTs suggests that momentary thermoregulatory behavior is controlled mainly by cooling skin temperature.     

Human responses to various conditions of water temperature

Skin-surface temperatures on thehuman hand were obtained immediately following six exposure times ranging from 5 to 60 sec. for water temperatures varying in 5° increments from 10° to 40°C. The surface of the skin was found to respond rapidly and regularly to both the temperature and time of exposure. In a second study 30 Ss exposed a hand for 5 or 30 sec. to water temperatures ranging from 10° to 45°C. and made ratings on scales of pain and comfort as well as attaching a verbal label (cold, cool, tepid, etc.) to each experience. The experience of cold became more intense over these time intervals while the experience of warmth became less, and with the threshold constant taken into account the sensations of pain and discomfort were found to follow a psychophysical power law. The usefulness of these sorts of data for interpreting the effects of noxious stimuli in basic learning studies is discussed.     

Psychophysical features of the transition from pure heat perception to heat pain perception

The psychophysical features of the transition from the pure heat to the heat pain range were studied in 25 healthy subjects (mean age 28.8 years). Thirty short heat stimuli from ?1.6° C to + 1.6° C relative to the pain threshold were applied to the thenar of the left hand with an apparatus containing a Peltier thermode (nine different temperatures at 0.4°C intervals). The subjects rated the sensation intensity on a visual analogue scale. The resulting stimulus/sensation intensity relations could be explained equally well (same goodness of fit) by a model with a power function (PF) and by a model with two linear regression lines (TLR), one for stimulus intensities below and one for those above the pain threshold and intersecting at the pain threshold. The slopes of the TLR model were significantly larger above the pain threshold than below it. The PF model produced exponents between 1.8 and 1.9. We conclude that to describe the transition area, it is sufficient to use simple linear models for both the pure heat and the heat pain ranges.     

The effect of skin temperature on vibrotactile sensitivity

The effect of skin temperature on detection of vibrotactile stimuli was measured for vibrations of 30 and 250 Hz. Data for the 250-Hz stimulus supported the results of Weitz (1941), who found that thresholds for 100-, 256-, and 900-Hz vibration varied as a If-shape function of skin temperature with a minimum at about 37°C. Temperature had a negligible effect on sensitivity at 30 Hz. A second experiment examined a range of frequencies between 30 and 250 Hz. Cooling greatly lowered sensitivity only to 150- and 250-Hz stimuli. Warming reduced sensitivity less, but more uniformly across frequencies. It was concluded that cooling may affect vibrotactile thresholds by decreasing the sensitivity of Pacinian corpuscles; the reason for the decrease in sensitivity due to warming is unclear.     

Directional sensitivity to a tactile point stimulus moving across the fingerpad

The ability of subjects to discriminate between directions of a point contact moving across the fingerpad was examined. Subjects were required to report, using an adaptive two-interval, two-alternative forced-choice procedure, whether in two sequential stimuli the direction of motion changed in a clockwise or counterclockwise direction. The overall mean orientation-change threshold across eight stimulus orientations was approximately 14°, with the lowest threshold for the point motion toward the wrist. This observed lower threshold in the distal-to-proximal direction is thought to be due to stretching of the skin at the tip of the fingernail, to which one may be particularly sensitive. For all orientations, thresholds were generally more uniform and higher than those reported on vibrotactile linear contactor arrays for horizontal and vertical orientations.     

Comparison of sensitivity of psychophysical and electrophysiological measures of scotopic thresholds in the vicinity of the blind spot

A section of the blind spot was mapped by obtaining detection and averaged EEG threshold measurements using three stimulus light intensities. It was found that averaged EEG and detection measures of the blind spot were equally sensitive when the two highest stimulus intensities were used, although more observations of the stimulus were required with averaged EEG. Detection thresholds were superior to averaged EEG measures with the dimmest stimulus.

     

Changes in threshold level produced by a signal preceding or following the threshold stimulus

In a previous experiment (Howarth and Treisman, 1958) it was shown that when a warning preceded a stimulus by a fixed interval, the threshold level for the stimulus was higher the longer the fixed interval. A model of this effect was proposed, assuming that the threshold criterion adopted by the subject at any moment was modified by his estimate of the probability of a stimulus at that moment.

Three predictions are derived and tested. It is found that: the standard deviation of the response is constant despite the shifts in threshold induced; the threshold continues to fall as the interval from warning to stimulus is decreased to zero, with the lowest threshold when the warning signal and the stimulus are simultaneous; and that a warning signal following the stimulus by an interval of less than 0 5 to 1 sec. also lowers the threshold.     

Tracking of nociceptive thresholds using adaptive psychophysical methods

Psychophysical thresholds reflect the state of the underlying nociceptive mechanisms. For example, noxious events can activate endogenous analgesic mechanisms that increase the nociceptive threshold. Therefore, tracking thresholds over time facilitates the investigation of the dynamics of these underlying mechanisms. Threshold tracking techniques should use efficient methods for stimulus selection and threshold estimation. This study compares, in simulation and in human psychophysical experiments, the performance of different combinations of adaptive stimulus selection procedures and threshold estimation methods. Monte Carlo simulations were first performed to compare the bias and precision of threshold estimates produced by three different stimulus selection procedures (simple staircase, random staircase, and minimum entropy procedure) and two estimation methods (logistic regression and Bayesian estimation). Logistic regression and Bayesian estimations resulted in similar precision only when the prior probability distributions (PDs) were chosen appropriately. The minimum entropy and simple staircase procedures achieved the highest precision, while the random staircase procedure was the least sensitive to different procedure-specific settings. Next, the simple staircase and random staircase procedures, in combination with logistic regression, were compared in a human subject study (n = 30). Electrocutaneous stimulation was used to track the nociceptive perception threshold before, during, and after a cold pressor task, which served as the conditioning stimulus. With both procedures, habituation was detected, as well as changes induced by the conditioning stimulus. However, the random staircase procedure achieved a higher precision. We recommend using the random staircase over the simple staircase procedure, in combination with logistic regression, for nonstationary threshold tracking experiments.     

Apparatus for Continuous Recording of the Visual Threshold by the Method of “Closed Loop Control”

An apparatus is described for the continuous recording of visual thresholds and the integration of visual thresholds over any given time period. The apparatus provides for the simultaneous but independent stimulation of the two eyes where either or both of the respective stimulus intensities may be under the control of the subject.     

Practice effects for visual resolution in the periphery

Resolution thresholds at 0° (fovea), 20°, 40°, and 60° along the horizontal meridian of the temporal visual field revealed a characteristic degradation in visual resolution with increasing stimulus eccentricity. However, substantial individual differences were found, particularly at 40° and 60° of eccentricity. Dramatic improvements in peripheral visual resolution occurred over a period of 11 practice sessions, with the time course of practice effects increasing for greater visual field eccentricities. Improvements with practice reduced, but did not eliminate, individual differences. The present visual resolution findings are compared to previous studies of peripheral motion detection and increment thresholds.     

Operant methods for mouse psychoacoustics

Tone detection thresholds for a 10-kHz tone in NMRI mice were determined in psychoacoustic experiments using both a constant-stimuli procedure and a two-down/one-up adaptive-tracking procedure in the same subjects and applying identical threshold criteria (70.7% response probability). Constant-stimuli thresholds were on average 24 dB lower than adaptive-tracking thresholds, and there was a trend indicating that constant-stimuli thresholds were less variable than adaptive-tracking thresholds. Furthermore, in the constant-stimuli procedure the number of trials constituting the psychometric function could be reduced from 100 to 50 trials without a large loss of accuracy of threshold determination. In the constant-stimuli procedure, the threshold value was affected by the threshold criteria. The lowest and least variable constant-stimuli thresholds were obtained by applying signal detection theory and a criterion ofd′=1. Thus, the constant-stimuli procedure in combination with signal detection theory appears to be better suited than the adaptive-tracking procedure to determine auditory sensory thresholds.     

Hearing threshold shift during auditory magnitude estimation.

The purpose of the present experiment was to determine the extent of hearing threshold shift that may occur during an auditory magnitude-estimation task involving stimulus intensities as great as 80 dB sensation level. Also, possible influences of hearing threshold shift on numerical magnitude-estimation responses and magnitude-function slopes were investigated. Results indicated that hearing threshold shift was insignificant (1-2 dB). Consistent small increases in numerical magnitude responses were observed on a magnitude-estimation task where hearing thresholds were retested between stimulus presentations versus a magnitude-estimation task where hearing thresholds were not retested. The stability of auditory magnitude functions across different conditions in the current investigation was in agreement with vibrotactile magnitude-scaling behavior observed by Fucci, et al. in 1989 and 1991. The over-all results supported the concept of an absolute, internal sensory-scaling mechanism being operable during magnitude estimation of auditory stimuli as discussed by Zwislocki and Goodman in 1980.     

Gustatory,salivary, and oral thermal responses to solutions of sodium chloride at four temperatures

Using eight highly trained Ss, sensitivity to near threshold levels of NaCl was significantly greater at solution temperatures of 22° and 37°C than at 0° or 55°C. Perceived intensity increased linearly with concentration (0.04%–0.64% NaCl) at all four solution temperatures, with the two lower considered slightly more intense than the two higher temperatures. Biomodal distributions were obtained for hedonic judgments at all temperatures, with three Ss showing greater liking and five Ss showing greater disliking of increasing concentrations. Parotid salivary flow was inversely related to the taste sensitivity, i.e., significantly lower flow rates were obtained for the intermediate than for the hot or cold solutions, independent of salt content. When solution temperature was O°C, the minimum temperature of the oral cavity was 9°–20°C; when solution temperature was 55°C, the maximum temperature of the oral cavity was46°–49°C.     

Dynamic, state-dependent thresholds for the perception of single-element apparent motion: Bistability from local cooperativity

Previous studies have indicated that the formation of coherent patterns for multielement motion displays depends onglobal cooperative interactions among large ensembles of spatially distributed motion detectors. These interactions enhance certain motion directions and suppress others. It is reported here that perceiving one element moving between two nearby locations likewise is subject to cooperative influences (possibly facilitating and inhibiting interactions within alocal ensemble of overlapping detectors). Thresholds depending on luminance contrast were measured for a generalized singleelement apparent-motion stimulus, and evidence for spontaneous switching and hysteresis effects indicated that motion perception near the 50% threshold was bistable. That is, for conditions in which motion and nonmotion were perceived half the time, the two percepts were distinct; when one was perceived, it clearly was discriminable from the other. These results indicated that (1) single-element apparent-motion thresholds depended on the immediately preceding state of the ensemble of motion detectors responding to the stimulus, and (2) the stimulus activation of individual motion detectors always might be influenced by recurrent, cooperative interactions resulting from the detectors’ being embedded within interconnected ensembles.     

Effect of masker level on infants’ detection of tones in noise

In adult listeners, the signal-to-noise ratio at masked threshold remains constant with increases in masker level over a wide range of stimulus conditions. This relationship was examined in 7-month-old infants by obtaining masked thresholds for .5- and 4-kHz tones presented in four levels of continuous masking noise. Adults were also tested for comparison. Masker spectrum levels ranged from 5 to 35 dB/Hz for .5-kHz tones, and from ?5 to 25 dB/Hz for 4-kHz stimuli. Thresholds were determined for stimuli of both 10 and 100 msec in duration. The results indicated that infants’ performance was more adultlike for 4-kHz stimuli. Although mean thresholds for both 10- and 100-msec, 4-kHz tones were approximately 7 dB higher in infants than in adults, E/N₀ at threshold remained essentially constant over the 30-dB range of maskers employed. By contrast, infants’ thresholds for .5-kHz tones were exceptionally high at lower levels of the masker. Threshold E/N0 decreased significantly as masker level increased from 5 to 35 dB/Hz, and this decrease was significantly greater for 10- than for 100-msec stimuli. Temporal summation of .5-kHz tones, measured as the difference between thresholds obtained at the two signal durations, was greater for infants than for adults at low levels of the masker. However, because infants’ thresholds improved more rapidly with level for 10- than for 100-msec tones, age differences in temporal summation were no longer significant when masker spectrum level was 35 dB/Hz. These results suggest that the relationship between signal-to-noise ratio at masked threshold and level of the masker is dependent on both signal frequency and duration during infancy.     

How skin and object temperature influence touch sensation

Twenty subjects made magnitude estimations of the apparent heaviness of metallic stimulators of various masses and temperatures (cold, neutral, and warm). The stimulators were placed on the forearm at normal skin temperature (about 33°C), at elevated skin temperature (38°C), and at lowered skin temperature (25°C). Under neutral conditions, we replicated earlier studies: cold objects felt considerably heavier than neutral ones, warm objects somewhat heavier than neutral objects. Warming the skin essentially obliterated the intensifying effect of the warm objects but left unaltered the intensifying effect of the cold objects. Cooling the aim also essentially obliterated the intensifying effect of warm objects. It also diminished, but far from eliminated, the intensifying effect of cold objects. Cold intensification of touch sensation is a large and robust phenomenon and, unlike warm intensification, appears to characterize all body regions.     

Loudness and reaction time: II Identification of detection components at different intensities and frequencies

Equal-loudness contours were first obtained for five stimulus frequencies at four stimulus intensities. These 20 stimuli were then presented as reaction-time signals in a Donders C paradigm. The Z-transform method of convolution, as applied in linear systems identification, was used to deconvolve an empirically generated response (or “residual”) distribution (T_R) from each of the 20 reaction-time (RT) distributions obtained at different intensities and frequencies. The resulting sensory-detection (t_d) models formed exponential densities at strong intensities (60 and 80 phons), but their shapes were either gamma or normal at relatively weak intensities (20 and 40 phons). Our analyses support the idea that the simple reactiontime process (RT) is a convolution (or sum) of two component stages: stimulus detection (t_d), followed by response evocation (t_r). Based on the shapes of t_d, a neural-impulse theory is offered to account for the detection of simple auditory RT signals.     

Effects of cold on human information processing: Application of a reaction time paradigm

Only a very few studies on the effects of cold on human information processing appear to exist. Therefore, the present experiment was designed to study the effects of the experimentally induced lowering of body core temperature on information processing, while applying a reaction time paradigm. Thirty healthy male volunteers performed a stimulus evaluation—response selection reaction time task after exposure to ambient temperatures of either 28 or 5°C. A 0.5°C-decrease in body core temperature resulted in a significant increase in both reaction and movement time indicating a general deteriorating effect of lowering of body core temperature on information processing. Mean reaction times were 538 ms and 549 ms for the control and the cold group, respectively (p<.05). The respective mean movement times were 298 ms and 269 ms (p<.001). Speed of stimulus evaluation was not sensitive to decreases in body core temperature. However, response complexity and body core temperature showed a significant interaction in their effect on movement time (p<.05), indicating that lowering of body core temperature is more likely to affect response-related stages of central information processing rather than stimulus evaluation. Furthermore, movement time appeared to be more sensitive to cold-induced effects on information processing as compared to reaction time. Additional correlational analyses suggest that the observed effects can be considered as independent of changes in skin temperature and experienced levels of thermal discomfort. Taken together, the results indicate that lowering of body core temperature differentially affects various stages of information processing.