无意识活动与静息态脑能量消耗

静息态脑活动的研究关注个体在清醒、静卧、闭眼时脑的活动情况,大量实验证明静息状态下大脑仍进行着持续不断的信息加工活动,并且消耗大量能量。本文在阐述无意识活动特性以及总结静息态脑能量消耗研究的基础上,提出用无意识活动解释静息态脑能量消耗的观点,强调在研究无意识活动的心理意义的同时,还要研究无意识活动的神经机制及其生理表现。     

Spontaneous startle activity in newborn infants

Spontaneous startles have been reported to occur most frequently in quiet sleep, less frequently in active sleep and drowse, and relatively nonexistent in the waking states. These findings may be a result of a focus on infants whose prenatal histories reflect a restricted range of the conditions to which normal newborns are exposed. The present study examined the spontaneous startle behavior of 30 newborn infants characterized by high numbers of obstetric complications and by indicators of prenatal malnutrition, but within the range of normal, healthy newborns. In this sample, startles were not limited to the sleep and drowse states. Because individual differences in a number of neonatal behaviors have been related to autonomic nervous system (ANS) functioning, the different pattern of spontaneous startles observed in this sample may be related to the functional integrity of this system.     

语言功能偏侧化及其与利手、功能连接的关系

对大脑语言功能偏侧化的探索起始于早期对脑损伤病人的研究。现代脑影像学研究发现, 语言功能偏侧化涉及额叶、颞叶、扣带回、梭状回和辅助运动区等脑区。语言偏侧化与利手和静息态功能连接之间的关系表现为：右利手的语言优势位于左半球, 而左利手的则分布在左半球、右半球或两个半球; 语言功能偏侧化与利手系数、静息态半球内功能连接之间具有正相关关系, 与半球间功能连接呈负相关, 并且语言功能偏侧化与静息态功能连接之间的关系在左右利手个体之间存在差异。总之, 大脑语言功能偏侧化、利手和静息态功能连接三者之间存在相互影响, 基于脑连接和遗传机制的研究将有望揭示出其底层的神经生理机制。     

Representations in the Human Prefrontal Cortex

ABSTRACT— The prefrontal cortex (PFC) in humans has been studied for more than a century, but many crucial questions about its functions remain unanswered. This paper will highlight a few key differences between human and animal PFCs, and between the human PFC (HPFC) and other parts of the human brain. We then make a case that the HPFC is critically important for executing behaviors over time and integrating disparate information from throughout the brain. Finally, we will focus on our position in the current debate regarding how the HPFC performs its functions and discuss future directions for research.     

舞动治疗：一种自下而上的精神分裂症干预探索

皮层-基底节-丘脑网络与脑岛网络属于感觉运动相关网络, 这两个网络的改变可能是导致精神分裂症的重要原因。目前主流研究与临床干预聚焦于患者的高级脑区异常, 对感觉运动系统的关注不足。对健康个体的研究发现舞蹈训练对感觉运动相关脑网络具有显著提升作用, 并自下而上地促进高级功能。以上研究提示舞蹈训练可能是干预精神分裂症、改善患者认知功能的新途径。本研究拟借助多模态磁共振成像技术, 以精神分裂症感觉运动相关网络为着力点, 通过分析精神分裂症患者在舞蹈训练前后的脑影像、临床症状及认知行为的改变, 揭示舞蹈训练临床干预的神经机制。     

试论以人为本的道德价值观

以人为本的道德价值观,也就是以人的属性、人的思维和人的境界为理论出发点的道德价值观。人的属性有主体性、社会性、自然性、精神性之分。人的思维具有个体本位、社群本位、自然本位、信仰本位四个维层。人的境界有伟人、英雄、模范、先进、普通之区别。     

Bilaterally recorded multiple-unit activity of the cingulate cortex during head turning conditioning with unilateral medial forebrain bundle stimulation

Cats were conditioned to turn their heads using a tone conditioned stimulus (CS) and medial forebrain bundle stimulation (MFB) unconditioned stimulus (US). The CS+ was delivered to one ear at a time, in random order, followed by the US. A tone of a different frequency was used as a CS-. The cats learned to respond differentially to the CSs showing head movements of greater acceleration to the CS+ than CS- over sessions. Bilateral recordings of cingulate cortex multiple-unit activity showed increased response amplitudes over sessions and larger responses in the hemisphere ipsilateral to the US. Since ipsilateral multiple-unit responses did not differ for the CSs, the asymmetry was probably due to the sensitizing effect of the unilateral US. Although increases in cingulate cortex neural activity coincided with increases in conditioned head movements, larger activation of the cingulate cortex ipsilateral to the US suggests that the neural changes were independent of these movements.     

阿尔兹海默症及轻度认知障碍静息态大尺度脑网络功能连接的改变

静息态功能磁共振成像作为非侵入性可视化成像方法, 且数据采集简便易行, 已成为探索阿尔兹海默症及轻度认知障碍脑功能变异的主要成像手段。近年来静息态研究显示在其前驱症状期轻度认知障碍阶段患者已显现出静息态脑网络的变异, 而阿尔兹海默症患者的网络改变更加弥散。研究发现随着病程推进, 患者显示出默认网络连接逐渐减弱以及额叶认知网络连接先增强后减弱的整体趋势。此外, 脑结构和功能网络的改变并非单向因果关系, 二者在病程进展中存在交互作用。未来研究可以从诊断的标志性神经通路、疗效的大尺度脑网络标记, 以及疾病的异质性等角度入手, 进一步探索静息态脑网络作为阿尔兹海默症诊断和病程监控指标的可能性。     

告子人性论思想新思考——以卢梭人性论思想为参照

人性论的研究有两条进路,一是从自然的层面上研究人性,另一是从道德形而上学的层面上研究人性.孟子的研究显然属于后者,而告子属于前者.从自然的层面研究人性并不意味着肤浅.例如,虽然告子的人性论思想往往被理解为材质之性,但实际上告子的人性论思想远不仅此,告子的人性论思想是复杂且深刻的.通过阅读卢梭对于人性的理解,我们发现卢梭与告子有许多相似之处.以卢梭的人性论思想为参照来理解告子的人性论思想,不仅可以加深对告子思想的理解,同时,卢梭的一些观点也是对告子思想的一种解释或者补充.     

Primate prefrontal neurons encode the association of paired visual stimuli during the pair-association task

The prefrontal cortex (PFC) is known to contribute to memory processes such as encoding representations into long-term-memory (LTM) and retrieving these representations from LTM. However, the details of the PFC's contribution to LTM processes are not well known. To examine the characteristics of the PFC's contribution to LTM processes, we analyzed single-neuron activity while monkeys performed a pair-association (PA) task using 12 pairs of complex visual images. Among 60 neurons with sample-period activity, 32% showed the strongest and second-strongest sample-period activities when a particular pair of stimuli was presented (pair selectivity). In addition, the mean latency of sample-period activity was 138 ms in the PFC, which was longer than that observed in ITC neurons under bottom-up conditions, but shorter than that under top-down conditions. These results indicate that the PFC participates in encoding and retrieving information in LTM processes and that pair-selective sample-period activity might be a candidate for the top-down signal that the PFC provides to the ITC during the retrieval of information from LTM.