The impact of cognitive deficits on conflict monitoring. Predictable dissociations between the error-related negativity and N2

Monitoring of ongoing processing plays a critical role in regulating cognitive function. Two event-related potential components, the error-related negativity (ERN) and N2, have been proposed to reflect this monitoring function. Specifically, it has been suggested that both components reflect the role of anterior cingulate cortex (ACC) in monitoring for the occurrence of response conflict. This view appears to be challenged by findings that alcohol consumption and lesions in ACC have dissociable effects on the ERN and N2. Using a computational model, the present research demonstrates that the conflict-monitoring theory can account for these dissociations in terms of the dissociable effects of alcohol and ACC lesions on processing of relevant stimulus information (which determines ERN amplitude) and processing of irrelevant, distracting information (which determines N2 amplitude). The simulation results suggest new interpretations of the cognitive deficits caused by alcohol consumption (impaired stimulus processing) and ACC lesions (impaired attentional control).     

Where did you go wrong? Errors, partial errors, and the nature of human information processing

Human performance is seldom perfect, and even when an overt response is correct it may be accompanied by partial-error activity that does not achieve the level of a complete incorrect response. Partial errors can be detected in measures of the lateralized readiness potential, of the electromyogram, and of response force. Correct responses accompanied by partial errors tend to have slower reaction times than “clean” correct responses (because of response competition), and condition differences in reaction time can, on some occasions, be explained in terms of differences in the incidence of partial errors. In two-choice reaction time tasks, partial errors are more frequent when the imperative stimulus contains information that favors both responses, than when it contains information that favors only one response. The non-random nature of partial errors supports the inference that partial information about the stimulus is used to guide responses. A similar inference is supported by the observation that, in hybrid choice Go/No-go tasks, the kinds of partial errors that follow a No-go stimulus represent activation of the response that would have been correct had the stimulus been a Go stimulus. Finally, we note that the human processing system is capable of monitoring its own behavior and of initiating remedial actions if necessary. The activity of an error-detection system, as revealed by measures of the error-related negativity, is related to the degree to which responses are slowed after errors.     

Performance monitoring and the causal attribution of errors

The present study investigated the role of causal attribution for performance monitoring in the medial frontal cortex. To this end, we compared internally and externally-caused errors in a selective attention task with respect to error-related EEG activity and error-induced adjustments of speed and attentional selectivity. Both error types evoked early negativities and later positivities in the response-locked event-related potential. However, whereas internally-caused errors caused posterror slowing, externally-caused errors were followed by reduced attentional selectivity. Moreover, the amount of reduced attentional selectivity was related to the amplitude of the early negativity on externally-caused errors. This suggests that posterror adjustments are initiated on the basis of perceived causality and, thus, causal attribution of errors.     

Changes in processing of masked stimuli across early- and late-night sleep: a study on behavior and brain potentials

Sleep has proven to support the memory consolidation in many tasks including learning of perceptual skills. Explicit, conscious types of memory have been demonstrated to benefit particularly from slow-wave sleep (SWS), implicit, non-conscious types particularly from rapid eye movement (REM) sleep. By comparing the effects of early-night sleep, rich in SWS, and late-night sleep, rich in REM sleep, we aimed to separate the contribution of these two sleep stages in a metacontrast masking paradigm in which explicit and implicit aspects in perceptual learning could be assessed separately by stimulus identification and priming, respectively. We assumed that early sleep intervening between two sessions of task performance would specifically support stimulus identification, while late sleep would specifically support priming. Apart from overt behavior, event-related EEG potentials (ERPs) were measured to record the cortical mechanisms associated with behavioral changes across sleep. In contrast to our hypothesis, late-night sleep appeared to be more important for changes of behavior, both for stimulus identification, which tended to improve across late-night sleep, and for priming, with the increase of errors induced by masked stimuli correlating with the duration of REM sleep. ERP components proved sensitive to presence of target shapes in the masked stimuli and to their priming effects. Of these components, the N2 component, indicating processing of conflict, became larger across early-night sleep and was related to the duration of S4 sleep, the deepest substage of SWS containing particularly high portions of EEG slow waves. These findings suggest that sleep promotes perceptual learning primarily by its REM sleep portion, but indirectly also by way of improved action monitoring supported by deep slow-wave sleep.     

The auditory-evoked N2 and P3 components in the stop-signal task: indices of inhibition, response-conflict or error-detection?

The N2 and P3 components have been separately associated with response inhibition in the stop-signal task, and more recently, the N2 has been implicated in the detection of response-conflict. To isolate response inhibition activity from early sensory processing, the present study compared processing of the stop-signal with that of a task-irrelevant tone, which subjects were instructed to ignore. Stop-signals elicited a larger N2 on failed-stop trials and a larger P3 on successful-stop trials, relative to ignore-signal trials, likely reflecting activity related to failed and successful stopping, respectively. ERPs between fast and slow reaction-time (RT) groups were also examined as it was hypothesised that greater inhibitory activation to stop faster responses would manifest in the component reflecting this process. Successful-stop P3 showed the anticipated effect (globally larger amplitude in the fast than slow RT group), supporting its association with the stopping of an ongoing response. In contrast, N2 was larger in the slow than fast RT group, and in contrast to the predictions of the response-conflict hypothesis, successful-stop N2 and the response-locked error-negativity (Ne) differed in scalp distribution. These findings indicate that the successful-stop N2 may be better explained as a deliberate form of response control or selection, which the slow RT group employed as a means of increasing the likelihood of a successful-stop. Finally, a comparison of stimulus and response-locked ERPs revealed that the failed-stop N2 and P3 appeared to reflect error-related activity, best observed in the response-locked Ne and error-positivity (Pe). Together these findings indicate that the successful-stop N2 and P3 reflect functionally distinct aspects of response control that are dependent upon performance strategies, while failed-stop N2 and P3 reflect error-related activity.     

Time-course of hemispheric preference for processing contralateral relevant shapes: P1pc, N1pc, N2pc, N3pc

A most sensitive and specific electrophysiological indicator of selective processing of visual stimuli is the N2pc component. N2pc is a negative EEG potential peaking 250 ms after stimulus onset, recorded from posterior sites contralateral to relevant stimuli. Additional deflections preceding or following N2pc have been obtained in previous studies, possibly produced by specific stimulus features or specific prime-target sequences. To clarify the entire time-course of the contralateral- ipsilateral (C-I) difference recorded from the scalp above visual cortex in response to left-right pairs of targets and distracters, C-I differences were here compared between two types of stimuli and between stimuli that were or were not preceded by masked neutral primes. The C-I difference waveform consisted of several peaks, termed here P1pc (60-100 ms after target onset), N1pc (120-160 ms), N2pc (220-280 ms), and N3pc (360-400 ms). Being markedly enhanced when stimuli were preceded by the neutral primes, P1pc may indicate a response to stimulus change. Also, when stimuli were primed, N2pc reached its peak earlier, thereby tending to merge with N1pc. N3pc seemed to increase when target discrimination was difficult. N1pc, N2pc, and N3pc appear as three periods of one process. N3pc probably corresponds to L400 or SPCN as described in other studies. These observations suggest that the neurophysiological basis of stimulus-driven focusing of attention on target stimuli is a process that lasts for hundreds of milliseconds, with the relevant hemisphere being activated in an oscillating manner as long as required by the task.     

Positive emotion impedes emotional but not cognitive conflict processing

Cognitive control enables successful goal-directed behavior by resolving a conflict between opposing action tendencies, while emotional control arises as a consequence of emotional conflict processing such as in irony. While negative emotion facilitates both cognitive and emotional conflict processing, it is unclear how emotional conflict processing is affected by positive emotion (e.g., humor). In 2 EEG experiments, we investigated the role of positive audiovisual target stimuli in cognitive and emotional conflict processing. Participants categorized either spoken vowels (cognitive task) or their emotional valence (emotional task) and ignored the visual stimulus dimension. Behaviorally, a positive target showed no influence on cognitive conflict processing, but impeded emotional conflict processing. In the emotional task, response time conflict costs were higher for positive than for neutral targets. In the EEG, we observed an interaction of emotion by congruence in the P200 and N200 ERP components in emotional but not in cognitive conflict processing. In the emotional conflict task, the P200 and N200 conflict effect was larger for emotional than neutral targets. Thus, our results show that emotion affects conflict processing differently as a function of conflict type and emotional valence. This suggests that there are conflict- and valence-specific mechanisms modulating executive control.     

内倾特质个体的自我参照加工程度效应

采用事件相关电位技术和三类刺激的经典oddball范式,以内隐的方式探讨内倾特质个体的自我参照加工程度效应及其神经机制。实验发现,在P2的波幅上,在电极前部、前中部和中部位置高自我相关的刺激比其它刺激诱发了更大的P2波幅。在P2的潜伏期上,在电极前部、中部、和中后部位置高自我相关的刺激比其它刺激诱发了更短的潜伏期。在N2的波幅上,高自我相关名字比其它刺激在左脑所诱发了更大的P2的波幅;对比内倾型被试,中间型被试的高自我相关名字比其它刺激诱发了更大的N2的波幅。在N2的潜伏期上,高自我相关的刺激在全脑都比其它刺激诱发了更短的N2潜伏期,且中后部电极位置的潜伏期最短;两类人格被试的高自我相关名字比其它刺激诱发了更短的N2潜伏期,但中间型人格被试的潜伏期最短。在P3平均波幅上,高自我相关的刺激在全脑都比其它刺激诱发了更大的P3波幅,其中中部脑区效应最大。研究结果表明内倾特质个体的自我参照加工具有程度效应,但对比中间型个体,内倾特质个体的自我参照加工的程度效应更弱。     

Induced gamma-band responses in the human EEG are related to attentional information processing

Synchronized neural activity in the frequency range above 20 Hz, the gamma-band, has been proposed as a signature of temporal feature binding. Here we suggest that selective attention facilitates synchronization of neural activity. Selective attention can be guided by bottom-up, stimulus driven, or top-down task-driven processes. Both processes will cause that stimuli are processed preferentially. While bottom-up processes might facilitate synchronization of neurons due to the salience of the stimulus, top-down processes may bias information selection by facilitating synchronization of neurons coding a certain location in space and/or of neurons related to the processing of certain features. Animal as well as human EEG studies support the notion of a link between induced gamma-band responses and attentive, sensory stimulus processing.     

Comparing the effects of light alcohol consumption on human response to auditory and visual stimuli

The purpose of this study is to examine the effects of various levels of alcohol consumption on human response to auditory and visual stimuli in terms of reaction time, movement time, total reaction time, and error rate. Placebo level and three low-level alcohol doses were randomly assigned to 20 male university student volunteers. 30 min. after consuming the alcohol or placebo, participants responded to either auditory or visual stimuli. Total reaction time increased significantly at the mid-low dose of alcohol (0.3 g/kg). For alcohol doses less than .5 g/kg, the change in total reaction time was confined to reaction time, i.e., the processing time between onset of stimulus and onset of movement. Effects of alcohol were significantly more pronounced in the choice-type tests. Notably, the effects of alcohol on total reaction time and error rate were significant for auditory but not visual stimuli.     

Why is it difficult to see in the fog? How stimulus contrast affects visual perception and visual memory

Processing visually degraded stimuli is a common experience. We struggle to find house keys on dim front porches, to decipher slides projected in overly bright seminar rooms, and to read 10th-generation photocopies. In this research, we focus specifically on stimuli that are degraded via reduction of stimuluscontrast and address two questions. First, why is it difficult to process low-contrast, as compared with high-contrast, stimuli? Second, is the effect of contrastfundamental in that its effect is independent of the stimulus being processed and the reason for processing the stimulus? We formally address and answer these questions within the context of a series of nested theories, each providing a successively stronger definition of what it means for contrast to affect perception and memory. To evaluate the theories, we carried out six experiments. Experiments 1 and 2 involved simple stimuli (randomly generated forms and digit strings), whereas Experiments 3–6 involved naturalistic pictures (faces, houses, and cityscapes). The stimuli were presented at two contrast levels and at varying exposure durations. The data from all the experiments allow the conclusion that some function of stimulus contrast combines multiplicatively with stimulus duration at a stage prior to that at which the nature of the stimulus and the reason for processing it are determined, and it is the result of this multiplicative combination that determines eventual memory performance. We describe a stronger version of this theory— the sensory response, information acquisition theory—which has at its core, the strong Bloch’s-law-like assumption of a fundamental visual system response that is proportional to the product of stimulus contrast and stimulus duration. This theory was, as it has been in the past, highly successful in accounting for memory for simple stimuli shown at short (i.e., shorter than an eye fixation) durations. However, it was less successful in accounting for data from short-duration naturalistic pictures and was entirely unsuccessful in accounting for data from naturalistic pictures shown at longer durations. We discuss (1) processing differences between short- and long-duration stimuli, (2) processing differences between simple stimuli, such as digits, and complex stimuli, such as pictures, (3) processing differences between biluminant stimuli (such as line drawings with only two luminance levels) and multiluminant stimuli (such as grayscale pictures with multiple luminance levels), and (4) Bloch’s law and a proposed generalization of the concept ofmetamers.     

Regional and inter-regional theta oscillation during episodic novelty processing

Recent event-related potential (ERP) and functional magnetic resonance imaging (fMRI) studies suggest that novelty processing may be involved in processes that recognize the meaning of a novel sound, during which widespread cortical regions including the right prefrontal cortex are engaged. However, it remains unclear how those cortical regions are functionally integrated during novelty processing. Because theta oscillation has been assumed to have a crucial role in memory operations, we examined local and inter-regional neural synchrony of theta band activity during novelty processing. Fifteen right-handed healthy university students participated in this study. Subjects performed an auditory novelty oddball task that consisted of the random sequence of three types of stimuli such as a target (1000 Hz pure tone), novel (familiar environmental sounds such as dog bark, buzz, car crashing sound and so on), and standard sounds (950 Hz pure tone). Event-related spectra perturbation (ERSP) and the phase-locking value (PLV) were measured from human scalp EEG during task. Non-parametric statistical tests were applied to test for significant differences between stimulus novelty and stimulus targets in ERSP and PLV. The novelty P3 showed significant higher amplitude and shorter latency compared with target P3 in frontocentral regions. Overall, theta activity was significantly higher in the novel stimuli compared with the target stimuli. Specifically, the difference in theta power between novel and target stimuli was most significant in the right frontal region. This right frontal theta activity was accompanied by phase synchronization with the left temporal region. Our results imply that theta phase synchronization between right frontal and left temporal regions underlie the retrieval of memory traces for unexpected but familiar sounds from long term memory in addition to working memory retrieval or novelty encoding.     

儿童与成人对社会和非社会正性情绪刺激脑电反应特征比较

采用事件相关电位技术探究不同年龄群体社会与非社会正性情绪刺激加工是否具有差异。研究发现：在P2成分上,成人在情绪刺激下诱发的波幅大于儿童;N2成分上,儿童在三种情绪刺激条件下波幅无显著差异。成人在社会性情绪刺激条件下诱发的脑电波幅大于在中性情绪刺激条件和非社会情绪刺激条件下诱发波幅;在LPP早、中、晚时间窗中,儿童的LPP波幅大于成人。由此,儿童与成人在社会和非社会正性情绪刺激加工上存在明显差异。     

Timing and reaction time.

Because reaction time (RT) tasks are generally repetitive and temporally regular, participants may use timing strategies that affect response speed and accuracy. This hypothesis was tested in 3 serial choice RT experiments in which participants were presented with stimuli that sometimes arrived earlier or later than normal. RTs increased and errors decreased when stimuli came earlier than normal, and RTs decreased and errors increased when stimuli came later than normal. The results were consistent with an elaboration of R. Ratcliff's diffusion model (R. Ratcliff, 1978; R. Ratcliff & J. N. Rouder, 1998; R. Ratcliff, T. Van Zandt, & G. McKoon, 1999), supplemented by a hypothesis developed by D. Laming (1979a, 1979b), according to which participants initiate stimulus sampling before the onset of the stimulus at a time governed by an internal timekeeper. The success of this model suggests that timing is used in the service of decision making.     

Seeing faces in the noise: Stochastic activity in perceptual regions of the brain may influence the perception of ambiguous stimuli

Research on binocular rivalry and motion direction discrimination suggests that stochastic activity early in visual processing influences the perception of ambiguous stimuli. Here, we extend this to higher level tasks of word and face processing. In Experiment 1, we used blocked gender and word discrimination tasks, and in Experiment 2, we used a face versus word discrimination task. Stimuli were embedded in noise, and some trials contained only noise. In Experiment 1, we found a larger response in the N170, an ERP component associated with faces, to the noise-alone stimulus when observers were performing the gender discrimination task. The noise-alone trials in Experiment 2 were binned according to the observer’s behavioral response, and there was a greater response in the N170 when they reported seeing a face. After considering various top-down and priming-related explanations, we raise the possibility that seeing a face in noise may result from greater stochastic activity in neural faceprocessing regions.     

Action monitoring and perfectionism in anorexia nervosa

To study action monitoring in anorexia nervosa, behavioral and EEG measures were obtained in underweight anorexia nervosa patients (n=17) and matched healthy controls (n=19) while performing a speeded choice-reaction task. Our main measures of interest were questionnaire outcomes, reaction times, error rates, and the error-related negativity ERP component. Questionnaire and behavioral results indicated increased perfectionism in patients with anorexia nervosa. In line with their perfectionism and controlled response style patients made significantly less errors than controls. However, when controlling for this difference in error rates, the EEG results demonstrated a reduced error-related negativity in the patient group. These seemingly contradictory outcomes of improved performance and reduced error monitoring are discussed in relation with indications of anterior cingulate cortex hypoactivity in anorexia nervosa patients.     

Font effects of Chinese characters and pseudo-characters on the N400: evidence for an orthographic processing view

Event-related brain potentials (ERPs) were recorded during a Chinese character decision task to examine whether N400 amplitude is modulated by stimulus font. Results revealed large negative-going ERPs in an N400 time window of 300-500ms to stimuli presented in degraded Xing Kai Ti (XKT) font compared with more intact Song Ti (ST) font regardless of whether the stimuli were real or pseudo-characters. ERPs for the pseudo-characters were more negative than for the real characters with similar timing and scalp distribution. The N400-like font effect on amplitude is interpreted as analogous to an N400 stimulus degradation effect, an extension to Holcomb (1993); the degraded perceptual cues provided by XKT supposedly account for this degradation effect. This effect is further interpreted to reflect relative difficulty, which results from orthographic processing difficulty, in retrieving the meaning of XKT stimuli compared with ST stimuli.     

Chronometric analysis of apparent spotlight failure in endogenous visual orienting

Subjects made speeded responses to peripheral luminance increments or decrements preceded by informative central precues. In 4 experiments one of these stimuli was much more likely to occur than the other. In a simple detection task, the likely and unlikely stimuli showed equivalent cuing effects. In a discrimination task (bright/dim), the likely stimuli showed cuing but the unlikely one did not (spotlight failure), and there was a tendency to make the likely response when the unlikely stimulus occurred at the cued location. In Experiment 5, the 2 stimuli were equally likely, and a choice was required. Large cuing effects were observed for both stimuli with no evidence of a speed-accuracy trade-off. A logogen-activation framework is described within which criterion and sensitivity adjustments are needed to accommodate the full pattern of results. Endogenous orienting appears to enhance processing of all stimuli at attended (relative to unattended) locations, an effect that may be masked by specific stimulus or response expectancies.     

错误信息特征对学科领域知识丰富性不同学生学习的错误监控之影响

采用Go/No-Go范式,26名中学生参与实验。考察在基于主体错误反应和基于客体错误信息两类错误监控条件下,学科领域知识教学实验组和对照组对不同类型错误信息监控的脑电成分。结果显示,(1) 错误反应监控条件下,实验组对要义特征的错误反应诱发的ERN较字面特征的更负,而对照组则相反。(2) 错误信息监控条件下,两组学生均表现出监控字面特征错误诱发的ERN波幅较监控要义特征错误的更大。(3) 两种监控条件均表现出实验组产生的ERN波形较对照组的更负。表明：虽然两类监控条件均能诱发明显的ERN,但其影响因素并不相同：基于主体错误反应的监控主要受个体对其错误加工深度的影响;基于客体错误信息的监控则受错误信息的清晰性影响。     

Visual form integration and discontinuity detection

Two experiments were conducted to determine if discontinuity detection limits the visual integration of two stimuli presented successively. If this is the case, then presenting two dim stimuli should permit better integration than presenting two bright stimuli. In Experiment 1, five observers named the position of the missing dot in a 5 x 5 dot matrix. Twelve randomly selected dots were presented in each of two stimulus presentations. The stimuli varied in intensity in a ratio of 15:1 and stimulus onset asynchrony (SOA) varied between 50 msec and 80 msec. At the longer SOAs, presenting two bright stimuli led to a higher percentage of correct responses than presenting two dim stimuli. There was no difference between those conditions at the shorter SOAs. In Experiment 2, 12 naive observers rated the amount of integration of the same stimuli on a 7-point scale, under the same presentation conditions. Rated integration was higher with two dim stimuli than with two bright stimuli. These apparently contradictory results are explained in terms of Hawkins and Shulman's distinction between two kinds of visual persistence. It is concluded that subjects can respond to integration and discontinuity detection separately. No evidence was found that discontinuity detection limits the integration.