Right Prefrontal Cortex Responds to Item Familiarity During a Memory Encoding Task

In a previous word-pair encoding study (Dolan & Fletcher, 1997), we examined the effect of introducing novelty, either in studied words or in their mutual associations. A left medial temporal lobe (MTL) sensitivity to novel words and left prefrontal cortex (PFC) to novel associations was observed. In this further report on the data, we explored the extent to which the right PFC, more generally implicated in retrieval operations (Fletcher, Frith, & Rugg, 1997), was sensitive to these manipulations. Specifically, we characterised changes associated with increasing familiarity of study material. We demonstrate that the response in right ventrolateral PFC is preferentially sensitive to a condition in which all material was familiar (that is, in which all material had been presented prior to scanning). A more dorsal region in right PFC was found to be relatively more active in association with a condition in which one item in the pair was familiar but was paired with a novel associate. Our results suggest that sensitivity to stimulus familiarity is expressed in right PFC, even within the context of an encoding task. The data also provide further evidence for functional heterogeneity within right PFC, with a more ventral region responding to familiarity of complete word pairs and a more dorsal region responding to familiar single words occurring in the context of new associative relationships.     

Enhancing visual working memory encoding: The role of target novelty

Perceptual salience improves the encoding of information into visual working memory (WM). However, the factors that contribute to this facilitation effect are not well understood. This study tested the influence of target familiarity on WM encoding. In each trial, participants were presented with either one or three targets and asked to encode their locations into WM. In Experiment 1, target familiarity was manipulated by presenting either an upright (familiar target) or upside-down (unfamiliar/novel target) A. Increasing the novelty of the targets led to improved performance in the spatial WM task. Experiment 2 showed that participants were faster in responding to novel versus familiar targets in a spatial detection task. Experiment 3 demonstrated that the beneficial effect of target novelty on WM encoding was not driven by differences in low-level features. Our results suggest that target novelty enhances the processes required for WM encoding, just as it facilitates perceptual processing.     

Eye movements,word familiarity,and vocabulary acquisition

Two experiments examined the effects of word familiarity on word recognition and text comprehension during silent reading. Readers' eye movements were monitored as they read sentences containing words that varied in familiarity as assessed by printed estimates of word frequency, subjective ratings of familiarity, and a multiple‐choice test of meaning knowledge. Effects of word frequency were unaffected by differences in subjective familiarity rating for high frequency words. Differential effects of familiarity rating were observed in low frequency conditions. In addition, processing time on high and low frequency words did not differ when familiarity was held constant for moderately familiar words. Readers spent more initial processing time on novel words than familiar words. Performance on a vocabulary test administered after the reading session demonstrated that readers successfully acquired and retained new word meanings. Finally, reanalysis of word processing time as a function of vocabulary test performance demonstrated a systematic relationship between online processing patterns and memory for novel word meaning.     

Novel popout and familiar popout in a brightness discrimination task

A single novel word among several familiarized words may be localized more effectively than the familiarized words (novel popout). Early demonstrations of novel popout attributed the effect to the capture of attentional resources by novel stimuli. Christie and Klein (1995, 1996) argued that differential recollection of novel versus familiar words could alternatively account for the popout effect. In the present experiments, participants judged which of four locations contained a physically brighter word. A bright novel word was localized significantly better than a bright familiar word in one-novel/three-familiar arrays, inconsistent with a retrievability account of novel popout. However, a bright familiar word was also localized better than a bright novel word in three-novel/one-familiar arrays, inconsistent with the mismatch theory proposed by Johnston and Hawley (1994). The results suggest that familiarity and novelty provide a perceptual segregation of the odd item; superior brightness discrimination at that location may be due either to attentional capture or to locational ambiguity within the larger group.     

Positivity can cue familiarity

Given that familiarity is closely associated with positivity, the authors sought evidence for the idea that positivity would increase perceived familiarity. In Experiment 1, smiling and thus positively perceived novel faces were significantly more likely to be incorrectly judged as familiar than novel faces with neutral expressions. In Experiment 2, subliminal association with positive affect (a positively valenced prime) led to false recognition of novel words as familiar. In Experiment 3, validity judgments, known to be influenced by familiarity, were more likely to occur if participants were in happy mood states than neutral mood states. Despite their different paradigms and approaches, the results of these three studies converge on the idea that, at least under certain circumstances, the experience of positivity itself can signal familiarity, perhaps because the experience of familiarity is typically positive.     

Repetition effects for words and nonwords as indexed by event-related fMRI: a preliminary study

We have previously shown differential effects of stimulus familiarity on the repetition-related responses in right fusiform cortex to both faces and symbols. Repetition of familiar stimuli produced a response decrease, whereas repetition of unfamiliar stimuli produced a response increase. In the present experiment, we used words and nonwords as the familiar and unfamiliar stimuli respectively. In this case, the only fusiform region showing the familiarity-by-repetition interaction was in anterior left fusiform. This left-lateralisation of the fusiform interaction is consistent with our hypothesis that these repetition-related effects occur in the same regions responsible for perceptual recognition of familiar stimuli.     

The role of familiar units in perception of words and nonwords

This paper investigates the effects of familiarity with whole-word units and letter-cluster units in perceptual encoding of letter strings. Subjects viewed brief, masked presentations of words and pronounceable pseudowords differing in letter cluster frequency. Identification of both display types was compared to control single letters. Perceptual accuracy was indexed by probe forced-choice responses and full verbal reports of the displays. Evidence that familiarity of whole-word units facilitated encoding was mixed but, on balance, favorable. Evidence that familiarity of letter-cluster units facilitated encoding was completely absent. This negative finding is surprising in view of the fact that we did obtain a large advantage of letters in pseudo-words as well as words over single letters. The discussion section considers an alternative to the view that perceivers use detectors for familiar letter-cluster units in the process of forming representations of pronounceable, orthographically regular letter strings.     

The effects of environmental context on recognition memory and claims of remembering

Recognition memory for words was tested in same or different contexts using the remember/know response procedure. Context was manipulated by presenting words in different screen colors and locations and by presenting words against real-world photographs. Overall hit and false-alarm rates were higher for tests presented in an old context compared to a new context. This concordant effect was seen in both remember responses and estimates of familiarity. Similar results were found for rearranged pairings of old study contexts and targets, for study contexts that were unique or were repeated with different words, and for new picture contexts that were physically similar to old contexts. Similar results were also found when subjects focused attention on the study words, but a different pattern of results was obtained when subjects explicitly associated the study words with their picture context. The results show that subjective feelings of recollection play a role in the effects of environmental context but are likely based more on a sense of familiarity that is evoked by the context than on explicit associations between targets and their study context.     

Encoding instructions and stimulus presentation in local environmental context-dependent memory studies

Murnane and Phelps (1993) recommend word pair presentations in local environmental context (EC) studies to prevent associations being formed between successively presented items and their ECs and a consequent reduction in the EC effect. Two experiments were conducted to assess the veracity of this assumption. In Experiment 1, participants memorised single words or word pairs, or categorised them as natural or man made. Their free recall protocols were examined to assess any associations established between successively presented items. Fewest associations were observed when the item-specific encoding task (i.e., natural or man made categorisation of word referents) was applied to single words. These findings were examined further in Experiment 2, where the influence of encoding instructions and stimulus presentation on local EC dependent recognition memory was examined. Consistent with recognition dual-process signal detection model predictions and findings (e.g., Macken, 2002; Parks & Yonelinas, 2008), recollection sensitivity, but not familiarity sensitivity, was found to be local EC dependent. However, local EC dependent recognition was observed only after item-specific encoding instructions, irrespective of stimulus presentation. These findings and the existing literature suggest that the use of single word presentations and item-specific encoding enhances local EC dependent recognition.     

Mommy and me: familiar names help launch babies into speech-stream segmentation

How do infants find the words in the tangle of speech that confronts them? The present study shows that by as early as 6 months of age, infants can already exploit highly familiar words-including, but not limited to, their own names-to segment and recognize adjoining, previously unfamiliar words from fluent speech. The head-turn preference procedure was used to familiarize babies with short passages in which a novel word was preceded by a familiar or a novel name. At test, babies recognized the word that followed the familiar name, but not the word that followed the novel name. This is the youngest age at which infants have been shown capable of segmenting fluent speech. Young infants have a powerful aid available to them for cracking the speech code. Their emerging familiarity with particular words, such as their own and other people's names, can provide initial anchors in the speech stream.     

Letter detection in very familiar texts

In the present study, we investigated whether patterns of letter detection for function and content words in texts are affected by the familiarity of the material being read. In Experiment 1, subjects searched for target letters in sentences that had been rehearsed prior to performing the letter detection on them as well as on unfamiliar sentences. In Experiment 2, subjects searched for target letters in highly familiar verses (e.g., nursery rhymes) and in unfamiliar sentences that were matched to the familiar verses. A disadvantage in letter detection for function as compared with content words consistently found with unfamiliar passages was reduced significantly with the familiar material in both experiments. Specifically, letter detection for content words grew worse in familiar text, but letter detection for function words showed a contrasting modest, though nonsignificant, improvement. The results are consistent with the proposition that in very familiar texts, parafoveal analysis permits the identification of generally less familiar content words. Simultaneously, the normal pattern of weighing the structure and content elements of text changes so that more fixations on function words occur than when one is reading unfamiliar texts.     

The impact of familiarization strategies on the missing-letter effect

When reading a text and searching for a target letter, readers make more omissions of the target letter if it is embedded in frequent function words than if it is in rare content words. While word frequency effects are consistently found, few studies have examined the impacts of passage familiarity on the missing-letter effect and studies that have present conflicting evidence. The present study examines the effects of passage familiarity, as well as the impacts of passage familiarization strategy promoting surface or deep encoding, on the missing-letter effect. Participants were familiarized with a passage by retyping a text, replacing all common nouns with synonyms, or generating a text on the same topic as that of the original text, and then completed a letter search task on the familiar passage as well as an unfamiliar passage. In Experiment 1, when both familiar and unfamiliar passages use the same words, results revealed fewer omissions for the retyping and synonyms conditions. However, in Experiment 2, when different words are used in both types of texts, no effect of familiarization strategy was observed. Furthermore, the missing-letter effect is maintained in all conditions, adding support to the robustness of the effect regardless of familiarity with the text.     

Familiarity, redundancy, and the spatial control of visual attention

Highly familiar letter sequences (English words) in noncued portions of a tachistoscopic display were shown to substantially reduce accuracy of partial report. These findings suggest that in addition to facilitating character scanning, familiarity may operate in automatically directing attentional resources to a particular spatial region of a display. Such attentional capture may be disruptive if the material to be reported is presented at another location.     

Electrophysiological response during source memory decisions in older and younger adults

We recorded event-related potentials (ERPs) as individuals made source monitoring decisions in a paradigm in which the influence of item familiarity and goal relevance could be separately evaluated. Younger and older adults read a list of words and subsequently distinguished these words from foils in a running recognition test in which some foils were repeated after a lag of 6 items, creating familiar lures. Behaviorally, older and younger adults performed equally well in the recognition of study words and the rejection of singly presented foils. However, older adults were more likely to respond to the familiar lures as though they had come from the study list, thus producing the expected group difference in source-monitoring error. For younger adults the ERPs elicited by the targeted study words were maximal at posterior sites and significantly greater than those elicited by either familiar lures or foils. Older adults generated far less differentiated ERP waveforms but with a markedly greater amplitude at frontal sites. We interpret this frontal maximum in the context of poorer source monitoring as suggesting that older adults are more dependent on controlled processes to make discriminations that seem to occur much earlier and more automatically for younger adults.     

Cross-modal working memory binding and L1-L2 word learning

The ability to create temporary binding representations of information from different sources in working memory has recently been found to relate to the development of monolingual word recognition in children. The current study explored this possible relationship in an adult word-learning context. We assessed whether the relationship between cross-modal working memory binding and lexical development would be observed in the learning of associations between unfamiliar spoken words and their semantic referents, and whether it would vary across experimental conditions in first- and second-language word learning. A group of English monolinguals were recruited to learn 24 spoken disyllable Mandarin Chinese words in association with either familiar or novel objects as semantic referents. They also took a working memory task in which their ability to temporarily bind auditory-verbal and visual information was measured. Participants’ performance on this task was uniquely linked to their learning and retention of words for both novel objects and for familiar objects. This suggests that, at least for spoken language, cross-modal working memory binding might play a similar role in second language-like (i.e., learning new words for familiar objects) and in more native-like situations (i.e., learning new words for novel objects). Our findings provide new evidence for the role of cross-modal working memory binding in L1 word learning and further indicate that early stages of picture-based word learning in L2 might rely on similar cognitive processes as in L1.     

A strict response criterion yields a mirror effect in the novelty paradigm

According to the novelty/encoding hypothesis (NEH; Tulving & Kroll, 1995), efficacy of encoding information into long-term memory depends on the movelty of the information. Recognition accuracy is higher for novel than for previously familiarized material. This novelty effect is not a mirror effect: the superiority of novel over familiar items is not found in the hit rates but only in the false-alarm rates. The main result in the present replication study was that novel hit rates were higher than familiar ones when the most confident responses were examined separately, and thus a mirror effect could be demonstrated for these data, for both the low- and the high-frequency words. Similarly, the word-frequency effect on hits was stronger when a stricter response criterion was applied. It was concluded that the novelty effect and the word-frequency effect are more similar to one another than has hitherto been thought.     

Prefrontal and hippocampal contributions to visual associative recognition: interactions between cognitive control and episodic retrieval

The ability to recover episodic associations is thought to depend on medial-temporal lobe mnemonic mechanisms and frontal lobe cognitive control processes. The present study examined the neural circuitry underlying non-verbal associative retrieval, and considered the consequences of successful retrieval on cognitive control demands. Event-related fMRI data were acquired while subjects retrieved strongly or weakly associated pairs of novel visual patterns in a two-alternative forced choice associative recognition paradigm. Behaviorally, successful retrieval of strongly associated relative to weakly associated pairs was more likely to be accompanied by conscious recollection of the pair's prior co-occurrence. At the neural level, right ventrolateral prefrontal cortex (VLPFC) and hippocampus were more active during successful retrieval of Strong than of Weak associations, consistent with a role in visual associative recollection. By contrast, Weak trials elicited greater activation in right anterior cingulate cortex (ACC), which may detect conflict between the similarly familiar target and foil stimuli in the absence of recollection. Consistent with this interpretation, stronger ACC activity was associated with weaker hippocampal and stronger right dorsolateral PFC (DLPFC) responses. Thus, recollection of relevant visual associations (hippocampus and VLPFC) results in lower levels of mnemonic conflict (ACC) and decreased familiarity-based monitoring demands (DLPFC). These findings highlight the interplay between cognitive control and episodic retrieval.     

Functional asymmetry of human prefrontal cortex: encoding and retrieval of verbally and nonverbally coded information

There are several views about the organization of memory functions in the human prefrontal cortex. One view assumes a process-specific brain lateralization according to different memory subprocesses, that is, encoding and retrieval. An alternative view emphasizes content-specific lateralization of brain systems involved in memory processes. This study addresses this apparent inconsistency between process- and content-specific lateralization of brain activity by investigating the effects of verbal and nonverbal encoding on prefrontal activations during encoding and retrieval of environmental novel sounds using fMRI. An intentional memory task was applied in which subjects were required either to judge the sounds' loudness (nonverbal encoding task) or to indicate whether or not a sound can be verbally described (verbal encoding task). Retrieval processes were examined in a subsequent yes/no recognition test. In the study phase the right posterior dorsolateral prefrontal cortex (PFC) was activated in both tasks. During verbal encoding additional activation of the left dorsolateral PFC was obtained. Retrieval-related fMRI activity varied as a function of encoding task: For the nonverbal task we detected an activation focus in the right posterior dorsolateral PFC whereas an activation in the left dorsolateral PFC was observed for the verbal task. These findings indicate that the right dorsolateral PFC is engaged in encoding of auditory information irrespective of encoding task. The lateralization of PFC activity during retrieval was shown to depend on the availability of verbal codes, with left hemispheric involvement for verbally and right hemispheric activation for nonverbally coded information.     

上下文熟悉效应对元记忆监测和记忆的影响

在认知任务中,伴随编码和检索的外围信息被称为上下文,其本身并不是编码或检索的目标。如果学习时的上下文在其后进行提取时重复出现,不管是否对应之前的学习项目,都会增加个体再认正确的概率。这种由于上下文增强项目熟悉感而促进记忆效果的现象就称为上下文熟悉效应。本研究通过两个实验探究上下文熟悉效应对元记忆监测及记忆的影响机制。其中,元记忆监测是以学习判断和信心判断为指标。记忆成绩则是以再认正确率为指标。研究结果显示:第一,上下文熟悉效应影响元记忆监测:学习判断等级上,恢复条件显著高于新条件,且不受任务难度影响; 信心判断等级上,简单任务时恢复条件与新条件无显著差异,困难任务时恢复条件显著高于新条件。第二,上下文熟悉效应影响记忆成绩:再认成绩上,简单任务时新条件显著高于恢复条件; 困难任务时恢复条件显著高于新条件。研究得出结论:上下文熟悉效应对元记忆监测和记忆都有显著影响,任务难度起调节作用。     

The effects of cue distinctiveness on odor-based context-dependent memory

The distinctiveness of an ambient odor was examined in relation to its success as a cue in contextdependent memory. Distinctiveness was examined in terms of both cue novelty and contextual appropriateness. Two experiments were conducted in which three different ambient odors that varied in familiarity and contextual appropriateness were manipulated at an incidental word learning encoding session and at a free recall retrieval session 48 h later. Experiment 1 revealed that when a novel ambient odor (osmanthus) was the available context cue, word recall was better than in any other condition. Further, among familiar odor cues, recall was better with a contextually inappropriate odor (peppermint) than with a contextually appropriate odor (clean fresh pine). Experiment 2 confirmed that superior word recall with osmanthus and peppermint depended on the odor cue’s being available at both encoding and retrieval, and that the relation of an odor to the situational context is a key factor for predicting its effectiveness as a retrieval cue.