Increased novelty-induced grooming in aged rats: a preliminary observation

Age-related changes in grooming activity in female Fischer-344 rats were observed in a home cage and in a novel testing chamber for 50 min. Compared to the home cage condition with brief handling treatment, excessive grooming was found in the novel situation. The amount of novelty-induced grooming of aged rats (26-28 months) was about two times that of young animals (6-8 months). This increase in novelty-induced grooming of aged animals was attributable to an increase in the number of grooming bouts, prolongation of each grooming bout, and a slight increase in the duration of licking elements. However, there were no age differences in the percentage of face washing and the duration of face-washing elements. These results are discussed in terms of behavioral aging and age-related changes in peptidergic pathways in the brain.     

《易》象与《诗》象:论《周易》的类艺术表现方式

文章从符号学角度,通过《诗》《易》比较,论述了《周易》的类艺术特征。在构成符号的综合性上,在篇章的结构、句式词语的使用上,在物象选择与深层意蕴上,《易》和《诗》具有异质同构的关系。后世艺术作品中出现的同类意象,其原型可溯到《诗》,更可求诸《易》。     

Clinicians’ Attitudes Toward Therapeutic Alliance in E-Therapy

Although therapeutic alliance is a crucial factor in face-to-face therapies, no data exist on clinicians’ attitudes towards alliance in E-therapy. The study explored clinicians’ perceived importance of alliance in E-therapy, clinicians’ confidence in their skills to develop alliance in E-therapy, and whether attitudes towards alliance in E-therapy are associated with intended E-therapy practice. Clinicians (n = 106) responded to an online survey. The majority of clinicians considered alliance to be extremely important in both face-to-face therapy and E-therapy. However, clinicians’ ratings of the importance of alliance in face-to-face therapies were significantly higher than their ratings of the importance of alliance in E-therapy. Clinicians reported less confidence in their skills to develop alliance in E-therapy than in face-to-face therapy. Intended E-therapy practice correlated with confidence in one's ability to develop alliance in E-therapy and with previous E-therapy practice.     

Strategies for visual word recognition and orthographical depth: a multilingual comparison

We investigated the psychological reality of the concept of orthographical depth and its influence on visual word recognition by examining naming performance in Hebrew, English, and Serbo-Croatian. We ran three sets of experiments in which we used native speakers and identical experimental methods in each language. Experiment 1 revealed that the lexical status of the stimulus (high-frequency words, low-frequency words, and nonwords) significantly affected naming in Hebrew (the deepest of the three orthographies). This effect was only moderate in English and nonsignificant in Serbo-Croatian (the shallowest of the three orthographies). Moreover, only in Hebrew did lexical status have similar effects on naming and lexical decision performance. Experiment 2 revealed that semantic priming effects in naming were larger in Hebrew than in English and completely absent in Serbo-Croatian. Experiment 3 revealed that a large proportion of nonlexical tokens (nonwords) in the stimulus list affects naming words in Hebrew and in English, but not in Serbo-Croatian. These results were interpreted as strong support for the orthographical depth hypothesis and suggest, in general, that in shallow orthographies phonology is generated directly from print, whereas in deep orthographies phonology is derived from the internal lexicon.     

The putative role of free radicals in the loss of neuronal functioning in senescence

One of the hallmarks of the aging process is a loss of sensitivity in central neuronal receptors to agonist stimulation. This appears to be especially true in central (hippocampal, striatal) muscarinic cholinergic systems and in the striatal dopamine systems. For these two systems, any decline in their sensitivity can be of extreme importance in determining the behavioral capabilities of the organism. Decrements in the striatal dopamine system may be reflected as motor behavioral deficits, while the central cholinergic systems play a major role in the processing of memory through the activation of muscarinic receptors (mAChR). Declines in the function of these receptors appear to be at least partially responsible for the marked deterioration of cognitive function in normal aging and, more notably, in Alzheimer’s disease (AD). Previous work has indicated only minimal success in improving performance in tasks that assess memory in senescent animals or humans with pharmacological agents which enhance cholinergic functioning. The present review describes research that indicates that two of the factors involved in this decline in receptor sensitivity include: (a) decreased receptor concentrations and (b) age-related decrements in signal transduction pathways. Studies are reviewed that indicate that the oxidative neural damage that occurs via kainic acid or ionizing radiation parallel those seen in aging. It is suggested that the common mechanism that may exist among all of the age-, disease-, excitatory amino acid- or radiation-induced deficits in neuronal transmission may involve free-radical-mediated alterations in membrane integrity through lipid peroxidation.     

1996-2004年中国大陆儒学研究的新进展

1996-2004年,中国大陆的孔子、儒学研究持续繁荣发展,在以下八个方面上,取得了新的进展: (1)儒学与世界和平; ( 2 )儒家人文精神; ( 3 )简帛儒家文献; ( 4 )儒学宗教性问题; (5)儒学与生态伦理; (6)儒学与普世伦理; (7)儒学与文化保守主义; (8)儒学与自由主义; (9)儒学与民主、人权; (10)儒学与全球化。     

Divided attention, aging, and priming in exemplar generation and category verification

Transfer-appropriate processing theories differentiate between conceptual- and perceptual-priming tasks. The former are said to be influenced by the nature of processing engaged in at study, but not by changes in modality between study and test; the latter are sensitive to changes in format between study and test, but not to variations in the extent of semantic processing at study. In the present experiments, we examined the effects of divided attention and aging on priming in exemplar generation and category verification, two tasks that require access to semantic information at test. Manipulations of attention during encoding affected the extent of priming in exemplar generation, but not in category verification. Priming effects were similar in young and older adults in exemplar generation following study in both full and divided attention. Although older adults did not demonstrate priming in category verification in one experiment, no effects of age or divided attention were observed in a second experiment. In addition, priming in category verification was unaffected by varying the level of processing at encoding. However, the absence of levels-of-processing and attention effects in category verification does not signal that priming in this task has a perceptual basis; priming in category verification was insensitive to modality shifts between study and test. The implications of these findings for theories of priming and cognitive aging are considered.     

Psychological abstracts and German-language psychology

The preparation of the present report was motivated by concern over the continuing reduction of the coverage of psychological materials published in German, and a complete cessation of the coverage in Psychological Abstracts (PA) in 1988. This report covers the following points: (1) The share of German Psychologists in the prehistory of PA; (2) Membership in the editorial board of PA; (3) Cessation of the coverage of books in PA; (4) German-language materials abstracted in PA; and (5) German-language materials in the database of the American Psychological Association in the years 1987-1989. Two addenda inform about citation of (6) German-language publications in early American journals and (7) the changing role of the German Journal of Psychology.     

What is the nature of increased Stroop interference in schizophrenia?

In comparison to controls, patients with schizophrenia classically display (1) an overall slowing in response times (RTs) and (2) a disproportionate slowing in RTs in the conflict condition of the Stroop color/word interference task. These two effects appear repeatedly in the card version of the Stroop task but were not replicated in a number of studies using a computer item-by-item version of the task. The present study was aimed at understanding the exact nature of the increased interference classically found in the performance of patients with schizophrenia in the card version of the Stroop task. We used a computer trial-by-trial version in which we investigated the effects of two major methodological differences between the two versions: (1) blocked (card version) versus mixed (computer version) presentation of the neutral, congruent and conflict conditions and (2) presence (card version) versus absence (computer version) of distractors in the spatial surrounding of the target. We found an overall slowing in performance and a disproportionate slowing in the conflict condition for patients with schizophrenia but only when the target was surrounded by distractors (in Experiments 2 and 3). The data are discussed in terms of a deficit in selective attention and inhibitory processes in schizophrenia.     

The effects of neonatal gonadectomy and prenatal stress on cortical thickness and asymmetry in rats

In Study I measures of cortical thickness were taken in 90-day-old male and female Sprague-Dawley, Wistar, and Long-Evans rats that were born to pregnant females shipped to the laboratory in late pregnancy and that were either gonadectomized at birth or left intact. No evidence for hemispheric differences in cortical thickness was found in any of the groups. Gonadectomy resulted in increased cortical thickness in male Sprague-Dawley and Wistar rats and in small increases in thickness of the left hemisphere in Long-Evans rats, especially males. No effects of gonadectomy were found in females of any strain. The lack of the expected right-over-left difference in cortical thickness in intact males may have been due to prenatal stress caused by housing, handling, and shipping. In Study 2 measures of cortical thickness were taken in 90-day-old male and female Sprague-Dawley rats that were bred in our laboratory, but otherwise similarly treated at birth. In this second study, the expected right-over-left hemispheric difference in cortical thickness was found in intact male rats; none was found in gonadectomized males or in either of the female groups. The lack of asymmetry in gonadectomized males appeared to be due to an increase in thickness in the left hemisphere. Taken together these studies provide support for the idea that hormones of testicular origin suppress cortical enlargement in the perinatal period, particularly in the left hemisphere.     

Learning from the patient: The East,synchronicity and transference in the history of an unknown case of C.G. Jung

This article presents the history of one until now unknown case of C.G. Jung: Maggy Reichstein. Born in Indonesia in 1894 in a very aristocratic family, she brought her sister to Zurich to be treated by Jung in 1919, and later she herself was in analysis with him. Jung used her case as example in his lecture in 1937 on the realities of practical psychotherapy, relating it to the process of transference and countertransference. Jung deepened his studies in Eastern psychology after a series of dreams she had, which culminated in the Yoga Kundalini Seminars. She was also the case presented in his article of 1951 on the concept of synchronicity. Jung wrote that her case, concerning synchronicity, remained unique in his experience. Jung also published some of her mandalas. He considered her able to understand his ideas in depth. Reichstein was for Jung an important case, which challenged and triggered his interests in different subjects.     

Bertrand Russell and the introduction of mathematical logic in China

Bertrand Russell was one of the most prominent figures in the formation and development of mathematical logic. It is widely acknowledged that his work in this field exerted tremendous influence in the West, especially in the first three decades of the twentieth century. The important role he played in inspiring Chinese interest in this subject, however, is virtually unknown. This paper describes Russell's contributions to the introduction of mathematical logic in China through a discussion of his lectures in Beijing in March of 1921, and the subsequent Chinese translations of his Introduction to Mathematical Philosophy and Principia Mathematica.     

A central circuit of the mind

The methodologies of cognitive architectures and functional magnetic resonance imaging can mutually inform each other. For example, four modules of the ACT-R (adaptive control of thought - rational) cognitive architecture have been associated with four brain regions that are active in complex tasks. Activity in a lateral inferior prefrontal region reflects retrieval of information in a declarative module; activity in a posterior parietal region reflects changes to problem representations in an imaginal module; activity in the anterior cingulate cortex reflects the updates of control information in a goal module; and activity in the caudate nucleus reflects execution of productions in a procedural module. Differential patterns of activation in such central regions can reveal the time course of different components of complex cognition.     

Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory

Although much has been learned about the role of the amygdala in Pavlovian fear conditioning, relatively little is known about an involvement of this structure in more complex aversive learning, such as acquisition of an active avoidance reaction. In the present study, rats with a pretraining injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, 2-amino-5-phosphonopentanoic acid (APV), into the basolateral amygdala (BLA) were found to be impaired in two-way active avoidance learning. During multitrial training in a shuttle box, the APV-injected rats were not different from the controls in sensitivity to shock or in acquisition of freezing to contextual cues. However, APV injection led to impaired retention of contextual fear when tested 48 h later, along with an attenuation of c-Fos expression in the amygdala. These results are consistent with the role of NMDA receptors of the BLA in long-term memory of fear, previously documented in Pavlovian conditioning paradigms. The APV-induced impairment in the active avoidance learning coincided with deficits in directionality of the escape reaction and in attention to conditioned stimuli. These data indicate that normal functioning of NMDA receptors in the basolateral amygdala is required during acquisition of adaptive instrumental responses in a shuttle box but is not necessary for acquisition of short-term contextual fear in this situation.     

Stimulus context and duration discrimination

The ability of human observers to discriminate duration was assessed in two types of tasks: (1) pulse tasks, in which the observer compared the duration of two brief increments in an ongoing sinusoid, and (2) gap tasks, in which the observer compared the duration of two brief interruptions in an ongoing sinusoid. Performance in these tasks was assessed in three different contexts: noise alone, noise plus continuous sinusoids, and noise plus continuous sinusoids chosen to induce a pitch segregation effect. Performance in the pulse task was independent of the changes in context; however, performance in the gap task changed as a function of context condition. There was a large decrement in the observers’ ability to discriminate duration when the stimulus ensemble induced the pitch segregation effect. The results are discussed in terms of the relationship between duration discrimination and stimulus variations which do not carry duration information.     

材料模式与认知负荷对小学生类比学习的影响

探讨学习材料不同模式和学习过程不同的认知负荷对小学生类比推理学习迁移的影响.包括两个分实验.实验1探讨学习材料的不同组织模式对小学生类比推理学习迁移的影响,两组小学生分别学习模式化与非模式化的材料,然后完成迁移程度远近不同的四类测题.结果表明,非模式化条件下完成远迁移题目的成绩显著优于模式化条件下的成绩.实验2探讨小学生在不同认知负荷条件下类比推理学习的迁移效果,两组小学生分别在高认知负荷与低认知负荷情况下学习类比推理的材料,然后完成上述四类测题.结果表明,高认知负荷条件下完成远迁移题目的成绩显著优于低认知负荷条件下的成绩.本实验结果表明,对于小学生类比推理的学习来说,非模式化、高负荷的学习更有利于促进迁移,支持了积极反应理论.     

Changes in excitability in motor cortex (representation of foreleg) of the dog depending on signal signification of flexor reaction during elaboration of trans switching

Excitability in a cortical representation of a foreleg was determined during elaboration of transswitching in dogs in three variations depending upon the stimulus used as a Conditioned stimulus (CS). If the flexor reaction to direct stimulation of the motor cortex was used as a CS, excitability changes of opposite signs appeared in the cortical representation of the foreleg, the threshold of flexion decreased in the alimentary situation and increased in the defense situation. Such changes in excitability were observed during instrumental conditioned transswitching. If subthreshold stimulation of the motor cortex was used as the CS, the threshold of flexion increased in both situations in approximately equal degree.     

Attention in Children: Conceptual and Methodological Issues

This commentary discusses conceptual and methodological issues in the assessment of attention in children. The five articles in this special issue are important advances in the study of attention in children with brain-related disorders. They provide important guidelines for future studies in this area: specification of the underlying model of attention, selection of tasks according to the model, and the use of multiple tasks in well-defined clinical populations.