Effects of ketamine on tunnel maze and water maze performance in the rat

The NMDA receptor, which has been implicated in memory formation, is noncompetitively blocked by ketamine. The present study examines the effect of ketamine (0, 3, 6, 12, and 25 mg/kg body wt; ip) on tunnel maze and water maze performance in Wistar rats. In the hexagonal tunnel maze (HTM) high doses of ketamine (12 and 25 mg/kg) decreased locomotor activity. Moreover, ketamine induced perimeter walking (6, 12, and 25 mg/kg) and attenuated exploratory efficiency (25 mg/kg). When the HTM was converted into a modified six-arm radial maze, ketamine impaired short-term but not long-term memory. In the Morris water maze, rats injected with ketamine (12 and 25 mg/kg) acquired a spatial navigation task more slowly than controls. When the escape platform was removed, the drug-treated rats did not preferentially search for it in the area where the platform had been during the acquisition phase. However, when the escape platform was visible, no differences in the performance of ketamine-treated and control rats could be found. In summary, ketamine seems to attenuate some but not all forms of learning in the tunnel maze and it impairs the acquisition of a spatial navigation task.     

The concurrent reinforcement of two interresponse times: the relative frequency of an interresponse time equals its relative harmonic length

The relative lengths of two concurrently reinforced interresponse times were varied in an experiment in which three pigeons obtained food by pecking on a single key. Visual discriminative stimuli accompanied the two time intervals in which reinforcements were scheduled according to a one-minute variable-interval. The steady-state relative frequency of an interresponse time approximately equalled the complement of its relative length, that is, its relative harmonic length. Thus, lengths of interresponse times and delays of reinforcement have the same effect on the relative frequencies of interresponse times and choices in one-key and two-key concurrent variable-interval schedules, respectively. A second experiment generalized further the functional equivalence between the effects of these one-key and two-key concurrent schedules by revealing that the usual matching-to-relative-immediacy in two-key concurrent schedules is undisturbed if reinforcement depends upon the occurrence of a response at the end of the delay interval, as it does in the one-key schedules. The results of both experiments are consistent with a quantitative theory of concurrent operant behavior.     

The effects of test anxiety, sex of subject, and type of verbal reinforcement on maze performance of elementary school children

The purpose of this study was to account for children's performance in an educational setting by evaluating individual difference factors and the subjects' differential responsivities to social reinforcement The child subjects performed on Porteus mazes, which were viewed as complex, stress-inducing tasks They were differentiated in terms of sex and test anxiety levels. Each child received the same number of noncontingent reinforcements, which consisted of either verbal praise or verbal criticism or no feedback The data yielded significant triple interaction effects among anxiety, sex, and social reinforcement for the time and error scores on the mazes The data were discussed in terms of their implications for remediating performance in educational settings and their support for the theoretical conception of test anxiety as a chronic drive state The authors concluded that the extrinsic, motivating effects of verbal reinforcement can be reasonably characterized, but only if one attends to individual differences among those subjects being reinforced.