Genetic and environmental structure of Cloninger's temperament and character dimensions

The multivariate genetic and environmental structure of Cloninger's Temperament and Character Inventory (TCI) was investigated in a sample of 617 pairs of adolescent and young adult twins from Japan. Additive genetic factors accounted for 22% to 49% of the variability on all TCI temperament scales. Although the theory predicts lower heritability for the character scales, all character subscales had a substantial genetic contribution, and nonshared environmental influences accounted for the remainder. Multivariate genetic analyses showed that several subscales used to define one dimension shared a common genetic basis with subscales defining others. Using the degree of shared genetic influence as the basis to rearrange the TCI subscales into new dimensions, it was possible to create genetically independent scales. The implications for personality measurement, theory, and molecular genetic research are discussed.     

The effect of inpatient cognitive-behavioral therapy for eating disorders on temperament and character

Personality traits seem to have an important role in the development, clinical expression, course, and treatment response in eating disorders (EDs). We investigated the effects of an inpatient cognitive-behavioral treatment (CBT) on the measures of temperament and character (Temperament and Character Inventory (TCI)) in 149 consecutive patients with EDs. Baseline assessment included anthropometry, the Eating Disorder Examination (EDE), the Beck Depression Inventory (BDI), and the TCI. Treatment was based on the transdiagnostic cognitive behavior theory and treatment of ED, adapted for an inpatient setting. Treatment effects were tested by paired ANOVA, adjusted for covariates. No effects were found on Novelty Seeking, Reward Dependence, and Cooperativeness. Harm Avoidance (F=18.17, p<0.001), Persistence (F=7.71, p=0.006), Self-Directedness (F=27.55, p<0.001), and Self Transcendence (F=16.38, p<0.001) significantly changed after treatment. Changes in TCI scores were wholly dependent on the changes in BDI and EDE, and independent of ED diagnosis and behavior and of BMI changes. We conclude that in ED, a few scales of both temperament and character are significantly modified by CBT, in relation to changes in psychopathology and depression, independently of nutrition. These results are relevant for future studies based on TCI.     

Fatigue: relationships with basic personality and temperament dimensions

This study examined the relationships between the Five-Factor-Model (FFM) personality dimensions (Extraversion, Agreeableness, Conscientiousness, Emotional Stability, Openness/Autonomy), the Pavlovian temperament variables (Strength of Excitation, Strength of Inhibition, Mobility), and fatigue. We expected that all these person characteristics would be negatively associated with fatigue. In a survey among persons working at least 20 h a week (N=765), respondents completed a personality questionnaire (the Five-Factor Personality Inventory), a temperament scale (the Pavlov Temperament Survey), and two fatigue questionnaires (the Checklist Individual Strength-20 and the Emotional Exhaustion scale of the Maslach Burnout Inventory). Results indicated that high scores on Autonomy, and low scores on Extraversion, Conscientiousness, Emotional Stability, and Strength of Excitation were, in various combinations, predictors of higher fatigue scores. Agreeableness, Strength of Inhibition, and Mobility did not play a role in the prediction of any fatigue score. In conclusion, personality and temperament dimensions explained significant proportions of the variance in fatigue. It is stated that there is an urgent need for longitudinal studies in order to examine the predictive value of the personality dimensions over time.     

The genetic structure of Cloninger's seven-factor model of temperament and character in a Japanese sample

Theoretical assumptions regarding the genetic and environmental structure of personality proposed in Cloninger's seven-factor model of temperament and character were verified in a Japanese sample by using the twin method. The Temperament and Character Inventory (TCI) was administered to 296 twin pairs ranging in age from 14 to 28 years old. Among four temperament dimensions (novelty seeking [NS], harm avoidance [HA], reward dependence [RD], and persistence [PS]), HA and PS showed significant additive genetic contributions and no shared environmental effect, supporting the original theoretical assumption. NS and RD could be explained by either genetic or shared environmental factors with nonshared environment. All three character dimensions (cooperativeness [CO], self-directedness [SD], and self-transcendence [ST]) could be explained exclusively by additive contributions and no shared environmental effect. Multivariate genetic analysis indicated that there were no significant associations between NS, HA, and RD, as the theory predicts, and the genetic components of PS, SD, and CO were derived from those of the temperament dimensions. The fourth genetic component, which had a substantial load specifically on ST and overlapped with PS, was identified. Although most of the nonshared environmental effects were trait-specific, the phenotypic correlation between NS and HA could be explained by nonshared environmental overlap.     

The association between low socioeconomic status and depressive symptoms depends on temperament and personality traits

Socioeconomic status and personality traits are known to be associated with depression risk. We examined whether temperament and personality traits modified the association between socioeconomic status and depressive symptoms. The participants were 2678 individuals from the Cardiovascular Risk in Young Finns study, aged 18-49 during the three study waves in 1997, 2001, and 2007 included in the present study. Temperament was assessed with the Temperament and Character Inventory, personality with the Five Factor Model, and depressive symptoms with a modified version of Beck’s Depression Inventory. Education, occupational status, and income level were used as indicators of socioeconomic status. Results of multilevel linear regression analysis indicated that low occupational status and income were associated with high depressive symptoms particularly in individuals with high neuroticism or harm avoidance, and with low extraversion or reward dependence. High persistence also strengthened the negative association between income and depressive symptoms, but this interaction effect was not observed with conscientiousness. The mental health risks of low socioeconomic status may therefore be most potent among individuals who are sensitive to negative and threatening stimuli.     

Bidirectional pathways between relational aggression and temperament from late childhood to adolescence

Relational aggression is linked to numerous adverse consequences. However, we know little about how temperament leads individuals to become perpetrators/victims of relational aggression, or how being a perpetrator/victim influences the development of temperament. We used longitudinal data from 674 Mexican-origin youth to examine relations between relational aggression and mother- and child-reported temperament from 5th grade (M_age = 10.8; SD = 0.60) through 11th grade (M_age = 16.8; SD = 0.50). Results show that: (a) high Negative Emotionality and low Effortful Control predicted increases in victimization; (b) low Effortful Control predicted increases in perpetration; (c) victims increased in Negative Emotionality and decreased in Effortful Control; and (d) perpetrators increased in Negative Emotionality and Surgency. Thus, temperament serves as both an antecedent to and a consequence of relational aggression.     

Relationships between regulatory temperament dimensions and self-regulatory behaviors at 4 and 6 months of age

The present study focused on relationships between temperament and behavior in early regulation development. Unlike most studies on the topic, we observed infant behavior in a naturalistic playful situation rather than in experimental stressful procedure, and employed temperament measures uniquely reflecting regulatory dispositions rather than a global measure of reactivity. The infant's self-regulatory behaviors were observed at 4 and 6 months during face-to-face interactions and regulatory dimensions were assessed at 4 months. We found that low intensity pleasure and soothability dimensions, related to the infant physical and social experience, respectively, significantly affected regulatory behavior and their influence showed to depend on the infant's age, with the former dimension being influential at the earlier age and the latter being influential when the behavior was observed at the later age. Results are interpreted on the light of a dynamic view of regulation development.     

Aggregate temperament scores from multiple countries: Associations with aggregate personality traits,cultural dimensions,and allelic frequency

Aggregate temperament scores were calculated across 17 studies for 18 countries. These scores were analyzed in relation to aggregate personality scores, cultural orientation, and allelic distribution reported in prior studies. Cross-culture patterns were largely consistent with those previously reported for personality: countries high on Surgency (SUR) were high on Extraversion, high Negative Affectivity (NEG) was consistent with Neuroticism, and Regulatory Capacity (RC) with Agreeableness. Regarding cultural orientation, aggregate SUR was associated with low Power Distance and Long-Term Orientation; NEG with low Individualism and high Masculinity and Uncertainty Avoidance; and RC with low Power Distance and Masculinity. Higher proportion of MAOA-uVNTR low expression alleles was associated with low SUR and low RC; and A118G G-form allele proportion with low RC.     

The relationship between temperamental dimensions and inhibitory control in early childhood: Implications for language acquisition

The present study investigates the latent organization of inhibitory control in children aged between 2;3 and 3;0 years. In addition, it explores the relationships between temperament dimensions - social orientation, motor activity, and attention -, inhibitory control and language. One-hundred-twelve typically developing children were evaluated with tasks for inhibitory control and lexical skills, while ratings of temperament and language were collected from their caregivers. A Confirmatory Factor Analysis reveals that inhibitory control seems to be best described by a unitary dimension. A Structural Equation Model suggests that 78 % of the variance in vocabulary is explained by a model considering the language observed measures, the three temperamental dimensions, and inhibitory control and in which both temperamental attention and the latent dimension of inhibitory control are significantly related to vocabulary. In addition, inhibitory control does not mediate the relationship between temperament and language.     

The role of temperament traits as predictors of depressive symptoms and resilience in adolescents

From the initial sample of 956 adolescents from the Basque Country (Spain), 790 (M_age = 14.56, 49.4% girls) completed at least two waves including Wave 1 (retention rate: 82.6%), analyzing temperament traits as longitudinal predictors of depression and resilience. Positive affectivity (PA) predicted decreased depression and increased resilience, while negative affectivity (NA) had the opposite effect, and effortful control (EC) predicted reduced depression. Results indicated that PA protects adolescents who are low in EC against depression. In contrast, high EC levels worsened the damaging effect of NA on depression. Resilience and depression were bidirectionally associated and mediated the effects of temperament traits. Findings highlight the need to consider the effect of the complex interplays between temperament traits on resilience and depression improvement.     

International comparison of Cloninger’s temperament dimensions

Cloninger’s Tridimensional Personality Questionnaire (TPQ) and Temperament and Character Inventory (TCI) have been developed to measure the following temperament dimensions: novelty seeking (NS), harm avoidance (HA), reward dependence (RD) and persistence (P). We used our previous Finnish normative study of the TPQ and TCI (Miettunen et al., 2004) to estimate correction coefficients to convert TPQ scales to comparable TCI scales. Our aim was to compare these corrected temperament dimension scores across 20 countries adjusting for study sample differences in age and gender. In all, some variations were found in these temperament scores between countries. Differences were especially apparent between the Asian and the Western countries. By far the lowest mean score of the RD was in Japan (11.2 vs. 15.4 for other countries; effect size Cohen’s d = −5.74; z-test p < 0.001) and the highest mean score in P was in USA (5.5 vs. 4.4; d = 4.24, p = 0.001). Some of the findings could be explained by sample differences (e.g. age and education); while some may reflect real differences in the ways which personality is related to cultural factors, such as individualism/collectivism. These differences should be considered when interpreting studies with data on TPQ/TCI from different countries.     

The longitudinal associations between temperament and sleep during the first year of life

Temperament and sleep in infants are related but also distinct concepts. The longitudinal effects of temperament on sleep in infancy remain unclear, although this information is potentially important for the prevention and treatment of early sleep problems. We examined how various temperament features influence sleep development during the first year of life in a large birth cohort. This study comprised mother-infant dyads with complete longitudinal data on sleep, temperament and sociodemographic measurements at six and 12 months (N = 1436). We observed that higher infant Negative Affectivity was related to several sleep problems, and that many subscales of Negative Affectivity and Orienting/Regulation predicted worse sleep and deterioration in sleep problems from six to 12 months. Few associations between Surgency and sleep were found. Our findings highlight especially Negative Affectivity as a risk factor for persistent and increasing sleep problems, and also the specific importance of the fine-grained aspects of temperament in predicting infant sleep development.     

General and supplementary factors of personality in genetic and environmental correlation matrices

Genetic and environmental correlation matrices among 7 personality scales were estimated, using samples of adult and young adult twins from Australia (2081 and 1178 pairs, respectively). A general factor of personality and two supplemental factors were obtained in each. The supplemental factors were tentatively identified as Social conformity and Other-dependence. Factors from the genetic and environmental correlations replicated well across samples, and they were similar in both the genetic and environmental covariation. It was concluded that the structure of personality is inherent in the evolved phenotype, and is not the immediate consequence of either genetic or environmental organizing factors.     

Getting to the heart of personality in early childhood: Cardiac electrophysiology and stability of temperament

Can detection of highly stable individual differences in temperament in early childhood be enhanced using measures of resting heart rate (HR) and respiratory sinus arrhythmia (RSA)? The current longitudinal study (N = 216, 50% female; two to four years old) tested the statistical moderating effects of longitudinal change in resting HR and RSA on stability of mother-rated temperament. Children with the smallest decreases in resting HR and smallest increases in resting RSA had the most stable individual differences in effortful control. In contrast, those with the largest increases in resting RSA had the most stable individual differences in surgency. Including information on HR and RSA can be useful, though the effects depend on the trait and physiological indicator in question.     

The association between temperament and depressive symptoms in adolescence: Brooding and reflection as potential mediators

This study examined whether rumination subtypes (brooding and reflection) mediated prospective associations between temperament (negative emotionality and positive emotionality) and depressive symptoms in a community sample of 423 adolescents. Effortful control and sex were examined as potential moderators of the mediated pathway. Youth self-reported negative emotionality (NE), positive emotionality (PE), and effortful control (EC) at age 12; brooding and reflection subtypes of rumination at age 14; and depressive symptoms at ages 12, 14, and 15. Hierarchical linear regression analyses indicated that, controlling for initial levels of depressive symptoms, high NE, but not low PE, predicted increases in depressive symptoms from age 12 to age 15. Brooding, but not reflection, mediated the association between NE and depressive symptoms. Neither sex nor EC moderated either indirect pathway in the mediated model. The results confirm and extend previous findings on the association between affective and cognitive vulnerability factors in predicting depressive symptoms in adolescence.     

A behavior genetic analysis of personality and loneliness

The phenotypic, genetic, and environmental correlations between the Big Five factors of personality and loneliness were examined. At the phenotypic level, loneliness had a strong significant positive correlation with neuroticism, significant moderate negative correlations with agreeableness, conscientiousness, and extraversion, and a small positive correlation with openness. Both loneliness and personality were found to be heritable. Bivariate genetic analyses resulted in significant positive genetic correlations between loneliness and neuroticism and openness, and significant negative genetic correlations with agreeableness, conscientiousness, and extraversion. Significant unique environment correlations were found between loneliness and four of the five personality factors (all negative except neuroticism) and a non-significant correlation with openness. The results suggest common genetic and unique environmental factors play a role in personality and loneliness.     

Stress-sensitivity and reciprocal associations between stressful events and adolescent temperament

This study aimed to elucidate the longitudinal, bidirectional associations between stressful life events (SLEs) and adolescent temperament. Subsequently, the study investigated whether the effects of SLEs on future temperament were moderated by (a) a cumulative sensitivity gene index (b) the 5-HTTLPR (the polymorphism most consistently indicated as a sensitivity genotype) and (c) pre/perinatal risk. Data were used from TRAILS, a large population cohort of Dutch adolescents (n = 1475). Temperament was assessed at 11, 16 and 19 years. Data of SLEs that occurred between age 0–11, 11–16, and 16–19 were captured using interviews. The results indicated that SLEs and temperament traits are associated from childhood to adolescence and that the direction of the effects differed between temperament traits. Whereas SLEs were found to predict subsequent fear, SLEs were predicted by, but not predictive of, shyness and affiliation. For effortful control and frustration a fully reciprocal model was found. The cumulative sensitivity gene index, 5-HTTLPR and the pre/perinatal risk did not moderate the effects of SLEs on future temperament.     

Emergence of temperament in the neonate: neonates who cry longer during their first bath still cry longer at their next bathings

We observed that neonates who cried during bathing on day 2 still cried on days 3 and 4. The correlation coefficient, for example, between day 2 and day 3 was r = 0.410, p < 0.001, n = 100. Neonates may already have a distinct temperament (withdrawal and adaptability) as early as day 2 after birth.     

Differences in infant temperament between Chile and the US

Temperament refers to individual differences in reactivity and self-regulation and is influenced by genetic and experiential variation and maturation. Temperament reflects biologically based individual differences that emerge in early life and remain relatively stable thereafter. Given the growing interest in cultural variation in infant temperament, this study examined the temperament of 12-month-old children in Chile and the US. The aims were to validate a version of the Infant Behavior Questionnaire – Revised – Very Short Form in Spanish for Chile and to compare Chilean and US infants’ temperament. For the first aim, 150 Chilean infants aged 10–15 months were assessed, and 73 US infants aged 10–15 months were examined for the second aim. The children’s parents completed a demographic questionnaire and the IBQ-R-VSF, which measures three dimensions of temperament: Surgency, Negative Affectivity, and Effortful Control. The reliability of each dimension for the Chilean sample was between 0.70 and 0.75, and significant differences between Chilean and US infants emerged. Parents of Chilean infants reported higher levels of Effortful Control, whereas US parents reported that their infants exhibited higher levels of Negative Affectivity. A relationship between parents’ higher educational level and infants’ higher levels of Surgency was found for both countries. No gender or age differences were observed for any of the three temperament dimensions. These results and their implications for cultural studies are discussed.     

气质与眼动控制的关系

本研究采用眼动追踪和问卷测量相结合的方法,对气质类型和眼动控制的关系进行了探讨。眼动实验为2（眼跳方向：朝向眼跳和反向眼跳）X 2（任务类型：重复眼跳和转换眼跳）组内设计;气质分数用陈会昌编制的《气质类型测试量表》测量。结果表明,气质分数与眼动特性之间存在显著的相关性,不同气质类型（神经活动类型）在抑制过程和任务重置过程中表现出不同的相互作用模式。具体而言,神经活动强度是一个基本维度,它与认知控制的抑制功能和转换功能都有着密切联系;而神经活动的灵活性和平衡性则分别是转换功能和抑制功能的重要条件。