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1.
Life-long environmental enrichment differentially affects the mnemonic response to estrogen in young, middle-aged, and aged female mice 总被引:2,自引:0,他引:2
The present study was designed to examine whether life-long exposure to standard or enriched housing affects the ability of estrogen to improve spatial and object memory throughout the lifespan. Three-week-old female mice were maintained in standard or enriched housing up to and through ovariectomy and behavioral testing at 5, 17, or 22 months of age. Spatial memory was tested in the Morris water maze and object memory was tested using an object recognition task. Immediately after training each day, mice were injected intraperitoneally with vehicle or 0.2 mg/kg 17beta-estradiol. Among young females, object recognition was enhanced by estradiol alone, an effect that was reduced by enrichment. In contrast, spatial water maze performance was impaired by estradiol alone, but improved by the combination of both estradiol and enrichment. At middle-age, object recognition was enhanced by estradiol or enrichment alone, and the combination of both treatments. Spatial memory in the water maze was also improved by both treatments at middle-age, but the beneficial effects of estradiol were limited to standard-housed females. Finally, whereas enrichment in aged females significantly enhanced performance in both tasks, estradiol had no effect at this age in either task. In total, the data indicate that life-long enrichment can significantly alter the extent to which estradiol affects memory in mice throughout the lifespan. Importantly, the interaction between these treatments is highly dependent on age and type of memory tested. 相似文献
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In a follow-up study, teacher ratings of behaviour at 13 years of age were analysed in relation to personality factors in adults (mean age 27 years) for a group of 77 male and 84 female subjects. In the male group, ratings of Aggressiveness, Motor Restlessness, and Concentration Dificulties correlated positively with a broad psychopathy-related factor. Furthermore, ratings of Timidity correlated positively with two anxiety factors. In the female group, ratings of Motor Restlessness correlated positively with an extraversion factor. The rated childhood behaviours and the adult personality factors were assumed to be a differential reflection of vulnerability to externalizing and internalizing psychosocial disturbances. 相似文献
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The capacity of prenatal stress to disrupt the placental transfer of maternal antibody was evaluated in neonatal squirrel monkeys (Saimiri boliviensis peruviensis) gestated under different pregnancy conditions. Normal squirrel monkey offspring (n = 63) were compared with infants generated from pregnancies that involved either a single or 3 periods of disturbance (ns = 21 and 29, respectively). At parturition, levels of antibody (IgG) were determined in mothers and neonates. Only the chronic disturbance condition significantly altered antibody levels in the mothers, resulting in lower IgG. Antibody transfer to the fetus was also affected only by chronic disturbance. In this case the effect was bidirectional, influenced by the sex of the infant. Males were born with lower levels, whereas female infants actually had higher-than-normal IgG, despite lower titers in their mothers. Because virtually all IgG is derived from the prenatal transfer of maternal antibody, it indicates that the sex of the fetus differentially affected this placental process. The IgG receptor may have been up-regulated selectively on the placentas of female fetuses, compensating for reduced antibody in the disturbed mothers. 相似文献
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Beverly I. Fagot 《Sex roles》1984,11(7-8):593-600
Children of two different age groups, 2-year-olds and 4-year-olds, were placed with male and female adults in a laboratory play situation where the children were forced to control the choice of toys and mode of interaction. The 4-year-old children elicited different types of play behaviors from male and female adults, while the younger children did not.Final preparations of this paper was completed on a post-doctoral fellowship (Grant No. 1 T32MH 16955-01) at Oregon Social Learning Center. The study with older children was presented at the biennial conference of the Society for Research in Child Development, San Francisco, March 1979. 相似文献
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Although postpartum aggression is primarily studied in laboratory mice and rats, it is unclear how the two species compare in terms of the factors associated with peak levels of aggressive behavior. Using the same experimental protocol, we assessed the relative effect of intruder sex and time since parturition on the frequency of maternal aggression in Long-Evans rats and CFW mice. Females were studied for 2 consecutive cycles of pregnancy and lactation. During the first lactation, aggression was tested 2 times per week for 3 weeks in order to select animals that attacked at least once. During the second lactation, both pup care and aggressive behavior were assessed in detail. Testing occurred twice in each lactation week, with postpartum days 1–7, 8–14, and 15–21 considered weeks 1, 2, and 3, respectively. Maternal behavior towards 3 pups was observed for 5 minutes, followed by a confrontation with an intruder. Lactating females encountered female intruders once per week, and male intruders in the alternate weekly test. The same behaviors were measured in the 2 species, except for the tail rattle exhibited by mice and the aggressive posture shown by rats. Lactating rats and mice show similar decreases in pup care behavior as lactation progresses in time; yet the factors associated with peak levels of aggression differ between species. In Long-Evans rats, female intruders receive more attacks, threats, and aggressive postures than males. Frequency of attack bite and sideways threat declines in each passing week of lactation. Lactating mice are more aggressive toward male intruders throughout the lactation period. Mice still attack and threaten during the third week of lactation, but less often in comparison to the first week. Therefore, peak levels of aggression vary in mice and rats both as a function of intruder sex and lactation week. 相似文献
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Pseudopregnant and normal cycling female Sprague-Dawley rats were trained on a delayed-spatial alternation task. After acquisition training, the subjects received frontal cortex lesions and were subsequently tested for retention. The pseudopregnant animals with lesions were less impaired than their normal cycling counterparts. Learning and retention testing were not affected by hormonal status in the noninjured controls. Histological examination showed that the normal cycling rats with frontal cortex lesions possessed enlarged ventricles, indicating the presence of edema in this surgical group. However, brain tissue of pseudopregnant subjects given the same lesion and sham operates of both hormonal states did not display this characteristic of edema. We speculate that the behavioral and anatomical impairment observed in the normal cycling females with brain injury is due to higher levels of vasopressin, a potent vasoconstrictor synchronized with brain injury in our manipulation. 相似文献
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Cahill BS Coolidge FL Segal DL Klebe KJ Marle PD Overmann KA 《Behavioral sciences & the law》2012,30(2):154-166
There are few published studies of attention-deficit/hyperactivity disorder (ADHD) in adult inmates, and even fewer studies that have considered ADHD in adult inmates by gender. The present study examined the prevalence of ADHD, its subtypes, and associated psychological and neuropsychological comorbidity as a function of gender in a sample of 3,962 inmates (3,439 men and 523 women; mean age = 33.6 years, range 17-73) who had completed the 250-item, self-report, Diagnostic and Statistical Manual of Mental Disorders, 4th edition (Text Revision) (DSM-IV-TR)-aligned Coolidge Correctional Inventory (CCI). The overall ADHD prevalence rate found was 10.5%, which is substantially higher than the rate among adults in the general population (2-5%). The female inmate ADHD prevalence rate (15.1%) was higher than the male inmate ADHD rate (9.8%), consistent with some previous studies. The most prevalent ADHD subtype for both genders was the hyperactive-impulsive subtype. The combined and inattentive ADHD subtypes had higher levels of comorbid psychopathology than the hyperactive-impulsive ADHD subtype. As the presence of ADHD and associated gender differentials may impact the success of rehabilitation and educative programs with inmates, the assessment of ADHD and comorbid psychopathology should be a priority in initial inmate screening and evaluation. 相似文献
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Prenatal stress (heat and restraint) significantly increased postpartum aggression (proportion of animals fighting and/or the intensity of the behavior) in C57BL/6J female mice and reduced the behavior in DBA/2J females. For intermale aggression, prenatal stress increased the behavior (intensity of aggression) in C57BL/6J males but did not affect aggressive behavior in DBA/2J animals. Infanticidal behavior (the killing of young) exhibited by male mice was not influenced by prenatal stress in either strain. Relative anogenital distance measurements in neonates at birth did not serve as a reliable predictor of strain variation in prenatal stress effects. Prenatal stress did not influence this measure of prenatal androgen exposure in DBA/2J or C57BL/6J females. For males, prenatal stress elevated relative anogenital distance in C57BL/6J mice and decreased this measure in DBA/2J animals. Prenatal stress effects on aggressive behavior in male and female mice therefore depend upon genotype. Strain-dependent differences may be modulated by differences in endocrine reactivity to prenatal stress/and or differential central neural tissue sensitivity to hormones. 相似文献
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W A Johnson 《Journal of comparative psychology (Washington, D.C. : 1983)》1975,89(5):433-441
Neonatally and adult castrated male hamsters as well as neonatally androgenized and nonandrogenized female hamsters were tested for both mounting and lordosis behaviors during treatment with either testosterone or ovarian hormones. Neonatal androgenization facilitated mounting behavior in adult animals administered either testosterone or ovarian hormones and suppressed lordosis behavior in adult ovarian-hormone-treated animals. Early androgen effects on the display of lordosis behavior during adult testosterone treatment were complex and varied with the exact timing of perinatal endogenous or exogenous androgenization. Species differences in hormone-behavior relationships and the possible role of perinatal androgenization in the development of rodents' ability to aromatize androgens were discussed. 相似文献
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Intrahippocampal muscimol shifts learning strategy in gonadally intact young adult female rats
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Learning strategy preferences depend upon circulating estrogen levels, with enhanced hippocampus-sensitive place learning coinciding with elevated estrogen levels. The effects of estrogen on strategy may be mediated by fluctuations in GABAergic function, given that inhibitory tone in the hippocampus is low when estrogen is high. We investigated the effects on learning strategy of intrahippocampal injections of a GABA(A) agonist in gonadally intact female rats. On the day of training, rats received 0.3 microL intrahippocampal infusions of muscimol (0.26 nmol or 2.6 nmol) or saline 20 min prior to training on a T-maze in which place (hippocampus-sensitive) or response (striatum-sensitive) strategies offer effective solutions. Muscimol treatment increased the use of the response strategy in a dose-dependent manner without influencing learning speed, indicating that muscimol modulated strategy and not learning ability. Furthermore, the muscimol-related shift to response strategies varied across the estrous cycle. The results indicate that increasing inhibition in the hippocampus biases rats away from hippocampus-sensitive place learning strategies and toward hippocampus-insensitive response learning strategies without a learning deficit. Furthermore, rats at proestrus demonstrated the most dramatic shift in learning strategy following muscimol treatment compared with control conditions, while rats at estrus demonstrated the most complete bias toward response strategies. The enhanced use of hippocampus-sensitive strategies at proestrus likely results from reduced hippocampal inhibition. 相似文献
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Monleón Verdú S Arenas Fenollar MC Vinader Caerols C Ferrer Añó A Parra Guerrero A 《Psicothema》2008,20(3):456-459
The antibiotic anisomycin inhibits protein synthesis, which much research has suggested is required for the formation of long-term memory. The present work studied the effects of acute subcutaneous administration of anisomycin on the consolidation of memory in an inhibitory avoidance task in CD1 mice of both sexes. The animals were separated by sex and randomly distributed into three groups: two groups were injected with 150 mg/kg anisomycin, one immediately after the training phase and the other 24 h later, while the control group received saline. The interval between training and test was four days. Anisomycin administrated immediately after training produced statistically significant impairment of memory, which was not observed when the drug was administered 24 h after training. No sex differences were observed in the effects of anisomycin. These results extend to female mice the memory impairing effects of anisomycin previously observed in males and endorse the hypothesis that the establishment of long-term memory depends on protein synthesis shortly after training. 相似文献
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ObjectivesIt has been proposed that regular exercisers may be less vulnerable to the effects of stress and better able to cope with aversive events than people who are sedentary, but findings have not been consistent. In the present study, physiological variables indicating specific relevant psychological processes were used to objectively assess women's responses to stressful events.Design and MethodNon-exercising (n = 56) and regularly exercising women (up to 4 h, n = 62, and more than 4 h per week, n = 50) were viewing an aversive film consisting of scenes of real injury and death, and their transient cardiac responses to sudden horrifying events happening to persons in the film were obtained, as well as changes of prefrontal-posterior coupling, measured by EEG.ResultsCompared to regularly exercising women, non-exercising women showed a clearly more pronounced second accelerative component of the transient heart rate response to the terrifying events, indicating greater sensitivity of the avoidance (defensive) motivational system and heightened sensitivity to aversive stimuli. Moreover, non-exercising women did not show the expected characteristic initial heart rate acceleration when the scene approached its fatal end, that is, more rigid responding, and EEG data indicated less susceptibility to affect-laden information at the perceptual level.ConclusionsThe findings support the notion of less adaptive coping with adverse events in sedentary compared to exercising women and add to the growing evidence suggesting a stress-buffering effect of regular exercise, therefore promoting resilience and resistance to the negative impact of stressor and trauma exposure. 相似文献
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Luci Paul 《Aggressive behavior》1986,12(1):1-11
Thirty-six percent of male mice from three strains attacked newborn pups sired by another male. No male attacked its own offspring. Females did not show differential aggression toward males likely (strangers) or unlikely (sires) to attack their pups. Both forms of aggression were unaffected by housing in rooms which did or did not contain the aggression targets. The three strains differed in strength of maternal aggression but not in the incidence of infanticide. Females showed more aggression when mated with males of the same, rather than a different, strain but no differences with intruders of the same or a different strain. Infanticide by males is best viewed as a postcopulatory, intermale-competition strategy, and maternal aggression as a counter strategy. 相似文献
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Formant frequency characteristics of children, young adult, and aged female speakers 总被引:1,自引:0,他引:1
Previous literature indicates that a difference may exist between formant frequencies (F1 and F2) of children, young adult, and elderly speakers. The purpose of this study was to compare F1 and F2 of 3 young, 6 young adult, and 3 elderly female speakers for the /i/, /ae/, /u/, and /a/ vowels. Analysis indicates a trend towards vowel reduction across the life span. These findings support previous research regarding age-associated acoustic changes as well as support for the possible anatomical and physiological alterations which may influence such changes. 相似文献
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Mihalick SM 《Neurobiology of learning and memory》2003,80(1):55-62
During late prenatal and early postnatal brain development, estrogen induces structural sex differences that correspond to behavioral differences in certain domains such as learning and memory. The typically superior performance of males is attributed to the action of elevated concentrations of estrogen, derived inside neurons from the aromatization of testosterone. In contrast, female performance appears dependent on minimal estrogenic activity. Rat models of the relationship between hormones and cognitive behavior predominate the field, but the advent of genetically modified mice as research tools necessitates development of analogous mouse models. This study examined how early postnatal exposure to the synthetic estrogen diethylstilbestrol (DES) affected the ability of male and female Swiss-Webster mice to learn a two-choice olfactory discrimination and three repeated reversals. Mice treated with subcutaneous injections of DES from postnatal days 1-10 learned reversals more readily than oil-treated controls, a difference that became evident after repeated testing. DES-exposed males and females learned reversals at a comparable rate, suggesting that early postnatal estrogen exposure does not influence this mode of learning through a sexually differentiated mechanism in mice. An analysis of response patterns during qualitatively different phases of reversal learning revealed that DES-induced improvements probably were not due to greater inhibitory control. Instead, DES appeared to enhance associative ability. Early postnatal estrogen exposure may have the potential to preserve certain cognitive skills in adulthood. 相似文献
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Van Haaren F Van Hest A Van De Poll NE 《Journal of the experimental analysis of behavior》1988,49(2):201-211
Eight male and 8 female Wistar rats were exposed to a discrete-trial procedure in which they chose between the presentation of a small (one pellet) or a large (three pellets) reinforcer. The delay to the small and large reinforcer was 6.0 s in the first condition of Experiment 1. Subjects consistently chose the large reinforcer. When the delay to the small reinforcer was decreased to 0.1 s in the next experimental condition, all subjects continued to choose the large 6.0-s delayed reinforcer. When the contingencies correlated with the two levers were reversed in the next experimental condition, the majority of subjects (5 males and 6 females) still chose the large delayed reinforcer over the small immediately presented reinforcer. The delay to the small reinforcer was maintained at 6.0 s, but the delay to the large reinforcer was varied among 9.0, 15.0, 24.0, and 36.0 s in Experiment 2, in which 4 males and 4 females participated. Most subjects consistently chose the large increasingly delayed reinforcer, although choice for the small 6.0-s delayed reinforcer developed in some females when the large reinforcer was delayed for 24.0 or 36.0 s. These choice patterns were not predicted from a literal application of a model that says choice should favor the alternative correlated with the higher (amount/delay) ratio. 相似文献