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Pharmaceuticals products have the lowest “effective patent life” of any product. So the length of time during which firms can sell their product without copy is too short. Effective patent-life has been shrinking and to compensate patent holders for marketing time lost while developing the product, policymakers have adopted regulations. The supplementary protection certificate (EU 1992) or patent term restauration (US -FDA 1988) or patent term extension system (Japan 1988). This article explains what products are included, what are the criteria for determining whether a patent for a human drug product is eligible for a patent extension, what is the maximum of time allowed, how the patent term extent is calculated. The regulations for supplementary protection of patent are nearly identicals but incentives established are critical to continued innovation.  相似文献   

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La signification quantitative de la sous-utilisation des qualifications immigrées peut être évaluée, quoique sans précision, dans l'analyse humain-capitale de revenus. Les déficits de revenus des immigrés peuvent surgir de: (a) la qualité immigrée inférieure de compétence, (b) sous-utilisation des qualifications immigrées, et (c) injustices de salaire pour des immigrés faisant la même chose fonctionnent les Canadiens indigènesoutenus. Conformé aux nombreuses études, données des micro-données 1996 de recensement prouvent que la sous-utilisation des qualifications immigrées est significative, cependant moins ainsi que le salaire inégal dans des métiers. En 1996 dollars, tout le déficit immigré annuel de revenus de chacune des trois sources était 15,0 milliards, dont15,0 milliards, dont 2,4 milliards ont été liés à la sous-utilisation de compétence, et 12,6 milliards ont été liés à linjustice de salaire. La discussion considère des ajustements à ces évaluations, tenant compte des difficultés mesurant les niveaux de compétence des métiers et de la qualité immigrée de compétence. < /div > < div classbstract» < a namebs2» < /a > The quantitative significance of the underutilization of immigrant skills may be assessed, albeit imprecisely, in human-capital earnings analysis. Earnings deficits of immigrants may arise from: (a) lower immigrant skill quality, (b) underutilization of immigrant skills, and (c) pay inequities for immigrants doing the same work native-born Canadians. Consistent with numerous studies, data from the 1996 census micro-data show that underutilization of immigrant skills is significant, though less so than unequal pay within occupations. In 1996 dollars, the total annual immigrant earnings deficit from all three sources was12,6 milliards ont été liés à l'injustice de salaire. La discussion considère des ajustements à ces évaluations, tenant compte des difficultés mesurant les niveaux de compétence des métiers et de la qualité immigrée de compétence.  相似文献   

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IntroductionThe disorders associated with the coping styles of detainees in prisons, including the interaction between individual and the environment, can be approached in two ways. Either as the result of a normal reaction of prisoners with regard to specific components in a pathogenic environment, or resulting from psychopathological determinants inherent to inmates prior to incarceration.ObjectivesThis study aims to measure the impact of components related to personality traits deemed stable and observed among inmates in regards to their modes of adaptations to the prison environment. More specifically, observing the types of adaptation of prisoners, according to their scores on the Hare psychopathy checklist (PCL-R).MethodsThe study is based on a series of interviews conducted on a sample of 26 inmates in three different detention centers located in France.ResultsThe results show a strong relationship between some psychopathic dimensions and characteristics of conduct disorder or disciplinary offenses in prison. High scores in both factor 1 (interpersonal and emotional relationship) and factor 2 (social deviance) strongly correlates with disciplinary problems such as heteroaggressive violence towards staff or other inmates. While a high score of factor 2 only increases the risk of disciplinary problems, such as group violence or involvement in trafficking.ConclusionsThe presence or absence of certain personality traits that characterize psychopathy could determine how an inmate would adapt to the prison environment.  相似文献   

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The purpose of this research was to determine whether perceived organizational support, leader membership exchange and social solidarity were related to employee commitment to the organization and to organizational citizenship behavior. A survey questionnaire measuring the relevant variables was sent to 276 employees from 3 organizations. The results of the study indicate that perceived organizational support, leader membership exchange and social solidarity were positively associated with affective organizational commitment and organizational citizenship behavior. Perceived organizational support is more strongly related to organizational citizenship behavior when poverty is low.  相似文献   

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This article aims to inform the intervention process and the institution of conflictuality around the criteria on quality of work in an Activity Clinic perspective. From the example of a recent intervention in sanitary service of a big city, this article instructs this process when the conflictuality around the criteria of quality of work can be instituted in the organization. When field professionals can do more authority on their activity in the organization, we then witness in action a modification of their role in decision process, regarding their own work. The article concludes with the contribution of the results produced to current reflections on the union work actuality.  相似文献   

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Present study aims at refining assessment of preschoolers’ behavior. Data was provided with questionnaires and observation on 118 preschoolers when recruited and 12 months later by their parents, their teachers and clinicians. The results confirmed high variations in informants’ ratings as well as negative effects of such variations regarding later child's development. The results imply the need for a multi-informant and multi-method assessment of preschoolers’ disruptive behavior. The implications of our findings for clinical purpose are discussed.  相似文献   

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The innovation is one of the possible answers to the actual global competitive context able to foster and cope the high standards necessary for survival and competition of the organisations. The objective of this study, realized in the health context, is the exploration of the relationships between the innovative work behaviour and three antecedents (proactive personality, job cognitive demands and empowering leadership) trying to maintain the interactionist perspective between individual factors and context factors. These relationships have been investigated with a mediator role of felt responsibility to change, the individual belief that has a person when has feeling of responsibility in a realisation of transformations and new and constructive changes.  相似文献   

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This study focuses on the relationship between workplace stressors and innovative work behavior. The joint analysis of the mediation process supporting this relationship as well as the influence of certain external conditions such as the moderating role of the supervisor has made it possible to highlight the dynamic that underlie the relationship between stressors and innovation behavior. Using the challenge-hindrance model, this theory proposes that challenge (i.e., role overload) and hindrance (i.e., role ambiguity and role conflict) stressors exert positive and negative indirect effects, respectively, on innovative work behavior through psychological empowerment (PE). Furthermore, empowering leadership (EL) has the potential to optimize the benefits of challenge stressors and reduce the effects of hindrance stressors on PE and indirectly on innovation work behavior. In support of these predictions, a time-lagged study of 146 employees from various Canadian firms reveals that hindrance stressors, particularly role ambiguity, are negatively related to innovative work behavior through PE. Moreover, when EL was high, the positive effects of role overload were enhanced through PE while the negative effects of role ambiguity and role conflict were attenuated. The implications of these findings for research and practice are discussed.  相似文献   

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The aim of this study was to test the impact of labeling over compliance, within the foot-in-the-door paradigm. We manipulated two types of labeling: social labeling — or positive labeling — and functional labeling. Whereas social labeling emphasizes the social value of the individual (what the individual is), functional labeling points out the efficiency of what has been done. As predicted, social labeling increases the compliance whereas functional labeling decreases it. These results are then discussed in terms of self-attribution and in terms of commitment.  相似文献   

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With about 28,000 asylum requests a year since 1990, Switzerland is one of the western countries with the highest inflow of refugees. The aim of this article is to answer two questions: What is the role of refugees in the Swiss economy? and what are the factors influencing their incorporation into the labour market? The research is based on the multivariate analysis of an individual database of 110,000 asylum seekers and refugees, in-depth interviews and 174 questionnaires to refugees and employers.  相似文献   

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Supervisor support enhances transfer of training, but the process by which it operates is still unknown. One specific question remains about the distinction between expected and perceived support. This study aimed to assess the influence of expected and perceived support on transfer, as well as to examine the effect of a perception gap between these two types of support. Results obtained from 76 trainees indicate that: (1) both expected and perceived support foster transfer, (2) expected support explains a significant part of the variance of transfer in the presence of perceived support, (3) the gap between the two types of support help explain the effect of supervisor support on training transfer.  相似文献   

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This study is about psychological distress lived by Canadian workers. Only a few studies considered personal traits in the comprehension of this phenomenon. This study aims to determine the moderator role of self-esteem, the sense of control and the sense of cohesion on the relation between the work organization conditions and psychological distress. Some longitudinal data (n=7338 workers) coming from five cycles (1994-2003) of the National Population Health Survey (NPHS) have been used to complete some multilevel analysis (n1=time and n2=individual). The results indicate that the sense of control and the sense of cohesion play a moderator role on the relation between some of the work organization conditions and the level of psychological distress.  相似文献   

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This study has used an Item Response Theory model (IRT model), specifically the Rasch model, to construct a new observational scale for the assessment of pain in infants less than 36 months old. Results showed that the Rasch model is ideally suited to building an assessment instrument for postoperative pain in this particular age group. Indeed, based on this methodology 21 dichotomous items have been selected that fit to the assessment of postoperative pain in infants aged three to 24 months. Despite some limitations, this study makes a convincing case for the use of Rasch model in instrument design and allowed us to highlight some developmental and behavioral dimensions of the postoperative pain experience in infants.  相似文献   

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