急性生理应激对大鼠的行为及脑神经颗粒素磷酸化水平的影响

突触特异性蛋白质在应激所致行为效应的中枢机制中的可能角色日益受到关注。神经颗粒素（Neurogranin,NG）是一种新发现的突触特异性蛋白质,主要分布在前额叶、杏仁核和海马区域,参与突触结构和功能可塑性机制,可能涉及到应激所致行为效应中枢机制。但是,关于NG、应激和行为之间的关系国内外尚缺乏系统的研究报道。本研究主要是探讨急性生理应激对大鼠行为和NG的作用,以及NG的变化与应激性行为效应之间的相互关系。以急性强迫性冷水游泳应激,建立生理应激动物模型。将40只雄性SD大鼠随机分为游泳应激组1（SS1,接受游泳应激和行为测试）、游泳应激组2（SS2,接受游泳应激而不接受行为测试）、正常对照组1（C1,接受行为测试）和正常对照组（C2,不给予任何处理）（n=10）。以旷场行为和高架十字迷宫任务来评定大鼠应激后的行为变化,Western blotting方法测定海马和前脑皮层中的NG含量和磷酸化水平。结果表明：应激后SS1组的呆滞行为增加,与C1组比较,差异有显著性, P<0.01; SS1组海马的NG含量和NG磷酸化水平增高,与C1和C2组相比,差异有显著性,均为P<0.05; SS1组皮层的NG含量增高,与C1和C2组相比,差异有显著性,均为P<0.01;SS1组皮层的NG磷酸化水平增高,与C1组相比,差异具有显著性,P<0.01;前脑皮层的NG磷酸化水平与呆滞行为之间的相关达显著水平。提示该应激源能诱发动物明显的恐惧反应,呆滞行为是反映急性生理应激导致行为障碍的敏感的行为学指标,海马和前脑皮层均是对急性生理应激反应敏感的脑区。NG的磷酸化水平可能是反映急性生理应激所致行为障碍的一项新的生物学指标     

Selective Mutism in Children: Comparison to Youths With and Without Anxiety Disorders

Fifteen children with selective mutism (SM), 15 children with anxiety disorders (AD) without selective mutism, and 15 children without anxiety disorders or selective mutism (CN) were compared to examine the relationship between selective mutism and anxiety. Data were collected from children (age 4–10 years), parents, teachers, and clinicians. Results indicated that children with SM closely resemble children with AD. All children with SM received a diagnosis of social anxiety disorder and 53% received a diagnosis for an additional anxiety disorder. In addition, the SM and AD groups differed substantially from controls with respect to parent- and teacher-rated internalizing behavior problems. No differences among the groups were found with respect to parent-and teacher-reported externalizing behavior problems. The results are consistent with prior research emphasizing the association between selective mutism and anxiety disorders, and suggest that selective mutism may be conceptualized, assessed, and treated as an anxiety-related problem.     

Social Media Use and Creativity: Exploring the Influences on Ideational Behavior and Creative Activity

This study explored the relationship between social media (SM) use and creativity. The data collected from 407 participants included indicators such as time spent using SM, frequency of SM use, purposes for using SM, and the nature of SM use. The data involved two aspects of creativity: ideational behavior and creative activity and accomplishment. Correlational analyses indicate that SM use is positively related to both creativity measures. Overall, the active use of SM (e.g., sending a post) is more related to creativity than the passive use (e.g., reading others’ posts); and the link between creativity and SM use is more evident for certain platforms (i.e., Twitter) than others (e.g., Instagram). Ideational behavior and creative activity were also found to be higher among those who use SM primarily for expressing their ideas and opinions, gleaning information on topics to discuss and self‐education and learning compared with those who use it primarily for entertainment or relaxation. None of the creativity measures used was related to extraversion and excessive use of SM. Our findings indicate that SM is not necessarily a negative factor for creativity; it may even be a useful platform to support new ideas and projects.     

Conservatism,sensation-seeking and music preferences

Wilson-Patterson Conservatism (C) and Zuckerman's Sensation-seeking (SS) scores were investigated in relation to music preferences in a group of 43 students. High C scorers preferred familiar pieces of music relative to low C scorers (r = 0.30, P < 0.05). A tendency for conservatives to prefer simple music just failed to reach significance. Relationships between SS scores and music preferences were non-significant with the present sample, though SS scores were inversely related to C scores (r = –0.48, P < 0.01).     

Examining a brief suicide screening tool in older adults engaging in risky alcohol use

Alcohol misuse increases risk of suicidal behavior in older adults. The Depressive Symptom Inventory‐Suicidality Subscale (DSI‐SS; Metalsky & Joiner, 1997) and its relation to suicide attempt history was examined to see if it differed for older adults as a function of their alcohol use. Structural equation modeling was used in a sample (N = 1,061) of older adult outpatients to examine the scale’s measurement invariance and population heterogeneity and its relation to suicide attempt history. Analyses supported the equivalence of the DSI‐SS in risky and nonrisky drinkers. The DSI‐SS significantly predicted past suicide attempts. Findings support the viability of the DSI‐SS as suicide screening tool for older adults.     

Contribution of strategy use to performance on complex and simple span tasks

Simple and complex span tasks are widely thought to measure related but separable memory constructs. Recently, however, research has demonstrated that simple and complex span tasks may tap, in part, the same construct because both similarly predict performance on measures of fluid intelligence (Gf) when the number of items retrieved from secondary memory (SM) is equated (Unsworth & Engle, Journal of Memory and Language 54:68–80 2006). Two studies (n = 105 and n = 152) evaluated whether retrieval from SM is influenced by individual differences in the use of encoding strategies during span tasks. Results demonstrated that, after equating the number of items retrieved from SM, simple and complex span performance similarly predicted Gf performance, but rates of effective strategy use did not mediate the span-Gf relationships. Moreover, at the level of individual differences, effective strategy use was more highly related to complex span performance than to simple span performance. Thus, even though individual differences in effective strategy use influenced span performance on trials that required retrieval from SM, strategic behavior at encoding cannot account for the similarities between simple and complex span tasks.     

The perception of available social support is related to reduced cardiovascular reactivity in phase II cardiac rehabilitation patients

Objective  Numerous studies have observed a relationship between social support (SS) and post coronary event survival. Laboratory research suggests one mechanism regulating this relationship may be exaggerated cardiovascular reactivity (CVR). What has not been as well explored is (1) whether the SS-CVR relationship holds up for a heart diseased sample, and (2) whether this relationship is evidenced only in supportive environments or can be found as a function of generalized perception of being socially supported. Thus, the purpose of this study was to examine the relationship of perceived SS and a locally supportive presence to CVR to a speech-induced stressor in post coronary event patients. Method  Forty-one Phase II cardiac rehabilitation patients participated in a research protocol that consisted of BP and HR measurement during two identical affective stress interviews where local support was systematically varied by presence or absence of a friendly small pet dog. Perception of SS was assessed by completion of psychosocial questionnaire packet that included measures of SS, anger expression and pet attachment. Results  Repeated measures ANCOVAs revealed that patients who believed they had greater SS available to them during difficult times exhibited significantly less CVR for MAP (p<.007) and DBP (p<.024). No significant main effects for local support (pet presence) and no interactions between local and perceived support were found. Conclusions  These findings are of interest as they: (a) demonstrate an association between reduced CVR and higher (amounts of) SS in a clinical sample; (b) demonstrate this effect in a sample medicated to dampen CV levels and surges; (c) suggest that perceived amount of SS provides an ameliorative influence on CVR independent of situational support; (d) suggest that for certain conditions pet-models of support may be ineffective at establishing an local support presence.     

The perception of available social support is related to reduced cardiovascular reactivity in Phase II cardiac rehabilitation patients.

OBJECTIVE: Numerous studies have observed a relationship between social support (SS) and post coronary event survival. Laboratory research suggests one mechanism regulating this relationship may be exaggerated cardiovascular reactivity (CVR). What has not been as well explored is (1) whether the SS-CVR relationship holds up for a heart diseased sample, and (2) whether this relationship is evidenced only in supportive environments or can be found as a function of generalized perception of being socially supported. Thus, the purpose of this study was to examine the relationship of perceived SS and a locally supportive presence to CVR to a speech-induced stressor in post coronary event patients. METHOD: Forty-one Phase II cardiac rehabilitation patients participated in a research protocol that consisted of BP and HR measurement during two identical affective stress interviews where local support was systematically varied by presence or absence of a friendly small pet dog. Perception of SS was assessed by completion of psychosocial questionnaire packet that included measures of SS, anger expression and pet attachment. RESULTS: Repeated measures ANCOVAs revealed that patients who believed they had greater SS available to them during difficult times exhibited significantly less CVR for MAP (p<.007) and DBP (p<.024). No significant main effects for local support (pet presence) and no interactions between local and perceived support were found. CONCLUSIONS: These findings are of interest as they: (a) demonstrate an association between reduced CVR and higher (amounts of) SS in a clinical sample; (b) demonstrate this effect in a sample medicated to dampen CV levels and surges; (c) suggest that perceived amount of SS provides an ameliorative influence on CVR independent of situational support; (d) suggest that for certain conditions pet-models of support may be ineffective at establishing an local support presence.     

Measuring Context-Specific and Cross-Contextual Components of Hierarchical Constructs

Rating scales are often used to measure behavioral constructs. Yet, different informants’ ratings may not necessarily agree. The situational specificity (SS) perspective postulates that discrepancies between ratings by different informants are primarily attributable to contextual behavior of the people being rated. The multitrait-multimethod (MTMM) perspective, however, attributes discrepancies between informants to rater bias, i.e., each informant provides a systematically distorted picture of the person being rated. Similarly, the Attribution-Bias-Context (ABC) perspective also attributes informant discrepancies to systematic biases. Within the context of measuring hierarchical constructs, we proposed a hybrid perspective that takes account of variance attributable to the behavior of the person being rated in a particular context from the perspective of a specific informant. We then provided a parametric representation of this perspective and analyses of mother, teacher, and self-ratings of Rule-Breaking and Aggressive Behavior to illustrate features of the model. Strengths and limitations of the SS, MTMM, and hybrid perspectives are discussed.     

Unmasking the component-general and component-specific aspects of primary and secondary memory in the immediate free recall task

The immediate free recall (IFR) task has been commonly used to estimate the capacities of the primary memory (PM) and secondary memory (SM) components of working memory (WM). Using this method, the correlation between estimates of the PM and SM components has hovered around zero, suggesting that PM and SM represent fully distinct and dissociable components of WM. However, this conclusion has conflicted with more recent studies that have observed moderately strong, positive correlations between PM and SM when separate attention and retrieval tasks are used to estimate these capacities, suggesting that PM and SM represent at least some related capacities. The present study attempted to resolve this empirical discrepancy by investigating the extent to which the relation between estimates of PM and SM might be suppressed by a third variable that operates during the recall portion of the IFR task. This third variable was termed “strength of recency” (SOR) in the present study as it reflected differences in the extent to which individuals used the same experimentally-induced recency recall initiation strategy. As predicted, the present findings showed that the positive correlation between estimates of PM and SM grew from small to medium when the indirect effect of SOR was controlled across two separate sets of studies. This finding is important because it provides stronger support for the distinction between “component-general” and “component-specific” aspects of PM and SM; furthermore, a proof is presented that demonstrates a limitation of using regression techniques to differentiate general and specific aspects of these components.     

The Influence of Candidate Social Effectiveness on Assessment Center Performance Ratings: A field study

The present research examined the influence of constructs representing social effectiveness on assessment center (AC) ratings in two samples. We expected different effects of self‐monitoring (SM) on different dimension ratings, a positive effect of the ability to identify criteria (ATIC) on the overall AC rating and a moderating effect of the ATIC on the relationship between SM and the dimension rating. Forty‐six (Study 1) and 115 (Study 2) applicants participated in ACs in field settings. Across both studies, SM had a negative effect on the integrity rating. No relationship was identified between SM and social sensitivity or problem solving ratings. In Study 1, the ATIC had a positive effect on the overall AC rating. No support was identified for a moderating effect of the ATIC on the relationship between SM and the social sensitivity rating.     

High Thrill and Adventure Seeking Is Associated with Reduced Interoceptive Sensitivity: Evidence for an Altered Sex‐specific Homeostatic Processing in High‐sensation Seekers

The personality trait of sensation seeking (SS) has been traditionally linked to the construct of exteroception, that is, sensing of the outside world. Little is known about the relationship between SS and interoception, that is, sensing originating in the body. Interoceptive sensations have strong affective and motivational components that may influence behaviours such as risk taking in SS. This investigation examined whether interoceptive differences contribute to different behavioural characteristics in SS. Using an inspiratory resistive load breathing task, the response to an aversive interoceptive stimulus as a basic homeostatic process was studied in 112 subjects (n = 74 women and 38 men). A linear mixed‐model approach was used to examine the influence of thrill and adventure seeking (TAS) on the interoceptive response across three levels of breathing resistances (10, 20, and 40 cm H₂O/L/second). High‐TAS relative to low‐TAS individuals were less responsive in evaluating intensities of perceived choking with increasing inspiratory resistive loads. This effect was driven by male, but not female, high‐TAS individuals and was particularly associated with reduced interoceptive sensitivity in men. The conceptualization of SS as primarily driven by exteroceptive stimuli can be expanded to a view of an altered homeostasis in SS, specifically in men. Copyright © 2013 European Association of Personality Psychology     

Influences of Upstream Social Factors on Downstream Perceptions of Social Support in Cardiac Rehabilitation1

Within Berkman et al.'s (2000) framework, we examined sociodemographic correlates of social networks (SN) and social support (SS) in 155 heart patients (33 women, 122 men), who completed measures of sociodemographics, SN, and SS. Hierarchical regression analyses examined the relationship between sociodemographic factors and SN; and between sociodemographic factors, SN, and SS. Higher social status and more income were related to larger, more diverse networks and more SS. Higher social status and being married were related to more SS. Being married was related to more belonging and tangible support. Results show the complex relationship between higher level social factors and specific SS functions offering areas for future interventions to increase SS in heart patients.     

Personality Correlates of the Common and Unique Variance Across Conduct Disorder and Substance Misuse Symptoms in Adolescence

Externalising behaviours such as substance misuse (SM) and conduct disorder (CD) symptoms highly co-occur in adolescence. While disinhibited personality traits have been consistently linked to externalising behaviours there is evidence that these traits may relate differentially to SM and CD. The current study aimed to assess whether this was the case, after examining the nature of the relationship between SM and CD symptoms in an adolescent sample (N?=?392), using structural equation modelling. Similar to those found in adults (Krueger et al. Journal of Abnormal Psychology 116: 645-666, 2007), results showed that CD and SM symptoms were organized hierarchically, with symptoms explaining a single broad, coherent construct of externalising behaviour, but also explaining specific factors of SM and CD that vary independently from the general externalising factor. Furthermore, disinhibited personality traits related differentially to these factors, with results showing that, even controlling for inhibited personality traits, impulsivity was associated with CD and the common variance shared by CD and SM, while sensation seeking was specifically associated with SM only. Hopelessness was also associated with the common variance shared by SM and CD. Results confirm impulsivity, hopelessness and sensation seeking as key correlates of externalising behaviour problems in adolescence, identifying them as clear targets for intervention and prevention strategies.     

自我控制资源水平及其变化对跨期选择的影响

自我控制资源（SCR）是个体执行自我控制活动时所需的有限心理资源,本文通过两项实验探讨个体的SCR水平与SCR变化对跨期选择的影响。结果发现：（1）控制知觉加工组和控制想法组在执行SCR操作任务后,其整体SCR下降,SS偏好增强;（2）控制知觉加工组的SCR降幅和SS偏好增幅均显著高于控制想法组;（3）SCR下降的被试在后测SS偏好和SS偏好增幅上都显著高于SCR不变和上升的被试,但SCR上升被试与不变被试的差异不显著。与以往研究相比,本研究采用了个体水平分析思路,揭示了个体SCR变化方向与跨期偏好的关系,并发现了两种SCR操作任务的效应差异。     

Heterogeneity in the Strength of the Relation Between Social Support and Post-Trauma Psychopathology

Potentially traumatic events (PTEs) increase risk for psychopathology, including posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and generalized anxiety disorder (GAD). Social support (SS) is associated with reduced symptoms for each disorder. Each disorder, however, is highly heterogeneous such that they are comprised of clusters of different symptoms. It is unclear if SS is associated with all clusters equally. The current study examined the relation between SS and the symptom clusters of each disorder. Participants completed a battery of self-report assessments for PTSD, MDD, GAD, and SS. All participants experienced a Criterion A traumatic event. Although SS was significantly associated with all symptom clusters, the strength of relations varied. The relation between SS and MDD-affective was significantly stronger than its association with all other factors. The relations between SS and GAD, MDD-somatic, PTSD-AAR, and PTSD-NACM did not significantly differ. These relations were stronger than the relations between SS and the remaining PTSD factors. There was no significant difference in the relations between SS and PTSD-intrusions or PTSD-avoidance. These results suggest that SS is more closely aligned to specific aspects of post-trauma psychopathology.     

Randomized Controlled Pilot Study of Cognitive-Behavioral Therapy in a Sample of Incarcerated Women With Substance Use Disorder and PTSD

This randomized controlled pilot study compared a cognitive-behavioral therapy (Seeking Safety; SS) plus treatment-as-usual (TAU) to TAU-alone in 49 incarcerated women with substance use disorder (SUD) and posttraumatic stress disorder (PTSD; full or subthreshold). Seeking Safety consisted of a voluntary group treatment during incarceration and individual treatment after prison release. TAU was required in the prison and comprised 180 to 240 hours of individual and group treatment over 6 to 8 weeks. Assessments occurred at intake, 12 weeks after intake, and 3 and 6 months after release from prison. There were no significant differences between conditions on all key domains (PTSD, SUD, psychopathology, and legal problems); but both conditions showed significant improvements from intake to later time points on all of these outcomes across time. Secondary analyses at follow-up found trends for SS participants improving on clinician-rated PTSD symptoms and TAU participants worsening on self-reported PTSD symptoms. Also, SS demonstrated continued improvement on psychopathology at 3 and 6 months, whereas TAU did not. However, alcohol use improved more for TAU during follow-up. Satisfaction with SS was high, and a greater number of SS sessions was associated with greater improvement on PTSD and drug use. Six months after release from prison, 53% of the women in both conditions reported a remission in PTSD. Study limitations include lack of assessment of SS outcomes at end of group treatment; lack of blind assessment; omission of the SS case management component; and possible contamination between the two conditions. The complex needs of this population are discussed.     

Effects of aging on the neural correlates of successful item and source memory encoding

To investigate the neural basis of age-related source memory (SM) deficits, young and older adults were scanned with fMRI while encoding faces, scenes, and face-scene pairs. Successful encoding activity was identified by comparing encoding activity for subsequently remembered versus forgotten items or pairs. Age deficits in successful encoding activity in hippocampal and prefrontal regions were more pronounced for SM (pairs) as compared with item memory (faces and scenes). Age-related reductions were also found in regions specialized in processing faces (fusiform face area) and scenes (parahippocampal place area), but these reductions were similar for item and SM. Functional connectivity between the hippocampus and the rest of the brain was also affected by aging; whereas connections with posterior cortices were weaker in older adults, connections with anterior cortices, including prefrontal regions, were stronger in older adults. Taken together, the results provide a link between SM deficits in older adults and reduced recruitment of hippocampal and prefrontal regions during encoding. The functional connectivity findings are consistent with a posterior-anterior shift with aging previously reported in several cognitive domains and linked to functional compensation.