Alcohol and drug abuse-dependence disorders in psychopathic and nonpsychopathic criminal offenders

Co-occurrence of psychopathy (assessed with the Psychopathy Checklist) and lifetime Diagnostic and Statistical Manual of Mental Disorders (3rd ed.) alcohol and drug disorders (assessed with the National Institute of Mental Health Diagnostic Interview Schedule) was examined in a sample of 360 male inmates. Consistent with previous research that used diagnoses of antisocial personality disorder, psychopaths were more likely than nonpsychopaths to have lifetime diagnoses of alcoholism, any drug disorder, and multiple drug disorders. We also examined the relation between substance abuse and the 2 factors of the Psychopathy Checklist. Substance abuse was significantly related to general social deviance (Factor 2) but was unrelated to core personality features of psychopathy (Factor 1). We present two possible models of psychopathy (unitary syndrome vs. dual-diathesis model) that may account for the association between psychopathy and substance abuse.     

Personality and drug use: Reciprocal effects across four years

In this paper, the controversy regarding whether attitudes predict behaviour or vice versa, is extended to question the personality and behaviour relationship. The present study examined the reciprocal influence of personality on drug use and drug use on personality from late adolescence to young adulthood using a structural modeling approach. Participants (n = 654) in this longitudinal study completed questionnaires which assessed multiple indicators for latent constructs of alcohol, cannabis, and hard drug use and also for the personality constructs of conscientiousness, extraversion, self-esteem, and social conformity. A series of cross-lagged latent-variable structural models were used to examine the across-time relationships between each pair of drug use and personality constructs separately by sex. More evidence was found for an impact of early personality traits affecting later substance use, rather than for the reverse. Particularly strong effects were noted between early social conformity and less alcohol and hard drug use in young adulthood. Gender differences are also discussed.     

Personality scores and licit and illicit substance use

The effects of personality structure on subsequent substance use was examined. Data were collected from 841 men from Zürich questioned twice at the age of 19 and 22 about drug use and personality. Multiple regression and canonical correlation analysis methodology indicated a significant relationship between personality and subsequent substance use. Illicit drug consumption was positively related to the personality scale Depressiveness and negatively to Dominance and Excitability, cigarette consumption correlated with Nervousness and Sociability and alcohol consumption was related to Nervousness, Depressiveness and Sociability. The association of illicit drug use with Emotional Lability decreased when cigarette and alcohol consumption was included in the analysis. The cannabis users described themselves less neurotic than the consumers of alcohol and cigarettes.     

Psychometric vs. attentional correlates of early onset alcohol and substance abuse

Adolescent inpatients with a diagnosis of alcohol abuse (n=28), nonalcohol substance abuse disorders (n=15), or psychiatric disorders without substance abuse (n=46) were examined on measures of attentional, intellectual, and personality functioning. High scores on a personality measure, the Substance Abuse Proclivity Scale (SAP), was the best predictor of substance abuse in general. Alcohol abusers were differentiated from other substance abusers by their increased impairment on the Continuous Performance Test. Adolescents with alcohol abuse did not manifest the types of cognitive impairments associated with chronic alcoholism. These data suggest that certain attentional impairments may be associated with early onset alcohol abuse and that earlier conceptions of the role of attentional impairments in risk prediction for alcohol abuse are supported.This research was supported by the Four Winds Foundation.     

Personality Traits Predict the Developmental Course of Externalizing: A Four‐Wave Longitudinal Study Spanning Age 17 to Age 29

The objective of the present study was to determine whether and how personality predicts the developmental course of externalizing problems, including antisocial behavior and substance dependence. In a large, population‐based longitudinal study (N = 1,252), the 11 personality traits assessed by the Multidimensional Personality Questionnaire were measured at age 17, and DSM diagnoses of adult antisocial behavior, alcohol dependence, and drug dependence were obtained at ages 17, 20, 24, and 29. We fit a quadratic multiple indicator latent growth model where the three diagnoses loaded onto an externalizing factor. This model fit the data well, and externalizing increased until it started to decline at age 24. High aggression and low control were the most significant predictors of the development of externalizing, with aggression playing a significant role in the development of externalizing across the 12‐year time span, and control predicting the development from age 17 to 24. The findings highlight the importance of considering the developmental course of externalizing in the context of personality and suggest that the specific personality traits of aggression and control might be targeted in externalizing prevention and intervention programs.     

Personality traits in late adolescence predict mental disorders in early adulthood: a prospective-epidemiological study

Prospective relations between personality traits and mental disorders were assessed in a longitudinal study of a representative birth cohort of young men and women from Dunedin, New Zealand. Personality traits were assessed via self-report questionnaire at age 18, and mental disorders were assessed via diagnostic interview at both ages 18 and 21. High "negative emotionality" (a propensity to experience aversive affective states) at age 18 was linked with affective, anxiety, substance dependence, and antisocial personality disorders at age 21 when corresponding mental disorders at age 18 were controlled. Low "constraint" (difficulty inhibiting the expression of affect and impulse) at age 18 was linked with substance dependence and antisocial personality disorders at age 21 when corresponding mental disorders at age 18 were controlled. The findings are discussed in terms of their implications for the development and treatment of mental disorders in young adulthood.     

Differential Determinants of Young Adult Substance Use and High‐Risk Sexual Behavior1

This investigation evaluated how personality traits, self‐efficacy, and outcome expectancies differentially relate to young adult substance use and high‐risk sex. Experiments I (N= 481) and 2 (N= 73) report the development of a new questionnaire to assess self‐efficacy for substance use and sexual behavior. Experiment 3 (N= 375) tested self‐efficacy, outcome expectancies, and trait measures of social conformity and sensation seeking as correlates of substance use and high‐risk sex. Using structural equation modeling, cross‐sectional analyses revealed that positive outcome expectancies had the largest association with substance use, whereas self‐efficacy had the largest association with sexual behavior. Further, personality traits were related to substance use and sexual behavior indirectly through outcome expectancies, with social conformity also having a direct effect on behavior. When examined longitudinally, past alcohol and drug use served as the final pathway by which expectancies and personality impacted substance use, whereas past behavior, self‐efficacy, and social conformity all contributed to high‐risk sex. Results support the utility of different models for explaining, and possibly preventing, young adult substance use and high‐risk sex.     

Development of psychiatric comorbidity with substance abuse in adolescents: effects of timing and sex.

Examined the impact of childhood psychiatric disorders on the prevalence and timing of substance use and abuse and tested for sex differences. A representative population sample of 1,420 children, ages 9, 11, and 13 at intake, were interviewed annually. American Indians and youth with behavioral problems were oversampled; data were weighted back to population levels for analysis. By age 16, more than half the sample reported substance use, and 6% had abuse or dependence. Alcohol use began by age 9, and smoking in the 13th year. Mean onset of dependence was 14.8 years, and mean onset of abuse was 15.1 years. Substance use began earlier in boys, but not girls, who later developed abuse or dependence. Disruptive behavior disorders and depression were associated with a higher rate and earlier onset of substance use and abuse in both sexes, but anxiety predicted later onset of smoking. Family drug problems were the strongest correlate of early onset. Despite differences in prevalence of psychopathology, boys and girls showed more similarities than differences in the course of early substance use and abuse, and its associations with psychopathology.     

Personality disorders associated with substance use among American and Greek adolescents

A study was conducted to investigate the association between personality disorder (PD) symptomatology and substance use among adolescents in community settings in the United States and Greece. The Structured Clinical Interview for DSM-IV Personality Disorders and the Adolescent Health Behavior Survey were completed by 37 male and 84 female adolescents, ages 15 to 18, who were recruited from an adolescent medical clinic and schools in and near New York City (n = 71) and Heraklion, Greece (n = 50). Results indicated that: (1) adolescents with PDs reported more frequent alcohol consumption during the past year than did those without PDs; (2) adolescents with borderline PD reported more cigarette smoking and heavy alcohol consumption than did those without borderline PD; (3) adolescents with antisocial PD symptomatology reported greater alcohol, cigarette, and illicit drug use than did those without antisocial PD symptomatology; and (4) although more American (30%) than Greek (4%) adolescents reported illicit substance use, differences were not observed in the prevalence of alcohol use, cigarette use, or personality disorders as a function of nationality.     

The longitudinal relationship of personality traits and disorders

Personality disorders are presumed to be stable because of underlying stable and maladaptive personality traits, but while previous research has demonstrated a link between personality traits and personality disorders cross-sectionally, personality disorders and personality traits have not been linked longitudinally. This study explores the extent to which relevant personality traits are stable in individuals diagnosed with 4 personality disorders (schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders) and examines the assumption that these personality disorders are stable by virtue of stable personality traits. This assumption was tested via the estimation of a series of latent longitudinal models that evaluated whether changes in relevant personality traits lead to subsequent changes in personality disorders. In addition to offering large consistency estimates for personality traits and personality disorders, the results demonstrate significant cross-lagged relationships between trait change and later disorder change for 3 of the 4 personality disorders studied.     

Age-based differences in treatment outcome among alcohol-dependent women

The literature suggests that women are at higher risk for negative consequences from alcohol use than men and that these risks are compounded by age. The current study investigated how alcohol-dependent women from different age groups might differ in terms of baseline functioning and treatment response. The sample consisted of 181 participants drawn from two randomized clinical trials of cognitive-behavioral treatments for alcohol-dependent women. Demographic and psychopathology data were obtained at baseline using the SCID (Structured Clinical Interview for DSM disorders) I for Axis I disorders and the SCID II or Personality Disorders Questionnaire for Axis II disorders. Social networks data were collected using the Important People and Activities Interview. Drinking data were collected at baseline and follow-up using the Timeline Follow Back Interview. ANOVAs revealed that older women had better psychosocial functioning in terms of being better educated and reporting fewer Axis I disorders. Also, older women had more supportive social networks in terms of more people, a smaller percentage of heavy drinkers, and a nondrinking spouse. Older women reported a less severe lifetime substance use history with a later age of first drink, later onset of alcohol use disorders, fewer lifetime abuse/dependence items, and less drug use. However, they reported drinking more frequently and more heavily over the 90 days prior to treatment. Finally, older women were more compliant with treatment and responded better by reducing drinking frequency and percentage of heavy drinking days. Suggestions to enhance treatment efficacy for younger women are made as well as suggestions for future research. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

P300 amplitude, externalizing psychopathology, and earlier- versus later-onset substance-use disorder

P300 amplitude predicts substance use or disorder by age 21. Earlier- versus later-onset substance disorders may reflect different levels of an externalizing psychopathology dimension. P300 in adolescence may not be as strongly related to later-onset substance problems as it is to earlier-onset ones. In the present study, visual P300 amplitude was measured at age 17 in a community-representative sample of young men. Substance and externalizing disorders were assessed at approximately ages 17, 20, and 24. Earlier-onset (by age 20) substance disorder was associated with higher rates of externalizing disorders than were later-onset problems. P300 amplitude was reduced in subjects with earlier-onset substance disorders, relative to later-onset and disorder-free subjects. Amplitude was also reduced in subjects with an externalizing disorder but no substance disorder. Earlier-onset subjects had reduced P300, even in the absence of an externalizing disorder. The results could not be attributed to a concurrent disorder or to recent substance use at the time of the P300 recording. The findings are consistent with P300 indexing an externalizing spectrum. Earlier-onset substance disorders are more strongly related to P300 and externalizing than are later-onset problems.     

Dependency,impulsivity, and self-harm: traits hypothesized to underlie the association between cluster B personality and substance use disorders

Cluster B personality disorders (PDs) (i.e., antisocial, borderline, histrionic, and narcissistic) typically show a high degree of comorbidity with substance use disorders (SUDs). Previous research suggests that the broad-based personality domains of Disinhibition and Negative Temperament/Neuroticism may be common factors to both types of disorders. Using a two-phase process (i.e., screening and follow-up), this study examined three lower-order personality traits (i.e., dependency, impulsivity, and self-harm) that fall within the Disinhibition and Neuroticism domains. The study evaluated the hypotheses that these traits (a) are related both to cluster B PDs and to SUDs; and (b) underlie the association between the two types of disorders. Results indicate that impulsivity and self-harm play a significant role in cluster B PDs and SUDs, as well as in their association with each other. However, dependency was not associated with either type of disorder. These results indicate that sets of individual traits can be of significant utility in understanding the comorbidity between PDs and SUDs.     

Measurement of Group Cohesion in U. S. Army Units

Two studies examined whether those identified as having a more present time perspective (PTP) are more likely to report using alcohol, drugs, and tobacco. In Study 1, across 2,627 participants from 15 samples, we found that PTP, as assessed by the Zimbardo Time Perspective Inventory, was related to more frequent self-reported alcohol, drug, and tobacco use (Substance Use scale: average r = .34, p <.001). Future time perspective (FTP) was negatively related to reported substance use (average r = -.16, p < .001), but the relation was weaker than that of PTP, suggesting that PTP and FTP are independent constructs. In Study 2, we found that PTP was a significant predictor of reported substance use even after controlling for many personality traits that have been related to increased substance use. These findings indicate that time perspective is an important individual difference construct that should be considered when examining health-related behaviors, such as substance use and abuse, and in planning intervention programs.     

Externalizing Disorders in Adolescence Mediate the Effects of Maternal Depression on Substance Use Disorders

Maternal depression has been linked to increased risk of substance use disorders (SUDs) in offspring. Cross-sectional studies have identified relationships among maternal depression, externalizing disorders and SUDs, but no longitudinal examination of causality has been undertaken. In order to address this gap in the literature, depression and externalizing disorders at or prior to age 15 were tested as mediators of the relationship between maternal depression and SUDs diagnosed between ages 16 and 20 in a sample of 702 Australian youth (363 women) using path models. Mothers’ and fathers’ substance diagnoses and earlier onset of substance abuse in youth were controlled for in all analyses. Consistent with previous work, maternal depression predicted SUDs between ages 16 and 20. An indirect effect of maternal depression through youth externalizing disorders diagnosed by age 16 was detected for alcohol and cannabis use disorders, but not drug disorders. Early adolescent depression was not a mediator of the relationship between maternal depression and any of the substance outcomes measured. To our knowledge, this study is the first to examine depression and externalizing disorders in early adolescence as mediators of the effect of maternal depression on psychopathology in later adolescence. Further work is needed to understand how family environment and genetic factors may explain the mediation by externalizing disorders.     

Preliminary Evidence for Associations of CHRM2 with Substance Use and Disinhibition in Adolescence

Evidence for shared heritable influences across domains of substance use suggests that some genetic variants influence broad risk for externalizing behaviors. Theories of externalizing psychopathology also suggest that genetic liability for substance use manifests as temperamental risk factors, particularly those related to behavioral disinhibition, during adolescence. The cholinergic muscarinic receptor 2 gene (CHRM2) is a promising candidate for studying genetic influences on broad-based risk for externalizing traits. This study examined a candidate CHRM2 polymorphism (rs1455858) in relation to substance use and personality measures of disinhibition in a sample of high-risk adolescents (n?=?124). Bivariate analyses and structural equation modeling (SEM) evaluated associations of rs1455858 with measures of drug involvement (alcohol, tobacco and marijuana) and disinhibition (indexed by impulsivity and sensation seeking scores). Bivariate analyses showed significant associations of CHRM2 with several behavioral phenotypes. In SEM analyses CHRM2 related significantly to latent measures of substance use and disinhibition; additionally, disinhibition mediated the association of CHRM2 with substance use. These results suggest that CHRM2 variants are potentially relevant for adolescent substance use and that temperamental risk factors could contribute to these associations.     

Borderline personality features predict alcohol use problems

This study assessed the relation between BPD features and problems associated with alcohol use 2 years later in young adults. Approximately 5,000 nonclinical young adults were screened for BPD features, and two cohorts of participants completed the laboratory phase of the study at Time 1 (total N = 421) and then again 2 years later at Time 2 (total N = 356). Measures included self-report and interview-based assessments of personality disorders, psychopathology in biological parents, Axis I psychopathology, and alcohol use problems. BPD features were found to significantly predict alcohol use problems 2 years later after controlling for parents' substance use disorders, Axis I psycho-pathology (including alcohol abuse/dependence), and non-BPD personality disorders. In addition, the BPD subscale that assesses impulsivity was found to be significantly associated with alcohol use problems once all predictors were entered into the model.     

Callous-Unemotional Traits as Unique Prospective Risk Factors for Substance Use in Early Adolescent Boys and Girls

Youth with elevated conduct disorder (CD) symptoms who also have callous-unemotional (CU) traits exhibit more antisocial behavior than youth without CU traits. However, evidence regarding whether CU traits increase risk of substance use over and above CD symptoms, and whether these associations differ for boys and girls, is scarce. Using the Developmental Pathways Project sample of 521 middle school students, we examined whether adolescent- and parent-reported CU traits measured in 6th grade prospectively predicted the onset and recurrence of substance use and use-related impairment by 9th grade. We also examined the degree to which CU traits uniquely predicted substance use and impairment over and above CD symptoms, as well as whether gender moderated these associations. Results indicated that adolescent-reported CU traits increased the likelihood of substance use and impairment onset and recurrence by 9th grade. Analyses revealed that CD symptoms accounted for prospective associations between adolescent-reported CU and substance use, but gender moderated these associations. Boys with elevated CU traits and CD symptoms were not more likely to report alcohol use onset or recurrence, but they were at highest risk of recurrent marijuana use, use of both alcohol and marijuana, and use-related impairment by 9th grade. Girls with low CU traits and high CD symptoms were most likely to report onset and recurrent use of alcohol, as well as recurrent marijuana use, use of both substances and impairment. Study findings highlight the importance of accounting for CD symptoms and gender when examining links between CU traits and substance use in early adolescence.     

Childhood conduct problems,attention deficit behaviors,and adolescent alcohol,tobacco, and illicit drug use

The relationships between conduct problems and attention deficit behaviors at age 8 years and the use of alcohol, tobacco, and illicit drugs at 15 years were studied in a birth cohort of over 900 New Zealand children. The analysis showed that while early conduct problems were significantly associated with later substance use there were no significant associations between early attention deficit behaviors and later substance use once the correlations between conduct problems and attention deficit behaviors were taken into account. These associations persisted after control for a range of potentially confounding covariates. Children who showed tendencies to conduct problems at age 8 consumed 1.5 to 1.9 times more alcohol and had rates of alcohol-related problems, daily cigarette smoking, and illicit drug use that were 1.9 to 2.0 times higher than children with low conduct problem scores. It is concluded that attention deficit behaviors, in the absence of conduct problems, are not associated with later substance use. However, even when due allowance is made for social and contextual factors associated with both early conduct problems and later substance use, early conduct problems are a risk factor for later substance use.This research was funded by grants from the Health Research Council of New Zealand and the National Child Health Research foundation.     

The Network Constellation of Personality and Substance Use: Evolution from Early to Late Adolescence

There is a well-established link between substance use and four personality traits of anxiety–sensitivity, hopelessness, impulsivity, and sensation-seeking. However, construct-level models of personality may conceal indicator-level personality–outcome associations. The current study aims to investigate evolution of the network constellation of personality and cannabis/alcohol use from early to late adolescence. Data comes from the longitudinal Co-Venture cohort (N = 3800). Personality indicators, measured by Substance Use Risk Profile Scale (SURPS) items, and the frequency of cannabis/alcohol use were assessed at four consecutive years (13–17 years old). Network constellations of the SURPS items and cannabis/alcohol use were estimated using Bayesian Gaussian graphical models at four time points. Results highlighted the age-specific associations between personality indicators and substance use. The positive role of the sensation-seeking trait (e.g. attitude towards transgression) was constant, whereas the positive role of hopelessness indicators (e.g. not being enthusiastic about future) and the negative role of anxiety–sensitivity indicators (e.g. fear of having unusual body sensations) were more prominent at early adolescence. The current study provides a novel perspective on the network structure of personality and substance use in adolescence and suggests substance-specific and age-adjusted targets in intervention efforts. © 2020 European Association of Personality Psychology