Oxytocin Receptor Gene Relates to Theory of Mind and Prosocial Behavior in Children

Individual social differences have been addressed in recent studies, and the oxytocin receptor gene (OXTR) is the major candidate in explaining various social phenotypes. To study the association between a well-known haplotype (rs53576) of OXTR and children's prosocial behavior and its relationship with theory of mind (ToM) ability, 87 children (aged 3 to 5 years old) participated in 3 prosocial tasks and ToM performance experiments. Participants who were homozygous for the G allele (GG) exhibited more prosocial behaviors than did those with 1 or 2 copies of the A allele (AA), and GG carriers also displayed better ToM ability than did AA individuals. Further tests showed differences between genotypes in helping and comforting, albeit not in sharing. The results demonstrated that OXTR rs53576 was related to individual differences in ToM and was associated with prosocial behavior.     

Sensitivity in detecting facial displays of emotion: Impact of maternal depression and oxytocin receptor genotype

The current study examined sensitivity in detecting emotional faces among children of depressed and non-depressed mothers. A second goal was to examine the potential moderating role of the oxytocin receptor gene (OXTR rs53576), which has been linked to emotion recognition in the past. Participants included 247 children (ages 8–14). Children completed a forced choice emotion identification task. Maternal history of major depressive disorder during children's lives was associated with children's sensitivity in detecting emotional faces among children homozygous for the OXTR rs53576 G allele, but not among carriers of the A allele. Among G homozygotes, children of depressed mothers exhibited increased sensitivity in detecting sad faces, and reduced sensitivity in detecting happiness, compared to children of non-depressed mothers.     

Experiences of physical and relational victimization in children with ADHD: The role of social problems and aggression

The social risk factors for physical and relational peer victimization were examined within a mixed‐gender sample of children with and without attention‐deficit/hyperactivity disorder (ADHD). Participants were 124 children (ages 8–12 years; 48% boys), with 47% exhibiting sub‐clinical or clinical elevations in ADHD symptoms. ADHD and oppositional defiant disorder (ODD) symptom counts were assessed based on parent‐ and teacher‐reports; parents rated children's social problems and teachers rated children's use of physical and relational aggression and experiences of physical and relational victimization. A multiple mediator model was used to test whether there were indirect effects of ADHD or ODD symptoms on physical and relational victimization through social problems, physical aggression, or relational aggression. At the bivariate level, ADHD and ODD symptoms were both significantly associated with higher rates of physical and relational victimization. In the mediational model, there were significant indirect effects of ADHD symptoms on relational victimization via social problems, of ODD on relational victimization via relational aggression, and of ODD symptoms on physical victimization via physical aggression. Results suggest that there are distinct risk factors implicated in the physical and relational victimization of youth with ADHD and that the co‐occurrence of ODD symptoms is important to assess. Clinical implications for addressing victimization in children with ADHD are discussed.

     

Gene–Environment Interaction of the Oxytocin Receptor Gene Polymorphism (rs53576) and Unresolved Attachment Status Predict Depersonalization Symptoms: An Exploratory Study

Depersonalization (DP), or feelings of detachment from one’s self or one’s surroundings (i.e., derealization, DR), is considered a maladaptive stress response, frequently occurring in anxiety disorders, depression or as a primary disorder. However, the pathogenesis of DP/DR symptoms is little understood. The present study aimed to elucidate the influence of unresolved attachment status and the oxytocin receptor gene (OXTR) rs53576 polymorphism on DP/DR symptoms. The study sample consisted of 84 women, including 43 depressed patients and 41 control subjects, aged 19–52. DP/DR symptoms were measured with the Cambridge Depersonalization Scale; unresolved attachment status was assessed with the Adult Attachment Interview. OXTR rs53576 genotypes were obtained from blood samples. We found a highly significant gene–environment interaction: Individuals with unresolved attachment status were significantly more depersonalized when they carried the GG-allele than A-allele carriers than not unresolved subjects. There was no statistically significant main influence of OXTR genotypes or unresolved attachment status on DP/DR symptoms. We suggest that the GG-allele and unresolved attachment status might be considered as risk factors in the etiology of DP/DR symptoms. Replication is needed in larger samples including male subjects.     

Aggression Norms in the Classroom Social Network: Contexts of Aggressive Behavior and Social Preference in Middle Childhood

In a cross‐sectional sample of African‐American 2nd–4th grade students (N = 681), we examine the moderating effects of classroom overt and relational aggression norms on peers’ social acceptance of classmates who exhibit overt and relational aggression in urban schools. Extending theory and research on classroom norms, we integrate social network data to adjust aggression norms based on children’s direct and indirect connections in the classroom. Results of multilevel models indicate that network‐based classroom aggression norms moderated relations between children’s aggressive behavior and their social preference. Specifically, children benefited socially when their form of aggressive behavior fit with what was normative in the classroom social context. The moderating effect of classroom aggression norms was stronger for the association between overt aggression and social preference than relational aggression and social preference. Relationally aggressive youth were socially preferred by peers regardless of the classroom norm, although this positive association was magnified in classrooms with higher levels of relational aggression. Future research focused on aggression norms within classroom social networks are discussed and implications for school prevention efforts are considered.     

Pubertal Timing and Youth Internalizing Psychopathology: The Role of Relational Aggression

The current study examined relational aggression as a potential mechanism that explains the association between off-time pubertal development and internalizing problems in youth. Youth gender was also examined as a moderator for the association between these variables. It was hypothesized that early pubertal maturation would be associated with higher levels of relationally aggressive behavior which, in turn, would be associated with elevated levels of internalizing problems. Parents of 372 children between the ages of 8 and 17 were recruited through Amazon’s Mechanical Turk. Parents responded to demographic information about themselves, as well as information about their child’s pubertal timing, relationally aggressive behavior, and anxiety and depressive symptoms. Findings indicated that early pubertal timing was associated with higher levels of anxiety directly, and higher levels of both anxiety and depressive symptoms indirectly through higher levels of relational aggression. In all but one of the pathways examined, gender was not found to moderate the associations between the study variables of interest. This study is the first to examine relational aggression as a mechanism by which early pubertal timing leads to internalizing problems. The findings suggest that relational aggression could be a target for intervention among early developing youth who are at risk for internalizing problems.     

Sex differences in the personal costs and benefits of relational and physical aggression in high school

While recent research using peer ratings demonstrates positive relations between youth's reputations for aggression and popularity, it is not clear whether aggressive youth themselves make these links. Using youth's self‐reports, this study assessed the associations of relational and physical aggression with indicators of both personal gains in peer relations (perceived popularity and receipt of prosocial attention) and personal costs in terms of retaliation or depressive responses (peer victimization and depressive symptoms) in a large sample (n=455) of eighth‐ to tenth‐grade students. Regression analyses reveal that more relationally aggressive youth report more prosocial attention but also more relational (but not physical) victimization. In contrast, more physically aggressive youth report more depressive symptoms and physical (but not relational) victimization. Findings suggest that some costs of aggression (victimization) are higher for boys while others (depressive symptoms) are greater for girls. Group differences were also found for aggressive, victimized, and aggressive/victimized youth compared to the typical low aggressive/low victimized youth. These data suggest that the costs of relational and physical aggression may outweigh benefits except for aggressive non‐victimized boys. Aggr. Behav. 32:409–419, 2006. © 2006 Wiley‐Liss, Inc.     

The Role of Intimate Exchange in the Link Between Reactive Aggression and Child Depressive Symptoms

Although the link between reactively aggressive behavior and depressive symptoms in childhood has been demonstrated in previous work, few studies have examined how peer factors may influence this association. Examining the role of peers in the link between reactive aggression and depressive symptoms is necessary, as peers have been found to buffer the impact of factors that contribute to depressive symptoms in childhood. Accordingly, we examined whether intimate exchange with a best friend moderated the association between reactive aggression and depression in childhood in a sample of 115 children (aged 5–14; M = 8.88; 87 % minority; 53 % male) who attended a community based summer program. Consistent with expectation, reactive aggression was positively associated with child depressive symptoms whereas proactive aggression was negatively associated with depressive symptoms. Further, the interaction between intimate exchange and reactive aggression was associated with child depressive symptoms. Specifically, the association between reactive aggression and depressive symptoms was weaker when levels of intimate exchange were high. Thus, the current study suggests that close peer relationships may help to buffer the link between reactively aggressive behavior and depressive symptoms. Implications for findings include the need to target friendships to help prevent depressive symptoms for reactively aggressive youth.     

Childhood Social Withdrawal,Interpersonal Impairment,and Young Adult Depression: A Mediational Model

Building on interpersonal theories of depression, the current study sought to explore whether early childhood social withdrawal serves as a risk factor for depressive symptoms and diagnoses in young adulthood. The researchers hypothesized that social impairment at age 15 would mediate the association between social withdrawal at age 5 and depression by age 20. This mediational model was tested in a community sample of 702 Australian youth followed from mother’s pregnancy to youth age 20. Structural equation modeling analyses found support for a model in which childhood social withdrawal predicted adolescent social impairment, which, in turn, predicted depression in young adulthood. Additionally, gender was found to moderate the relationship between adolescent social impairment and depression in early adulthood, with females exhibiting a stronger association between social functioning and depression at the symptom and diagnostic level. This study illuminates one potential pathway from early developing social difficulties to later depressive symptoms and disorders.     

A Test of Interpersonal Theory of Depression in Youth Psychiatric Inpatients

Coyne's (1976b) interpersonal theory of depression postulated that the combination of depressive symptoms and excessive reassurance-seeking leads to interpersonal problems (e.g., loneliness, devaluation). The present study is one of the first to test this model among youth, particularly a clinical sample of youth. Sixty-eight youth psychiatric inpatients (35 girls; 33 boys; mean age = 13.34 years, SD = 2.50) completed self-report measures of excessive reassurance-seeking, depressive symptoms, and interpersonal rejection. Results conformed to the hypothesis: The statistical interaction of excessive reassurance-seeking and depressive symptoms predicted interpersonal rejection, such that high-reassurance-seeking youth with depressive symptoms reported the most interpersonal rejection. Implications of the findings for interpersonal theory of depression in youngsters are discussed.     

Depressive Symptoms and Conversational Self-Focus in Adolescents’ Friendships

This multi-method, longitudinal study considered the interplay among depressive symptoms, aversive interpersonal behavior, and interpersonal rejection in early and middle adolescents’ friendships. In particular, the study examined a newly identified interpersonal process, conversational self-focus (i.e., the tendency to redirect conversations about problems to focus on the self). Traditional interpersonal theories of depression suggest that individuals with depressive symptoms engage in aversive behaviors (such as conversational self-focus) and are rejected by others. However, in the current study, not all adolescents with depressive symptoms engaged in conversational self-focus and were rejected by friends. Instead, conversational self-focus moderated prospective relations of depressive symptoms and later friendship problems such that only adolescents with depressive symptoms who engaged in conversational self-focus were rejected by friends. These findings are consistent with current conceptualizations of the development of psychopathology that highlight heterogeneity among youth who share similar symptoms and the possibility of multifinality of outcomes.     

Differential susceptibility in spillover between interparental conflict and maternal parenting practices: evidence for OXTR and 5-HTT genes

Guided by the affective spillover hypothesis and the differential susceptibility to environmental influence frameworks, the present study examined how associations between interparental conflict and mothers' parenting practices were moderated by serotonin transporter (5-HTT) and oxytocin receptor (OXTR) genes. A sample of 201 mothers and their 2-year old child participated in a laboratory-based research assessment. Results supported differential susceptibility hypotheses within spillover frameworks. With respect to OXTR rs53576, mothers with the GG genotype showed greater differential maternal sensitivity across varying levels of interparental conflict. Mothers with one or two copies of the 5-HTTLPR S allele demonstrated differential susceptibility for both sensitive and harsh/punitive caregiving behaviors. Finally, analyses examined whether maternal depressive symptoms and emotional closeness to their child mediated the moderating effects. Findings suggest that maternal emotional closeness with their child indirectly linked OXTR with maternal sensitivity. The results highlight how molecular genetics may explain heterogeneity in spillover models with differential implications for specific parenting behaviors. Implications for clinicians and therapists working with maritally distressed parents are discussed.     

A Test of the Perfectionism Social Disconnection Model among Ethnic Minority Youth

Perfectionistic self-presentation (PSP) has been identified as a vulnerability factor in the development of depressive disorders during early adolescence. The Perfectionism Social Disconnection Model (PSDM) offers a theoretical framework suggesting PSP leads to depressive symptoms via interpersonal problems and social disconnection. Previous studies have supported the role of social disconnection as a mediator in the relation between PSP and suicidal ideation, but have not evaluated interpersonal problems in the model. Furthermore, the generalizability of the model has not been established for community and ethnic minority samples. Using cross-sectional data, the present study addresses these gaps by evaluating the PSDM and including social anxiety and loneliness as indicators of interpersonal problems and social disconnection, respectively, as predictors of youth depressive symptoms. The sample includes 289 (51.2% females) predominately low income and Latino and African American youth in fifth through seventh grade in three public schools. As predicted, social anxiety mediates the relationship between both PSP and loneliness and PSP and depressive symptoms. Moreover, mediational analyses indicate that social anxiety accounts for the relation between PSP and depression. Consistent with the PSDM model, the relationship between PSP and youth depressive symptoms is mediated sequentially through both social anxiety and loneliness, but primarily among the Latino sample.     

Relation of Depression and Anxiety to Self‐ and Peer‐Reported Relational Aggression

The primary purpose of this multimethod and multimeasure study was to identify how the peer relationships of Australian adolescents (ages 9–15 years; N = 335) at school, including relational aggression and victimization, correlated with their symptoms of depression and anxiety. Moreover, relational aggression and victimization were measured via both self‐ and peer report, and discrepancies between reports were considered as correlates of symptoms and peer relationship status. Adolescents who reported more symptoms of depression and anxiety also self‐reported more relational victimization and reported their peers as less trustworthy. Adolescents who overreported their own relational victimization and aggression compared with peer report had more symptoms compared with those who agreed with their peers or underreported their aggression and victimization. Adolescents who underreported their own aggression were not only more socially prominent but were also more disliked by their peers. When considered independent of self‐reports, no measure of peer‐reported peer status, aggression, or victimization was associated with depressive symptoms; but adolescents reported as more accepted by their peers had fewer anxiety symptoms. Longitudinal research should be conducted to examine adolescents' increasing socioemotional problems as correlates of discrepancies between self‐ and peer reports of relational aggression and victimization. Aggr. Behav. 38:16‐30, 2012. © 2011 Wiley Periodicals, Inc.     

Interpersonal predictors of onset of depression during the transition to adulthood

There is evidence that depression during adolescence and early adulthood is marked by deficits in interpersonal functioning. However, few studies have prospectively examined whether interpersonal difficulties are a risk factor for depression onset, so it is unclear whether these deficits in interpersonal functioning are products or predictors of depression. The present study aimed to clarify the direction of association between interpersonal factors and depression by examining whether social factors longitudinally predicted onset of depression in a diverse sample of young women with no history of depression. Hierarchical multiple regression analyses controlling for baseline depressive symptoms indicated that poorer family relationship quality and anxious attachment cognitions predicted onset of depressive episodes during the 2‐year period. Further, a wide variety of interpersonal factors predicted depressive symptoms over 6 months, including poor peer and family relationship quality, difficulty being close to others, and difficulty depending on others, controlling for baseline depressive symptoms and college attendance. The results provide evidence for the importance of an interpersonal perspective on vulnerability to depression.     

Maternal borderline personality disorder symptoms and adolescent psychosocial functioning

Borderline personality disorder (BPD) is characterized by severe disruption of interpersonal relationships, yet very little research has examined the relationship between maternal BPD and offspring psychosocial functioning. The present study examined 815 mothers and their 15-year-old children from a community-based sample to determine (1) if there is an association between mothers' BPD symptoms and the interpersonal functioning, attachment cognitions, and depressive symptoms of their offspring, and (2) if the association of maternal BPD and youth outcomes is independent of maternal and youth depression. Measures of youth psychosocial functioning included self, mother, interviewer rated, and teacher reports. Results indicated that there was a significant association between maternal BPD symptoms and youth outcomes, and that this association remained even after controlling for maternal lifetime history of major depression, maternal history of dysthymic disorder, and youth depressive symptoms. This study provides some of the first empirical evidence for a link between mother's BPD symptoms and youth psychosocial outcomes.     

The Role of Relationships in Understanding the Alexithymia–Depression Link

Alexithymia is associated with increased depressive symptoms in both clinical and community samples. One way that alexithymia may lead to depression is through its impact on interpersonal relationships. Individuals with alexithymia report lower perceived social support, intimacy, and relationship satisfaction. Furthermore, poor relationship functioning is a clear risk factor for depressive symptoms. Given the established alexithymia–depression link and marital dysfunction–depression link, a logical next step is to examine whether relationship dysfunction (low social support, intimacy, negative relationship behaviours, and relationship dissatisfaction) mediates the association between alexithymia and depressive symptoms. The hypothesized mediation model was assessed in a sample of 104 community couples with two analytical approaches—first with cross‐sectional measures using path analysis and second with daily diary measures collected over a seven‐day period using a multilevel modelling approach. Poor relationship functioning mediated the association between alexithymia and depressed mood in the daily diary data and partially mediated that association with the cross‐sectional measures. These results identify alexithymia as an important variable in understanding the marital functioning–depression association, and this finding has implications for treatment. Copyright © 2012 European Association of Personality Psychology     

An Examination of Network Position and Childhood Relational Aggression: Integrating Resource Control and Social Exchange Theories

Applying resource control theory and social exchange theory, we examined the social network conditions under which elementary age children were likely to engage in relational aggression. Data on classroom peer networks and peer‐nominated behaviors were collected on 671 second‐ through fourth‐grade children in 34 urban, low‐income classrooms. Nested regression models with robust cluster standard errors demonstrated that the association between children's number of relationships and their levels of relational aggression was moderated by the number of relationships that their affiliates had. Children with more peer relationships (i.e., higher network centrality) exhibited higher levels of relational aggression, but only when these relationships were with peers who had fewer connections themselves (i.e., poorly connected peers). This finding remained significant even when controlling for common predictors of relational aggression including gender, overt aggression, prosocial behavior, victimization, social preference, and perceived popularity. Results are discussed in terms of their implications for advancing the literature on childhood relational aggression and their practical applications for identifying children at risk for these behaviors.     

Humor styles impact the relationship between symptoms of social anxiety and depression

Recent research suggests that examining humor styles may contribute to our understanding of clinical problems, such as risk and resiliency. The goal of the current study was to examine whether humor styles moderate the association between social anxiety and depressive symptoms in an unselected sample. Three-hundred and six participants (66% female) at a large Southern US university completed self-report measures of humor styles and symptoms of social anxiety and depression. Regression analyses suggested that affiliative and self-defeating humor styles individually moderated the relationship between social anxiety and depressive symptoms. Clinical implications regarding the monitoring of humor use as a means of understanding the maintenance of depressive symptoms among socially anxious individuals are discussed.     

COMT基因rs6267多态性与母亲教养行为对青少年身体攻击和关系攻击的交互作用

遗传与环境如何交互作用影响儿童青少年的攻击行为是当前攻击研究中的重要前沿课题之一。近年来, 分子遗传学关于人类攻击的研究已拓展到对不同攻击亚类(身体攻击和关系攻击)的遗传基础的探讨。本研究运用问卷法与DNA分型技术, 对1258名儿童进行为时4年(四年级—七年级)的追踪调查, 考察COMT基因rs6267多态性与母亲教养行为对青少年身体攻击和关系攻击的交互作用以及性别在其中的调节作用。结果发现, COMT基因rs6267多态性与母亲教养行为仅交互作用于男青少年的身体攻击, 母亲教养行为显著预测GG 基因型男青少年的身体攻击, 但对T等位基因男青少年身体攻击的预测作用并不显著。COMT基因rs6267多态性与母亲教养行为对青少年关系攻击的交互作用不显著。本研究结果表明, 身体攻击和关系攻击具有不同遗传基础和发生机制。