Computerized assessment of syntactic complexity in Alzheimer’s disease: a case study of Iris Murdoch’s writing

Currently, the majority of investigations of linguistic manifestations of neurodegenerative disorders such as Alzheimer’s disease are conducted based on manual linguistic analysis. Grammatical complexity is one of the language use characteristics sensitive to the effects of Alzheimer’s disease and is difficult to operationalize and measure using manual approaches. In the current study, we demonstrate the application of computational linguistic methods to automate the analysis of grammatical complexity. We implemented the Computerized Linguistic Analysis System (CLAS) based on the Stanford syntactic parser (Klein and Manning, Pattern Recognition, 38(9), 1407–1419, 2005) for longitudinal analysis of changes in syntactic complexity in language affected by neurodegenerative disorders. We manually validated CLAS scoring and used it to analyze writings of Iris Murdoch, a renowned Irish author diagnosed with Alzheimer’s disease. We found clear patterns of decline in grammatical complexity consistent with previous analyses of Murdoch’s writing conducted by Garrard, Maloney, Hodges, and Patterson (Brain, 128(250–260, 2005). CLAS is a fully automated system that may be used to derive objective and reproducible measures of syntactic complexity in language production and can be particularly useful in longitudinal studies with large volumes of language samples.     

Working memory capacity and spontaneous emotion regulation in generalised anxiety disorder

Researchers have postulated that deficits in cognitive control are associated with, and thus may underlie, the perseverative thinking that characterises generalised anxiety disorder (GAD). We examined associations between cognitive control and levels of spontaneous state rumination following a stressor in a sample of healthy control participants (CTL; n?=?27) and participants with GAD (n?=?21). We assessed cognitive control by measuring working memory capacity (WMC), defined as the ability to maintain task-relevant information by ignoring task-irrelevant information. To this end, we used an affective version of the reading span task with valenced (negative or neutral) distractors. Lower WMC in the presence of negative distractors was associated with greater state rumination in the GAD group, but not in the CTL group. These findings suggest that difficulty maintaining task-relevant information due to interference from negative distractors contributes to perseverative thinking in GAD.     

Visual complexity attenuates emotional processing in psychopathy: Implications for fear-potentiated startle deficits

A long-standing debate is the extent to which psychopathy is characterized by fundamental deficits in attention or emotion. We tested the hypothesis that the interplay of emotional and attentional systems is critical for understanding processing deficits in psychopathy. A group of 63 offenders were assessed using the Psychopathy Checklist: Screening Version. Event-related brain potentials (ERPs) and fear-potentiated startle (FPS) reflexes were collected while participants viewed pictures selected to disentangle an existing confound between perceptual complexity and emotional content in the pictures typically used to study fear deficits in psychopathy. As predicted, picture complexity moderated the emotional processing deficits. Specifically, the affective–interpersonal features of psychopathy were associated with greater allocation of attentional resources to processing emotional stimuli at initial perception (visual N1), but only when the picture stimuli were visually complex. Despite this, results for the late positive potential indicated that emotional pictures were less attentionally engaging and held less motivational significance for individuals high in affective–interpersonal traits. This deficient negative emotional processing was observed later in their reduced defensive fear reactivity (FPS) to high-complexity unpleasant pictures. In contrast, the impulsive–antisocial features of psychopathy were associated with decreased sensitivity to picture complexity (visual N1) and were unrelated to emotional processing, as assessed by both ERPs and FPS. These findings are the first to demonstrate that picture complexity moderates FPS deficits, and they implicate the interplay of attention and emotional systems as deficient in psychopathy.     

Relations among cognitive,semantic, and syntactic variables in children's comprehension of the minimum distance principle: A 2-year developmental study

Theoretical issues regarding cognitive aspects of the semantic interpretation of two syntactic structures were examined. A 2-year study was conducted investigating possible developmental trends in children's sentence-processing strategies. Experimental materials incorporated two levels of role expectations and two levels of syntactic complexity. Subjects were initially 6–10 years old; 12 original subjects from each age group were retested a year later. Exceptional and typical syntactic structures were not of significantly different difficulty either year. Semantic and cognitive complexity, as reflected in the two levels of expectation, was significant both years (p<0.001). Performance improved, over the 12-month period, in all but the 7- to 8-year-old group (p<0.005). Results are discussed with reference to cognitive strategies in sentence processing.This article is based on research reported at the annual meeting of the Northeastern Educational Research Association, Ellenville, New York, October 29–31, 1975.     

The Relationship Among Major Depression, Depressive Symptoms, and Self-Preoccupation

The present study investigates whether highly self-preoccupied people (exhibiting a tendency to focus primarily on the self and to maintain self-focused attention) were more likely to experience major depressive episodes (MDEs) than those without such tendencies. One hundred nineteen young community residents, aged 18 to 21, took part in semistructured interviews, during which we investigated their past and present history of mental illness, including MDEs, as delineated by the Diagnostic and Statistical Manual of Mental Disorders (3rd ed. rev.; DSM-III-R). Self-preoccupation was measured by the Self-Preoccupation Scale (SPS). Of the 119 participants interviewed, the lowest and highest quarters in the SPS scores formed the low- and high-self-preoccupation (SP) groups. The lifetime prevalence of the DSM-III-R MDE was significantly greater among those high in SP than in the low SP group. Moreover, the high-SP group had significantly more depressive symptoms than the low-SP group. The contributory role of self-preoccupation to suicide ideation and the interpersonal aspects of self-preoccupation were discussed.     

Linguistic correlates of asymmetric motor symptom severity in Parkinson’s Disease

Asymmetric motor severity is common in Parkinson’s Disease (PD) and provides a method for examining the neurobiologic mechanisms underlying cognitive and linguistic deficits associated with the disorder. In the present research, PD participants (N = 31) were assessed in terms of the asymmetry of their motor symptoms. Interviews with the participants were analyzed with the Linguistic Inquiry and Word Count (LIWC) program. Three measures of linguistic complexity – the proportion of verbs, proportion of function words, and sentence length – were found to be affected by symptom asymmetry. Greater left-side motor severity (and hence greater right-hemisphere dysfunction) was associated with the production of significantly fewer verbs, function words, and shorter sentences. Hence, the production of linguistic complexity in a natural language context was associated with relatively greater right hemisphere involvement. The potential neurobiological mechanisms underlying this effect are discussed.     

Emotion regulation and biological stress responding: associations with worry,rumination, and reappraisal

ABSTRACT

Individual differences in the habitual use of emotion regulation strategies may play a critical role in understanding psychological and biological stress reactivity and recovery in depression and anxiety. This study investigated the relation between the habitual use of different emotion regulation strategies and cortisol reactivity and recovery in healthy control individuals (CTL; n?=?33) and in individuals diagnosed with social anxiety disorder (SAD; n?=?41). The tendency to worry was associated with increased cortisol reactivity to a stressor across the full sample. Rumination was not associated with cortisol reactivity, despite its oft-reported similarities to worry. Worry and rumination, however, were associated with increased cortisol during recovery from the stressor. The only difference between CTL and SAD participants was observed for reappraisal. In the CTL but not in the SAD group, reappraisal predicted recovery, such that an increased tendency to reappraise was associated with greater cortisol recovery. These results suggest an important role of the habitual use of emotion regulation strategies in understanding biological stress reactivity and recovery.     

Verb deficits in Alzheimer's disease and agrammatism: implications for lexical organization

This study examined the nature of verb deficits in 14 individuals with probable Alzheimer's Disease (PrAD) and nine with agrammatic aphasia. Production was tested, controlling both semantic and syntactic features of verbs, using noun and verb naming, sentence completion, and narrative tasks. Noun and verb comprehension and a grammaticality judgment task also were administered. Results showed that while both PrAD and agrammatic subjects showed impaired verb naming, the syntactic features of verbs (i.e., argument structure) influenced agrammatic, but not Alzheimer's disease patients' verb production ability. That is, agrammatic patients showed progressively greater difficulty with verbs associated with more arguments, as has been shown in previous studies (e.g., Kim & Thompson, 2000; Thompson, 2003; Thompson, Lange, Schneider, & Shapiro, 1997), and suggest a syntactic basis for verb production deficits in agrammatism. Conversely, the semantic complexity of verbs affected PrAD, but not agrammatic, patients' performance, suggesting "bottom-up" breakdown in their verb lexicon, paralleling that of nouns, resulting from the degradation or loss of semantic features of verbs.     

Age, working memory, and on-line syntactic processing in sentence comprehension

One hundred twenty-seven individuals who ranged in age from 18 to 90 years were tested on a reading span test and on measures of on-line and off-line sentence processing efficiency. Older participants had reduced working-memory spans compared with younger participants. The on-line measures were sensitive to local increases in processing load, and the off-line measures were sensitive to the syntactic complexity of the sentences. Older and younger participants showed similar effects of syntactic complexity on the on-line measures. There was some evidence that older participants were more affected than younger participants by syntactic complexity on the off-line measures. The results support the hypothesis that on-line processes involved in recognizing linguistic forms and determining the literal, preferred, discourse-coherent meaning of sentences constitute a domain of language processing that relies on its own processing resource or working-memory system.     

Syntactic agreement attraction reflects working memory processes

Does producing syntactic agreement rely on syntactic or memory-based retrieval processes? The present study investigated the extent to which syntactic processing deficits and working memory (WM) deficits predict susceptibility to agreement attraction [Bock, K., &; Miller, C. A. (1991). Broken agreement. Cognitive Psychology, 23, 45–93], where speakers tend to erroneously produce plural agreement for a singular subject when another noun in the sentence is grammatically plural. Four brain-injured patients with varying degrees of grammatical and WM deficits completed sentences with local nouns that matched or mismatched in number with the head noun, and that were plausible or implausible subjects. Both aspects of grammatical deficits and the extent of WM deficits predicted the extent of agreement attraction effects. These data are consistent with the proposal that producing an agreeing verb involves a cue-based search in WM for an appropriate controlling noun, which is subject to interference from other elements in memory with similar properties [cf. Badecker, W., &; Kuminiak, F. (2007). Morphology, agreement and working memory retrieval in sentence production: Evidence from gender and case in Slovak. Journal of Memory and Language, 56(1), 65–85. doi:10.1016/j.jml.2006.08.004].     

Syntactic Complexity Effects in Sentence Production: A Reply to MacDonald,Montag, and Gennari (2016)

In our article, “Syntactic complexity effects in sentence production” (Scontras, Badecker, Shank, Lim, & Fedorenko, 2015 ), we reported two elicited production experiments and argued that there is a cost associated with planning and uttering syntactically complex, object‐extracted structures that contain a non‐local syntactic dependency. MacDonald et al. ( 2016 ) have argued that the results of our investigation provide little new information on the topic. We disagree. Examining the production of subject versus object extractions in two constructions across two experimental paradigms—relative clauses in Experiment 1 and wh‐questions in Experiment 2—we found a strikingly similar pattern: reliable differences in latency and word durations, as well as in rates of disfluencies, signaling a greater cost associated with planning and uttering the syntactically more complex object extractions. MacDonald et al. reject that interpretation, namely that the differences we observed in the production of subject versus object extractions demonstrate asymmetric production difficulties. Here we address the concerns they raise by clarifying confusion and presenting novel experimental evidence in support of our original claims.     

Associations Between Family Environment, Parenting Practices, and Executive Functioning of Children with and Without ADHD

We examined the relationships between executive functioning, family environment, and parenting practices in children diagnosed with ADHD as compared to children without ADHD. Participants were parents (N = 134) of 6- to 12-year-old ADHD and non-ADHD-diagnosed children. Compared to the control group, parents of children diagnosed with ADHD reported their children as exhibiting greater problems with behavioral control and metacognitive abilities, and described their family environments as less organized and higher in family conflict. Family environment and parenting practices were not correlated with behavioral control or metacognitive abilities in children with ADHD. In children without ADHD, higher levels of family cohesion, organization, and expressiveness, and lower levels of family conflict, were significantly correlated with greater behavioral control. Higher levels of family cohesion and organization were significantly and positively associated with regulation of metacognitive abilities in children without ADHD. In general, aspects of the family environment and parental limit setting appear to be associated with the development of executive functions in children not diagnosed with ADHD; however, family environment and parenting practices were not associated with executive functions in children diagnosed with ADHD.     

Hyperactivity and pediatrician diagnoses,parental ratings,specific cognitive abilities,and laboratory measures

Children diagnosed as hyperactive and treated for hyperactivity by private pediatricians were compared to a large unselected sample of children on parental ratings of behavioral problems (Conners Symptoms Rating Questionnaire), laboratory measures (a week-long assessment of locomotion as measured by pedometers, sustained attention, selective attention, fidgeting, and aggressiveness), and 10 tests of specific cognitive abilities (verbal reasoning, spatial reasoning, memory, and perceptual speed). Test-retest reliability was obtained for all measures. The results indicated that pediatrician diagnoses of hyperactivity are related to parental ratings but not to laboratory assessments. Diagnoses by private pediatricians may include more heterogeneous and nonspecific behavioral problems than diagnoses made in most research contexts. Pediatrician diagnoses were related to deficits in specific cognitive abilities, most notably perceptual speed and verbal ability. Hyperactivity as diagnosed by private pediatricians may reflect deficits in skills necessary to pace oneself appropriately in school-related tasks. In general, these results suggest that the criteria and methods used to diagnose hyperactivity deserve greater attention.We are grateful to the Spencer Foundation for their support of this research. Preparation of this report was supported in part by a Research Scientist Development Award (AA-00041) from the ADAMHA NIAAA.     

Homophobia in physical education and sport: The role of physical/sporting identity and attributes,authoritarian aggression,and social dominance orientation

We examined levels of, and reasons for, anti‐gay and anti‐lesbian prejudice (homophobia) in pre‐service physical education (PE) and non‐physical education (non‐PE) university students. Participants (N = 409; 66% female; N = 199 pre‐service physical educators) completed questionnaires assessing anti‐gay and lesbian prejudice, authoritarianism, social dominance orientation (SDO), physical/athletic identity and self‐concept, and physical attributes. ANCOVAs revealed that PE students had higher levels of anti‐gay (p = .004) and lesbian prejudice than non‐PE students (p = .008), respectively. Males reported greater anti‐gay prejudice (p < .001), but not anti‐lesbian prejudice, than females. Authoritarian aggression was positively associated with greater anti‐gay (β = .49) and lesbian prejudice (β = .37) among male participants. Among females, higher authoritarian aggression and SDO was associated with greater anti‐gay (β = .34 and β = .25, respectively) and lesbian (β = .26 and β = .16, respectively) prejudice. The physical identity‐related constructs of athletic self‐concept (β = .?15) and perceived upper body strength (β = .39) were associated with anti‐gay attitudes among male participants. Physical attractiveness (β = ?.29) and upper body strength (β = .29) were also associated with male participants’ anti‐lesbian prejudice. Regression analyses showed that the differences between PE and non‐PE students in anti‐gay and lesbian prejudice were largely mediated by authoritarianism and SDO. The present study is the first to examine the relationship between investment in physical/sporting identity and attributes and anti‐gay and lesbian prejudice in PE/sport participants. In the present sample, anti‐gay and lesbian prejudice was greater in pre‐service PE students than non‐PE students, but these differences appear to be explained by differences in conservative ideological traits. Additionally, physical identity and athletic attributes based around masculine ideals also appear to contribute to this prejudice in males.     

Autonomy and defensiveness: Experimentally increasing adaptive responses to health-risk information via priming and self-affirmation

Health information is often ineffective in motivating health-behaviour change. One way to improve information effectiveness might be to highlight autonomy, which is associated with less defensiveness and more adaptive psychological functioning. Three studies assessed whether experimentally elevating autonomy led to adaptive responses to risk information about alcohol consumption. In Study 1 (N?=?104), participants completed either an autonomy prime or a neutral prime task and read either risk information about the dangers of alcohol consumption or neutral information. Among high-risk participants in the autonomy prime condition, those who read risk information reported greater autonomous motivation towards moderate alcohol consumption than did those in the neutral information condition. Study 2 (N?=?157) compared two types of autonomy prime tasks with a neutral condition. For high-risk participants who read risk information, the autonomy prime tasks elicited greater autonomous motivation, more positive attitudes and greater intentions to drink in moderation than did the neutral prime task. Study 3 (N?=?130) found that for high-risk participants who read risk information, autonomy prime participants reported less subsequent alcohol consumption than did neutral prime participants. The results are discussed in terms of the benefits of autonomy for adaptive responses to risk information.     

Implicit and explicit COVID-19-vaccine harmfulness/helpfulness associations predict vaccine beliefs,intentions, and behaviors

We investigated the role of implicit and explicit associations between harm and COVID-19 vaccines using a large sample (N = 4668) of online volunteers. The participants completed a brief implicit association test and explicit measures to evaluate the extent to which they associated COVID-19 vaccines with concepts of harmfulness or helpfulness. We examined the relationship between these harmfulness/helpfulness COVID-19 vaccine associations and vaccination status, intentions, beliefs, and behavior. We found that stronger implicit and explicit associations that COVID-19 vaccines are helpful relate to vaccination status and beliefs about the COVID-19 vaccine. That is, stronger pro-helpful COVID-19 vaccine associations, both implicitly and explicitly, related to greater intentions to be vaccinated, more positive beliefs about the vaccine, and greater vaccine uptake.     

Building Syntactic Structure in Speaking

We investigated how people produce simple and complex phrases in speaking using a newly developed immediate recall task. People read and tried to memorize a target sentence, then read a prime sentence, then did a distractor task involving the prime sentence. Despite the delay and activity between memory and recall, people could still recall the target sentence although the syntactic form of the recalled sentence was influenced by the syntactic form of the prime sentence. This result replicates the syntactic priming effect found with other experimental paradigms. Using this task, we tested how people used abstract syntactic plans to produce simple and complex noun phrases. We found syntactic priming both when targets and prime sentences matched in complexity and when they did not match, suggesting that simple and complex noun phrases are built by the same syntactic routines during speech production.     

Conceptualizing the Prospective Relationship Between Social Support,Stress, and Depressive Symptoms Among Adolescents

The goal of the current study is to examine the relationship amongst social support, stress, and depressive symptoms within a transactional and diathesis-stress framework using a multi-wave, longitudinal design. At the initial assessment, adolescents (n = 258) completed self-report measures assessing social support (peer, classmate, parent, and total), dependent interpersonal stress, anxious symptoms, and depressive symptoms. Additionally, participants reported stress and symptomology in each of the four waves spanning six months. Results of time-lagged, idiographic, multilevel modeling indicated that stress mediated the relationship between lower parental, classmate, and total social support and subsequent depressive, but not anxious, symptoms. In contrast, lower levels of peer support were not associated with higher levels of stress and subsequent depressive symptoms. Additionally, only classmate support deficits significantly moderated the relationship between stress and depressive symptoms. Overall, the results suggest that deficits in parental and classmate support may play a greater role in contributing to adolescent depression as compared to deficits in peer support.     

The costs of suppressing stressful memories

We investigated the costs of suppressing emotional and nonemotional memories, as evidenced in response times on a concurrent sentence verification task with three levels of syntactic complexity. Participants suppressing memories of personal negative experiences (n=26) had slower response times compared to the control group (n=23) and to participants suppressing nonemotional memories (n=25) particularly on the most complex sentences. Participants suppressing nonpersonal negative experiences (n=26) did not differ from either of the other two suppression groups. Suppression failures did not differ between conditions, but failures during the sentence task were related to the intrusiveness of the memory being suppressed. The findings indicate that different kinds of memories have different suppression costs and that even successful thought suppression can impair performance on concurrent tasks, supporting Wegner's ironic processing model in which suppression attempts must compete with other ongoing tasks for scarce mental resources.