Basal Ganglia and Thalamic Contributions to Language Function: Insights from A Parallel Distributed Processing Perspective

Neuropsychology Review - Cerebral representations are encoded as patterns of activity involving billions of neurons. Parallel distributed processing (PDP) across these neuronal populations provides...     

Cerebellum and conditioned reflexes

The central assumption of existing models of motor learning in the cerebellum is that cerebellar mossy fibres signal information about the context in which a movement is to be performed and climbing fibres signal in relation to a movement error. This leads to changes in the responsiveness of Purkinje cells, which on the next occasion will generate a corrected output in a given context. Support for this view has come mainly from work on adaptation of the vestibulo-ocular reflex. The discovery that classically conditioned eyeblink responses depend critically on the cerebellum offers the possibility to study the learning of a novel behaviour, rather than modification of an existing reflex. After repeated pairing of a neutral stimulus, such as a tone, with a blink-eliciting stimulus, the tone will acquire the ability to elicit a blink on its own. We review evidence from studies employing a wide variety of techniques that the cerebellum is critical in this type of learning as well as evidence that mossy and climbing fibres have roles assigned to them in cerebellar learning models.     

A Biologically Plausible Action Selection System for Cognitive Architectures: Implications of Basal Ganglia Anatomy for Learning and Decision‐Making Models

Several attempts have been made previously to provide a biological grounding for cognitive architectures by relating their components to the computations of specific brain circuits. Often, the architecture's action selection system is identified with the basal ganglia. However, this identification overlooks one of the most important features of the basal ganglia—the existence of a direct and an indirect pathway that compete against each other. This characteristic has important consequences in decision‐making tasks, which are brought to light by Parkinson's disease as well as genetic differences in dopamine receptors. This paper shows that a standard model of action selection in a cognitive architecture (ACT‐R) cannot replicate any of these findings, details an alternative solution that reconciles action selection in the architecture with the physiology of the basal ganglia, and extends the domain of application of cognitive architectures. The implication of this solution for other architectures and existing models are discussed.     

The Lateralized Linguistic Cerebellum: A Review and a New Hypothesis

During the past 2 decades the collaboration across disciplines and the methodologic and conceptual advances of contemporary neuroscience have brought about a substantial modification of the traditional view of the cerebellum as a mere coordinator of autonomic and somatic motor functions. Growing insights in the neuroanatomy of the cerebellum and its interconnections, evidence from functional neuroimaging and neurophysiological research, and advancements in clinical and experimental neuropsychology have established the view that the cerebellum participates in a much wider range of functions than conventionally accepted. This increase of insight has brought to the fore that the cerebellum modulates cognitive functioning of at least those parts of the brain to which it is reciprocally connected. This article reviews the recently acknowledged role of the cerebellum in cognition and addresses in more detail experimental and clinical data disclosing the modulatory role of the cerebellum in various non-motor language processes such as lexical retrieval, syntax, and language dynamics. In agreement with the findings indicating a topographical organization of the cerebellar structures involved in language pathology we advance the concept of a "lateralized linguistic cerebellum." In our view crossed cerebral diaschisis processes, reflecting a functional depression of supratentorial language areas due to reduced input via cerebellocortical pathways, might represent the relevant pathomechanism for linguistic deficits associated with cerebellar pathology.     

Working Memory,Cerebellum, and Creativity

There is little doubt that career experiences contribute to scientific achievement; however this relationship has yet to be thoroughly investigated in terms the effects on scientific creativity. In this study, a historiometric approach was used to examine 3 areas of adult career experiences common to scientific achievement. In doing so, prior theoretical work was used to identify career experiences relevant to scientific achievement, and 3 theoretical models were proposed to account for these experiences—adversity, collaborations, and work strategies. Biographies of eminent scientists were then content coded and analyzed. The results indicated that the adversity model did not predict scientific creativity. However, the work strategies model and, to some degree, the collaborations model showed some promise in understanding the development of creative potential in scientists. The nature of the significant relationships among the model components and scientific creativity are discussed in addition to their implications for the development of the creative potential of scientists.     

The Role of Subsidies in Coordination Games with Interconnected Risk

Can subsidies promote Pareto‐optimum coordination? We found that partially subsidizing the cooperative actions for two out of six players in a laboratory coordination game usually produced better coordination and higher total social welfare with both deterministic and stochastic payoffs. Not only were the subsidized players more likely to cooperate (choose the Pareto‐optimum action), but the unsubsidized players increased their expectations on how likely others would cooperate, and they cooperated more frequently themselves. After removal of the subsidy, high levels of coordination continued in most groups with stochastic payoffs but declined in deterministic ones. This carry‐over disparity between the deterministic and stochastic settings was consistent with the economic theories that agents were more likely to keep the status quo option under uncertainty than without uncertainty. Hence, players with stochastic payoffs were more likely to keep the high coordination level (status quo) brought by the subsidy in the previous subsidy session. A post‐game survey also indicated that with stochastic payoffs, players focused on risk reduction. Temporary subsidies promoted lasting coordination because even after subsidy was removed, players still assumed that others players would prefer reduced risks from cooperation. With deterministic payoffs, however, the subsidy might crowd out other rationales for coordination, with many players indicating that the subsidy was the only reason for anyone to cooperate. Hence, the coordination level dropped when the subsidy was removed. Copyright © 2014 John Wiley & Sons, Ltd.     

The Cerebellum in Frontotemporal Dementia: a Meta-Analysis of Neuroimaging Studies

Neuropsychology Review - Frontotemporal dementia (FTD) is a neurodegenerative brain disorder primarily affecting the frontal and/or temporal lobes. Three main subtypes have been recognized:...     

The Interconnected Self: The Social Individual is More Than Just Social + Individual

Although decades of research provide consistent evidence supporting the perspective that the self is divided into social and personal components each with unique and predictable motivational associations, the current paper argues that something important has been overlooked. Specifically, what has been lost is the acknowledgment that although different components of self can be activated, and can have important implications, the two aspects of self are highly interconnected. Specifically in this paper, it is argued that (i) the independent self is affected by social motivations and (ii) the social self is affected by independent motivations. Two studies are presented in support of these hypotheses. We conclude by comparing our perspective with existing theories of the self and by discussing implications for the study of the self.     

Best Practices for Teaming and Collaboration in the Interconnected Systems Framework

The Interconnected Systems Framework (ISF) blends school mental health practices, systems, and resources into all levels of a multitiered system of supports (e.g., positive behavior interventions and supports). The ISF aims to improve mental health and school performance for all students by emphasizing effective school-wide promotion and prevention; early identification; and social-emotional, behavioral, and mental health intervention. Teaming is 1 of 3 foundational components of quality ISF implementation at school, district, and state levels. After introducing the ISF, the authors highlight the core implementation components (i.e., teaming, data-based decision making, and evidence-based practices) and then elaborate on characteristics of well-functioning ISF teams. The authors provide a case example to illustrate each characteristic and review 5 measures teams may consider using to evaluate their functioning and SF implementation.     

From Incubation to Insight: Working Memory and the Role of the Cerebellum

An experiment involving 90 students in the 1st, 3rd, and 5th grades investigated how visual examples and grade (our surrogate for age) affected variability in a drawing task. The task involved using circles as the main element in a set of drawings. There were two examples: One was simple and single (a smiley face inside a circle); the other, complex and dual (a fishbowl extending outside a circle and a bicycle using two circles). There were significant effects of both example and grade on variability. Between-grades, 3rd and 5th graders were more variable than 1st graders with the complex (but not the simple) set of examples. Within-grades, 3rd and 5th graders were more variable with the complex (compared to the simple) set of examples. First graders' variability levels did not change with examples. The discussion focuses on how examples have and should be used to increase variability in drawings of both younger and older children.     

The Effects of Selective Cholinergic Basal Forebrain Lesions and Aging upon Expectancy in the Rat

The effects of selective cholinergic cell loss within the basal forebrain (BF) were determined using a task that requires shifting of attention between two visual stimuli. Discriminability between two stimuli and response bias were determined in young and old F-344 rats given BF injections of IgG-192 saporin (100 ng). The lesion reduced ChAT activity in the frontal and parietal cortices, hippocampus, and olfactory bulbs. The lesion did not significantly alter Na⁺/K⁺-ATPase activity in cortex, hippocampus, or olfactory bulbs, or endogenous levels of neuropeptide Y and neurokinin B within the BF. The BF lesions impaired both stimulus discriminability and response bias in young and old rats. The BF lesions had a significantly greater effect upon stimulus discriminability and response bias in aged rats, compared to young rats, only when the stimulus duration was very brief, i.e., when the task was most difficult to solve. At longer stimulus durations, aging and lesions showed no interaction. The results suggest that the selective loss of cholinergic cells in the BF, but not normal aging, impairs the ability to discriminate between independent sensory stimuli. The loss of these cells confers a response bias in simple operant tasks involving motor responses to reward-related visual stimuli.     

道德是朴素的

本文结合历史伦理文化资源的分析对道德话语的平实质朴、道德以社会公利为目标的朴素原理等问题进行了探讨,并分析了其借鉴启示意义。