情绪冲突：一个新的研究主题

情绪冲突是心理学中一个新的研究主题,相关研究主要源自认知冲突的研究。本文分三部分对情绪冲突进行了介绍,包括：（1）情绪冲突的溯源,概括介绍了认知冲突领域的研究情况;（2）与情绪冲突有关的行为研究,包括采用情绪Stroop范式、词－面孔Stroop范式、情绪启动范式和情绪Flanker范式等进行的研究;（3）情绪冲突的脑成像研究,主要包括情绪冲突的检测和解决的脑机制。未来的研究,需要广泛借鉴认知冲突的研究范式,对情绪冲突发生的条件、影响因素、动态变化及相应的神经机制进行深入研究,并结合对情绪障碍（如抑郁症和焦虑症）患者的考察,将基础研究转化为实际应用     

痛苦共情的功能性核磁共振成像研究述评

对他人痛苦的共情是指自动模拟受痛者的情感和运动状态,以及在自我-他人区分的基础上替代性地分享和理解他人由于受痛所引发的情绪状态.痛苦共情的fMRI研究常用图片诱导范式和线索诱导范式.痛苦共情的神经机制,包括(1)疼痛矩阵(该区域在个体自身受痛时也会激活)和(2)观点采择的相关脑区.痛苦共情的水平会受到实验范式和任务,以及共情者对于受痛者态度两方面因素的共同影响.加强应用研究和推出新型范式是痛苦共情研究的当务之急.     

自闭特质对疼痛共情的影响：疼痛负性情绪和认知的中介作用

已有研究提示自闭症个体的疼痛共情缺陷可能源于自身疼痛的异常。鉴于高自闭特质与自闭症的相似性,本研究分别通过实验范式和问卷调查评估了状态和特质共情,旨在刻画自闭特质、自身疼痛与共情之间的联系。在假双人疼痛共情范式中,高自闭特质个体在目睹他人接受疼痛时P2响应更强,不愉悦度评分更高,且部分源于对疼痛的高恐惧水平。问卷调查结果发现,自闭特质水平越高,在共情特质量表的观点采择维度得分越低,而个人痛苦维度得分越高,其中疼痛恐惧和灾难化中介了自闭特质与个人痛苦之间的联系。因此,高自闭特质个体表现出高水平的状态和特质情绪共情,且部分源于对疼痛存在更为负面的情绪和认知。这支持从自身疼痛异常的角度去理解高自闭特质和自闭症群体的共情等社会功能障碍,为临床治疗和干预提供了潜在的靶点。     

心理理论的自发反应范式：方法、结果与解释

近30年来, 心理理论一直是认知发展领域关键而充满挑战的研究主题, 儿童理解他人错误信念的能力是心理理论发展的标志。诱导反应范式(elicited-response tasks)的研究结果表明4岁时儿童获得心理理论, 但是自发反应范式(spontaneous-response tasks)的研究结果表明婴儿15个月大时就已经具备心理理论。自发反应范式(spontaneous-response task) 是近些年来心理理论研究领域发展起来的研究范式。针对幼儿能通过自发反应范式却不能通过诱导反应范式这一问题, 已有三种相关的理论解释：早期能力掩盖说、内隐知识解释论和观点追踪解释论。未来心理理论研究应注意将自发反应范式运用于特殊儿童, 并进一步验证和研究心理理论的发展机制。     

干扰条件与情绪启动关系的实验研究

在线索提示范式下,设置无干扰条件和干扰条件的阈上和阈下情绪启动,以此考察干扰条件与情绪启动的关系.研究发现:在无干扰条件与干扰条件下均存在显著的阈上情绪启动和阈下情绪启动,并且干扰条件下阈上情绪启动程度明显降低而阈下情绪启动程度不受影响.文章从情绪启动与注意关系的角度讨论了干扰条件与情绪启动的这种表现对于理解情绪启动加工属性及意识与无意识分离现象的意义.     

情绪通路异常与认知情绪偏差:慢性痛与抑郁症共病的神经心理机制

慢性疼痛与抑郁症具有高度共病性,但迄今尚无成熟理论能够阐释二者共病的神经心理机制。对慢性痛与抑郁的脑机制研究提示,慢性痛和抑郁常常涉及到相似的情绪脑区活动的异常改变;与此相对应的是,行为学研究发现,疼痛患者与抑郁患者在加工疼痛或抑郁相关信息时表现出了模式相似的认知情绪偏差(CAB)。近年来,越来越多证据趋于一致,指出慢性痛和抑郁共有的情绪通路异常变化可能导致了相似的信息加工异常,是二者共病的神经心理基础,而认知情绪偏差则在行为上反映了这种变化,并且很可能是共病发生、发展及维持的重要因素。     

质的研究:医学教育研究的另一种范式

通过将质的研究与定量研究、定性研究进行各维度对比,充分显示了质的研究范式的独特个性.并使用文献分析法,分析了我国医学教育领域中,医学教育研究方法应用的现状.进而探讨了质的研究范式在医学教育研究领域应用的意义及其优势,以及该研究范式在医学教育研究中如何引入的问题.     

测验范式对位置来源提取的影响—— 事件相关电位研究

采用事件相关电位方法, 通过两个实验分别考察不同测验范式(排除范式和三键范式)对图形位置来源提取头皮分布特性的影响, 以检验前人得出的测验范式对颜色来源提取ERPs影响较小的结论是否适用于其他来源类型这一问题。结果显示, 相比于项目再认, 实验一中与图形位置来源提取关联的正走向新/旧效应的头皮分布更广; 实验二则得出反映位置来源提取的晚期负走向新/旧效应。可见, 两类测验范式条件下与位置来源提取关联新/旧效应的头皮分布时空特征有所不同。上述结果表明：与颜色来源研究不同, 测验范式对位置来源提取关联的神经机制具有明显调节作用。     

选择性注意的两种负启动效应研究回顾及比较

通过比较特性负启动和位置负启动两种实验范式．对选择性注意的负启动研究进行回顾与总结：从研究方法、行为及脑成像结果等方面对特性和位置负启动研究进行比较分析;简要介绍负启动机制,并从客体与空间选择性注意的分离、视觉加工神经通道和工作记忆等方面对特性和位置负启动异同的原因进行初步探讨。对特性和位置负启动及其脑机制的差异研究将有利于对负启动效应及其机制的进一步考察．并指出负启动范式在分心抑制等研究方向具有广泛的应用前景。     

视觉特征捆绑：基于时间同步还是基于相同空间位置？

通过操纵客体呈现的空间位置和时间顺序,来考察视觉特征捆绑是基于相同空间位置线索还是基于时间邻近线索。在两个实验中,给被试在固定的注视点位置（固定呈现条件）或在注视点上/下位置（变换呈现条件）快速地系列呈现刺激,记录靶子前后各两个时间位置（-2、-1、+1、+2）的错觉性结合（IC）率。结果发现,在固定呈现条件下,IC更多地出现在-1和+1的时间位置上;而在变换呈现条件下,错觉性结合更多地出现在-2和+2时间位置上。为了进一步排除特定实验范式的影响,在实验3中,我们采用特征分离范式,使被分离的刺激特征同时呈现在相同（相同位置同步）或不同（不同位置同步）的空间位置上。结果表明,这两种条件下的IC率无显著差异,这说明错觉性结合不受时间同步模式的影响。综上所述,来自三个实验的结果表明,时间范围内的特征捆绑机制是按空间位置,而不是按时间邻近,线索进行的：若特征的空间位置相同,时间邻近的特征才被捆绑起来;若空间位置不同,即使时间邻近的特征也不能被捆绑到一起。     

条件反射性免疫抑制研究的新进展

条件反射性免疫抑制 (CIS)模式基于巴甫洛夫条件反射的机理 ,通过大脑对免疫系统进行调节 ,是一种重要的心理神经免疫学方法。近 10年来的研究取得了一些重要的进展。首先 ,条件反射性免疫抑制模型已证实是非常稳定可靠的心理神经免疫模型。其次 ,关于CIS的机制在体液、细胞、神经学方面都有广泛的研究 ,而近年来更趋向于对神经性通路的探讨。而CIS的临床应用性研究也在实验动物身上取得了稳定可靠的结果 ,证实了其未来临床应用的可行性及潜力     

条件反射性免疫抑制激活过程中下丘脑核团c-fos的表达

利用经典条件反射性免疫抑制的动物模型,以糖精水为条件刺激（CS）,免疫抑制剂-环磷酰胺为非条件刺激 （UCS）,观测两次CS-UCS结合训练后,再次条件刺激诱发条件反射性免疫抑制作用的动态改变,获得条件反射性免疫抑制和味觉厌恶性条件反射各自保持的情况,并在此基础上,采用c-fos免疫组化技术, 进一步观察再次条件刺激诱发条件反射性免疫抑制反应时大鼠下丘脑各核团内FOS蛋白的表达情况。结果表明,条件反射性免疫抑制作用在训练后第5天较强,第30天基本消失,而味觉厌恶性条件反射始终稳定保持到第30天。进一步研究显示出,下丘脑室旁核FOS蛋白表达在第5天非常密集,而第30天几乎没有表达,与细胞免疫功能改变在时程和趋势上具有一致性。通过FOS蛋白表达时程差异比较,提示下丘脑室旁核可能是CNS内介导CS诱导的免疫抑制效应的重要核团。     

味觉厌恶性条件反射与条件反射性免疫抑制的研究

以环磷酰胺的注射为非条件刺激（ＵＣＳ）,糖精水的摄入为条件刺激（ＣＳ）,并以血白细胞和淋巴细胞数量及脾淋巴细胞的转化反应为免疫指标,糖精水的饮用量为行为指标,通过改变条件刺激与非条件刺激结合的次数来观察条件反射性厌恶行为与条件反射性免疫抑制的反应。结果表明不管是一次性的还是两次性的ＣＳ－ＵＣＳ结合训练都能使动物明显地建立起味觉厌恶性条件反射,然而条件反射性免疫抑制只在两次性ＣＳ－ＵＣＳ结合训练后才     

Return of experimentally induced chocolate craving after extinction in a different context: divergence between craving for and expecting to eat chocolate

Unlike in fear conditioning, little attention has been devoted to extinction and renewal in appetitive conditioning, despite its relevance for extinction-based addiction treatments. We developed a paradigm, using a specific tray as a conditioned stimulus (CS) for eating chocolate (unconditioned stimulus, US), to investigate the effects of context change on acquisition and extinction of conditioned chocolate craving using an ABA renewal design. In Study 1 (n=32), participants successfully acquired chocolate craving, but unlike what is commonly observed in fear conditioning, craving did not extinguish. In Study 2, we separately assessed craving and US expectancy in a between-subjects design (n=64). US-expectancy data showed acquisition, extinction and renewal in the ABA group. The craving data did not follow this pattern, suggesting different mechanisms for craving and US expectancy. Similarities and differences between craving and US expectancy, as well as practical implications, are discussed.     

纳络酮、地卓西平(MK-801)对大鼠食物渴求的影响

实验以条件性位置偏爱（CPP）的表达为渴求模型观察纳络酮及MK-801对大鼠食物CPP表达,探讨摄食行为调控的心理机制。48只SD大鼠分成食物组（24）与对照组（24）,3轮食物匹配训练后,在CPP表达前分别注射生理盐水、纳络酮（1.0 mg˙kg -1）及MK-801(0.1 mg˙kg -1),观察各组动物在食物匹配训练侧停留时间的变化。结果发现,MK-801促进食物CPP的表达,但纳络酮对食物CPP的表达没有显著影响。以上结果表明MK-801（0.1mg˙kg -1）增强动物的食物渴求至少是其增加摄食量的原因之一,而1.0 mg˙kg -1的纳络酮降低动物的摄食量并不是由于食物渴求的下降导致的。MK-801与纳络酮调节动物摄食行为的心理机制可能不一致。     

Contextual Pavlovian conditioning in the crab Chasmagnathus

In contextual conditioning, a complex pattern of information is processed to associate the characteristics of a particular place with incentive or aversive reinforcements. This type of learning has been widely studied in mammals, but studies of other taxa are scarce. The context-signal memory (CSM) paradigm of the crab Chasmagnathus has been extensively used as a model of learning and memory. Although initially interpreted as habituation, some characteristics of contextual conditioning have been described. However, no anticipatory response has been detected for animals exposed to the training context. Thus, CSM could be interpreted either as an associative habituation or as contextual conditioning that occurs without a context-evoked anticipatory response. Here, we describe a training protocol developed for contextual Pavlovian conditioning (CPC). For each training trial, the context (conditioned stimulus, CS) was discretely presented and finished together with the unconditioned stimulus (US). In agreement with the CSM paradigm, a robust freezing response was acquired during the 15 training trials, and clear retention was found when tested with the US presentation after short (2 and 4 h) and long (1–4 days) delays. This CPC memory showed forward but not simultaneous presentation conditioning and was context specific and protein synthesis dependent. Additionally, a weak CPC memory was enhanced during consolidation. One day after training, CPC was extinguished by repeated CS presentation, while one presentation induced a memory labilisation–reconsolidation process. Finally, we found an anticipatory conditioned response (CR) during the CS presentation for both short-term (4 h) and long-term memory (24 h). These findings support the conditioning nature of the new paradigm.     

条件性恐惧提取消退的性别差异

基于记忆再巩固理论的提取消退范式能够有效地削弱非适应性恐惧记忆。性别差异是个体差异性研究的关键变量, 但在提取消退范式的研究中仍然比较少见关于性别差异的探索。因此本研究以立体几何图形作为条件刺激, 腕部电击作为非条件刺激, 皮肤电反应为恐惧反应指标, 探究提取消退范式在恐惧消退效果上是否存在性别差异。结果表明, 在恐惧自发恢复测试中, 提取消退范式的所有被试都成功抑制了恐惧复发, 但恐惧重建测试中只有女性被试抑制了恐惧复发。这说明, 提取消退范式在抑制恐惧自发恢复方面效果显著, 在恐惧重建上女性的消退效果显著优于男性。     

伏隔核和中脑腹侧被盖区内食欲素在吗啡奖赏中的作用

实验采用条件性位置偏爱（CPP）模型考察中脑腹侧被盖区（VTA）和伏隔核壳区（NAcSh）内食欲素（orexin）在吗啡奖赏中的作用。Wistar大鼠分为盐水训练组和吗啡训练组。3轮吗啡（或盐水）匹配训练前,双侧VTA或NAcSh内给予OXR1拮抗剂SB334867（VTA: 0, 1, 5μg;NAcSh: 0, 1, 3μg）;或2轮吗啡（或盐水）匹配训练前NAcSh内给予orexin A（0, 2, 4, 6μg）,观察其对吗啡CPP建立的影响。结果表明,VTA内给予SB334867抑制吗啡CPP建立,并存在剂量效应关系;NAcSh内给予SB334867或orexin A均未影响吗啡CPP建立,而orexin A可增加吗啡处理大鼠的运动性。以上结果表明,VTA和NAcSh内的orexin在吗啡奖赏中扮演的角色不同,可能调控成瘾行为的不同成分     

Conditioned nausea after cancer chemotherapy and autonomic nervous system conditionability

There are marked individual differences in conditioned nausea after cancer chemotherapy. To examine if part of this variation is associated with individual differences in autonomic nervous system conditionability, the present study addressed whether patients with conditioned nausea acquired conditioned heart rate and electrodermal responses at a different rate than patients without conditioned nausea. Of 28 relapse-free patients who had completed cisplatinum treatment for testicular cancer between 1981 and 1986, 10 reported persistent conditioned nausea, 8 extinguished conditioned nausea and 10 no conditioned nausea. These three groups were subjected to a differential conditioning paradigm with 8 sec pictorial stimuli (circles and triangles) serving as conditioned stimuli for an unconditioned electric shock while heart rate and electrodermal activity was monitored. There were 4 habituation, 8 acquisition and 8 extinction trials with each of the two cues. Analyses of variance using nausea status as the independent variable and physiological responses as the dependent lended some support to the notion that conditioned heart rate deceleration developed in response to the reinforced compared to the nonreinforced cue during acquisition in the two groups with persistent or extinguished conditioned nausea but not in the group with no conditioned nausea. In addition, patients that displayed good, as compared to poor heart rate conditionability during acquisition, were more likely to have persistent conditioned nausea, whereas those who showed poor heart rate conditioning mostly were those without conditioned nausea. Electrodermal variables revealed no systematic differences between groups. This tentatively supports that individual differences in parasympathetic but not sympathetic nervous system conditionability may be associated with individual differences in conditioned nausea resulting from cancer chemotherapy.     

The effects of preexposure-test and conditioning-test intervals on the magnitude of latent inhibition

Using the conditioned taste aversion paradigm, two experiments were conducted to examine the effects of the interval between preexposure and test and that between conditioning and test on the magnitude of latent inhibition. Experiment 1 revealed that the degree of latent inhibition was attenuated when rats were given a 21‐day interval between preexposure and test. It was also found that this attenuation was more marked in subjects which were given conditioning immediately after preexposure than those which were conditioned shortly before the test. Retention interval between preexposure and test was reduced to 12 days in Experiment 2, and exactly the same pattern of results as those found in Experiment 1 was obtained. These findings suggest that the memory of conditioning as well as that of preexposure decreases its retrievability after a long retention interval, although the former is more retainable than the latter.