进展性脑梗死的形成机制与防治策略

进展性脑梗死是临床上常见的一种缺血性脑卒中,其发病率高,致残率高,预后较差,严重危害患者的生命和健康,成为临床卒中治疗的一大难题。本文结合近年来的有关研究文献,就进展性脑梗死的临床分型、形成机制、可能的危险因素及其防治策略等方面的研究进展作一综合性介绍。     

进展性脑梗死的形成机制与防治策略

进展性脑梗死是临床上常见的一种缺血性脑卒中,其发病率高,致残率高,预后较差,严重危害患者的生命和健康,成为临床卒中治疗的一大难题.本文结合近年来的有关研究文献,就进展性脑梗死的临床分型、形成机制、可能的危险因素及其防治策略等方面的研究进展作一综合性介绍.     

脑卒中诊治观念转变的思考

脑卒中是一种常见病,伴有较高的病死率和致残率。近年来脑卒中诊治方面取得了不少进展,许多有关脑卒中的诊治的观念发生了巨大的转变,如卒中后血压的控制,高血压脑出血的止血治疗,急性脑梗死的溶栓治疗,卒中单元以及卒中的预防等方面。从这些转变中渗透着许多哲学观点,如否定之否定规律,科学假说与理论之间的关系,系统论的应用等。运用哲学的观点认识脑卒中的诊断治疗的转变,对日后的临床和科研有着一定的指导意义。     

脑卒中诊治观念转变的思考

脑卒中是一种常见病,伴有较高的病死率和致残率.近年来脑卒中诊治方面取得了不少进展,许多有关脑卒中的诊治的观念发生了巨大的转变,如卒中后血压的控制,高血压脑出血的止血治疗,急性脑梗死的溶栓治疗,卒中单元以及卒中的预防等方面.从这些转变中渗透着许多哲学观点,如否定之否定规律,科学假说与理论之间的关系,系统论的应用等.运用哲学的观点认识脑卒中的诊断治疗的转变,对日后的临床和科研有着一定的指导意义.     

症状性颅内动脉狭窄研究热点透视

颅内动脉狭窄是缺血性脑卒中的重要原因之一,其病因及诊治尚存在争议。本文简要介绍该病的发病机制、治疗选择,重点对药物治疗和血管内治疗的现状进行探讨。     

症状性颅内动脉狭窄研究热点透视

颅内动脉狭窄是缺血性脑卒中的重要原因之一,其病因及诊治尚存在争议.本文简要介绍该病的发病机制、治疗选择,重点对药物治疗和血管内治疗的现状进行探讨.     

特发性肺间质纤维化合并肺癌的诊疗进展

特发性肺间质纤维化(IPF)是一种病因未明的慢性进展性致纤维化性间质性肺炎。多项临床研究证实IPF患者易合并肺癌。这两种疾病在发病机制上有一些共同通路,可以成为未来潜在的治疗靶点。由于治疗方案的选择受到限制,IPF合并肺癌(IPF-LC)患者生存期短,预后不佳。近年来出现的两种新药(吡非尼酮和尼达尼布)给IPF-LC的治疗带来了新的转机。本文主要对IPF-LC的流行病学、发病机制、临床特点及治疗的最新研究进展进行综述。     

糖尿病伴发脑卒中病例临床特点分析

探讨2型糖尿病患者伴发脑卒中的发生率及相关危险因素,采用头CT扫描,化验血糖、胆固醇、甘油三酯、高密度脂蛋白、纤维蛋白原。对我院自2005年7月-2007年7月间收治的2型糖尿病合并脑卒中患者与非糖尿病发生脑卒中患者进行比较分析。200例患者中糖尿病88例,患病率44％,两组患者比较糖尿病并发脑卒中发生多灶性梗死（P〈0．01）,血流变学分析（P〈0．01）其差异有统计学意义。糖尿病合并脑卒中的患者与多种危险因素有关,必须及早控制,防止脑卒中发生、发展,减少致残率。     

美国肝病研究学会(AASLD)急性肝衰竭诊治指南(2011更新版)简介

急性肝衰竭是多种因素引起的严重肝脏损害,以凝血机制障碍和肝性脑病、黄疸等为主要临床特征,病死率极高.由于急性肝衰竭疾病进展迅速,因此单纯依靠传统的经验治疗往往会捉襟见肘,实施规范化的诊疗对挽救患者生命具有重要意义.美国肝病研究学会(AASLD)根据最新的循证医学证据和治疗理念于2011年9月出版了《急性肝衰竭诊治指南,2011更新版》,提出诊疗建议共48项,每项建议均作了相应的解读.这些建议包含了最新的循证医学证据,对临床上诊疗急性肝衰竭具有重要的借鉴和指导价值.     

炎症性肠病的临床治疗新进展

炎症性肠病是一种累及胃肠道的慢性疾病,目前主要治疗药物如氨基水杨酸制剂和免疫抑制剂均有一定的局限性.英夫利昔等多种生物制剂的使用,临床已取得可靠疗效,为患者带来更多治疗机会.随着对炎症性肠病发病机制认识的不断深入,针对免疫功能异常的新的治疗手段也越来越被人们所接受和使用,本文就目前IBD的生物免疫治疗进展做一综述.     

Therapist factor in the treatment of insomnia

This quasi-experiment attempted to replicate the finding of Turner and Ascher (1979) in contrasting progressive relaxation, stimulus control and paradoxical intention therapies for the treatment of insomnia using clinicians-in-training as therapists. Progressive relaxation and stimulus control were again shown to be effective, paradoxical intention instructions were not. A significant therapist effect was found which is discrepant with previous findings in the field.     

中西医结合脑卒中治疗新模式的探讨

卒中是危害人类健康最严重的疾病之一,其发病率高、死亡率高、致残率高,已成为世界范围内的健康问题。卒中单元已被证实是目前治疗卒中最有效的方法,组织化卒中医疗作为卒中单元的进一步发展,成为脑卒中治疗模式新的趋势;中医强调整体观念和辨证论治,将中西医结合起来,建立和实施中西医结合脑卒中治疗新模式,有助于降低脑卒中患者的死亡率,减少并发症,提高生活质量。通过探讨一种中西医结合脑卒中治疗模式的特点和运作方式,为脑卒中治疗模式的发展提供新的思路。     

Neuroprotection and stroke rehabilitation: modulation and enhancement of recovery

Recent advances in research are modifying our view of recovery after nervous system damage. New findings are changing previously held concepts and providing promising avenues for treatment of patients after stroke. This review discusses mechanisms of neuronal injury after brain ischemia and the attempts to study neuroprotection options based on such mechanisms. It also considers measures available at present to improve outcome after stroke and presents new areas of research, particularly stimulation techniques, neurogenesis and trophic factors to enhance recovery. In order to improve outcomes, medications that may be detrimental to recovery should be avoided, while symptomatic therapy of problems such as depression, pain syndromes and spasticity may contribute to better results. Continued surveillance and early treatment of complications associated with acute stroke, along with supportive care remain the mainstay of treatment for stroke patients in the recovery phase. Present research on limiting brain damage and improving recovery and plasticity enhance the prospects for better clinical treatments to improve recovery after stroke.     

社区医师应成为脑卒中治疗的重要环节

我国现代医疗技术对脑卒中的诊断和治疗手段越来越完善,但对于脑卒中的急救和预防水平却不尽人意,应当重视社区医院、社区医生在脑卒中急救、预防、治疗、康复中的重要作用,建立符合我国国情的“卒中单元”,使社区医生成为脑卒中治疗体系的起始点和终结点。     

阿司匹林在缺血性脑卒中二级预防应用的现况调查

调查缺血性脑卒中患者二级预防中阿司匹林的使用情况,并初步分析其影响因素。本研究为现况调查,调查对象为神经内科门诊与病房就诊既往诊断明确的脑梗死或短暂性脑缺血发作患者,调查其近两周内的阿司匹林使用情况及相关影响因素。经过调查初步得出缺血性脑卒中幸存者应该给予抗血小板药物,除非预计患者不久将死亡或有严重的禁忌证,阿斯匹林应用比例少,剂量不足,应引起患者及医务人员的重视,临床医师应遵循临床指南给与正确的指导。     

Auditory hallucinations in acute stroke

Auditory hallucinations are uncommon phenomena which can be directly caused by acute stroke, mostly described after lesions of the brain stem, very rarely reported after cortical strokes. The purpose of this study is to determine the frequency of this phenomenon. In a cross sectional study, 641 stroke patients were followed in the period between 1996-2000. Each patient underwent comprehensive investigation and follow-up. Four patients were found to have post cortical stroke auditory hallucinations. All of them occurred after an ischemic lesion of the right temporal lobe. After no more than four months, all patients were symptom-free and without therapy. The fact the auditory hallucinations may be of cortical origin must be taken into consideration in the treatment of stroke patients. The phenomenon may be completely reversible after a couple of months.     

Suicide prevention in the psychiatric hospital

It is currently impossible to distinguish between patients with depression who will make a suicide attempt and those who will not. Prevention, therefore, must be based on the assumption that any patient with more than mild symptoms of depression is at risk of suicide, and can only be effective if it is applicable to all patients with moderate to severe depression. A treatment strategy that differentiated between regressive and progressive therapeutic measures was developed for patients admitted to a psychiatric hospital. Regressive, as opposed to progressive, treatment meant that the patient was temporarily relieved of virtually all responsibilities for self and others. Progressive measures were strictly avoided for all patients with symptoms of depression, regardless of the primary diagnosis. This strategy was tested on 5,149 inpatients and day patients over a period of 6.25 years and compared with 6,891 patients over the 15.75 years prior to this period. The suicide rate was 97 (per 100,000 admissions) compared with 319 in the previous period. The treatment method appears to be able to reduce the suicide rate. Although this result was achieved with hospital patients, it suggests that a regressive treatment method could be promising if developed for outpatient treatment as well.     

Consequences of right cerebrovascular accident on emotional functioning: diagnostic and treatment implications

The relationship between lesion location and neuropsychiatric sequelae in stroke patients has been extensively studied. Emotional disorders associated with right hemisphere stroke include depression, anxiety, anger, and/or mania. Pharmacotherapy, electroconvulsive therapy, and/or psychotherapy are common treatments for these disorders. This article reviews the clinical presentations of seven right hemisphere stroke patients. The treatment rationale and course of treatment are described for two of these patients. The aims of this paper are to explore the appropriateness of various assessment tools and treatment modalities for stroke patients as well as to demonstrate the techniques of psychotherapy as applied to the two cases featured in this article. Specific factors that may significantly influence treatment outcome, such as lesion location and degree of cognitive impairment, are considered.     

Is problem solving dependent on language?

There has been a long-standing debate in the fields of philosophy and cognitive science surrounding the relationship of language to cognition, but the exact nature of this relationship is still unclear (Sokolov, 1968/1972). In the current study, we explored the role of language in one aspect of cognition, namely problem solving, by administering the Wisconsin Card Sorting Test (WCST) to stroke patients with varying degrees of language impairment (Experiment 1) and to normal participants under conditions of articulatory suppression (Experiment 2). In Experiment 1, there was a significant correlation between performance on the WCST and language measures such as comprehension and naming. Demonstrating the specificity of this result, we also found a significant relationship between language performance and another test of problem solving, the Raven's Colored Progressive Matrices, but no relationship between language and a test of visuospatial functioning. In Experiment 2, normal participants were significantly impaired on the WCST under conditions of articulatory suppression, relative to a baseline condition. Together, these findings suggest that language plays a role in complex problem solving, possibly through covert language processes.     

Central Nervous System Complications of Sickle Cell Disease in Children: An Overview

Complications involving the central nervous system are among the most devastating manifestations of sickle cell disease. Although overt stroke occurs in 1 in 10 children with Hemoglobin SS, “silent cerebral infarcts” are even more frequent. Both are associated with significant neuropsychological deficits. The end result of these effects on the CNS often is diminished school performance. The use of transcranial Doppler ultrasonography screening allows the identification of patients at high risk for clinical stroke as well as stroke prevention by chronic transfusion. However, definitive prophylaxis and treatment for most CNS complications of sickle cell disease have yet to be determined.