Low- and high-testosterone individuals exhibit decreased aversion to economic risk

Testosterone is positively associated with risk-taking behavior in social domains (e.g., crime, physical aggression). However, the scant research linking testosterone to economic risk preferences presents inconsistent findings. We examined the relationship between endogenous testosterone and individuals' economic preferences (i.e., risk preference, ambiguity preference, and loss aversion) in a large sample (N = 298) of men and women. We found that endogenous testosterone levels have a significant U-shaped association with individuals' risk and ambiguity preferences, but not loss aversion. Specifically, individuals with low or high levels of testosterone (more than 1.5 SD from the mean for their gender) were risk and ambiguity neutral, whereas individuals with intermediate levels of testosterone were risk and ambiguity averse. This relationship was highly similar in men and women. In contrast to received wisdom regarding testosterone and risk, the present data provide the first robust evidence for a nonlinear association between economic preferences and levels of endogenous testosterone.     

Reactive aggression tracks within‐participant changes in women's salivary testosterone

The relation between testosterone and aggression has been relatively well documented in men, but it is less well understood in women. Here we assessed the relationship between salivary testosterone and reactive aggression (i.e., rejection rate for unfair offers) in the Ultimatum Game. Forty naturally cycling women were tested twice, once in the late follicular phase (around ovulation) and once during the luteal phase. Ovulation was determined using urine test strips measuring luteinizing hormone levels. Salivary samples were assayed for testosterone, estradiol, progesterone, and cortisol at both test sessions. There was no association with the cycle, but multilevel modeling revealed a significant within‐participant association between testosterone and rejection rate for extremely unfair offers (i.e., high reactive aggression), indicating that women showed greater reactive aggression when their testosterone levels were higher. Additionally, we found that women with relatively high individual concentrations of testosterone were more likely to reject extremely unfair offers than women with relatively low concentrations of testosterone. This study is the first to demonstrate that women react more aggressively in response to provocation when their testosterone level is high than when their testosterone is low, suggesting that testosterone plays an important role in the regulation of women's aggressive behavior following social provocation.

     

睾酮对价值加工的影响——基于“累积前景”理论框架的决策行为研究

较多研究支持睾酮和决策中的风险寻求行为呈正相关,但是也有其他的研究未能发现这种关系。基于决策的累计前景理论,本研究使用动态估计参数估计任务(DEEP),结合计算模型的方法,对120名双盲给药、有安慰剂对照的被试进行睾酮对价值加工过程作用的探究。结果显示,睾酮减少了个体的概率扭曲以及增加了损失规避,但是没有引发明显的风险寻求行为,研究结果表明睾酮对个体的价值加工过程产生了影响,使个体对概率的感知更接近于客观值并且增加了对损失的敏感性。     

Seasonal variation in human functional cerebral lateralization and free testosterone concentrations

Men have previously been reported to exhibit seasonal fluctuations on specific types of cognitive performance. It has been speculated that this performance variability is a result of changes in cerebral asymmetry due to lowered testosterone concentrations in the spring relative to the fall. In the present study, functional cerebral lateralization was measured in a group of men and women in the spring and fall. Free testosterone concentrations were assessed for participants to determine what associations might exist between seasonal variability in lateralization and seasonal fluctuations in testosterone exposure. Men and women tested in the spring exhibited exaggerated patterns of asymmetry compared to participants tested in the fall. Lower testosterone concentrations were observed in the spring compared to the fall in women, but not men. No direct associations between testosterone and lateralization were detected for either sex at either season. These results illustrate that seasonal fluctuations in testosterone exposure do not directly influence seasonal changes in functional lateralization patterns.     

Status,testosterone, and human intellectual performance: stereotype threat as status concern

Results from two experiments suggest that stereotype-threat effects are special cases of a more general process involving the need to maintain or enhance status. We hypothesized thatsituations capable of confirming a performance stereotype might representeither a threat to status or an opportunity for enhancement of status,depending on the nature of the stereotype. The positive relationship betweenbaseline testosterone and status sensitivity led us to hypothesize that hightestosterone levels in males and females would amplify existing performanceexpectations when gender-based math-performance stereotypes were activated.In Study 1, high-testosterone females performed poorly on a math test when anegative performance stereotype was primed. In Study 2, high-testosteronemales excelled on a math test when a positive performance stereotype wasprimed. The moderating effect of testosterone on performance suggests that astereotype-relevant situation is capable of conferring either a loss or again of status on targets of the stereotype.     

The mismatch effect: when testosterone and status are at odds

Why do some people strive for high status, whereas others actively avoid it? In the present studies, the authors examined the psychological and physiological consequences of a mismatch between baseline testosterone and a person's current level of status. The authors tested this mismatch effect by placing high and low testosterone individuals into high or low status positions using a rigged competition. In Study 1, low testosterone participants reported greater emotional arousal, focused more on their status, and showed worse cognitive functioning in a high status position. High testosterone participants showed this pattern in a low status position. In Study 2, the emotional arousal findings were replicated with heart rate, and the cognitive findings were replicated using a math test. In Study 3, the authors demonstrate that testosterone is a better predictor of behavior than self-report measures of the need for dominance. Discussion focuses on the value of measuring hormones in personality and social psychology.     

Genetically based correlates of serum oxytocin and testosterone in autism and schizotypy

The hormones oxytocin and testosterone have been implicated in autism spectrum and schizophrenia-spectrum cognition and disorders, but their roles in mediating these psychological phenotypes remain largely unknown. We genotyped a large set of healthy individuals for loci that represent established genetic indicators of serum testosterone and oxytocin levels, and tested for associations of these genetic indices of hormone levels with self-report measures of autistic and schizotypal cognition. A low genetic index of testosterone, a high genetic index of oxytocin, and/or a low ratio of testosterone to oxytocin indices were positively correlated with high imagination (by the Autism Quotient) and high positive and total schizotypy (by the Schizotypal Personality Questionnaire). The genetic indices for oxytocin, and testosterone relative to oxytocin, also showed significant correlations with a metric of positive schizotypy relative to autism, implicating higher oxytocin and lower testosterone in increased positively-schizotypal traits combined with decreased autism-associated traits. These results link genetic indicators of serum hormone levels with measures of schizotypy and autism among healthy individuals.     

Testosterone and Proactive-Reactive Aggression in Youth: the Moderating Role of Harsh Discipline

This study tests a biosocial model of the link between testosterone and proactive-reactive aggression in youth at varying levels of harsh discipline. Given that proactive aggression is used to gain power and status and the importance of social learning in its formation, we hypothesized that testosterone would be associated with proactive aggression at higher levels of harsh discipline, and that this relationship would be more pronounced in boys than girls. Participants (n?=?445; 50% male; M age?=?11.92 years; 80% African-American) and their caregivers completed questionnaires including demographics, conflict tactics, and proactive-reactive aggression. Youth also provided a saliva sample for testosterone. Analyses revealed an interaction between testosterone and harsh discipline on proactive aggression in both boys and girls, and an interaction between testosterone and harsh discipline on reactive aggression in boys only. For those experiencing high levels of harsh discipline, testosterone was positively associated with proactive aggression, with the magnitude of the association increasing as harsh discipline increased. For below average levels of harsh discipline, there were protective effects of high testosterone for boy’s reactive aggression and for girl’s proactive aggression. The findings support basic tenets of the biosocial model which suggest that links between testosterone and aggressive behavior are dependent on contextual forces, highlighting the complex relationship between hormones, social context, and aggression. Novel findings include protective effects of high testosterone for those exposed to low levels of harsh discipline. Findings are discussed in light of the context-contingency effect and also within the differential susceptibility framework.     

Handedness and immune function

Geschwind, Galaburda, and Behan (GBG) have suggested that in utero levels of testosterone influence both cerebral and immune system developments (Geschwind and Behan, 1982; Geschwind and Galaburda, 1984; Geschwind and Galaburda, 1985). According to this theory, high levels of testosterone result in greater incidences of left-handedness, deviations from standard distribution of cerebral functions (known as anomalous dominance), and increased autoimmune dysfunction. While the original data supported these assertions, more recent tests of the hypothesis have been equivocal. One criticism of these studies is that the definition of both handedness and anomalous dominance are too vague. It was one of the aims of this project to investigate and clarify the GBG model by examining four different aspects of handedness as well as a more direct measure of anomalous dominance. In order to extend the GBG model, degree of left-handedness, general immune system functioning, and current testosterone levels were also examined. First, it was predicted and found that left handers had a higher incidence of autoimmune diseases in their immediate families than did right handers. Second, those left handers with an incidence of at least one autoimmune disease were more strongly left-handed than were those with no incidence of autoimmunity. Finally, it was observed that higher testos terone levels were supportive of general immunity. The present findings both support and expand the GBG model.     

Cognitive-behavioral stress management increases free testosterone and decreases psychological distress in HIV-seropositive men.

The effects of a 10-week group-based cognitive-behavioral stress management (CBSM) intervention on psychological distress and plasma free testosterone in symptomatic, HIV-seropositive men were examined. Participants were randomized to either CBSM (n = 42) or a wait-list control group (n = 23). Men in the CBSM intervention showed significant increases in testosterone, whereas control participants showed significant decreases. Those participating in CBSM had significant distress reductions, whereas controls showed no such change. Alterations in free testosterone were inversely related to changes in distress states over time, independent of any changes in cortisol. These findings demonstrate that a short-term CBSM intervention increases free testosterone levels among symptomatic, HIV-seropositive men, and alterations in free testosterone are associated with changes in psychological distress observed during CBSM.     

Stress induces glucocorticoid-mediated apoptosis of rat Leydig cells in vivo

Stress can disrupt endocrine signalling in the male reproductive axis through high concentrations of glucocorticoids, the hallmark of stress. Our previous work revealed that a stress level of exogenous glucocorticoids could induce apoptosis of rat Leydig cells, which are the primary source of testosterone. The aim of this study was to investigate whether stress can induce apoptosis in rat Leydig cells in vivo and, if so, whether the process is the result of a direct effect of glucocorticoids. In a chronically stressed rat model, serum corticosterone concentration was increased significantly whereas serum testosterone was decreased. The frequency of apoptotic Leydig cells in stressed rats was also increased. Adrenalectomised rats subjected to chronic stress showed an elevated serum testosterone, while the apoptotic frequency of Leydig cells was not increased. It was established that glucocorticoid-induced Leydig cell apoptosis is mediated by glucocorticoid receptors (GRs), which translocate from cytoplasm to nucleus. Adenovirus microRNA-induced downregulation of GR expression in vitro alleviated the corticosterone-induced increase in apoptosis of Leydig cells. These results indicate that the stress-induced increase in corticosterone secretion resulted in apoptosis in rat Leydig cells in vivo, and thereby decreased testosterone synthesis.     

Effects of chronic administration with high doses of testosterone propionate on behavioral and physiological parameters in mice with differing basal aggressiveness

The effects of testosterone propionate, an anabolic‐androgenic steroid, on the behavior displayed during a social encounter by gonadally intact male mice were investigated. Animals were distributed into three groups according to their attack latency in a pre‐screening test (high‐, moderate‐, and low‐ attacking mice) and each group received weekly injections of 60 or 120 mg/kg of testosterone or sesame oil for 10 weeks. Behavioral tests were then carried out. Afterwards, organs were weighed and blood samples collected in order to obtain hormonal data. Treatment had a differential impact on attack in the three groups of animals. Only the high‐attacking testosterone‐treated mice showed lower total duration of attack than their controls. Those that received 60 mg/kg spent more time exhibiting exploratory behaviors. As an index of the anabolic activity of the drug, all testosterone‐treated mice had heavier kidneys and, as an index of the androgenic activity of testosterone propionate, they had heavier seminal vesicles, lighter testes, and showed higher testosterone levels in a dose‐dependent way than their controls. Hence, the effect of treatment on peripheral physiological parameters was similar in all three groups whereas behavioral effects differed depending on basal aggressiveness, considered a characteristic of coping style. Aggr. Behav. 29:173–189, 2003. © 2003 Wiley‐Liss, Inc.     

睾酮素与反社会倾向未成年犯的攻击行为：敌意注意偏向的中介和皮质醇的调节作用

为考察睾酮素与反社会倾向未成年犯攻击行为的关系,在整合攻击行为生物激素视角和社会认知视角的基础上,探究敌意注意偏向的中介作用与皮质醇的调节作用。对84名未成年犯的激素水平、敌意注意偏向以及攻击行为进行调查。结果显示：(1)敌意注意偏向(注意不稳定性、注意回避)在睾酮素对攻击行为的影响中起完全中介作用;(2)皮质醇调节睾酮素与敌意注意偏向的关系,仅在高皮质醇水平下,敌意注意偏向的中介效应显著。基于生物激素影响攻击行为的中介机制和调节机制,可尝试从增加对敌意刺激的注意回避和提高皮质醇水平两个方面对反社会倾向未成年犯的攻击暴力行为进行干预。     

Androgen dynamics in the context of children's peer relations: an examination of the links between testosterone and peer victimization

Testosterone levels have been shown to decrease in the face of social defeat in several mammalian species. Among humans, the loss of social status has been studied primarily in the context of athletic competition, with winners having higher testosterone levels than losers. This study examined testosterone levels in relation to peer victimization (bullying) in a sample of 151 boys and girls aged 12–13. Statistically controlling for age and pubertal status, results indicated that on average verbally bullied girls produced less testosterone and verbally bullied boys produced more testosterone than their nonbullied counterparts. Similar trends were evident comparing social and physical bullying with testosterone. Sex differences are discussed in terms of empirically validated differences in coping styles, as girls tend to internalize, whereas boys tend to externalize, their abuse. Aggr. Behav. 35:103–113, 2009. © 2008 Wiley‐Liss, Inc.     

Relationships between digit ratio (2D:4D) and sex-typed play behavior in pre-school children

Juvenile play shows sex differences in animals and humans. Animal studies and a recent study in humans suggest that testosterone exposure during early development plays a key role. Here we report on the relationship between children’s sex-typed play behavior and digit ratio (2D:4D), a putative negative correlate of prenatal testosterone. 2D:4D and sex-typed play behavior as assessed by parents were negatively correlated in a sample of 83 pre-school boys but not in a sample of 93 girls. This finding lends some support to the ideas that early testosterone has a masculinising effect upon sex-typed play behavior in humans and that 2D:4D is a valuable tool for studying effects of early testosterone on human behavior.     

Vaginal bleeding and spotting in transgender men after initiation of testosterone therapy: A prospective cohort study (ENIGI)

Abstract

Background: Previous studies have cross-sectionally described amenorrhea in cohorts of transgender men on intramuscular or subcutaneous testosterone injections. It remains uncertain which testosterone preparations most effectively suppress vaginal bleeding and when amenorrhea occurs after testosterone initiation.

Aim:To investigate the clinical effects of various testosterone preparations on vaginal bleeding and spotting in transgender men.

Methods: This prospective cohort study was part of the European Network for the Investigation of Gender Incongruence (ENIGI). Data on the persistence and intensity of vaginal bleeding and spotting, serum sex steroid levels and body composition were prospectively and cross-sectionally assessed in 267 transgender men during a three-year follow-up period, starting at the initiation of various testosterone preparations.

Results: After three months of testosterone, 17.9% of transgender men reported persistent vaginal bleeding and 26.8% reported spotting. The percentages reporting vaginal bleeding and spotting decreased over the first year of testosterone (bleeding 4.7% and spotting 6.9% at 12?months, respectively), with no participants reporting vaginal bleeding or spotting after 18?months of testosterone. Factors associated with vaginal bleeding or spotting included lower serum testosterone levels and being on testosterone gel as compared to injections (e.g., esters or undecanoate preparations). If vaginal bleeding persisted, starting progestogens at three months resulted in a decrease in the intensity of vaginal bleeding and spotting.

Discussion: Transgender men and hormone-prescribing providers can be reassured that vaginal bleeding and spotting usually stop within three months after testosterone initiation. If not, serum testosterone levels should be measured and testosterone dose adjusted to achieve serum testosterone levels in the physiologic male range. Adding a progestin can be considered after three to six months if bleeding persists. Providers should be aware that cessation of bleeding can be more difficult to achieve in transgender men with lower serum testosterone levels or those on testosterone gel.     

Role of neonatal androgens in sexual differentiation of brain structure, scent marking, and gonadotropin secretion in gerbils

Gerbils display a sexually dimorphic scent marking behavior that responds to testosterone (T) in adulthood and develops under the influence of testosterone perinatally. A complex of cell groups between the preoptic area and anterior hypothalamus of the gerbil brain is also sexually dimorphic and responsive to testosterone. One of these cell groups, the sexually dimorphic area pars compacta (SDApc), usually exists only in males. Even when given testosterone, adult female gerbils rarely have an SDApc. To determine if the SDApc develops under the influence of testosterone, male gerbils were castrated or given sham operations on the day they were born or 1 day later, or were not manipulated. Female gerbils were injected subcutaneously with 0, 50, or 100 micrograms testosterone propionate (TP) on the day after birth. When given ovarian transplants as adults, neonatally castrated males scent marked at low levels typical of females. Neonatally androgenized females given testosterone as adults scent marked at high levels typical of males. Neonatal castration did not affect the probability that the SDApc would develop, but neonatal androgenization did. Half the females given either dose of TP as neonates had SDApcs bilaterally. The sizes of the SDApcs present in females depended on the dose of testosterone given neonatally. The larger dose produced larger SDApcs. The 100-micrograms dose of TP also defeminized gonadotropin secretion, but the 50-micrograms dose did not. The castration of males neonatally prevented the defeminization normally caused by endogenous testosterone. Both groups of neonatally castrated males formed corpora lutea in their ovarian transplants, but control males did not.     

The social endocrinology of dominance: basal testosterone predicts cortisol changes and behavior following victory and defeat

Past research suggests that individuals high in basal testosterone are motivated to gain high status. The present research extends previous work by examining endocrinological and behavioral consequences of high and low status as a function of basal testosterone. The outcome of a competition--victory versus defeat--was used as a marker of status. In Study 1, high testosterone men who lost in a dog agility competition rose in cortisol, whereas high testosterone men who won dropped in cortisol. Low testosterone men's cortisol changes did not depend on whether they had won or lost. Study 2 replicated this pattern of cortisol changes in women who participated in an experimental laboratory competition, and Study 2 extended the cortisol findings to behavior. Specifically, high testosterone winners chose to repeat the competitive task, whereas high testosterone losers chose to avoid it. In contrast, low testosterone winners and losers did not differ in their task preferences. These results provide novel evidence in humans that basal testosterone predicts cortisol reactivity and behavior following changes in social status. Implications for the social endocrinology of dominance are discussed.     

Rapid stimulatory effects of testosterone upon myotubule metabolism and sugar transport,as assessed by silicon microphysiometry

A considerable number of studies have revealed behavioral circumstances that give rise to small or transient differences in circulating testosterone concentrations; however, careful consideration of androgen physiology leads to the disquieting conclusion that these differences are often unlikely to have much physiologic or behavioral significance. In the present report, we observe that small transients of testosterone secretion could have very rapid anabolic effects on a cultured muscle-derived cell line. Specifically, we have examined the effects of testosterone on metabolism in cultured C2C12 myotubules, using a silicon microphysiometer. The instrument monitors cellular extrusion of protons and acidic metabolites, and such extrusion is directly linked to ATP hydrolysis, thus providing a real-time measure of cellular metabolism. Testosterone caused a small but significant increase in metabolism. The most striking feature of this effect was its rapidity, in that it occurred within 3 hr. This rapid enhancement of metabolism suggested that testosterone might be enhancing substrate uptake even more rapidly. Indeed, we found that testosterone increased 2-deoxyglucose uptake within 1 min. The rapidity of this effect seemed to preclude mediation by classical intracellular steroid receptors. In support of this, we were unable to detect specific intracellular binding of testosterone. These findings show that testosterone can exert rapid anabolic effects on substrate transport and metabolism in myotubules. Should this finding general to muscle in vivo, it suggests that relatively small individual differences in testosterone profiles, in response to various social interactions, may have very real consequence for subsequent muscle physiology. © 1996 Wiley-Liss, Inc.     

Effects of implicit power motivation on men's and women's implicit learning and testosterone changes after social victory or defeat

Two studies examined interactions of implicit power motivation and experimentally varied victory or defeat in a contest on implicit learning of a visuomotor sequence associated with the contest outcome and changes in testosterone and self-reported affect. In men and women, power motivation predicted enhanced learning (sequence-execution accuracy) after a victory and impaired learning after a defeat. In men, power motivation predicted testosterone increases among winners and decreases among losers, and testosterone decreases mediated the negative effect of power motivation on learning in losers. In women, power motivation predicted postcontest testosterone increases, particularly among losers. In both men and women, self-reported affective states were influenced only by contest outcome and were unrelated to participants' testosterone changes or implicit learning.