Should protections for research with humans who cannot consent apply to research with nonhuman primates?

Research studies and interventions sometimes offer potential benefits to subjects that compensate for the risks they face. Other studies and interventions, which I refer to as “nonbeneficial” research, do not offer subjects a compensating potential for benefit. These studies and interventions have the potential to exploit subjects for the benefit of others, a concern that is especially acute when investigators enroll individuals who are unable to give informed consent. US regulations for research with human subjects attempt to address this concern by mandating strict protections for nonbeneficial research with subjects who cannot consent. Typically, humans who cannot consent, such as children, may be enrolled in nonbeneficial research only when it poses low risks and has the potential to gather information of sufficient value to justify the risks, an appropriate surrogate gives permission on the individual’s behalf and the individual agrees (assents). In contrast, US regulations for nonbeneficial research with nonhuman primates do not include these protections, even though it too involves subjects who cannot consent and who face risks for the benefit of others. Is this difference in regulatory protections justified? Or does the principle of fairness—treat like cases alike—imply that regulations for nonbeneficial research with nonhuman primates should include protections similar to those that apply to nonbeneficial research with humans who cannot consent?     

Disposition to recognize goals in infant chimpanzees

Do nonhuman primates attribute goals to others? Traditional studies with chimpanzees provide equivocal evidence for “mind reading” in nonhuman primates. Here we adopt looking time, a methodology commonly used with human infants to test infant chimpanzees. In this experiment, four infant chimpanzees saw computer-generated stimuli that mimicked a goal-directed behavior. The baby chimps performed as well as human infants, namely, they were sensitive to the trajectories of the objects, thus suggesting that chimpanzees may be endowed with a disposition to understand goal-directed behaviors. The theoretical implications of these results are discussed.     

Inherent directionality of “even if” counterfactual conditionals

In this research, we investigate whether semifactual conditionals such as “even if there had been an A, there would have been a B” are understood by thinking initially of the antecedent “A”, as was found with factual conditionals. The “inherent directionality” hypothesis assumes that for the comprehension of most relational statements, a presuppositional element (i.e. the “relatum”) is initially established. For “even if”, both terms could work as “relatum”. This is because on the one hand, people tend to infer “B” from “A” and “not-A” and, on the other hand, “B” could work as a pragmatic presupposition. In the present experiment, semifactual and factual conditionals were tested with a sentence-picture verification task. Results were consistent with the “inherent directionality” hypothesis: only “if then” factual conditionals, but not semifactuals, showed a preference for reasoning from the antecedent, with faster verifications.     

Mistakes Around the Clock: Errors in Memory for the Orientation of Numerals

Recent research has demonstrated that when participants are required to draw from memory a standard clock with numbers represented by Roman numerals, they typically misrepresent the four as “IV” rather than as the correct “III.” Participants do not make this mistake when they simply copy the clock while it remains in full view. A reanalysis of the data presented by Richards, French, and Harris (1996) is reported in which we investigated the representation of the orientation of the Roman numerals on the clockface and found that participants in the memory conditions (surprise and forewarned) were more likely than participants in the copy (control) condition to draw the numerals vertically rather than in their correct centripetal orientation. In addition, we found this error was even more likely to occur for participants when they had no warning that a memory task would take place.     

A neglected response to the paradoxes of confirmation

Hempel's paradox of the ravens, and his take on it, are meant to be understood as being restricted to situations where we have no additional background information. According to him, in the absence of any such information, observations of FGs confirm the hypothesis that all Fs are G. In this paper I argue against this principle by way of considering two other paradoxes of confirmation, Goodman’s “grue” paradox and the “tacking” (or “irrelevant conjunct”) paradox. What these paradoxes reveal, I argue, is that a presumption of causal realism is required to ground any confirmation; but once we grant causal realism, we have no reason to accept the central principles giving rise to the paradoxes.     

Partnerschaften von Sexualstraftätern

Intimate relationships of convicted and released sexual offenders have hardly been the topic of systematic research. This article presents a systematic review of this topic. Only nine articles were found in a systematic literature search which investigated this topic with qualitative and quantitative methods. These studies were dominated by the determination of multiple deficits in the sexual offenders, such as intimacy and empathy problems, high frequencies of conflicts and aggression in the relationships as well as social isolation of the female partners. The female partners of sexual offenders also showed a high tendency to denial and minimization similar to the offenders and blamed the victims for the offence. The women seemed to like their status as a “martyred wife” and gave their husbands a “second chance in life”. However, the currently available studies have barely investigated the “sexual offender couple” and the dynamics of their relationship to elucidate stabilizing factors. In a pilot study on the topic of “partnerships of sexual offenders” 17 “sex offender couples” were questioned by interviews and questionnaires to collate the dynamics of the partnership, which was published in the Journal of Sex and Marital Therapy. In the quantitative results it was found that the female partners of sex offenders predominantly demonstrated an insecure preoccupied attachment style and this influence on the relationship stability is discussed. Further studies are needed in this field of research to gain detailed data of “sex offender couples” for relapse prevention and therapeutic implications.     

Development of the AAS Statement on “Suicide” and “Physician Aid in Dying”

In August 2017, the American Association of Suicidology board passed a statement titled “Suicide” is not the same as “Physician aid in dying,” which was developed partly in response to the fact that aid in dying is now legal in a number of jurisdictions. In Phase 1, eight members of the AAS who had indicated interest in this issue were asked to independently draft such a statement; the convener consolidated these drafts and comments into an initial statement. In Phase 2, five additional experts who might be expected to object were asked for their independent input; the convener consolidated these with the previous draft. No one objected to the statement altogether; extensive copyediting and rewording suggestions focused primarily on issues of overlap between “suicide” and “physician aid in dying.” The resulting document represents an effort to try to accommodate the basic concerns of all participants. The document does not speak for or against legalization of this practice, but it may have bearing on whether suicide prevention professionals have an obligation to try to prevent such deaths and whether they may serve as consultants for psychological or psychiatric evaluations as sometimes required under US state law.     

The use of syntactic information in filling gaps

Two sentence-comprehension time experiments replicated and extended previously reported research indicating that readers initially make a quick, heuristic assignment of fillers to gaps in temporarily ambiguous sentences such as “Who did John beg to sing?” and “Who did John beg to sing for?” The Most Recent Filler heuristic readers seemed to adopt made the former “distant filler” sentence harder to comprehend than the latter “recent filler” sentence. Readers did not in general use all available sources of information in making this assignment. In particular, they usually delayed their use of verb control information so that substituting the unambiguous-control verbs “force” or “begin” for “beg” did not eliminate the distant filler inferiority. the experiments counter some criticisms that have been made of the previously reported research. The possibility that readers delay using an interesting natural category of information was raised, and its implications for the mental grammar were considered.     

Bouncers and barroom aggression: A review of the research

Bouncers (also referred to as “doormen,” “door staff,” “security personnel,” etc.) have received a great deal of attention in the available research on barroom aggression. All too often, researchers blame bouncers for provoking and escalating aggressive episodes in bars rather than functioning in a capacity that controls or prevents such incidents. The primary aim of this review paper is to provide an overview of the available research on bouncers and barroom aggression. Specifically, research on barroom aggression that implicates bouncers as one of possibly several environmental predictors of such incidents, as well as a growing body of research that provides a more focused exploration of the role of bouncers in barrooms and their impact on aggression, is examined and evaluated. Attempts to address problem bouncers and suggestions for future research are discussed.     

The perils of protection: vulnerability and women in clinical research

Subpart B of 45 Code of Federal Regulations Part 46 (CFR) identifies the criteria according to which research involving pregnant women, human fetuses, and neonates can be conducted ethically in the United States. As such, pregnant women and fetuses fall into a category requiring “additional protections,” often referred to as “vulnerable populations.” The CFR does not define vulnerability, but merely gives examples of vulnerable groups by pointing to different categories of potential research subjects needing additional protections. In this paper, I assess critically the role of this categorization of pregnant women involved in research as “vulnerable,” both as separate entities and in combination with the fetuses they carry. In particular, I do three things: (1) demonstrate that pregnant women qua pregnancy are either not “vulnerable” according to any meaningful definition of that term or that such vulnerability is irrelevant to her status as a research participant; (2) argue that while a fetus may be vulnerable in terms of dependency, this categorization does not equate to the vulnerability of the pregnant woman; and (3) suggest that any vulnerability that appends to women is precisely the result of federal regulations and dubious public perceptions about pregnant women. I conclude by demonstrating how this erroneous characterization of pregnant women as “vulnerable” and its associated protections have not only impeded vital research for pregnant women and their fetuses, but have also negatively affected the inclusion of all women in clinical research.     

正念是什么——从正念内涵研究发展角度的思考

"正念是什么"是正念研究中的基本问题,也是长期困扰研究者的难题,造成此困境的重要原因是正念跨越了佛学与心理学两种语境。在正念内涵研究历程中,研究者们先后试图以"去神秘化"、"去语境化"及"整合化"来解决跨语境所造成的问题。本研究认为:正念为多维概念,其内涵的复杂性决定了研究者对正念的认识并非静态的判断,而是逐步成熟的过程;应深入整合佛学与心理学语境,以发展的视角看待正念。     

Redefining dementia care barriers for ethnic minorities: the religion–culture distinction

Barriers to healthcare services experienced by black and minority ethnic (BME) persons with dementia are labelled as “cultural” in existing research. This is a promising shift from an ethno-centric approach to dementia care provision, yet very little research is dedicated to specifically how religion – as distinct from culture – influences healthcare practice. Further consideration of the religion–culture distinction is required; religion and culture are two distinct entities, which inevitably interlink. Cultural themes such as “God's will”, “Religious Ritual” and “Religious Duty”, warrant re-categorisation as “religious”. Sensitivity to the nuances between cultural and religious themes will provide clearer knowledge of how and why BME persons with dementia experience barriers to accessing care services. Further research is needed with regard to the role of religion specifically on dementia care access for BME persons to aim to improve care provision for this underrepresented demographic.     

Investigating the role of response in spatial context learning

Recent research has shown that simple motor actions, such as pointing or grasping, can modulate the way we perceive and attend to our visual environment. Here we examine the role of action in spatial context learning. Previous studies using keyboard responses have revealed that people are faster locating a target on repeated visual search displays (“contextual cueing”). However, this learning appears to depend on the task and response requirements. In Experiment 1, participants searched for a T-target among L-distractors and responded either by pressing a key or by touching the screen. Comparable contextual cueing was found in both response modes. Moreover, learning transferred between keyboard and touch screen responses. Experiment 2 showed that learning occurred even for repeated displays that required no response, and this learning was as strong as learning for displays that required a response. Learning on no-response trials cannot be accounted for by oculomotor responses, as learning was observed when eye movements were discouraged (Experiment 3). We suggest that spatial context learning is abstracted from motor actions.     

How the Thatcher illusion reveals evolutionary differences in the face processing of primates

Face recognition in humans is a complex cognitive skill that requires sensitivity to unique configurations of eyes, mouth, and other facial features. The Thatcher illusion has been used to demonstrate the importance of orientation when processing configural information within faces. Transforming an upright face so that the eyes and mouth are inverted renders the face grotesque; however, when this “Thatcherized” face is inverted, the effect disappears. Due to the use of primate models in social cognition research, it is important to determine the extent to which specialized cognitive functions like face processing occur across species. To date, the Thatcher illusion has been explored in only a few species with mixed results. Here, we used computerized tasks to examine whether nonhuman primates perceive the Thatcher illusion. Chimpanzees and rhesus monkeys were required to discriminate between Thatcherized and unaltered faces presented upright and inverted. Our results confirm that chimpanzees perceived the Thatcher illusion, but rhesus monkeys did not, suggesting species differences in the importance of configural information in face processing. Three further experiments were conducted to understand why our results differed from previously published accounts of the Thatcher illusion in rhesus monkeys.     

Play,Precariousness, and the Negotiation of Shared Meaning: A Developmental Research Perspective on Child Psychotherapy

Recent work in developmental psychology and primatology indicates that human infants are distinguished from other primates by the end of the 1st year by their awareness that others have subjective states like their own. This early appearing awareness of the subjectivity of others forms the basis for the subsequent negotiation and elaboration of “we-ness,” that is, of shared orientations toward the world that allow the child to enter into collaborative relations with others. It is argued that this gradual working out of collaborative strategies for the elaboration of shared meanings is a principal function of joint pretend play in early childhood, and this is one of the critical developmental functions addressed in psychodynamic play therapy. Developmental theory and research contributing to this perspective is integrated with excerpts from children's joint pretend play and from play therapy case material to illustrate the precarious and improvisational nature of the negotiation of shared meaning.     

The Role of Propulsive Muscles of the Shoulder During Quadrupedalism in Vervet Monkeys (Cercopithecus aethiops)

In comparative anatomical studies of the shoulder, the humeral retractors are often grouped together as propulsive muscles, which are important in the propulsive stroke of the forelimb during quadrupedal locomotion. Electromyographic (EMG) analyses of these muscles in opossums, cats, and dogs in general have confirmed such conclusions. An EMG study of chimpanzee shoulder muscles during knuckle-walking found, however, that the humeral retractors are either inactive or perform a function unrelated to propulsion (Larson & Stern, 1987). This contrast in muscle recruitment patterns between chimpanzees and more “typical” mammalian quadrupeds was attributed to the derived morphology of the chimpanzee shoulder. The present study examines the activity patterns of the humeral retractors in the vervet monkey, a primate more closely resembling nonprimate mammals in its shoulder morphology. The results of this EMG analysis show that despite the significant differences in anatomy between chimpanzees and vervets, the two species display very similar muscle recruitment patterns during quadrupedalism, and there is evidence for this same pattern in other species of primates. These differences in muscle activity patterns between primates and nonprimate mammals may be related to changes in the neurological control of locomotion in primates due to the evolutionary development of manipulative abilities in the primate forelimb.     

What makes an angry face look so … angry? Examining visual attention to the shape of threat in children and adults

Threatening facial expressions like anger can signal potential danger. Past research has established that both adults and children have an attentional bias for angry faces, visually detecting their presence more quickly than happy or neutral faces. More recent research has suggested that specific features of angry faces (such as the downward-pointing “V” shaped brow) are the effective stimulus in their rapid detection. However, research examining this issue has only been done with adults. In the current research, we examine the detection of the features of the downward-pointing “V” in both adults and preschool children using a touchscreen visual search procedure. In two experiments, both adults and children detected the downward-pointing “V” more quickly than an upward-pointing “V”. As the first evidence that young children exhibit the same superior detection of the features of threatening facial expressions that adults do, this research provides important support for the existence of an evolved attentional bias for threatening stimuli.     

Bilinguals who stutter: A cognitive perspective

PurposeBrain differences, both in structure and executive functioning, have been found in both developmental stuttering and bilingualism. However, the etiology of stuttering remains unknown. The early suggestion that stuttering is a result of brain dysfunction has since received support from various behavioral and neuroimaging studies that have revealed functional and structural brain changes in monolinguals who stutter (MWS). In addition, MWS appear to show deficits in executive control. However, there is a lack of data on bilinguals who stutter (BWS). This literature review is intended to provide an overview of both stuttering and bilingualism as well as synthesize areas of overlap among both lines of research and highlight knowledge gaps in the current literature.MethodsA systematic literature review on both stuttering and bilingualism studies was conducted, searching for articles containing “stuttering” and/or “bilingualism” and either “brain”, “executive functions”, “executive control”, “motor control”, “cognitive reserve”, or “brain reserve” in the PubMed database. Additional studies were found by examining the reference list of studies that met the inclusion criteria.ResultsA total of 148 references that met the criteria for inclusion in this paper were used in the review. A comparison of the impact of stuttering or bilingualism on the brain are discussed.ConclusionPrevious research examining a potential bilingual advantage for BWS is mixed. However, if such an advantage does exist, it appears to offset potential deficits in executive functioning that may be associated with stuttering.