The effects of formaldehyde on voluntary ethanol consumption in the laboratory rat: a comparison of two methods of determination of a single test solution

The effect of formaldehyde on voluntary alcohol intake in rats was examined. Alcohol intake was measured using individually determined alcohol concentrations. The results did not support the tension reduction hypothesis: Stress induction did not enhance alcohol intake. It is concluded that a revision of the tension reduction hypothesis should be formulated.     

Changes in alcohol intake in response to transdiagnostic cognitive behaviour therapy for eating disorders

Objective

The aim of this study was to examine how alcohol intake changes during and after transdiagnostic cognitive behaviour therapy for eating disorders (CBT-E). Additionally, the paper considers the relationship between alcohol consumption, eating disorder diagnosis and current major depressive episode at the time of first assessment.

Method

One hundred and forty nine outpatients with an eating disorder (body mass index over 17.5) were divided into high or low alcohol intake groups (HIG and LIG) according to their intake at pre-treatment assessment. Their alcohol intake and eating disorder psychopathology were examined over the course of treatment and follow-up.

Results

There was no difference between the groups on response of the eating disorder to treatment. The HIG significantly reduced their alcohol intake following treatment whilst the intake of the LIG remained stable over the course of treatment and follow-up. There were no group differences in major depression and overall severity of eating disorder at baseline.

Conclusions

The response to CBT-E was not influenced by baseline level of alcohol use. The mean alcohol intake of the heavy drinking subjects decreased without being specifically addressed by the treatment.     

Differential effects of a 5-HT2 receptor blocker on alcohol intake in rats selectively bred for high and low catecholamine responses to stress

The effect of the selective 5-HT2 receptor blocker ritanserin on alcohol consumption was investigated in two strains of rats selectively bred for high and low catecholamine responses to stress. Rats were forced to drink a 5% alcohol solution for 10 days. For the subsequent six days, animals were injected subcutaneously with 2.5 mg/kg/2 ml ritanserin or vehicle only, and both a 5% solution of alcohol and water were presented to the animals. Ritanserin affected neither water nor total fluid intake. Furthermore, no effect of ritanserin on alcohol consumption could be demonstrated in high-responding rats, whereas in low-responding rats a very pronounced ritanserin-induced reduction in alcohol intake was observed. Results are discussed in terms of mediating effects of serotonergic neurons on mesolimbic dopaminergic reward systems related to drug addiction.     

Self-focused attention and the experience of alcoholic intoxication

The present study investigates the relationship between self-focused attention and the experience of emotional and bodily concomitants of alcoholic intoxication. It was hypothesized that self-focused attention would amplify salient mood and bodily concomitants of intoxication after alcohol intake and counteract these concomitants after placebo treatment. Self-focused attention was assessed by measures of private body consciousness, private self-consciousness, and of self-awareness. Since alcohol intake did not influence mood, it was not possible to test our main-hypothesis linking self-focused attention with the experience of mood concomitants of intoxication. As to bodily concomitants of intoxication a strong effect of alcohol intake was disclosed. Further analysis revealed the predicted relationship between self-awareness and private body consciousness on one hand and the experience of bodily concomitants of intoxication, on the other. The relationship between private body consciousness and experience of bodily concomitants of intoxication was moderated by the amount of experience with alcohol. No significant relationship between private self-consciousness and experience of bodily concomitants of intoxication was found.     

Sexual willingness with same- and other-sex prospective partners: Experimental evidence from the bar scene

Sex is ubiquitous in the media, but only a fraction depicts sexual interactions between same-sex partners. This field study, conducted outside of bars in the Midwestern United States, examined 83 heterosexuals’ sexual willingness with a same- or other-sex partner. Participants viewed a randomly assigned video vignette of a same- or other-sex partner. Alcohol intake, partner attractiveness, and sexual willingness were measured. Using moderated regression analysis, we found that alcohol intake predicted sexual willingness with the male target for both men and women, but not with the female target. The attractiveness of same-sex partners was related to sexual willingness. Sexual willingness was only influenced by alcohol intake and perceived attractiveness of a same-sex prospective partner. Most notably, alcohol intake was related to increased sexual willingness of men with a same-sex partner, suggesting a potential shift in normative casual sexual behavior among heterosexual men.     

Combination pharmacotherapy in alcoholism: a novel treatment approach

Combination pharmacotherapy has proven effective in a number of psychiatric disorders, including depression and schizophrenia. However, compared with other affective disorders, few studies have explored the use of combination therapy in alcoholism, and the majority have been limited to animal models. There is evidence to support a role for combination therapy in alcoholism. For example, several neurochemical systems, including the dopaminergic, serotonergic, and opioidergic, appear to affect alcohol intake. Studies in several different types of alcohol-preferring rats have suggested that coadministration of agents to target more than one of these systems simultaneously may produce beneficial effects on alcohol intake, while avoiding problematic effects, such as alterations in food or water intake. Data from preliminary clinical studies have shown trends toward combination therapy reducing alcohol intake in humans. While such findings are encouraging, they must be explored further in larger, randomized, double-blind trials.     

Retrograde Enhancement of Human Kinesthetic Memory by Alcohol: Consolidation or Protection against Interference?

Alcohol intake is known to impair memory in animals and humans. However, five studies reported that “medium” (0.05 ml/kg body weight) to “high” (1.0 ml/kg body weight) doses of alcohol improved memory when drunk immediately after initial learning of verbal or visual material. It was proposed that alcohol brought about this retroactive facilitation either through enhanced consolidation of memory traces or by protecting against retroactive interference. The present double blind study compared the performances of an alcohol and a placebo group on a kinesthetic memory task before alcohol or placebo intake and at retest 1 h after consumption. A second experiment was identical to the first except that all subjects carried out two trials on a T maze in the hour between testing and retesting. The alcohol group in the first experiment performed significantly better than the placebo group at retest (p< .05) but this was not the case in the second experiment. Alcohol therefore enhanced performance on the kinesthetic memory task in the first experiment but may not have protected against the moderate interference from the T maze in the second. The low levels of alcohol could have had a stimulant effect on trace consolidation, perhaps via raised blood glucose levels.     

Learning techniques for alcohol abuse

Eighteen month follow-up data are presented for two projects evaluating the effectiveness of learning techniques for treating alcohol abuse and achieving moderation using three groups of subjects-inpatient alcoholics, outpatient alcoholics and problem drinkers. Subjects received various combinations of the following procedures: videotape self-confrontation of drunken comportment, blood alcohol concentration discriminating training, aversion training for overconsumption, avoidance practice, behavior counseling and alternatives training, and alcohol education. While the loss of subjects was considerable between 12 and 18 months follow-up, the data were very similar. Subjects in all groups improved in terms of reductions in alcohol intake and on drinking-related variables. Significant between-groups differences in favor of subjects whose training included actual experience in drinking moderately were found only for the inpatient alcoholics. In this research, the best candidate for moderation was the less chronic. younger drinker with a relatively lower alcohol intake, a more stable vocational record and no history of hospitalization for alcohol abuse or physical deterioration from drinking. We believe that the techniques with the greatest potential for the prevention and treatment of alcohol abuse are videotape self-confrontation, blood alcohol discrimination training, and alcohol education/alternatives training.     

Validity of self-reports of alcohol and other drug use: a multitrait-multimethod assessment

Four methods (self-reported rating, self-reported intake, peer-reported rating, peer-reported intake) and multiple analytical criteria were employed to assess the construct validity of reports of three types of substance use (alcohol, marijuana, and cigarettes) in a study of 194 college students who were members of friendship pairs. The resulting multitrait-multimethod matrix was analyzed in the traditional fashion as well as with confirmatory factor analysis. Convergent and discriminant validity for the three substance use traits were quite adequate, although the validity of one measure (the peer-reported intake measure of alcohol use) may be considered inadequate according to some criteria. This study demonstrates the usefulness of multimethod assessment and confirmatory factor analysis for research on construct validity and for derivation of more accurate measures of drug use.     

小剂量酒精伤害驾驶行为的时序效应

酒后开车普遍存在并致交通肇事居高不下的现实,对法定酒精限量的科学性提出质疑.本实验在多数国家交通法规采用的体内血液酒精水平BAL＜0.5‰的标准以下,设计三项任务对12名被试在酒前酒后四段时间内的行为实施测试,结果表明个体无法准确估计安全的酒精摄入量;小剂量酒精仍具有伤害行为的效应;酒精影响依行为复杂程度呈现时序效应.     

Stages of change for health-related behaviours in 18 year-old Australians

Abstract This study investigated the validity of a Stages of Change algorithm with respect to independent measures of physical activity and fitness. dietary intake and alcohol consumption in 18 year-old Ausmlian men (n = 301) and women (n = 282). Stage of Change categories were related to fat and fibre intakes in men and fibre intake in women as well as hit and vegetable intakes in men and women. Physical activity and fitness for men and women also showed significant linear associations with Stage of Change categories. Alcohol consumption was significantly associated with Stage of Change categories for men but not for women although recorded alcohol consumption was very variable for women. However, the algorithm was valid for both men and women when drinking alcohol consistent with national guidelines on safe drinking was used. In summary, with reference to actual health behaviours, the Stages of Change algorithm was valid for young men and women for diet. physical activity and alcohol drinking. Independent behavioural data were not available for smoking behaviours. Using the algorithm, there were significant associations in men between prccontemplation status for diet and drinking and diet and physical activity, in women between diet and smoking and in both men and women between drinking and smoking. Covariance between precontemplation status for different health behaviours therefore suggests the need for multimodal interventions.     

Getting a grip on drinking behavior: training working memory to reduce alcohol abuse

Alcohol abuse disrupts core executive functions, including working memory (WM)--the ability to maintain and manipulate goal-relevant information. When executive functions like WM are weakened, drinking behavior gets out of control and is guided more strongly by automatic impulses. This study investigated whether training WM restores control over drinking behavior. Forty-eight problem drinkers performed WM training tasks or control tasks during 25 sessions over at least 25 days. Before and after training, we measured WM and drinking behavior. Training WM improved WM and reduced alcohol intake for more than 1 month after the training. Further, the indirect effect of training on alcohol use through improved WM was moderated by participants' levels of automatic impulses: Increased WM reduced alcohol consumption in participants with relatively strong automatic preferences for alcohol. These findings are consistent with the theoretical framework and demonstrate that training WM may be an effective strategy to reduce alcohol use by increasing control over automatic impulses to drink alcohol.     

Ritanserin and voluntary alcohol intake in rats

In a previous study (Rammsayer & Vogel, 1991), rats selectively bred for high and low catecholamine responses to stress showed a selective response to the 5-HT2 receptor blocker ritanserin. However, it remained unclear whether selective breeding resulted in a decrease in 5-HT responsivity, as suggested by the lack of an effect in high stress responding rats, or in an increase in 5-HT responsivity, as suggested by ritanserin-induced reduction in alcohol intake in low-responding rats. To answer this question, nonselectively bred rats were forced to drink a 5% alcohol solution for 10 days. For the subsequent six days, animals were injected subcutaneously with 2.5 mg/kg/2 ml ritanserin or vehicle only, and both a 5% solution of alcohol and water were presented to the animals. Ritanserin neither affected alcohol nor total fluid intake suggesting that in the general population of N/NIH (Hansen) rats as well as in rats of the same strain selectively bred for high catecholamine responses, mesolimbic dopaminergic activity is not effectively modulated by specific blockade of 5-HT2 receptors. However, a very pronounced ritanserin induced difference in daily water intake between nonbred male and female rats became evident.     

Physiological drives investigated by means of injections into the cerebral ventricles of the rat

A technique is described for permanently implanting a cannula in the lateral ventricle of the rat, and the effects on certain physiological drives of various substances injected by this route were investigated.

Food intake was significantly reduced by intraventricular glucose, while intra-ventricular fructose, insulin, glucagon and a lipid-mobilizing agent were without effect. Drinking was elicited by hypertonic saline and suppressed by hypotonic solutions. The intake of salt was not effected by intraventricular low-sodium solutions. Intraventricular procaine, but not alcohol, induced an akinetic state. Intraventricular glucose failed to relieve hypoglycaemic coma.

The significance of some of these findings is discussed in relation to the hypothalamic regulation of hunger.     

Stages of change for health-related behaviours in 18 year-old Australians

Abstract

This study investigated the validity of a Stages of Change algorithm with respect to independent measures of physical activity and fitness. dietary intake and alcohol consumption in 18 year-old Ausmlian men (n = 301) and women (n = 282). Stage of Change categories were related to fat and fibre intakes in men and fibre intake in women as well as hit and vegetable intakes in men and women. Physical activity and fitness for men and women also showed significant linear associations with Stage of Change categories. Alcohol consumption was significantly associated with Stage of Change categories for men but not for women although recorded alcohol consumption was very variable for women. However, the algorithm was valid for both men and women when drinking alcohol consistent with national guidelines on safe drinking was used. In summary, with reference to actual health behaviours, the Stages of Change algorithm was valid for young men and women for diet. physical activity and alcohol drinking. Independent behavioural data were not available for smoking behaviours. Using the algorithm, there were significant associations in men between prccontemplation status for diet and drinking and diet and physical activity, in women between diet and smoking and in both men and women between drinking and smoking. Covariance between precontemplation status for different health behaviours therefore suggests the need for multimodal interventions.     

Inebriation and Inspiration? A Review of the Research on Alcohol and Creativity

There is a conception that a uniquely positive correlation prevails between the intake of alcohol and creativity, but only a few experimental studies address this subject. Existing studies together with recent experiments are reviewed. This later series of experiments explored whether or not moderate alcohol intoxication (1.0 ml of 100% alcohol/kg body weight) facilitated different phasesof the creative process, i.e. preparation, incubation, illumination, verification, and restitution. A hypothesis is derived which postulates that modest alcohol consumption inhibits aspects of creativity based mainly on the secondary process (preparation, certain parts of illumination, and verification), and disinhibits those based mainly on the primary process (incubation, certain parts of illumination, and restitution).     

Alcohol self-administration by rats in the presence of a tangible object

The authors used the sucrose-substitution procedure to train operant self-administration of a 10% alcohol solution in 8 Long-Evans rats. After they established stable responding, they began a 10-session baseline. A 10-session experimental phase followed the baseline phase. During the experimental phase, the authors placed a large glass marble in the center of the experimental chambers before self-administration sessions. The presence of the marble decreased the rats' responding and alcohol intake significantly. The authors discussed the results in terms of distraction and the effects of concurrently available reinforcers on alcohol self-administration.     

Group and individual change in the treatment of drug addictions: a follow-up study in therapeutic communities

The pre-post treatment change of 112 patients in two therapeutics Spanish communities is described. The Addiction Severity Index (ASI) was used at intake and at the end of the treatment program. Results of the treatment program were evaluated by applying composite scores (CS) of the ASI, and the evolution of each patient was evaluated using the Reliable Change Index (RCI). 69.7% of the sample completed treatment, and 30.3% dropped out prematurely. At intake, the percentage of people who could improve in the different areas of the ASI ranged between 35.1% for alcohol consumption and 95.3% for family relationships. At the follow-up, the percentage of subjects who showed significant statistical improvements in the different areas varied between 7.9% in family relations and 66.7% in alcohol consumption. The percentage of patients who deteriorated was less than 10% for all variables. Implications for further research and clinical practice are commented upon.     

Relationships between perceived stress and health behaviors in a sample of working adults.

The study examined associations between perceived stress and fat intake, exercise, alcohol consumption, and smoking behaviors. Data were from surveys of 12,110 individuals in 26 worksites participating in the SUCCESS project (D. J. Hennrikus, R. W. Jeffery, & H. A. Lando, 1995), a study of smoking cessation interventions. Linear regression analyses examined cross-sectional associations between stress level and health behaviors. Analyses were stratified by gender and controlled for demographics. High stress for both men and women was associated with a higher fat diet, less frequent exercise, cigarette smoking, recent increases in smoking, less self-efficacy to quit smoking, and less self-efficacy to not smoke when stressed. Stress was not associated with alcohol intake. Findings suggest that the association between stress and disease may be moderated in part by unhealthy behaviors.     

An experimental analysis of aversive imagery versus electrical aversive conditioning in the treatment of chronic alcoholics

A series of three experiments is described comparing an aversive imagery and an electrical escape conditioning procedure in the treatment of chronic alcoholics. Treatment effects were objectively measured by recording subjects' alcohol consumption in a semi-naturalistic laboratory setting. In contrast to conventional group outcome studies, the use of single-subject methodology provided a fine-grained analysis of individual response patterns. The aversive imagery and escape conditioning methods did not differ from each other, and were relatively ineffective in suppressing alcohol intake. In contrast, a punishment procedure in which shock was contingent on drinking did effectively suppress drinking. The data suggest that alcoholics can control their drinking by self-administered shock. The implications for the analysis and treatment of alcoholics are discussed.