Effects of reinforcement history on response rate and response pattern in periodic reinforcement

Several researchers have suggested that conditioning history may have long-term effects on fixed-interval performances of rats. To test this idea and to identify possible factors involved in temporal control development, groups of rats initially were exposed to different reinforcement schedules: continuous, fixed-time, and random-interval. Afterwards, half of the rats in each group were studied on a fixed-interval 30-s schedule of reinforcement and the other half on a fixed-interval 90-s schedule of reinforcement. No evidence of long-term effects attributable to conditioning history on either response output or response patterning was found; history effects were transitory. Different tendencies in trajectory across sessions were observed for measures of early and late responding within the interreinforcer interval, suggesting that temporal control is the result of two separate processes: one involved in response output and the other in time allocation of responding and not responding.     

An inverse relationship between baseline fixed-interval response rate and the effects of a tandem response requirement.

Previous experiments examining the effects of adding a tandem fixed-ratio response requirement on fixed-interval schedule performance have reported inconsistent results. One variable that may account for such inconsistencies is the baseline response rate in the fixed-interval condition. This possibility was investigated in the present study. Rats were given histories with either interresponse times greater than 11 s or fixed-ratio 40 schedules of reinforcement, which engendered either relatively low or high rates of responding, respectively, in the subsequent fixed-interval condition. A tandem ratio response requirement (fixed-ratio 9) was then introduced. The effects of adding this tandem response requirement were inversely related to the baseline fixed-interval response rates; low rates of responding in the fixed-interval condition were markedly increased, whereas high rates of responding were relatively unaffected. This inverse relationship appears to be similar to the rate-dependent relations observed in behavioral pharmacology. These results may provide an explanation for the inconsistent findings reported in previous studies on tandem fixed-interval fixed-ratio schedules and suggest that principles of behavioral pharmacology research may be applicable to the study of the effects of nonpharmacological variables on schedule-controlled behavior.     

The effects of fixed‐interval schedules on variability of pigeons' pecking location

Many studies that have investigated performance under reinforcement schedules have measured response rate or interresponse time, which reflect the temporal dimension of responding; however, relatively few studies have examined other dimensions. The present study investigated the effects of fixed‐interval schedules on the location of pigeons' pecking response. A circular response area 22.4 cm in diameter was used so that the pecking responses were effective over a wide range. Pigeons were exposed to a fixed‐interval schedule whose requirement was systematically varied between conditions. Response location moved closer to the location of the last reinforced response as time elapsed in each trial. Additionally, as the fixed‐interval duration requirement increased, response locations shifted to the border of the response area and the variability of response locations increased. These results suggest that fixed‐interval schedules systematically control response location.     

Effects of d-amphetamine, cocaine, and phencyclidine on the acquisition of response sequences with and without stimulus fading.

In each of three components of a multiple schedule, monkeys were required to emit a different sequence of four responses in a predetermined order on four levers. Sequence completions produced food on a fixed-ratio schedule. Errors produced a brief timeout. One component of the multiple schedule was a repeated-acquisition task where the four-response sequence changed each session (learning). The second component of the multiple schedule was also a repeated-acquisition task, but acquisition was supported through the use of a stimulus-fading procedure (faded learning). In a third component of the multiple schedule, the sequence of responses remained the same from session to session (performance). At higher doses, d-amphetamine, cocaine, and phencyclidine decreased the overall rate of responding and increased the percent errors in all three components. At lower doses, however, the three drugs produced selective effects on errors. Errors were increased in the learning component at lower doses than those required to disrupt the behavior in the faded-learning component. The performance component tended to be the least sensitive to disruptive drug effects. The data are consistent with the view that stimulus fading can modulate the effects of drugs on acquisition.     

The long-term effect of high- and low-rate responding histories on fixed-interval responding in rats

Tell rats were given extended lever-press training on a fixed-interval (FI) 30-s food reinforcement schedule from the outset or following exposure to one or two previous reinforcement schedules. For 4 rats the previots schedule was either fixed-ratio 20, which generated high response rates, or differential-reinforcement-of-low-rate 20 s, which produced low response rates. For 4 additional rats the extended training on FI 30 s was preceded by experience with two schedules: fixed-ratio 20 followed by differential-reinforcement-of-low-rate 20 s; or the same two schedules in the reverse order. Fixed-interval response rates were initially affected by the immediately preceding schedule, but after 80 to 100 sessions, all traces of prior schedule history had disappeared. The results also showed no long-term effect of schedule history on the interfood-interval patterns of responding on the FI 30-s schedule. These results support one of the most central tenets of the experimental analysis of behavior: control by the immediate consequences of behavior.     

Effects of reinforcement schedule on facilitation of operant extinction by chlordiazepoxide

Learning and memory are central topics in behavioral neuroscience, and inbred mice strains are widely investigated. However, operant conditioning techniques are not as extensively used in this field as they should be, given the effectiveness of the methodology of the experimental analysis of behavior. In the present study, male C57B1/6 mice, widely used as background for transgenic studies, were trained to lever press on discrete-trial fixed-ratio 5 or fixed-interval (11 s or 31 s) schedules of food reinforcement and then exposed to 15 extinction sessions following vehicle or chlordiazepoxide injections (15 mg/kg i.p., administered either prior to all extinction sessions, or prior to the final 10 extinction sessions). Extinction of operant behavior was facilitated by drug administration following training on either schedule, but this facilitation only occurred once a number of extinction sessions had taken place. The extinction process proceeded more rapidly following fixed-interval training. Resistance to extinction was equally high following training with either schedule type, and was reduced by drug administration in both cases. These phenomena were evident in individual cumulative records and in analyses of group data. Results are interpreted in terms of phenomena of operant extinction identified in Skinner's (1938) Behavior of Organisms, and by behavioral momentum theory. These procedures could be used to extend the contribution of operant conditioning to contemporary behavioral neuroscience.     

Effects of reinforcer probability, delay, and response requirements on the choices of rats and pigeons: possible species differences

In Experiment 1 with rats, a left lever press led to a 5-s delay and then a possible reinforcer. A right lever press led to an adjusting delay and then a certain reinforcer. This delay was adjusted over trials to estimate an indifference point, or a delay at which the two alternatives were chosen about equally often. Indifference points increased as the probability of reinforcement for the left lever decreased. In some conditions with a 20% chance of food, a light above the left lever was lit during the 5-s delay on all trials, but in other conditions, the light was only lit on those trials that ended with food. Unlike previous results with pigeons, the presence or absence of the delay light on no-food trials had no effect on the rats' indifference points. In other conditions, the rats showed less preference for the 20% alternative when the time between trials was longer. In Experiment 2 with rats, fixed-interval schedules were used instead of simple delays, and the presence or absence of the fixed-interval requirement on no-food trials had no effect on the indifference points. In Experiment 3 with rats and Experiment 4 with pigeons, the animals chose between a fixed-ratio 8 schedule that led to food on 33% of the trials and an adjusting-ratio schedule with food on 100% of the trials. Surprisingly, the rats showed less preference for the 33% alternative in conditions in which the ratio requirement was omitted on no-food trials. For the pigeons, the presence or absence of the ratio requirement on no-food trials had little effect. The results suggest that there may be differences between rats and pigeons in how they respond in choice situations involving delayed and probabilistic reinforcers.     

Progressive-ratio schedules: effects of later schedule requirements on earlier performances

Four rats were studied with variants of a progressive-ratio schedule with a step size of 6 in which different terminal components followed completion of the 20th ratio: (a) a reversal of the progression, (b) a fixed-ratio 6 schedule, or (c) extinction. Responding in the progressive-ratio components of these schedules was compared to performances under conventional progressive-ratio baselines. Under baseline conditions, postreinforcement pauses increased exponentially as a function of increasing ratio size, whereas running rates showed modest declines. The procedure of linking the progressive-ratio schedule to the reversed progression or to the fixed-ratio component resulted in decreased pausing. Linking the progressive-ratio schedule to the extinction component had the opposite effect, that of producing weakened progressive-ratio performances as evidenced by increased pausing. Subjects whose responses were reinforced on half of the ratios also showed exponential increases; however, pauses were substantially shorter following ratios on which the reinforcer was omitted. The results suggested that progressive-ratio pausing reflects the influence of remote as well as local contingencies.     

Rats' performance on variable-interval schedules with a linear feedback loop between response rate and reinforcement rate

Three experiments investigated whether rats are sensitive to the molar properties of a variable-interval (VI) schedule with a positive relation between response rate and reinforcement rate (i.e., a VI+ schedule). In Experiment 1, rats responded faster on a variable ratio (VR) schedule than on a VI+ schedule with an equivalent feedback function. Reinforced interresponse times (IRTs) were shorter on the VR as compared to the VI+ schedule. In Experiments 2 and 3, there was no systematic difference in response rates maintained by a VI+ schedule and a VI schedule yoked in terms of reinforcement rate. This was found both when the yoking procedure was between-subject (Experiment 2) and within-subject (Experiment 3). Mean reinforced IRTs were similar on both the VI+ and yoked VI schedules, but these values were more variable on the VI+ schedule. These results provided no evidence that rats are sensitive to the feedback function relating response rate to reinforcement rate on a VI+ schedule.     

Reinforcement probability and ordinal position of response in fixed-interval schedules

Four rats pressed levers and received food pellets under fixed-interval reinforcement schedules of 20, 60, and 180 seconds. The number of responses in each interval was recorded. From these data, the probability of reinforcement was determined as a function of response count. These functions were generally increasing. This finding is consistent with previous suggestions that increasing response rates within fixed intervals may be a function of response count in addition to or instead of elapsed or remaining time.     

Behavior of rats under fixed consecutive number schedules: effects of drugs of abuse.

Four rats responded under a simple fixed consecutive number schedule in which eight or more consecutive responses on the run lever, followed by a single response on the reinforcement lever, produced the food reinforcer. Under this simple schedule, dose-response curves were determined for diazepam, morphine, pentobarbital, and phencyclidine. The rats were then trained to respond under a multiple fixed consecutive number schedule in which a discriminative stimulus signaled when the response requirement on the run lever had been completed in one of the two fixed consecutive number component schedules. Under control conditions, the percentage of reinforced runs under the multiple-schedule component with the discriminative stimulus added was much higher than the percentage of reinforced runs under the multiple-schedule component without the discriminative stimulus. All of the drugs decreased the percentage of reinforced runs under each of the fixed consecutive number schedules by increasing the conditional probability of short run lengths. This effect was most consistently produced by morphine. The drugs produced few differences in responding between the multiple fixed consecutive number components. Responding under the simple fixed consecutive number schedule, however, was affected at lower doses of the drugs than was responding under the same fixed consecutive number schedule when it was a component of the multiple schedule. This result may be due to the difference in schedule context or, perhaps, to the order of the experiments.     

Separating response dependency and response-reinforcer contiguity within a recycling conjunctive schedule

A procedure is described which disrupts response-reinforcer contiguity and response dependency and which demonstrates how the location of the response dependency in interval schedules can be regarded as a controlling variable in its own right. Rats' lever pressing produced sucrose on a recycling conjunctive fixed-time 30-second fixed-ratio 1 schedule of reinforcement. Reinforcement occurred only at the end of the fixed-time component on this schedule and only if a response had occurred during that component. This produced a pause-respond-pause pattern during the interreinforcer interval for all animals. When the location of the response dependency was then restricted to a 10-second period in the middle of the fixed-time component, the pattern was accentuated and response rates increased for all animals, while postreinforcement pauses decreased sharply for two animals. When responding was required in the first 10 seconds of the fixed-time component, responding peaked earlier in the interval for all animals. Response rates were slightly below those in the previous conditions, while postreinforcement pauses were between 2 and 6 seconds across animals.     

Effects of magnitude of food reinforcement on free-operant response rates

In Experiment 1 rats were trained to press a lever on a variable-ratio schedule of food presentation and were then exposed to progressively increasing magnitudes of food reinforcement. Response running rates (rates exclusive of the postreinforcement pause) were found to increase as a function of increasing reinforcement magnitudes. The effect of reinforcement magnitude on response rates inclusive of the postreinforcement pause, however, was less pronounced. Increases in the magnitude of reinforcement were also found to increase the length of the postreinforcement pause. Rats in Experiment 2 were trained to respond on a chained differential-reinforcement-of-low-rate variable-ratio schedule, and were exposed to increasing magnitudes of reinforcement as in Experiment 1. Response running rates increased in the variable-ratio component but decreased in the other component of the schedule. The results are discussed with reference to incentive accounts of reinforcement and the action of reinforcement on the response units generated by the operative contingencies.     

Effects of cocaine on fixed-interval responding reinforced by the opportunity to run

Rate-dependent drug effects have been observed for operant responding maintained by food, water, heat, light onset, electrical brain stimulation, shock-stimulus termination, and shock presentation. The present study sought to determine if the effects of cocaine on lever pressing maintained by the opportunity to run could also be described as rate dependent. Seven male Wistar rats were trained to respond on levers for the opportunity to run in a wheel. The schedule of reinforcement was fixed-interval 60 s, and the reinforcing consequence was the opportunity to run for 60 s. On this schedule, overall rates of responding were low, usually below six presses per minute, and pauses frequently exceeded the 60-s interval. Despite these differences, an overall scalloped pattern of lever pressing was evident for each rat. Doses of 1, 2, 4, 8, and 16 mg/kg cocaine were administered 10 min prior to a session. Only at the 16 mg/kg dose did the responding of the majority of rats change in a manner suggestive of a rate-dependent drug effect. Specifically, lower response rates at the beginning of the intervals increased and higher rates at the end of the intervals decreased, as indicated by the fact that slopes from the regression of drug rates on control rates decreased. These data provide tentative support for the generalization of rate-dependent effects to operant responding maintained by wheel running. Differences in the baseline performance maintained by wheel running compared to those for food and water point to the need for further experimentation before this effect can be firmly established.     

Maximizing present value: A model to explain why moderate response rates obtain on variable-interval schedules

In Phases 1 and 3, two Japanese monkeys responded on a multiple variable-ratio 80 variable-interval X schedule, where the value of X was adjusted to ensure equal between-schedule reinforcement rates. Components strictly alternated following the delivery of a food pellet, and each session ended following 50 components. Phase 2 differed from the others only in that the 50 pellets previously earned during the session were delivered together at session's end. Variable-ratio response rates did not decrease across phases, but variable-interval response rates decreased substantially during the Phase 2 procedure. This rate decrease was attributed to the food-at-session's-end manipulation removing the greater immediacy of reinforcement provided by short interresponse times relative to long interresponse times. Without this time preference for short interresponse times, the variable-interval interresponse-time reinforcement feedback function largely controlled response emission, dictating a response-rate reduction. This result was explained in terms of the economic notion of “maximizing present value.”     

Effects of a variable-ratio conditioning history on sensitivity to fixed-interval contingencies in rats.

We investigated the possibility that human-like fixed-interval performances would appear in rats given a variable-ratio history (Wanchisen, Tatham, & Mooney, 1989). Nine rats were trained under single or compound variable-ratio schedules and then under a fixed-interval 30-s schedule. The histories produced high fixed-interval rates that declined slowly over 90 sessions; differences as a function of the particular history were absent. Nine control animals given only fixed-interval training responded at lower levels initially, but rates increased with training. Despite differences in absolute rates, rates within the intervals and postreinforcement pauses indicated equivalent development of the accelerated response patterns suggestive of sensitivity to fixed-interval contingencies. The finding that the histories elevated rates without retarding development of differentiated patterns suggests that the effective response unit was a burst of several lever presses and that the fixed-interval contingencies acted on these units in the same way as for single responses. Regardless of history, the rats did not manifest the persistent, undifferentiated responding reported for humans under comparable schedules. We concluded that the shortcomings of animal models of human fixed-interval performances cannot be easily remedied by including a variable-ratio conditioning history within the model.     

Control rate of response or reinforcement and amphetamine's effect on behavior.

The roles of control response rate and reinforcement frequency in producing amphetamine's effect on operant behavior were evaluated independently in rats. Two multiple schedules were arranged in which one variable, either response rate or reinforcement frequency, was held constant and the other variable manipulated. A multiple differential-reinforcement-of-low-rate seven-second yoked variable-interval schedule was used to equate reinforcement frequencies at different control response rates between multiple-schedule components. Amphetamine increased responding under the variable-interval component. In contrast, amphetamine decreased responding equivalently between components of a multiple random-ratio schedule that produced similar control response rates at different reinforcement frequencies. The results provide experimental support to the rate-dependency principle that control rate of responding is an important determinant of amphetamine's effect on operant behavior.     

Effects of response variability on the sensitivity of rule-governed behavior

Two experiments examined the relation between response variability and sensitivity to changes in reinforcement contingencies. In Experiment 1, two groups of college students were provided complete instructions regarding a button-pressing task; the instructions stated “press the button 40 times for each point” (exchangeable for money). Two additional groups received incomplete instructions that omitted the pattern of responding required for reinforcement under the same schedule. Sensitivity was tested in one completely instructed and one incompletely instructed group after responding had met a stability criterion, and for the remaining two groups after a short exposure to the original schedule. The three groups of subjects whose responding was completely instructed or who had met the stability criterion showed little variability at the moment of change in the reinforcement schedule. The responding of these three groups also was insensitive to the contingency change. Incompletely instructed short-exposure responding was more variable at the moment of schedule change and was sensitive to the new contingency in four of six cases. In Experiment 2, completely and incompletely instructed responding first met a stability criterion. This was followed by a test that showed no sensitivity to a contingency change. A strategic instruction was then presented that stated variable responding would work best. Five of 6 subjects showed increased variability after this instruction, and all 6 showed sensitivity to contingency change. The findings are discussed from a selectionist perspective that describes response acquisition as a process of variation, selection, and maintenance. From this perspective, sensitivity to contingency changes is described as a function of variables that produce response variability.     

A pharmacological examination of the resistance-to-change hypothesis of response strength.

The effects of d-amphetamine sulfate, sodium pentobarbital, haloperidol, and cholecystokinin-octapeptide were examined within the context of Nevin's (1974, 1979) resistance-to-change hypothesis of response strength. In three experiments, rats' responding was reinforced by delivery of food under chained random-interval 30-s random-interval 30-s, multiple fixed-interval 30-s fixed-interval 120-s, or multiple random-interval 30-s random-interval 120-s schedules. Each rat received several doses of each drug and changes in response rate were measured. The resistance-to-change hypothesis predicts greater disruption of response rate relative to baseline in the initial component of the chained schedule and in the 120-s component of the multiple schedules. In the chained schedule cholecystokinin-octapeptide produced greater reductions in response rate relative to baseline in the initial component. However, no differences between components were observed with haloperidol or sodium pentobarbital, and high doses of d-amphetamine reduced response rate in the terminal component relatively more than in the initial component. In the multiple schedules either no differences were observed between components or response rate was reduced more relative to baseline in the 30-s component. The data fail to support the notion that drugs may be viewed within the same context as other response disruptors such as extinction, satiation, and the presentation of alternative reinforcement.     

Differential effects of pentobarbital and cocaine on punished and nonpunished responding.

Similar rates of punished and nonpunished responding, maintained with equated rates of reinforcement, were established in pairs of rats. One subject of each pair was exposed to a random-ratio schedule of food presentation. The interreinforcement intervals for this subject comprised the intervals of a random-interval schedule of reinforcement for the other (yoked) rat. The random-ratio schedule maintained rates of responding higher than those maintained by the same rate of reinforcement schedule according to the yoked random-interval contingency. A random-ratio schedule of electric foot shock added to the random-ratio schedule of food presentation suppressed rates of responding such that similar rates of responding were observed in rats of both groups. Pentobarbital (3.0 to 17.0 mg/kg) increased punished responding at doses that had little effect on or decreased nonpunished responding, whereas cocaine (5.6 to 30 mg/kg) increased nonpunished responding at doses that decreased or did not alter punished responding. Qualitatively different effects of pharmacological agents on punished and nonpunished responding can be obtained using procedures that generate similar rates and temporal patterns of punished and nonpunished responding. The effects of pentobarbital and cocaine on responding can be determined by factors other than simply the baseline rate of responding.