The contribution of the inferior parietal cortex to spoken language production

This functional MRI study investigated the involvement of the left inferior parietal cortex (IPC) in spoken language production (Speech). Its role has been apparent in some studies but not others, and is not convincingly supported by clinical studies as they rarely include cases with lesions confined to the parietal lobe. We compared Speech with non-communicative repetitive tongue movements (Tongue). The data were analyzed with both univariate contrasts between conditions and probabilistic independent component analysis (ICA). The former indicated decreased activity of left IPC during Speech relative to Tongue. However, the ICA revealed a Speech component in which there was correlated activity between left IPC, frontal and temporal cortices known to be involved in language. Therefore, although net synaptic activity throughout the left IPC may not increase above baseline conditions during Speech, one or more local systems within this region are involved, evidenced by the correlated activity with other language regions.     

Argument structure and the child's contribution to language learning

One of the oldest questions in cognitive science asks whether children are able to learn language (or anything) because they are equipped with a very powerful general-purpose learning mechanism or because they are equipped with a domain-specific constrained language acquisition device. Recent advances in statistical approaches to language learning seem to boost the plausibility of general-purpose learning. However, in this article we propose that in the domain of verb learning, children rely more on their internally generated preconceptions about linguistic structure than on robust cues in the input, suggesting that at least in this aspect of language learning, domain-specific grammatical knowledge guides linguistic development.     

Exploring the contribution of the cerebral hemispheres to language comprehension deficits in adults with developmental language disorder

A divided visual field, priming paradigm was used to observe how adults who have a history of developmental language disorder (DLD) access lexically ambiguous words. The results show that sustained semantic access to subordinate word meanings (such as BANK-RIVER), which is seen in control subjects, is disrupted in the right cerebral hemisphere for this special population of readers. In the left hemisphere, only the most dominant meaning of the ambiguous word shows sustained priming in both controls and DLD participants. Therefore, for the DLD readers the subordinate meanings of words are not primed in either hemisphere and, thus, may not be available during online processing and integration of discourse. This right hemisphere lexical access deficit might contribute to the language comprehension difficulties exhibited by adult readers with a history of DLD.     

The phonological-distributional coherence hypothesis: cross-linguistic evidence in language acquisition

Several phonological and prosodic properties of words have been shown to relate to differences between grammatical categories. Distributional information about grammatical categories is also a rich source in the child's language environment. In this paper we hypothesise that such cues operate in tandem for developing the child's knowledge about grammatical categories. We term this the Phonological-Distributional Coherence Hypothesis (PDCH). We tested the PDCH by analysing phonological and distributional information in distinguishing open from closed class words and nouns from verbs in four languages: English, Dutch, French, and Japanese. We found an interaction between phonological and distributional cues for all four languages indicating that when distributional cues were less reliable, phonological cues were stronger. This provides converging evidence that language is structured such that language learning benefits from the integration of information about category from contextual and sound-based sources, and that the child's language environment is less impoverished than we might suspect.     

The contribution of functional near-infrared spectroscopy (fNIRS) to the presurgical assessment of language function in children

Before performing neurosurgery, an exhaustive presurgical assessment is required, usually including an investigation of language cerebral lateralization. Among the available procedures, the intracarotid amobarbital test (IAT) was formerly the most widely used. However, this procedure has many limitations: it is invasive and potentially traumatic, especially for children. To overcome these limitations, neuroimaging techniques such as functional magnetic resonance imaging (fMRI) have been used. Again, these methods are difficult to use with children, who must remain motionless during data acquisition. Functional near-infrared spectroscopy (fNIRS) is a noninvasive functional imaging technique that is easily applied to pediatric and cognitively limited patients. It has been used recently in epileptic children for presurgical assessment of expressive and receptive language brain lateralization. The aim of this review is to present the contribution of fNIRS to the presurgical assessment of language function in children with neurological diseases.     

Pretrial EEG coherence as a predictor of semantic priming effects

Twenty subjects were presented 240 randomized trials of a lexical decision task (LDT) while connected to a 16-electrode EEG montage. EEG data were acquired for 2 sec prior to the onset of each LDT trial. Alpha (9-13 Hz) coherence, alpha power, and 3- to 30-Hz power from five different combinations of EEG electrodes were used to predict semantic effects in the LDT trials. High pretrial coherence in the Right Hemisphere and Left Posterior-Parietal regions was associated with greater semantic facilitation (faster reaction times) in related-prime trials and greater semantic inhibition (slower reaction times) in unrelated-prime trials, relative to neutral-prime trials. No power variables were associated with semantic effects. Results support an information flow model of the functional significance of EEG coherence to cognitive processing.     

An EEG investigation of awareness during anaesthesia

Previous studies of awareness during anaesthesia have used patients undergoing surgery. In an attempt to overcome the complications of anxiety and specific stimuli of surgery, this study used healthy volunteers in a laboratory setting. No evidence of recall of events taking place during light anaesthesia was found.     

Decrease of prefrontal-posterior EEG coherence: loose control during social-emotional stimulation

In two experiments we aimed to investigate if individual differences in state-dependent decreases or increases of EEG coherence between prefrontal and posterior cortical regions may be indicative of a mechanism modulating the impact social-emotional information has on an individual. Two independent samples were exposed to an emotional stimulation paradigm in which the participants were invited to get involved and sympathize with the persons they were watching (study 1) or listening to (study 2), and who were expressing sadness or anxiety. The two studies yielded consistent results. Higher scores in trait absorption and in the propensity to ruminate were associated with decreased EEG beta coherence during the stimulation, whereas coherence increased in individuals low in absorption or rumination. Coherence changes did not predict to which degree the participants felt infected by the displayed emotions, but in individuals showing decreased prefrontal-posterior coupling during the stimulation, feelings of sadness and anxiety had a greater tendency to persist. The findings suggest that more loose prefrontal-posterior coupling may be related to loosening of control of the prefrontal cortex over incoming social-emotional information and, consequently, to deeper emotional involvement and absorption, whereas increased prefrontal-posterior coupling may be related to strong control, dampening of emotional experience, and not letting oneself become emotionally affected.     

On the neurobiological investigation of language understanding in context

There are two significant problems in using functional neuroimaging methods to study language. Improving the state of functional brain imaging will depend on understanding how the dependent measure of brain imaging differs from behavioral dependent measures (the "dependent measure problem") and how the activation of the motor system may be confounded with non-motor aspects of processing in certain experimental designs (the "motor output problem"). To address these problems, it may be necessary to shift the focus of language research from the study of linguistic competence to the understanding of language use. This will require investigations of language processing in full multi-modal and environmental context, monitoring of natural behaviors, novel experimental design, and network-based analysis. Such a combined naturalistic approach could lead to tremendous new insights into language and the brain.     

Words in the brain's language: an experimental investigation

According to Pulvermüller (1999), words are represented in the brain by cell assemblies (Hebb, 1949) distributed over different areas, depending on semantic properties of the word. For example, a word with strong visual associations will be represented by a cell assembly involving neurons in the visual cortex, while a word suggesting action will selectively activate neurons in the motor areas. The present work aims to test the latter hypothesis by means of behavioural measures. Specifically it tests the prediction that there should be a selective influence (in terms either of interference or priming) of performed/observed movements on the performance (reaction times and accuracy) of lexical decision involving words with a strong action association. Similarly, a selective influence of visual images on lexical decision involving words with strong visual associations should be observed. Two experiments were carried out. Results provided partial support for the hypothesis.     

A study of EEG coherence in DCD children during motor synchronization task

This paper investigates the hypothesis that the coordination difficulties of DCD children are associated with an increased coherence in the cortical motor regions, which persists with age. Forty-eight children participated in the study (24 DCD and 24 Controls). Their ages ranged from 8 to 13 years, divided into three groups (8-9, 10-11, and 12-13 years old). Children were required to perform finger flexion or extension either in synchrony or in syncopation with a rhythmic metronome, while a 32-channel EEG was recorded. Along with stability measures of motor performance, we analyzed the spectral EEG coherence between intrahemispheric (left frontal/left central; left central/left parietal) and interhemispheric (left central/right central) sites. Spectral coherence assesses functional coupling between distant areas of the brain. Two frequency bands related to sensorimotor activation were chosen: alpha (8-12 Hz) and beta (12-30 Hz). The synchrony task was chosen as a rest condition against which the two syncopation conditions at 0.5 Hz and 1.3 Hz were contrasted. For intrahemispheric comparison, 8-9-year-old DCD children showed that coherence between fronto-central regions increased for both rhythms and conditions, as compared to controls. No difference was found for interhemispheric comparisons. As frontal sites are related to motor planning, our results suggest that youngest DCD children were forced to maintain a high level of pre-programming to compensate for the difficulties caused by the perceptual-motor requirements of the task in light of their coordination disorder.     

An investigation into the relationships between gender and language

The present investigation focused upon the impact of gender and various powerful and less powerful linguistic features on the communication of unfamiliar male and female college students. Same-sex and mixed-sex dyads were recorded as they engaged in discussions regarding suggestions for a bogus freshman orientation booklet. Although few gender differences were found, the result of a factor analysis yielded three factors: questions, suggestions, and process variables. These factors are consistent with a power perspective in the use of various linguistic features. However, the present findings suggest that gender and power alone cannot explain differences in communication styles. Rather, the results suggest the need to consider other aspects of the speaker to explain differences that occur in the use of language.     

The contribution of the thumb to reaching movements

Transport of the hand towards an object and the formation of grasp are logically separable components of reaching. It has been suggested that, although the two components must be temporally co-ordinated, their spatial parameters are under the control of independent visuo-motor channels. A case study of reaching by a proficient user of a manually-operated artificial hand is presented. A pattern of natural hand usage was observed in which the index finger rather than the thumb was responsible for reduction of grasp aperture as the hand approached an object. The same pattern of usage was also observed in the artificial hand even though the mechanics of that hand make it no easier to move the finger than the thumb. This suggests that the relative stability of the thumb in the natural hand is determined, not simply by anatomy, but by a role in guiding the transport component of reaching. At least part of the spatial aspect of grasp formation is closely related to the transport component of reaching and this is evidence against theories postulating two independent visuo-motor channels controlling the spatial parameters of grasp and transport.     

An investigation of the ability to process inferences in language following right hemisphere brain damage

Twenty-two right hemisphere brain-damaged and 22 non-brain-damaged patients were given a multiple-choice recognition task which contained true statements, statements which were inferentially true but not actually heard before, and false statements. It was hypothesized that if right hemisphere brain damage disturbs the ability to comprehend inferences, these subjects, unlike their normal counterparts, would not falsely recognize true inferences as heard before. This hypothesis was not confirmed. However, the right hemisphere group was poorer than controls at rejecting false statements. This behavior was speculated to be a retrieval difficulty, which was exacerbated if the information contained spatial or semantically similar material.     

The glucocorticoid contribution to obesity

Obesity is fast becoming the scourge of our time. It is one of the biggest causes of death and disease in the industrialized world, and affects as many as 32% of adults and 17% of children in the USA, considered one of the world's fattest nations. It can also cost countries billions of dollars per annum in direct and indirect care, latest estimates putting the USA bill for obesity-related costs at $147 billion in 2008. It is becoming clear that the pathophysiology of obesity is vastly more complicated than the simple equation of energy in minus energy out. A combination of genetics, sex, perinatal environment and life-style factors can influence diet and energy metabolism. In this regard, psychological stress can have significant long-term impact upon the propensity to gain and maintain weight. In this review, we will discuss the ability of psychological stress and ultimately glucocorticoids (GCs) to alter appetite regulation and metabolism. We will specifically focus on (i) GC regulation of appetite and adiposity, (ii) the apparent sexual dimorphism in stress effects on obesity and (iii) the ability of early life stress to programme obesity in the long term.