早期胃癌直径、淋巴结微转移与组织E1AF、MMP-7mRNA表达临床研究

早期胃癌内镜下切除的安全性取决于严格的术前分期、肿瘤直径及有无淋巴结转移。研究证实早期胃癌组织分型、肿瘤直径、淋巴结微转移与E1AF、MMP-7mRNA表达具有相关性,并使其具有侵袭转移的生物行为。根据临床病理特征及相关组织内E1AFmRNA、MMP-7mRNA表达选择治疗方式,以获取更好疗效。     

The Relation of Social Support and Coping to Positive Adaptation to Breast Cancer

Survivors of childhood cancer are at risk of compromised physical and psychological functioning as a result of disease and treatment. However, survivors experiencing similar physical problems vary considerably in their self-reported Quality of Life (QOL) raising questions about the processes underlying adjustment and maintenance of QOL. Seventy seven survivors of either Acute Lymphoblastic Leukaemia (ALL) or tumours of the Central Nervous System (CNS) completed a standardised measure of QOL and semi-structured interview. Based on theoretical assumptions that QOL reflects a difference between what survivors can, and would like to be able to do, interviews were coded for reports of discrepancies and any coping strategy employed. Survivors of tumours of the CNS reported worse QOL and more discrepancies than survivors of ALL. A significant relationship was found between QOL measured by questionnaire and number of reported discrepancies. Five kinds of strategies to reduce discrepancies were identified: changing activity, devising a “plan of action”, emotional denial, making social comparisons, and seeking social support. Survivors who reported neither discrepancies nor strategies had better QOL than those who reported both discrepancies and strategies or discrepancies but no strategies. Data are discussed in terms of rehabilitation of survivors of childhood cancer.     

CXCR4和CXCR7在甲状腺癌中的表达及病理意义

研究甲状腺癌组织中趋化因子4受体（CXCR4）和趋化因子7受体（CXCR7）的表达情况及临床病理意义。应用免疫组织化学PV-6000法及Westernblot法检测CXCR4与CXCR7在甲状腺癌中的表达。二者在甲状腺癌与甲状腺良性疾病组织的差异均具有统计学意义（P〈0．05）,在甲状腺癌中表达仅与淋巴结转移有关（P〈0．05）,CXCR4与CXCR7之间呈正相关。Westernblot结果提示二者在甲状腺癌中的表达率高于癌旁及甲状腺腺瘤。CXCR4和CXCR7的表达水平与淋巴结转移相关,可作为甲状腺癌预后的判断指标。     

The Development of Narrative Comprehension and Its Relation to Other Early Reading Skills

The first goal of this study was to examine young children's developing narrative comprehension abilities using theory-based, authentic measures of comprehension processes. The second goal was to examine the relations among young children's comprehension abilities and other early reading skills. Children ages 4 and 6 listened to or watched two authentic narratives. We measured their comprehension of these narratives as well as vocabulary and skills associated with word decoding. The results revealed that even the younger children were sensitive to the underlying structure of the narratives and that this sensitivity increased with age. Measures of narrative comprehension were not consistently correlated with skills associated with word decoding, such as phonological awareness. The results are discussed in terms of theoretical models of comprehension and of reading development. Practical implications of the findings are also explored.     

青少年早期内化问题的稳定性及其与母亲教养的关系

通过对502名11岁城市青少年为期2年的追踪调查,考察了青少年早期内化问题发展的稳定性及母亲教养对1年后青少年内化问题的预测.结果发现:(1)青少年早期的内化问题具有较高的稳定性,与男青少年相比,女青少年保持较高的内化问题水平;(2)母亲控制惩罚教养可以正向预测1年后男青少年的内化问题,母亲温情引导可以负向预测女青少年的内化问题.青少年先前的内化问题对母亲教养与其1年后内化问题之间关系的调节作用存在性别差异:对于先前内化问题水平较高的男青少年而言,母亲较高的温情引导和控制惩罚教养正向预测其1年后的内化问题;对于先前内化问题水平较高的女青少年而言,母亲较多的温情引导则负向预测其1年后的内化问题.     

The Relation of Psychological Needs for Autonomy and Relatedness to Vitality,Well-Being,and Mortality in a Nursing Home1

Drawing from both self-determination theory (Deci & Ryan, 1991) and Carstensen's (1993) socioemotional selectivity theory, we hypothesized that well-being and health would be facilitated by: (a) greater personal autonomy; (b) perceived support for autonomy from both nursing-home staff and residents friends and relatives; and (c) the emotional quality (rather than quantity) of residents' contacts with friends and family. Results based on structured interview and survey data from 50 nursing-home residents, showed that both autonomy support and relatedness indexes correlated with psychological out-comes. Personal autonomy also was significantly related to mortality at a 1-year follow-up. It also was found that subjective vitality (Ryan & Frederick, 1997) was associated with lower distress and greater well-being, and perceived autonomy and relatedness.     

Great Expectations: The Relation Between Expectancies and Adjustment During the Transition to University1

The nature of students' expectations about university, and their relation with adjustment in university, were examined in a longitudinal investigation. Prior to starting university, participants responded to open‐ended questions regarding their expectations about university. At this time, and during their 1st, 2nd, and 4th years of study, measures of adjustment were completed. Four distinct types of expectations about university were identified: optimistic, prepared, fearful, and complacent. Students whose expectations were fearful reported more stress, depression, and poorer university adjustment than did individuals with other types of expectations, particularly prepared. Moreover, group differences in university adjustment existed throughout students' 4 years at university, and were not attributable to self‐reported previous levels of personal adjustment or academic achievement.     

The Relation of Parental Emotionality and Related Dispositional Traits to Parental Expression of Emotion and Children's Social Functioning

The purpose of this study was to test relations between parental temperamental emotionality and regulation or related personality characteristics and parental behavior, children's regulation, and children's social functioning. Mothers and fathers reported on their own personality and/or temperament and expressivity in the family (mothers only); parents and teachers rated children (71 girls and 99 boys; M age = 73 months) on their temperamental regulation, social competence, and problem behavior. Mothers also were observed interacting with their child, and behavioral measures of children's regulation were obtained. In general, high parental regulation and low negative emotionality were associated with positive developmental outcomes in children and more positive parental behaviors, and mothers' expression of positive emotion in the family mediated some of the relations of their dispositions to children's socioemotional functioning.     

SOD在消化性溃疡、胃癌患者血浆、组织中活性的测定及临床意义

研究SOD活性在正常成人与消化性溃疡、胃癌患者血浆和胃黏膜病变组织中的变化.用改良邻苯三酚自氧化法测定正常人与消化性溃疡和胃癌患者血浆、组织中超氧化物歧化酶(SOD)活性.结果显示,溃疡患者血浆SOD活性为3.555U/μl,与正常人相比(P＞0.05);组织中SOD活性为1.502U/μl,低于正常人(P＜0.001);胃癌患者血浆中SOD活性为3.081U/μl,组织中SOD活性为0.55U/μl,均低于正常对照与溃疡病患者(P＜0.001).溃疡、癌症时组织中SOD活性均降低,后者明显低于前者.SOD活性测定有可能成为胃癌诊断中一个敏感的有价值的临床生化检验指标.     

HPV DNA整合、E2缺失与宫颈癌演变的关系

高危型人乳头瘤病毒（HPV）感染是宫颈癌发病的必要条件,而HPV DNA与宿主基因组的整合及由此导致的E2基因断裂可能是宫颈癌致癌机制的关键。本文将从HPV感染、病毒基因组与宿主染色体整合及宫颈癌的演变历程中以哲学视角思考HPV DNA整合、E2基因缺失及宫颈癌演变的辩证关系,以期更好地解读宫颈癌发病原理并最终应用于临床治疗。