Placebo-mediated, Naloxone-sensitive suggestibility of short-term memory performance

Physiological studies of placebo-mediated suggestion have been recently performed beyond their traditional clinical context of pain and analgesia. Various neurotransmitter systems and immunological modulators have been used in successful placebo suggestions, including Dopamine, Cholecystokinin and, most extensively, opioids. We adhered to an established conceptual framework of placebo research and used the μ-opioid-antagonist Naloxone to test the applicability of this framework within a cognitive domain (e.g. memory) in healthy volunteers. Healthy men (n=62, age 29, SD=9) were required to perform a task-battery, including standardized and custom-designed memory tasks, to test short-term recall and delayed recognition. Tasks were performed twice, before and after intravenous injection of either NaCl (0.9%) or Naloxone (both 0.15 mg/kg), in a double-blind setting. While one group was given neutral information (S-), the other was told that it might receive a drug with suspected memory-boosting properties (S+). Objective and subjective indexes of memory performance and salivary cortisol (as a stress marker) were recorded during both runs and differences between groups were assessed. Short-term memory recall, but not delayed recognition, was objectively increased after placebo-mediated suggestion in the NaCl-group. Naloxone specifically blocked the suggestion effect without interfering with memory performance. These results were not affected when changes in salivary cortisol levels were considered. No reaction time changes, recorded to uncover unspecific attentional impairment, were seen. Placebo-mediated suggestion produced a training-independent, objective and Naloxone-sensitive increase in memory performance. These results indicate an opioid-mediated placebo effect within a circumscribed cognitive domain in healthy volunteers.     

Predicting depression using earliest childhood memories

In order to investigate the utility of earliest childhood memories (EMs) in clinical assessment, this study investigated the value of EMs in predicting naturally occurring depressive mood states. Of interest were those features of EMs that discriminate depressed from nondepressed individuals. Subjects were 212 undergraduate volunteers who completed the Beck Depression Inventory, the Profile of Mood States, and a self-administered EM questionnaire. Utilizing thematic predictors derived from cognitive and psychodynamic theories of depression, depressed subjects were differentiated from nondepressed subjects at a rate significantly greater than chance, p less than .001, with a highly respectable estimate of cross-validation shrinkage. The findings demonstrate the phenomenon of mood dependent recall in autobiographical memory, namely, that memory attributes are strongly influenced by current mood state. Consistent with psychodynamic theories of depression and in contrast to cognitive theory, depressive mood states appear to facilitate retrieval of memory schemas involving deprivation and disturbing human interaction. Schemas involving loss of control, failure, or reactions to noncontingent reinforcement (perceptions of the self as agent) appear less salient than relationship schemas (perceptions of the self as related) in depressive experience.     

一种混合型前瞻记忆的加工机制

通过两个实验, 对以往研究忽略的一种基于事件进行反应、且具有时间线索的混合型前瞻记忆的加工过程进行考察。结果表明, 这种混合型的前瞻记忆可以通过控制加工或自动加工提取, 还可能两种加工交替存在, 被试在执行过程中, 根据时间信息, 有选择地、动态地将注意资源投入于不同时间段, 现有理论不能解释这种现象。对多重加工理论进行补充, 使之能够解释这种混合型前瞻记忆的加工机制。     

状态焦虑对时距知觉的影响：认知评价和注意偏向有调节的中介作用

探讨状态焦虑对时距知觉的影响以及注意偏向与认知评价在其中的中介和调节作用。招募大学生60人, 随机分为高、低状态焦虑组, 用情绪诱导程序诱导高、低状态焦虑; 用点探测范式测量注意偏向; 用时间再现任务测量时距知觉; 用视觉模拟心境量表测量认知评价。结果发现：(1)状态焦虑会导致对2000 ms时距的高估; (2)注意偏向在状态焦虑对2000 ms时距知觉的影响中具有部分中介作用; (3)状态焦虑通过注意偏向影响时距知觉的中介过程受到认知评价的调节作用：只有当认知评价得分较高时, 即个体认为焦虑对心理健康有害程度较高时, 状态焦虑通过注意偏向影响2000 ms时距知觉。研究结果揭示了焦虑个体时距知觉的内部过程, 丰富了焦虑通过注意偏向影响时距知觉的解释视角, 为通过认知评价和注意偏向的调整改善焦虑个体时距偏差现象提供了重要参考。     

Emotion and prior knowledge in memory and judged comprehension of ambiguous stories

Abstract

Two experiments investigated the effects of experimentally induced mood states on memory and judged comprehension of stories. The experiments examined the issue of whether induction of a depressed mood would affect prose memory and comprehension and impair the ability of individuals to use prior knowledge, activated by way of a title, in remembering the passage. In Experiment 1, depressed subjects who were given a title for the passage recalled fewer idea units when compared with neutral control conditions, but no depressive deficit in recall occurred in the absence of a title. In Experiment 2 the same pattern of results occurred when subjects learned two successive passages. The depressive deficits obtained were interpreted in terms of a resource allocation model which proposes that emotional states increase the production of irrelevant, competing thoughts that interfere with processes important in remembering the criterion passage. Alternative explanations involving cognitive initiative and schema theory were discussed. Finally, judgments of comprehension predicted passage recall and were better predictors for neutral than depressed mood subjects. A depressed mood state did not affect average judgments of comprehension even when recall was correspondingly impaired.     

Media multitasking and failures of attention in everyday life

Using a series of online self-report measures, we examine media multitasking, a particularly pervasive form of multitasking, and its relations to three aspects of everyday attention: (1) failures of attention and cognitive errors (2) mind wandering, and (3) attentional control with an emphasis on attentional switching and distractibility. We observed a positive correlation between levels of media multitasking and self-reports of attentional failures, as well as with reports of both spontaneous and deliberate mind wandering. No correlation was observed between media multitasking and self-reported memory failures, lending credence to the hypothesis that media multitasking may be specifically related to problems of inattention, rather than cognitive errors in general. Furthermore, media multitasking was not related with self-reports of difficulties in attention switching or distractibility. We offer a plausible causal structural model assessing both direct and indirect effects among media multitasking, attentional failures, mind wandering, and cognitive errors, with the heuristic goal of constraining and motivating theories of the effects of media multitasking on inattention.     

The effect of trait anxiety and mood manipulation on the breadth of attention

Eysenck (1992) predicts that among trait‐anxious individuals high levels of state anxiety broaden the attentional beam in order to facilitate the detection of threat. An experiment was therefore conducted to investigate the interactive role of trait anxiety and mood manipulation on attentional broadening. Target material varying in threat‐relatedness and concern‐relevance was presented to participants' central (parafoveal) and peripheral visual field. Whilst a mood manipulation was associated with a broadening of the attentional beam, it occurred irrespective of trait anxiety. However, differences in the processing of target material were determined by an interaction between trait anxiety and the mood manipulation. Specifically, when placed in an anxiety‐provoking mood manipulation, those high in anxiety increased in their vigilance for concern‐relevant threatening material. These results are discussed in light of Eysenck's hypervigilance theory of anxiety and attention. Copyright © 1999 John Wiley & Sons, Ltd.     

The influence of positive mood on different aspects of cognitive control

Some evidence suggests that positive mood influences cognitive control. The current research investigated whether positive mood has differential effects on two aspects of cognitive control, working memory and prepotent response inhibition. In Study 1, following either a positive or neutral mood induction, participants completed the Running Memory Span (RMS), a measure primarily of working memory storage capacity, and the Stroop task, a measure of prepotent response inhibition. Results were that the positive mood group performed worse on the RMS task but not on the Stroop task. In Study 2, participants completed the RMS and another measure of prepotent response inhibition, the Flanker task. Results were that when in a positive mood state participants performed worse on the RMS but not on the Flanker task. Overall, this research suggests that positive mood has differential effects on cognitive control, impairing working memory but having no effect on prepotent response inhibition.     

Individual differences in everyday retrospective memory failures

The present study examined individual differences in everyday retrospective memory failures. Undergraduate students completed various cognitive ability measures in the laboratory and recorded everyday retrospective memory failures in a diary over the course of a week. The majority of memory failures were forgetting information pertaining to exams and homework, forgetting names, and forgetting login and ID information. Using latent variable techniques the results also suggested that individual differences in working memory capacity and retrospective memory were related to some but not all everyday memory failures. Furthermore, everyday memory failures predicted SAT scores and partially accounted for the relation between cognitive abilities and SAT scores. These results provide important evidence for individual differences in everyday retrospective memory failures as well as important evidence for the ecological validity of laboratory measures of working memory capacity and retrospective memory.     

Effects of induced elation-depression on the accessibility of memories of happy and unhappy experiences

Elated and depressed moods were induced in student volunteers on separate occasions. On each occasion they retrieved past real-life experiences associated to stimulus words presented. Subjects subsequently rated the experiences for happiness-unhappiness and pleasantness-unpleasantness on a third occasion in a neutral mood state. Extremely unhappy memories were significantly more likely to be retrieved in the depressed mood than in the elated mood. Extremely happy memories were significantly more likely to be retrieved in the elated mood than in the depressed mood. Measures of latency of retrieval showed a significant interaction between mood state and type of memory. The results confirm the generality of previous findings in suggesting an effect of mood state on the accessibility of different types of cognition. The results are considered in relation to mood as a context in contextual-specific encoding and retrieval, and in relation to models and treatment of clinical conditions.     

Vulnerability to depression: cognitive reactivity and parental bonding in high-risk individuals

Although various conceptual proposals have suggested that disruptions in childhood bonding processes may be linked to the origins of these cognitive structures, little research has tested these proposals. This study assessed the information processing of vulnerable individuals and its relationship to childhood bonding. Formerly depressed (vulnerable) and never depressed (nonvulnerable) individuals participated in a mood induction task followed by an attentional allocation task. Results indicated that vulnerable individuals uniquely diverted attention toward negative stimuli when they were in a negative mood. Furthermore, level of maternal caring was found to be associated with performance on this task for vulnerable individuals in this mood state. These data support the idea that cognitive variables form a pathway between troublesome parental-child/adolescent interactions and depression.     

前瞻记忆意图后效中执行错误的机制

前瞻记忆意图后效是指已完成或取消的意图失活失败对当前认知任务造成的干扰。近期研究采用前瞻记忆任务范式探究意图后效的影响因素及认知机制。自发提取-抑制失败和预备性监控两种认知机制的分歧在于提取旧意图是否依赖注意资源的参与。脑成像研究也证实意图提取存在两条神经通路：自发提取通路和预备性监控提取通路。未来研究应探索兼容有意遗忘失败、旧意图再提取、抑制失败三者的研究范式以及降低执行错误的有效措施。     

The illusion of the positive: The impact of natural and induced mood on older adults' false recall

ABSTRACT Recent research suggests that affective and motivational processes can influence age differences in memory. In the current study, we examine the impact of both natural and induced mood state on age differences in false recall. Older and younger adults performed a version of the Deese-Roediger-McDermott (DRM; Roediger & McDermott, 1995 , Journal of Experimental Psychology: Learning, Memory, and Cognition, 21, 803) false memory paradigm in either their natural mood state or after a positive or negative mood induction. Results indicated that, after accounting for age differences in basic cognitive function, age-related differences in positive mood during the testing session were related to increased false recall in older adults. Inducing older adults into a positive mood also exacerbated age differences in false memory. In contrast, veridical recall did not appear to be systematically influenced by mood. Together, these results suggest that positive mood states can impact older adults' information processing and potentially increase underlying cognitive age differences.     

Bidirectional interactions between circadian entrainment and cognitive performance

Circadian rhythms influence a variety of physiological and behavioral processes; however, little is known about how circadian rhythms interact with the organisms' ability to acquire and retain information about their environment. These experiments tested whether rats trained outside their endogenous active period demonstrate the same rate of acquisition, daily performance, and remote memory ability as their nocturnally trained counterparts in tasks of sustained attention and spatial memory. Furthermore, we explored how daily task training influenced circadian patterns of activity. We found that rats demonstrate better acquisition and performance on an operant task requiring attentional effort when trained during the dark-phase. Time of day did not affect acquisition or performance on the Morris water maze; however, when animals were retested 2 wk after their last day of training, they showed better remote memory if training originally occurred during the dark-phase. Finally, attentional, but not spatial, task performance during the light-phase promotes a shift toward diurnality and the synchronization of activity to the time of daily training; this shift was most robust when the demands on the cognitive control of attention were highest. Our findings support a theory of bidirectional interactions between cognitive performance and circadian processes and are consistent with the view that the circadian abnormalities associated with shift-work, aging, and neuropsychiatric illnesses may contribute to the deleterious effects on cognition often present in these populations. Furthermore, these findings suggest that time of day should be an important consideration for a variety of cognitive tasks principally used in psychological and neuroscience research.     

Reduced specificity of autobiographical memories following a negative mood induction

Reduced autobiographical memory specificity (AMS) to emotional and neutral cue words appears to be a stable cognitive marker of clinical depression. For example, reduced AMS is present in remitted/recovered depressed patients and shows no reliable relationship with current levels of depressed mood in correlational studies. The present study examined whether reduced AMS could be induced in healthy volunteers with no history of depression, using a negative mood manipulation and whether levels of AMS and induced mood were positively correlated. Results showed a reduction in AMS following negative mood induction, compared to a neutral induction, whereas positive mood induction had no effects on AMS. Furthermore, lower happiness following the induction phase correlated positively with reduced AMS, and the extent of happiness reduction from pre- to post-induction correlated positively with reduction in AMS. These results suggest that AMS is, at least in part, a function of current emotion state. The implications for the literature on AMS as a stable marker of clinical depression are discussed.     

Thought suppression and its effects on thought frequency, appraisal and mood state in individuals with obsessive-compulsive disorder

Leading models of obsessive-compulsive disorder (OCD) implicate thought suppression as a key factor in the escalation and persistence of the disorder. This experiment examined the effects of suppression on the frequency of obsessional thoughts in 50 individuals with a primary diagnosis of OCD, and also investigated the effects of participants' appraisals regarding their failures in thought control on distress about intrusive thoughts and on mood. Participants' most upsetting obsessional thought was primed and they then monitored its occurrence over two 4-min intervals. In the first interval, half of the participants were instructed to suppress their obsessional thought and half were instructed not to suppress any thoughts. In the second interval, all participants were given the 'Do Not Suppress' instructions. Participants rated their suppression effort and discomfort over thought occurrences after each interval and recorded their appraisals of thought recurrences during the first interval. Mood state was then reassessed. No ironic effect of suppression on frequency was noted. However, negative appraisals of thought recurrences were associated with more discomfort over thought occurrences and more negative mood at Time 2. These findings suggest that interpretations regarding failures in thought control may be of central importance in understanding obsessional problems.     

Negative prospective memory: Remembering not to perform an action

Sometimes it is important to remember not to perform an action, such as remembering to stop taking seasonal allergy medicine when it is no longer needed. Mistakes in accomplishing this goal can involve prospective memory commission errors when individuals mistakenly perform a prospective response. In two experiments, we investigated the role of attentional resources in preventing prospective memory errors to cues that had been associated with a habitual prospective response. In Phase 1 of our experiments, participants performed a prospective memory task during which they either routinely responded to prospective memory cues or responded to these cues one time only. On a subsequent prospective memory task, the participants who had routinely responded to prospective memory cues were vulnerable to commission errors when their attentional resources were taxed. By contrast, dividing attention did not increase commission errors to cues that had not been routinely performed on an earlier task. These data indicate that attentional resources are needed to withhold making habitual prospective memory responses, and they suggest that inhibitory failures are a cause of these prospective memory errors. Finally, we suggest a broader definition of prospective memory that includes remembering to withhold performing actions.     

基于记忆的注意捕获和注意抑制效应：ERP证据

采用工作记忆与视觉搜索双任务范式, 通过操作匹配试次出现概率来诱发不同水平的认知控制动机, 考察了基于记忆的注意引导过程的时程特点。结果：记忆匹配刺激首先诱发了N2pc成分, 随后诱发了与抑制过程相关的差异正波。并且, 认知控制动机水平越高, N2pc波幅越小、潜伏期越短; 抑制性差异正波波幅越大。结论：基于记忆的注意引导过程包括早期的注意捕获和后期的注意抑制两个阶段; 其效应量和时程受到认知控制动机水平的调节。     

前瞻记忆后效的加工机制：对自发提取观点和抑制观点的检验

摘 要 实验1探究前瞻记忆后效的产生是否消耗认知资源,实验2进一步探究前瞻记忆后效产生过程中消耗的认知资源的去向。实验1结果显示在完成阶段,相比于基线条件,其它四种实验条件的进行中任务反应速度均较慢,实验2结果显示无论线索是否显著,前瞻记忆后效均会随着认知负荷的提高而提高。结果表明前瞻记忆后效产生过程中会消耗认知资源对原意向进行抑制。本研究支持了抑制的观点。     

Relationship between frequency of involuntary autobiographical memories and cognitive failure

Involuntary autobiographical memories are memories of personal experiences that pop into mind without a conscious attempt at their retrieval. This study investigated individual differences in the number of involuntary autobiographical memories, and explored the relationship between the frequency of occurrence in involuntary autobiographical memory and cognitive failures in everyday memory, as indexed by metamemory questionnaires. A total of 24 undergraduate students reported involuntary autobiographical memories in controlled field interviews, and completed the Everyday Memory Questionnaire and the Cognitive Failures Questionnaire. The results showed that, despite controlled conditions, considerable individual differences were observed in the number of involuntary autobiographical memories reported while walking along a prescribed route on the campus, and that reported memories were predominantly serving self function. In addition, the number of involuntary autobiographical memories was positively related to cognitive failures in everyday memory: participants who acknowledged more problems in everyday memory had a higher frequency of involuntary memories. The implications of these results are discussed in terms of the complementary function of involuntary autobiographical memory in everyday life.