Oral contraceptive use and hemodynamic, lipid, and fibrinogen responses to smoking and stress in women.

The effects of acute smoking and oral contraceptive (OC) use on cardiovascular, lipid, and fibrinogen stress responses were examined in 52 female smokers and nonsmokers, half of whom were using OCs. Women smoked or sham-smoked a cigarette and then performed 2 stressful tasks. Stress elicited increases in total and low-density lipoprotein cholesterol, and in triglycerides among women who smoked, and in fibrinogen among all women. Smokers who used OCs had greater blood pressure increases to smoking and to stress than did smokers who did not use OCs. OC use was also associated with enhanced total peripheral resistance stress responses among women who smoked and cardiac output stress responses among women who sham-smoked. Results suggest that OC use moderates cardiovascular reactivity in smokers but not nonsmokers, enhancing vascular responsivity to smoking combined with stress and myocardial responsivity to stress alone.     

Dissecting adrenal and behavioral responses to stress by targeted gene inactivation in mice

To define the molecular pathways modulating adrenal and behavioral responses to stress, we have generated mice with inactivation of hypothalamic neuropeptides and signaling pathways. Studies in mice deficient in corticotropin-releasing hormone (CRH) have revealed the essential role for CRH in adrenal glucocorticoid production in response to many physiological and psychological stressors. Immune system activation in CRH-deficient mice provides a unique exception to the necessity for CRH in stimulating adrenal glucocorticoid production. By analyzing mice deficient in interleukin-6 (IL-6) and CRH, we find that restoration of glucocorticoid output with inflammation is largely mediated by dysregulated IL-6 production. Current studies focus on identifying cellular and gene targets by which glucocorticoids regulate immune system function. In contrast to impaired adrenocortical responses to stress, CRH-deficient mice exhibit normal behavioral responses to stress. To determine signaling pathways that may contribute to the behavioral responses to stress, we have generated and analyzed mice deficient in adenylyl cyclase type 8 (AC8). AC8 deficient mice have intact adrenocortical responses to stress, but an inability to undergo stress-induced alterations in behavior.     

The influence of gender, hypertension risk, and aerobic fitness on cardiovascular responses to laboratory-induced stress

The study sought to evaluate the influence of gender, hypertension risk, and aerobic fitness on cardiovascular responses to laboratory-induced stress. Sixty nonsymptomatic subjects (30 males, 30 females) participated in the experiment. Half of the subjects had at least one biological parent with hypertension, while half had no parental history of hypertension and served as comparison subjects. Subjects completed a laboratory procedure measuring cardiovascular responses (i.e., pulse rate and blood pressure) while performing stressful laboratory tasks (i.e., the Stroop Color Naming Test and a sham IQ test). Aerobic fitness (i.e., VO_2max using the Bruce protocol) was also determined using a submaximal treadmill test in the laboratory. Results suggest that males with a family history of hypertension were more stress responsive based on systolic blood pressure, while females were more stress-responsive according to pulse rate activity. Fitness levels were significantly associated with diastolic blood pressure throughout the stress and recovery periods but were unrelated to pulse rate and systolic blood pressure.     

A note on responses to ethyl alcohol before and after smoking1

Differential sensitivity was measured before and after smoking a cigarette by 10 smokers, using 10 nonsmokers as controls. Stimuli consisted of reagent grade ethanol in eight concentrations ranging from 4% to 12%. No significant differences were observed between smokers and nonsmokers or before vs after smoking, although slightly higher overall correct responses and correspondingly smaller jnds were obtained for the nonsmokers. No practice affects were noted among the control group between the first and second set of samples. The findings confirm previous results which had been recently questioned.     

Race,gender, and the response to stress: Autoworkers' vulnerability to long-term unemployment

A three-wave panel study of auto plant closings focused on the mental health effects of unemployment on blue-collar workers. This paper explores how the impact of long-term unemployment varies across race and gender. We also examine whether other demographic factors can themselves modify the impactsof race and gender. Dependent variables include two measures of distress and two drinking measures. Results showed that the effect of long-term unemployment on distress and drinking was more severe among less educated workers, and responses of blacks were especially sensitive to level of education. In addition, men showed a greater association of long-term unemployment with depression (and to some extent anxiety) than did women. Marriage affected the responses of men but not of women, and of whites but not of blacks. Explanatory variables—the worker's experiences of financial hardship, other negative life events, and lack of a confidant—largely accounted for male-female differences. We conclude by discussing theoretical implications of these effects and address the limitations of the traditional term “vulnerability” in describing them. A prior version of this paper was presented at the North Central Sociological Association meeting in Dearborn, Michigan, April 25, 1991. Funds for the research were provided by the Michigan Health Care Research and Education Foundation and by the International Union-UAW. We are especially grateful to the men and women of the UAW, whose experiences and views form this investigation. We thank Kiseon Chung, Scott McKearney, David Rauma, and the anonymous reviewers for their comments on earlier drafts.     

Race and genetics: controversies in biomedical, behavioral, and forensic sciences

Among biomedical scientists, there is a great deal of controversy over the nature of race, the relevance of racial categories for research, and the proper methods of using racial variables. This article argues that researchers and scholars should avoid a binary-type argument, in which the question is whether to use race always or never. Researchers should instead focus on developing standards for when and how to use racial variables. The article then discusses 1 context, criminology, in which the use of racial variables in behavioral genetics research could be particularly problematic. If genetic studies of criminalized behavior use forensic DNA databanks or forensic genetic profiles, they will be confounded by the many racial biases of the law enforcement and penal system.     

Discrimination, dispositions, and cardiovascular responses to stress.

OBJECTIVE: Recent research suggests that past exposure to discrimination may influence perceptions of, and physiological responses to, new challenges. The authors examined how race and trait levels of hostility and optimism interact with past exposure to discrimination to predict physiological reactivity and recovery during an anger recall task. DESIGN: A community sample of 165 normotensive Black and White adults participated in an anger recall task while having their cardiovascular function monitored. MAIN OUTCOME MEASURES: Blood pressure and heart rate indicators of physiological reactivity and recovery. RESULTS AND CONCLUSION: Participants had higher reactivity and slower recovery to the anger recall task when they had high past discrimination, low cynicism, or high optimism. The pattern of effects was similar for both racial groups, but Blacks had more acute reactivity and slower recovery than Whites. These results are consistent with the perspective of discrimination as a chronic stressor that is related to acute stress responses, particularly for Blacks.     

Early environment, emotions, responses to stress, and health

A harsh early family environment is related to mental and physical health in adulthood. An important question is why family environment in childhood is associated with these outcomes so long after its initial occurrence. We describe a program of research that evaluates a model linking these variables to each other. Specifically, we hypothesize that low social competence and negative emotional states may mediate relations between a harsh early family environment and physiological/neuroendocrine responses to stress, as well as long-term health outcomes. We report evidence that the model characterizes self-rated health, cortisol responses to stress, and, in males only, elevated cardiovascular responses to stress. We discuss how the social context of early life (such as SES) may affect the family environment in ways that precipitate adverse health consequences. Perspectives on comorbidities in physical and mental health are discussed.     

Verbal and behavioral responses to familiar and unfamiliar music

Thirty adult subjects completed an Operant Music Listening Recorder (OMLR) task with two unfamiliar and two familiar music channels (one “popular” and one “classical” in each case), then rated the music on each channel on seven-point scales for liking, quality, and familiarity. The two familiar music channels received significantly higher ratings than the two unfamiliar channels on all three rating scales, and there were no significant main effects or interactions involving musical style. The predictions (a) that subjects would spend more time listening to the familiar channels on the OMLR task, and (b) that measures of listening time would display higher correlations with ratings of liking than with those of quality both received weak support from the direction of the results, but neither was confirmed by statistical significance tests. The results are discussed in terms of the fragmentation between the affective and evaluative components of attitudes toward music.     

Children's affective,behavioral, and cognitive responses to social comparison

Relative outcomes in social commerce with peers are potent determinants of cognitions and behavior in young children. Although there has been considerable attention given to the behavioral consequences of social comparisons following the receipt of rewards, there has been less concern with cognitive or affective consequences. Additionally, little is known about the accrued effects of multiple social comparison experiences that may be consistent or inconsistent with one another. In the present study, young children received a constant level of reward but the amount they saw a peer receive was varied. There were two sequences of reward distribution, and in a given sequence children received either the same number of rewards as the peer (=), more (+), or fewer (?). In a 3 × 3 factorial design all possible combinations occurred. A negative inequality in reward distribution, no matter where it fell in a sequence, made children sad and inclined children to distribute fewer rewards to peers. When a sequence contained an initial experience of positive inequality, children decreased subsequent levels of self-reward. Experiencing a comparison that revealed a negative inequality in reward distribution also disrupted children's accuracy in appraising the overall distribution of rewards: even when an initial negative inequality was completely offset by an equivalent experience of positive inequality, children inaccurately concluded that they had received fewer rewards than their peers.     

Affective and behavioral responses to health-related social control.

Social control has the potential to encourage engagement in a healthy lifestyle, but its effectiveness may depend on the nature of the influence attempt. Participants (N = 282) described a situation in which someone attempted to influence their health-related behavior. Experiencing positive social control was associated with a greater tendency to change the behavior and less ignoring/doing nothing, whereas negative social control was associated with a lesser tendency to change the behavior and more hiding of unhealthy behavior. These associations could be accounted for by affective responses to the social control attempts. Results emphasize the need to better understand the regulatory influence of relationships on health behavior and the conditions under which social control is most likely to have health-promoting effects.     

Patterns of cardiovascular responses to stress as a function of race and parental hypertension in men

This study investigated cardiovascular responses to two stressors known to elicit either beta-adrenergic (mental arithmetic) or alpha-adrenergic (forehead cold pressor) reactivity in Black and White men. Participants in each group were selected for presence or absence of parental hypertension. Based on previous research, Blacks were expected to show smaller cardiovascular responses to the beta-adrenergic mental arithmetic task and greater responses to the alpha-adrenergic cold pressor relative to the Whites. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, forearm blood flow, and forearm vascular resistance were assessed during a resting baseline, a prestress period, and during and after each experimental procedure. Unlike previous findings, no significant racial differences in cardiovascular responses were found during either task. However, Black participants had significantly higher SBP and DBP levels throughout the cold pressor periods. Parental history did not significantly influence cardiovascular responses in either group. The results are discussed in relation to previous research on racial differences in stress reactivity and their implications for future research.     

Adrenal gland responses to lipopolysaccharide after stress and ethanol administration in male rats

All forms of stress, including restraint stress (RS) and lipopolysaccharide (LPS) administration, activate the hypothalamic-pituitary-adrenal (HPA) axis. LPS binds to a recognition protein (CD14) and toll-like receptor 2/4 in different cells and tissues, including the adrenal gland, to induce the production of cytokines and cause upregulation of cyclooxygenase and nitric oxide synthase (NOS) enzymes. Acute ethanol exposure activates the HPA axis, but in some conditions prolonged administration can dampen this activation as well as decrease the inflammatory responses to LPS. Therefore, this study was designed to evaluate the adrenal response to a challenge dose of LPS (50 μg/kg) injected i.p., after submitting male rats to RS, twice a day (2 h each time) for 5 days and/or ethanol administration (3 g/kg) by gavage also for 5 days, twice daily. At the end of the experiment, plasma corticosterone concentrations and adrenal gland content of prostaglandin E (PGE) and NOS activity were measured as stress mediators. The results showed that repetitive ethanol administration attenuated the adrenal stress response to LPS challenge alone and after RS, by preventing the increase in plasma corticosterone concentrations and by decreasing the PGE content and NOS activity in the adrenal gland. Therefore, we conclude that moderate alcohol consumption could attenuate the effects of psychophysical stress and impair an inflammatory response.     

Vasopressin response to osmotic and hemodynamic stress: neurotransmitter involvement

Osmotic and hemodynamic stress are the two primary regulators of vasopressin (VP) release from the posterior pituitary. The pathways providing information about plasma osmolality and blood pressure or blood volume are distinct and utilize different chemical neurotransmitters. Osmotic regulation of VP release is dependent upon afferents from the lamina terminalis region. Glutamate is an important transmitter in this system and angiotensinergic afferents from this region to the VP neurons modulate responses to osmotic challenges. Hemodynamic information is transmitted to the VP neurons via multisynaptic pathways from the brainstem with the A1 catecholamine neurons of the ventrolateral medulla providing the final link for information about decreases in blood pressure and volume. Several neurotransmitters and neuropeptides are expressed in the A1 neurons including norepinephrine (NE), ATP, neuropeptide Y, and substance P. The impact of co-release of these agents on VP release is reviewed and the potential physiological significance is discussed.     

Type A behavior, personality hardiness, and cardiovascular responses to stress

Type A behavior and hardiness were examined as predictors of cardiovascular responses to stress in 68 male undergraduates. Systolic and diastolic blood pressure (SBP and DBP) and heart rate were monitored while subjects performed a difficult mirror-tracing task. Type A assessments based on the Structured Interview, but not those based on the Jenkins Activity Survey, were associated with significantly enhanced SBP and DBP elevations. Hardiness was associated with significantly reduced DBP responsiveness. In addition, a significant interaction indicated that the Type B-high hardiness group showed the least DBP reactivity. A near-significant interaction (p = .06) suggested that Type B-high hardiness subjects also reported the least anger. Further exploration of the data indicated that the challenge component of hardiness accounted for its relationship to DBP reactivity. These results have implications both for the psychophysiologic study of Type A behavior and for understanding the health-promoting effects of hardiness.     

Race and vulnerability to stress: an examination of differential vulnerability

In this article the possibility of race differences in vulnerability to stress is considered. Structural models linking socioeconomic status, age, and life-change events to psychological distress are fit to blacks' and whites' data, which were obtained in a community survey of 829 Florida residents to evaluate differences in vulnerability. Life-change-distress paths were slightly larger among blacks than among whites, though not significantly so. The possible adaptive or coping resources provided by supportive social ties and by fatalistic responses to chronic stress are suggested as topics for further research with regard to psychological well-being among disadvantaged groups.     

Body fat distribution and hemodynamic stress responses in premenopausal obese women: a preliminary study.

To examine the relationship between body fat distribution and hemodynamic stress responses, cardiovascular responses to a speech task and a forehead cold pressor task were evaluated with 24 premenopausal women classified a priori as either centrally or peripherally obese. Results showed that women with central adiposity exhibited greater stress-related increases in diastolic blood pressure and total peripheral resistance, whereas women with peripheral adiposity exhibited greater stress-related increases in cardiac output. Depression, self-consciousness, hostility, and mood scores did not explain significant variance in the stress response differences between regional adiposity groups. The findings suggest that central adiposity may increase the risk of cardiovascular disease in women at least in part by enhancing vascular responses to stress.     

Infant behavioral responses to infant-directed singing and other maternal interactions

Seventy, 6-9-month-old infants were videotaped during six interactions: mother sings assigned song, "stranger" sings assigned song, mother sings song of choice, mother reads book, mother plays with toy, and mother and infant listen to recorded music. Infant-directed (ID) singing conditions elicited moderately positive cognitive behavior, low levels of positive physical behavior and minimal amounts of vocal behaviors, mostly negative. Across all conditions, cognitive scores remained positive at low to moderate levels. Physical responses were most positive during book and toy, most negative during recorded music, and differed by gender, especially during ID singing. Vocally, infants responded positively to toy, and 8-month-old infants vocalized more than younger infants, particularly during ID singing conditions. ID singing appears just as effective as book reading or toy play in sustaining infant attention and far more effective than listening to recorded music, while interactions involving objects may provide opportunity for shared attention.