Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams

Gestational cocaine treatment results in significantly increased maternal aggression towards an intruder by postpartum day six, while acute postpartum treatment dose dependently decreases maternal aggressive (MA) behavior. Both increased and decreased aggression in the cocaine-treated dams are correlated with either decreased or increased levels of oxytocin in the amygdala, respectively. The current study was an effort to determine whether the effect of gestational cocaine on maternal aggression is transient or would continue into the postpartum period; whether an intermittent cocaine treatment regimen, which incorporates gestational and postpartum intermittent cocaine treatment, would differ from chronic daily gestational treatment; and finally, whether next generation female offspring of cocaine-treated or control dams would have altered MA behavior and oxytocin system changes attributable to either prenatal drug exposure, rearing condition or both. We now report no increase in maternal aggression following chronic gestational treatment and significantly lower levels of aggression in intermittently treated dams on postpartum day eight, with no significant effects in either group on postpartum day 12. Young adult female offspring of the cocaine-treated and control dams, who reared their own natural litters and were tested on postpartum day eight for maternal aggression, had higher levels of maternal aggression towards an intruder attributable to both prenatal cocaine exposure and rearing condition. Higher aggression in cocaine-reared next generation dams was associated with lower levels of oxytocin in the amygdala. Intergenerational effects of cocaine were apparent with respect to aggression and oxytocin system changes.     

慈悲冥想对利他行为的影响及其认知神经机制

慈悲冥想是一类旨在培养对自己和他人无条件的善意与同情的冥想练习方法, 主要包括慈心禅和怜悯禅修。诸多研究表明, 慈悲冥想可以促进练习者的利他行为。就影响机制而言, 慈悲冥想可能是通过增强对他人不幸的共情反应, 促进情绪的有效调控和提高亲社会动机来影响练习者的利他行为。未来的研究需选择更具生态效度的利他行为测量方法, 深入挖掘慈悲冥想影响利他行为的动态神经加工过程, 并尝试将慈悲冥想应用于临床群体。     

The neurogenetics of nice: receptor genes for oxytocin and vasopressin interact with threat to predict prosocial behavior

Oxytocin, vasopressin, and their receptor genes influence prosocial behavior in the laboratory and in the context of close relationships. These peptides may also promote social engagement following threat. However, the scope of their prosocial effects is unknown. We examined oxytocin receptor (OXTR) polymorphism rs53576, as well as vasopressin receptor 1a (AVPR1a) polymorphisms rs1 and rs3 in a national sample of U.S. residents (n = 348). These polymorphisms interacted with perceived threat to predict engagement in volunteer work or charitable activities and commitment to civic duty. Specifically, greater perceived threat predicted engagement in fewer charitable activities for individuals with A/A and A/G genotypes of OXTR rs53576, but not for G/G individuals. Similarly, greater perceived threat predicted lower commitment to civic duty for individuals with one or two short alleles for AVPR1a rs1, but not for individuals with only long alleles. Oxytocin, vasopressin, and their receptor genes may significantly influence prosocial behavior and may lie at the core of the caregiving behavioral system.     

安全依恋对共情和利他行为的影响

利他行为(Altruistic behavior)指以增加其他个体的福利为最终目标的行为, 它既是社会心理学领域的重要研究主题也是社会和谐稳定的需要。共情(Empathy)指个体感知或想象他人的情感, 并部分体验到他人感受的心理过程, 是利他行为的内在动机。已有研究证明, 安全依恋风格和安全依恋启动对个体共情和利他行为有积极影响。根据依恋理论和相关文献可以推测, 情绪调节和认知图式可能是安全依恋影响个体共情和利他行为的两种心理机制。未来可以探讨利他行为实施者与接受者的关系远近及双方依恋风格匹配程度的调节作用, 进一步验证安全依恋影响共情和利他行为的心理机制, 探讨利他行为对安全依恋的反向促进作用以及开发通过安全依恋培养个体共情能力和利他行为的干预方案。     

Belief in altruistic human nature and prosocial behavior: a serial mediation analysis

According to the theory of internal working model, belief in altruistic human nature positively influences prosocial behavior. However, the precise influencing mechanism remains unclear. Based on the determinants of human behavior theory and self-efficacy theory, we hypothesized that belief in altruistic human nature indirectly influences prosocial behavior through causally linked multiple mediators of prosocial attitude and prosocial self-efficacy. The results of the current research supported our hypothesis and demonstrated that this serial mediation model could be generalized across individualistic and collectivistic cultures.     

Intergenerational continuity of parental rejection and depressed affect.

Using survey and observational data from a sample of 451 intact families, this study used structural equation modeling to examine the intergenerational continuity of depressed mood and rejecting parenting. The model partially replicated the intergenerational model of Elder, Caspi, and Downey (1986) that indicates a cyclical transmission process by which parents' personality traits affect parent-child interaction, which, in turn, increases the propensity for developmental problems among offspring. The results indicated a pattern of intergenerational transmission of depressed mood through parental rejection of offspring. Multiple reporters and multiple indicators strengthen previous intergenerational findings by reducing some of the method variance biases that have been problematic in prior studies.     

Strategy-dependent changes in memory: Effects on behavior and brain activity

In the present study, an implicit strategy manipulation was used to explore the contribution of memory strategy to brain activation and behavioral performance. Participants were biased to use either a short-term (maintenance-focused) or long-term (retrieval-focused) memory strategy within a single memory task through manipulation of task context. In comparing directly matched trials across the different task contexts, we observed clear changes in both behavioral performance and brain activity across a network of regions located primarily within lateral and medial frontal cortex. These effects of the memory strategy manipulation suggest that when a retrieval-focused strategy is induced, mnemonic processes are preferentially engaged during the encoding period. In contrast, when a maintenance-focused strategy is induced, mnemonic processes are preferentially engaged during the delay and response periods. Taken together, the results imply that covert cognitive strategies play an important role in modulating brain activation and behavior during memory tasks.     

Peer rejection in childhood: effects on maternal depression and behavior problems in toddlers.

The aim of this study was to develop a conceptual model that would clarify how a woman's recollections of peer and parent rejection in childhood influence her emotional well-being and, resultantly, her own child's behavior problems. Given current interest in peer versus parent influences, the authors used a design and analysis to reveal the unique contributions of peer and parent rejection. The participants were a community sample of 88 mothers and their 2 1/2-year-old children. The study found that mothers' recollections of peer rejection in childhood were significantly associated with depressive symptomatology, but recollections of parental rejection in childhood were unrelated to current depressive symptoms. Recollections of peer rejection during childhood, internal representation of self, and depressive symptoms made significant, unique contributions to the variance in behavior problems in their children. Together, these variables significantly explained 27% of the variance in the final model.     

On the relationship of frontal brain activity and anger: Examining the role of attitude toward anger

Activity in the left frontal cortex has been associated with positive affective traits, and activity in the right frontal cortex has been associated with negative affective traits. However, in this past research, the valence of the affect (positive vs. negative) was confounded with the direction of the motivation (approach vs. withdrawal). Recent research found that trait anger, a negative affect with approach tendencies, relates to increased left frontal activity. The present research addressed an alternative explanation for these past results—that the relationship between anger and increased left frontal activity is due to anger being regarded as a positive feeling. After developing a reliable and valid instrument that measures attitude toward anger, research indicated that trait anger related to relative left frontal activity and this relationship was not due to the anger being associated with a positive attitude toward anger.     

Unraveling mechanisms for expert object recognition: bridging brain activity and behavior

Behavioral sensitivity to object transformations and the response to novel objects (Greebles) in the fusiform face area (FFA) was measured several times during expertise training. Sensitivity to 3 transformations increased with expertise: (a) configural changes in which halves of objects were misaligned, (b) configural changes in which some of the object parts were moved, and (c) the substitution of an object part with a part from a different object. The authors found that holistic-configural effects can arise from object representations that are differentiated in terms of features or parts. Moreover, a holistic-inclusive effect was correlated with changes in the right FFA. Face recognition may not be unique in its reliance on holistic processing, measured in terms of both behavior and brain activation.     

Child personality and parental behavior as moderators of problem behavior: variable- and person-centered approaches

Parenting x Child Personality interactions in predicting child externalizing and internalizing behavior were investigated in a variable-centered study and a person-centered study. The variable-centered study used data from a 3-year longitudinal study of 600 children 7 to 15 years old at Time 1 and 512 children 10 to 18 years old at Time 2. Parents rated child personality (five factor model), negative control, positive parenting, and child problem behavior, whereas children rated parental behavior. Hierarchical moderated regression analyses showed significant Parenting x Child Personality (benevolence and conscientiousness) interactions, principally for externalizing behavior. The interactions were largely replicable across informants and across time. The person-centered study, which classified participants into 3 types, showed that negative parental control was more related to externalizing behavior for undercontrollers than for resilients. Negative parental control enhanced internalizing behavior for overcontrollers.